SI1539746T1 - Spojine n-substituirane-1h-indol-5-propionske kisline kot agonisti ppar, ki so uporabne za zdravljenje diabetesa - Google Patents

Spojine n-substituirane-1h-indol-5-propionske kisline kot agonisti ppar, ki so uporabne za zdravljenje diabetesa

Info

Publication number: SI1539746T1
Authority: SI; Slovenia
Prior art keywords: indol; diabetes; substituted; treatment; propionic acid
Prior art date: 2002-09-12

Application number

SI200330631T

Other languages

English (en)

Inventor

Alfred Binggeli

Uwe Grether

Hans Hilpert

Roland Humm

Hans Iding

Bernd Kuhn

Hans-Peter Maerki

Markus Meyer

Peter Mohr

Beat Wirz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2003-09-04

Publication date

2007-04-30

2003-09-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-04-30 Publication of SI1539746T1 publication Critical patent/SI1539746T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

SI200330631T 2002-09-12 2003-09-04 Spojine n-substituirane-1h-indol-5-propionske kisline kot agonisti ppar, ki so uporabne za zdravljenje diabetesa SI1539746T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP02020477		2002-09-12
EP03747962A EP1539746B1 (en)	2002-09-12	2003-09-04	N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
PCT/EP2003/009819 WO2004024726A1 (en)	2002-09-12	2003-09-04	N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes

Publications (1)

Publication Number	Publication Date
SI1539746T1 true SI1539746T1 (sl)	2007-04-30

Family

ID=31985028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200330631T SI1539746T1 (sl)	2002-09-12	2003-09-04	Spojine n-substituirane-1h-indol-5-propionske kisline kot agonisti ppar, ki so uporabne za zdravljenje diabetesa

Country Status (29)

Country	Link
US (1)	US6890947B2 (sl)
EP (1)	EP1539746B1 (sl)
JP (1)	JP4286782B2 (sl)
KR (1)	KR100645684B1 (sl)
CN (1)	CN100577660C (sl)
AR (1)	AR041218A1 (sl)
AT (1)	ATE345340T1 (sl)
AU (1)	AU2003267041B2 (sl)
BR (1)	BR0314261A (sl)
CA (1)	CA2494601C (sl)
DE (1)	DE60309719T2 (sl)
DK (1)	DK1539746T3 (sl)
ES (1)	ES2275105T3 (sl)
GT (1)	GT200300194A (sl)
HR (1)	HRP20050212A2 (sl)
MX (1)	MXPA05002704A (sl)
MY (1)	MY135646A (sl)
NO (1)	NO20050667L (sl)
NZ (1)	NZ537979A (sl)
PA (1)	PA8581701A1 (sl)
PE (1)	PE20050050A1 (sl)
PL (1)	PL375878A1 (sl)
PT (1)	PT1539746E (sl)
RU (1)	RU2296759C2 (sl)
SI (1)	SI1539746T1 (sl)
TW (1)	TWI248933B (sl)
UY (1)	UY27975A1 (sl)
WO (1)	WO2004024726A1 (sl)
ZA (1)	ZA200501273B (sl)

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WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

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2003
- 2003-09-04 JP JP2004535427A patent/JP4286782B2/ja not_active Expired - Fee Related
- 2003-09-04 MX MXPA05002704A patent/MXPA05002704A/es active IP Right Grant
- 2003-09-04 PL PL03375878A patent/PL375878A1/xx not_active Application Discontinuation
- 2003-09-04 DK DK03747962T patent/DK1539746T3/da active
- 2003-09-04 AT AT03747962T patent/ATE345340T1/de not_active IP Right Cessation
- 2003-09-04 EP EP03747962A patent/EP1539746B1/en not_active Expired - Lifetime
- 2003-09-04 CN CN03821483A patent/CN100577660C/zh not_active Expired - Fee Related
- 2003-09-04 PT PT03747962T patent/PT1539746E/pt unknown
- 2003-09-04 BR BR0314261-2A patent/BR0314261A/pt not_active IP Right Cessation
- 2003-09-04 DE DE60309719T patent/DE60309719T2/de not_active Expired - Lifetime
- 2003-09-04 CA CA002494601A patent/CA2494601C/en not_active Expired - Fee Related
- 2003-09-04 AU AU2003267041A patent/AU2003267041B2/en not_active Ceased
- 2003-09-04 RU RU2005110921/04A patent/RU2296759C2/ru not_active IP Right Cessation
- 2003-09-04 HR HR20050212A patent/HRP20050212A2/hr not_active Application Discontinuation
- 2003-09-04 SI SI200330631T patent/SI1539746T1/sl unknown
- 2003-09-04 ES ES03747962T patent/ES2275105T3/es not_active Expired - Lifetime
- 2003-09-04 KR KR1020057004166A patent/KR100645684B1/ko not_active Expired - Fee Related
- 2003-09-04 WO PCT/EP2003/009819 patent/WO2004024726A1/en not_active Ceased
- 2003-09-04 NZ NZ537979A patent/NZ537979A/en unknown
- 2003-09-08 TW TW092124737A patent/TWI248933B/zh not_active IP Right Cessation
- 2003-09-09 PA PA20038581701A patent/PA8581701A1/es unknown
- 2003-09-10 US US10/659,664 patent/US6890947B2/en not_active Expired - Fee Related
- 2003-09-10 PE PE2003000917A patent/PE20050050A1/es not_active Application Discontinuation
- 2003-09-10 GT GT200300194A patent/GT200300194A/es unknown
- 2003-09-10 AR ARP030103266A patent/AR041218A1/es unknown
- 2003-09-10 MY MYPI20033416A patent/MY135646A/en unknown
- 2003-09-11 UY UY27975A patent/UY27975A1/es not_active Application Discontinuation
2005
- 2005-02-08 NO NO20050667A patent/NO20050667L/no not_active Application Discontinuation
- 2005-02-11 ZA ZA200501273A patent/ZA200501273B/en unknown

Also Published As

Publication number	Publication date
NO20050667L (no)	2005-06-08
DE60309719D1 (de)	2006-12-28
RU2296759C2 (ru)	2007-04-10
NZ537979A (en)	2007-08-31
BR0314261A (pt)	2005-07-26
HRP20050212A2 (en)	2006-05-31
PT1539746E (pt)	2007-02-28
RU2005110921A (ru)	2006-01-20
KR20050042809A (ko)	2005-05-10
MXPA05002704A (es)	2005-05-05
MY135646A (en)	2008-06-30
CA2494601C (en)	2009-09-29
ATE345340T1 (de)	2006-12-15
CA2494601A1 (en)	2004-03-25
CN1681808A (zh)	2005-10-12
AU2003267041B2 (en)	2007-03-29
KR100645684B1 (ko)	2006-11-15
PA8581701A1 (es)	2004-04-23
WO2004024726A1 (en)	2004-03-25
US6890947B2 (en)	2005-05-10
AU2003267041A1 (en)	2004-04-30
PE20050050A1 (es)	2005-02-18
AR041218A1 (es)	2005-05-11
GT200300194A (es)	2004-04-15
EP1539746A1 (en)	2005-06-15
US20040053979A1 (en)	2004-03-18
PL375878A1 (en)	2005-12-12
ZA200501273B (en)	2006-08-30
DE60309719T2 (de)	2007-09-20
TWI248933B (en)	2006-02-11
ES2275105T3 (es)	2007-06-01
EP1539746B1 (en)	2006-11-15
TW200418845A (en)	2004-10-01
JP2006503029A (ja)	2006-01-26
CN100577660C (zh)	2010-01-06
UY27975A1 (es)	2004-03-31
DK1539746T3 (da)	2007-03-26
JP4286782B2 (ja)	2009-07-01

Publication	Publication Date	Title
IL175550A0 (en)	2006-09-05	Heterocyclic boronic acid compounds
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