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WO2007092909A8 - Molecular interaction sensors - Google Patents

Molecular interaction sensors Download PDF

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Publication number
WO2007092909A8
WO2007092909A8 PCT/US2007/061808 US2007061808W WO2007092909A8 WO 2007092909 A8 WO2007092909 A8 WO 2007092909A8 US 2007061808 W US2007061808 W US 2007061808W WO 2007092909 A8 WO2007092909 A8 WO 2007092909A8
Authority
WO
WIPO (PCT)
Prior art keywords
molecular interaction
linker
coupled
preferred embodiments
detectable label
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/061808
Other languages
French (fr)
Other versions
WO2007092909A2 (en
WO2007092909A3 (en
Inventor
Mitchell C Sanders
Andrei Rakitin
James C Comolli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ECI Biotech Inc
Original Assignee
ECI Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ECI Biotech Inc filed Critical ECI Biotech Inc
Publication of WO2007092909A2 publication Critical patent/WO2007092909A2/en
Anticipated expiration legal-status Critical
Publication of WO2007092909A3 publication Critical patent/WO2007092909A3/en
Publication of WO2007092909A8 publication Critical patent/WO2007092909A8/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/12—Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Toxicology (AREA)
  • Composite Materials (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

In preferred embodiments, the present invention provides a specific molecular interaction sensor and methods of use thereof, comprising at least one molecular interaction complex comprising a disruptable linker having first and second end, the first end being coupled to a detectable label and the second end being coupled to a surface of a support, wherein the linker is disrupted by a specific predetermined target molecule; a detector adapted to detect the label; and at least one readout device. In preferred embodiments, the detectable label is a superparamagnetic nanoparticle and the detector is a magnetoresistive device.
PCT/US2007/061808 2006-02-07 2007-02-07 Molecular interaction sensors Ceased WO2007092909A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77110706P 2006-02-07 2006-02-07
US60/771,107 2006-02-07

Publications (3)

Publication Number Publication Date
WO2007092909A2 WO2007092909A2 (en) 2007-08-16
WO2007092909A3 WO2007092909A3 (en) 2008-11-13
WO2007092909A8 true WO2007092909A8 (en) 2009-07-16

Family

ID=38345949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061808 Ceased WO2007092909A2 (en) 2006-02-07 2007-02-07 Molecular interaction sensors

Country Status (1)

Country Link
WO (1) WO2007092909A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003212897B2 (en) 2002-01-31 2007-08-02 Expressive Constructs, Inc. Method for detecting microorganisms
GB0618524D0 (en) 2006-09-20 2006-11-01 Isis Innovation Multimeric particles
EP2227567A4 (en) * 2007-10-28 2011-03-30 Eci Biotech Inc Sensors for measuring contaminants
DE102007057667A1 (en) 2007-11-30 2009-09-03 Siemens Ag Device for detecting particles in a fluid
US9958442B2 (en) 2009-02-11 2018-05-01 Duke University Sensors incorporating antibodies and methods of making and using the same
US9599591B2 (en) * 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
WO2010121223A2 (en) * 2009-04-17 2010-10-21 California Institute Of Technology Electromagnetic molecular sensors and methods of using same
FR2963106A1 (en) * 2010-07-21 2012-01-27 Ecole Polytechnique Dgar METHOD AND DEVICE FOR ANALYZING MOLECULAR INTERACTIONS, AND USES THEREOF
US8815610B2 (en) * 2010-10-15 2014-08-26 International Business Machines Corporation Magnetic nanoparticle detection across a membrane
US9303063B2 (en) 2011-03-18 2016-04-05 Duke University Peptide compounds for suppressing inflammation
SG192773A1 (en) 2011-03-18 2013-09-30 Univ Duke Peptides for suppressing inflammation
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
US10407716B2 (en) 2014-03-13 2019-09-10 Duke University Electronic platform for sensing and control of electrochemical reactions
EP2930497A1 (en) * 2014-04-07 2015-10-14 Institut Pasteur Enzyme-independent photon emission
US20160011182A1 (en) * 2014-07-09 2016-01-14 Zepto Life Technology, LLC Method and system for substance detection with a magnetic sensor
EP2977347A1 (en) * 2014-07-22 2016-01-27 Niklas Anttu Optical molecular nanowire sensor
CN106248944A (en) * 2016-06-30 2016-12-21 深圳市亚辉龙生物科技股份有限公司 A kind of CPn IgG chemiluminescence immune detection reagent kit and preparation method thereof
US11952612B2 (en) 2016-11-14 2024-04-09 Commonwealth Scientific And Industrial Research Organisation Protease sensor molecules
US20200131558A1 (en) * 2017-04-21 2020-04-30 Colorado State University Research Foundation Paper-based assay for antimicrobial resistance
SG11202001121WA (en) 2017-08-08 2020-03-30 Commw Scient Ind Res Org Carbohydrate sensors
WO2020023903A1 (en) 2018-07-27 2020-01-30 Zepto Life Technology, LLC System and method for gmr-based detection of biomarkers
US11291997B2 (en) 2018-08-02 2022-04-05 Colorado State University Research Foundation Rotary manifold for paper-based immunoassays
EP4090987A4 (en) 2020-01-17 2024-01-17 Zepto Life Technology, LLC SYSTEMS AND METHODS FOR ANALYTE DETECTION IN MRG DETECTION OF BIOMARKERS
ES3042384T3 (en) * 2021-06-17 2025-11-20 Hoffmann La Roche Method for immunosensing on a lipid layer using magnetic tunnel junctions
CN117546023A (en) * 2021-06-17 2024-02-09 豪夫迈·罗氏有限公司 Method for immunosensing on lipid layers
CN117501121A (en) * 2021-06-17 2024-02-02 豪夫迈·罗氏有限公司 Methods for immunosensing of lipid layers using magnetic tunnel junction II
US20220404347A1 (en) * 2021-06-17 2022-12-22 Roche Diagnostics Operations, Inc. Methods for detecting an analyte using structure switching binding agents
WO2023009896A2 (en) * 2021-07-30 2023-02-02 President And Fellows Of Harvard College Single-molecule protein identification via stretching
CN114152742B (en) * 2021-11-30 2024-05-28 深圳市易瑞生物技术股份有限公司 Kit for photoexcitation chemiluminescence immunoassay containing magnetic luminescence microspheres and application of kit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1110970B1 (en) * 1999-12-22 2008-05-14 Dade Behring Marburg GmbH Anti-Procalcitonin antibodies, their production and use
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

Also Published As

Publication number Publication date
WO2007092909A2 (en) 2007-08-16
WO2007092909A3 (en) 2008-11-13

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