[go: up one dir, main page]

WO2009046251A3 - Specificity and sensitivity enhancement in piezoelectric cantilever sensing - Google Patents

Specificity and sensitivity enhancement in piezoelectric cantilever sensing Download PDF

Info

Publication number
WO2009046251A3
WO2009046251A3 PCT/US2008/078675 US2008078675W WO2009046251A3 WO 2009046251 A3 WO2009046251 A3 WO 2009046251A3 US 2008078675 W US2008078675 W US 2008078675W WO 2009046251 A3 WO2009046251 A3 WO 2009046251A3
Authority
WO
WIPO (PCT)
Prior art keywords
specificity
sensor system
piezoelectric cantilever
sensitivity enhancement
cantilever sensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/078675
Other languages
French (fr)
Other versions
WO2009046251A2 (en
Inventor
Wei-Heng Shih
Wan Y Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drexel University
Original Assignee
Drexel University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/943,790 external-priority patent/US8491818B2/en
Application filed by Drexel University filed Critical Drexel University
Priority to US12/677,613 priority Critical patent/US8481335B2/en
Publication of WO2009046251A2 publication Critical patent/WO2009046251A2/en
Publication of WO2009046251A3 publication Critical patent/WO2009046251A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor system may be particularly beneficial in the field of medical diagnostics, bio-defense, food safety, water safety and general chemical detection.
PCT/US2008/078675 2006-11-27 2008-10-03 Specificity and sensitivity enhancement in piezoelectric cantilever sensing Ceased WO2009046251A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/677,613 US8481335B2 (en) 2006-11-27 2008-10-03 Specificity and sensitivity enhancement in cantilever sensing

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US97777607P 2007-10-05 2007-10-05
US60/977,776 2007-10-05
US11/943,790 US8491818B2 (en) 2006-11-27 2007-11-21 Synthesis of water soluble non-toxic nanocrystalline quantum dots and uses thereof
US11/943,790 2007-11-21
US4689908P 2008-04-22 2008-04-22
US61/046,899 2008-04-22

Publications (2)

Publication Number Publication Date
WO2009046251A2 WO2009046251A2 (en) 2009-04-09
WO2009046251A3 true WO2009046251A3 (en) 2009-08-13

Family

ID=40526956

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/078675 Ceased WO2009046251A2 (en) 2006-11-27 2008-10-03 Specificity and sensitivity enhancement in piezoelectric cantilever sensing

Country Status (1)

Country Link
WO (1) WO2009046251A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7497133B2 (en) 2004-05-24 2009-03-03 Drexel University All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement
US8481335B2 (en) 2006-11-27 2013-07-09 Drexel University Specificity and sensitivity enhancement in cantilever sensing
EP2100125A4 (en) 2006-11-28 2012-02-15 Univ Drexel PIEZOELECTRIC MICROCANTILEVER SENSORS FOR BIOSENSORS
US8241569B2 (en) 2007-11-23 2012-08-14 Drexel University Lead-free piezoelectric ceramic films and a method for making thereof
WO2009126378A2 (en) 2008-03-11 2009-10-15 Drexel University Enhanced detection sensitivity with piezoelectric microcantilever sensors
KR20110049748A (en) 2008-05-16 2011-05-12 드렉셀유니버시티 Systems and Methods for Assessing Organizations
US9599612B2 (en) 2009-02-26 2017-03-21 Drexel University Flow-based enhancement of specificity for label-free biochemical assays
US8722427B2 (en) 2009-10-08 2014-05-13 Drexel University Determination of dissociation constants using piezoelectric microcantilevers
CN102749452B (en) * 2012-07-26 2015-01-14 山东大学 Near-infrared electro-generated chemiluminescence immunodetection method
CN102830230A (en) * 2012-08-28 2012-12-19 暨南大学 Ractopamine-clenbuterol fluorescent microsphere detection test strip and preparation method and application
WO2015100170A1 (en) 2013-12-23 2015-07-02 Drexel University Piezoelectric plate sensor and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020094528A1 (en) * 2000-11-29 2002-07-18 Salafsky Joshua S. Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interations
US20020117659A1 (en) * 2000-12-11 2002-08-29 Lieber Charles M. Nanosensors
US20050287680A1 (en) * 2004-06-25 2005-12-29 Srivatsa Venkatasubbarao Multianalyte assay method
US20070141721A1 (en) * 2002-04-29 2007-06-21 The Regents Of The University Of California Microcantilevers for biological and chemical assays and methods of making and using thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020094528A1 (en) * 2000-11-29 2002-07-18 Salafsky Joshua S. Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interations
US20020117659A1 (en) * 2000-12-11 2002-08-29 Lieber Charles M. Nanosensors
US20070141721A1 (en) * 2002-04-29 2007-06-21 The Regents Of The University Of California Microcantilevers for biological and chemical assays and methods of making and using thereof
US20050287680A1 (en) * 2004-06-25 2005-12-29 Srivatsa Venkatasubbarao Multianalyte assay method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
QIANG ZHAO ET AL.: "Array adsorbent-coated lead zirconate titanate (PZT)/stainless steel cantilevers for dimethyl methylphosphonate (DMMP) detection.", SENSORS AND ACTUATORS B, vol. 117, 2006, pages 74 - 79 *
THOMAS PONS ET AL.: "Solution-phase single quantum dot fluorescence resonance energy transfer.", J. AM. CHEM. SOC., vol. 128, 2006, pages 15324 - 15331 *

Also Published As

Publication number Publication date
WO2009046251A2 (en) 2009-04-09

Similar Documents

Publication Publication Date Title
WO2009046251A3 (en) Specificity and sensitivity enhancement in piezoelectric cantilever sensing
EP2649191A4 (en) ANALYTE SENSORS WITH DETECTION SURFACE HAVING SMALL SENSING POINTS
WO2010062627A3 (en) Biosensors based on optical probing and sensing
WO2007086997A3 (en) Sensors
WO2009048673A3 (en) Stochastic confinement to detect, manipulate, and utilize molecules and organisms
WO2009111788A3 (en) Sensor electrode and method for the electrochemical detection of nucleotides
WO2008048300A3 (en) Pathogen detection biosensor
WO2009006500A3 (en) Dialysis system having non-invasive temperature sensing
EP4449978A3 (en) Tissue-integrating sensors
EP2240781A4 (en) METHODS OF DETECTING SIGNATURES OF DISEASE OR STATES IN BODY FLUIDS
FR2941533B1 (en) SURFACE TECHNOLOGY INERTIAL OR SURFACE SENSOR WITH OFFSETTING DETECTION BY STRAIN GAUGE.
WO2008094902A3 (en) Compositions and methods for the detection of a nucleic acid using a cleavage reaction
WO2008027098A3 (en) Biosensor for measurement of species in a body fluid
EP2212342A4 (en) Electrochemical assay for the detection of enzymes
WO2010047797A3 (en) Single quantum-dot-based aptameric sensors
WO2009031045A3 (en) Anti-chikungunya monoclonal antibodies and uses thereof
WO2009126378A3 (en) Enhanced detection sensitivity with piezoelectric microcantilever sensors
FR2934684B1 (en) METHOD OF DETECTING INTERNALIZATION OF MEMBRANE PROTEINS.
EP2103929A4 (en) SUBSTANCE DETECTION SENSOR
WO2011045570A3 (en) Elisa signal amplification system using magnetic bead movement detection
WO2008105918A3 (en) Methods of detection using acousto-mechanical detection systems
WO2010044006A3 (en) Biosensor with quadrupole magnetic actuation system
WO2009129628A8 (en) Integrated shear-vertical surface acoustic wave and surface plasmon resonance sensing device and method.
WO2011062407A3 (en) Method and device for detecting analytes
WO2010021521A3 (en) Method for increasing sensitivity using linker and spacer in carbon nanotube-based biosensor

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08835793

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12677613

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08835793

Country of ref document: EP

Kind code of ref document: A2