[go: up one dir, main page]

WO2007084549A3 - Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation - Google Patents

Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation Download PDF

Info

Publication number
WO2007084549A3
WO2007084549A3 PCT/US2007/001214 US2007001214W WO2007084549A3 WO 2007084549 A3 WO2007084549 A3 WO 2007084549A3 US 2007001214 W US2007001214 W US 2007001214W WO 2007084549 A3 WO2007084549 A3 WO 2007084549A3
Authority
WO
WIPO (PCT)
Prior art keywords
plaque
detergent
angioplasty procedure
eluting stent
dissolving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/001214
Other languages
French (fr)
Other versions
WO2007084549A2 (en
Inventor
Filiberto Zadini
Giorgio Zadini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2007084549A2 publication Critical patent/WO2007084549A2/en
Publication of WO2007084549A3 publication Critical patent/WO2007084549A3/en
Priority to US12/024,908 priority Critical patent/US8304383B2/en
Anticipated expiration legal-status Critical
Priority to US12/211,754 priority patent/US20090035348A1/en
Priority to US13/633,704 priority patent/US8697633B2/en
Priority to US13/871,904 priority patent/US20140234398A1/en
Priority to US14/164,648 priority patent/US20140142071A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/422—Anti-atherosclerotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

A drug eluting stent for release over time of a detergent in loco at the site of an angioplasty procedure for the dissolution of the fatty component of the atherosclerotic plaque. The detergent has the capability of passing thru the fibrous cap and of targeting the fatty components of the plaque. The detergent is aimed at dissolving the cholesterol aggregates of the plaque post angioplasty procedure, plaque which is fractured, compressed, locally redistributed by the angioplasty procedure but that it is still present within the artery wall post angioplasty procedure. Numerous other pharmacological compounds with different targeted functions can be combined with the detergent in the stent including Antineoplastics, Immnunosuppressants, Migration inhibitors, Enhanced Healing Factors, Collagen and Proteoglycan degrading enzymes. The drug eluting stent by providing the dissolution of one of the major plaque components i.e. the fatty component is expected to greatly reduce the chance of restenosis.
PCT/US2007/001214 2005-11-22 2007-01-16 Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation Ceased WO2007084549A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/024,908 US8304383B2 (en) 2005-11-22 2008-02-01 Dissolution of arterial plaque
US12/211,754 US20090035348A1 (en) 2005-11-22 2008-09-16 Dissolution of arterial plaque
US13/633,704 US8697633B2 (en) 2005-11-22 2012-10-02 Dissolution of arterial plaque
US13/871,904 US20140234398A1 (en) 2005-11-22 2013-04-26 Dissolution of Arterial Plaque
US14/164,648 US20140142071A1 (en) 2005-11-22 2014-01-27 Regression of arterial plaque

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76047106P 2006-01-20 2006-01-20
US60/760,471 2006-01-20

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2006/044619 Continuation-In-Part WO2007061820A2 (en) 2005-11-22 2006-11-16 Dissolution of arterial cholesterol plaques by a class of pharmacological compounds
US12/024,908 Continuation-In-Part US8304383B2 (en) 2005-11-22 2008-02-01 Dissolution of arterial plaque
US12/211,754 Continuation-In-Part US20090035348A1 (en) 2005-11-22 2008-09-16 Dissolution of arterial plaque

Publications (2)

Publication Number Publication Date
WO2007084549A2 WO2007084549A2 (en) 2007-07-26
WO2007084549A3 true WO2007084549A3 (en) 2007-12-21

Family

ID=38288202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001214 Ceased WO2007084549A2 (en) 2005-11-22 2007-01-16 Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation

Country Status (1)

Country Link
WO (1) WO2007084549A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727949A (en) * 2011-10-25 2012-10-17 上海交通大学附属第一人民医院 Drug eluting stone-dissolving bile duct stent and preparation method thereof
CN102727943A (en) * 2011-11-14 2012-10-17 上海市第一人民医院 Biodegradable polymer braided stone-dissolving bile duct stent and preparation method thereof
JP6720180B2 (en) * 2014-12-19 2020-07-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． Stent with anti-migration element

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020091111A1 (en) * 1998-04-08 2002-07-11 Galmed International Limited Bile salt conjugates
US20040143322A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for treating vulnerable artherosclerotic plaque
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US20040267354A1 (en) * 1994-05-13 2004-12-30 Ringeisen Timothy A. Method for making a porous polymeric material
US20050070997A1 (en) * 2003-09-29 2005-03-31 Ronan Thornton Laminated drug-polymer coated stent with dipped and cured layers
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US20050177225A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and anti-scarring agents
US20050249770A1 (en) * 1996-12-02 2005-11-10 Angiotech International Ag Compositions and methods for treating or preventing inflammatory diseases
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040267354A1 (en) * 1994-05-13 2004-12-30 Ringeisen Timothy A. Method for making a porous polymeric material
US20050249770A1 (en) * 1996-12-02 2005-11-10 Angiotech International Ag Compositions and methods for treating or preventing inflammatory diseases
US20020091111A1 (en) * 1998-04-08 2002-07-11 Galmed International Limited Bile salt conjugates
US6780849B2 (en) * 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
US20040143322A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for treating vulnerable artherosclerotic plaque
US20050070997A1 (en) * 2003-09-29 2005-03-31 Ronan Thornton Laminated drug-polymer coated stent with dipped and cured layers
US20050177225A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and anti-scarring agents

Also Published As

Publication number Publication date
WO2007084549A2 (en) 2007-07-26

Similar Documents

Publication Publication Date Title
WO2008088537A3 (en) Stent with a coating for delivering a therapeutic agent
WO2007089544A3 (en) Biodegradable non-ophthalmic implants and related methods
WO2008060359A3 (en) Biodegradable ocular implants and methods for treating ocular conditions
WO2010009111A3 (en) A drug depot implantable within a synovial joint
IL198207A0 (en) Drug-delivery endovascular stent and method of use
MY173994A (en) Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
SI2040713T1 (en) Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions
WO2010101707A3 (en) Random generated display associated with gaming device
ZA201104059B (en) Infarct area perfusion-improving compositions and methods of vascular injury repair
SG170044A1 (en) Ocular allergy treatments
WO2010093800A3 (en) Multiple drug delivery from a balloon and a prosthesis
WO2008011335A3 (en) Metal binding compounds, metal binding compositions, and their uses
WO2009158031A3 (en) Methods and compositions for therapeutic treatment
WO2009104080A3 (en) Cns pharmaceutical compositions and methods of use
GEP20125464B (en) Dha esters and use thereof in treatment and prevention of cardiovascular disease
WO2009108934A3 (en) Injectable calcium phosphate cememts formulated with bioactive agents and methods for making same
PT2001891E (en) Buprenorphine derivatives and uses thereof
WO2007084549A3 (en) Drug-eluting stent with atherosclerotic plaques dissolving pharmacological preparation
EG25345A (en) Method of producing disposable pants-type diaper and the pants-type diaper.
EP2384769A3 (en) Ophthalmic visualization compositions and methods of using same
EP2481429A3 (en) MMP Activated Vascular Disrupting Agents
IL173762A0 (en) A device and method for the prolonged delivery of an active agent to a body cavity
WO2011058373A3 (en) Drug combination with theobromine and its use in therapy
WO2008070361A3 (en) Stent coating including therapeutic biodegradable glass, and method of making
WO2007100562A3 (en) Use of dha and ara in the preparation of a composition for reducing triglyceride levels

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07716717

Country of ref document: EP

Kind code of ref document: A2