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WO2007061236A1 - Nettoyant pour les soins preventifs de sabot de vache, procede de fabrication de celui-ci, et procede d'utilisation de celui-ci - Google Patents

Nettoyant pour les soins preventifs de sabot de vache, procede de fabrication de celui-ci, et procede d'utilisation de celui-ci Download PDF

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Publication number
WO2007061236A1
WO2007061236A1 PCT/KR2006/004950 KR2006004950W WO2007061236A1 WO 2007061236 A1 WO2007061236 A1 WO 2007061236A1 KR 2006004950 W KR2006004950 W KR 2006004950W WO 2007061236 A1 WO2007061236 A1 WO 2007061236A1
Authority
WO
WIPO (PCT)
Prior art keywords
hoof
cow
weight
hooves
cleaning agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2006/004950
Other languages
English (en)
Inventor
Kwang Soo Baek
Jae Ki Kim
Hyun Seob Kim
Soo Bong Park
Sung Jae Park
Byung Soon Jeon
Kook Hyun Seo
Tae-Yeong Hur
Seok Jin Kang
Byoung Seok Ahn
Sun Hee Jung
Byoung Hak Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Rural Development Administration
Original Assignee
Korea Rural Development Administration
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Rural Development Administration filed Critical Korea Rural Development Administration
Priority to JP2008539942A priority Critical patent/JP4843680B2/ja
Priority to KR1020087012344A priority patent/KR100997709B1/ko
Priority to CN2006800427462A priority patent/CN101309677B/zh
Publication of WO2007061236A1 publication Critical patent/WO2007061236A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01L—SHOEING OF ANIMALS
    • A01L15/00—Apparatus or use of substances for the care of hoofs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present invention relates to a hoof cleaning agent for prevention of cow's hoof disorders, and preparation and use thereof. More specifically, the present invention relates to a hoof cleaning agent for prevention of cow's hoof disorders, which is used as a raw material of a hoof cleaning solution of a hoof bath for cow's hooves and has combined functions of washing and sterilization, and use and preparation thereof.
  • hoofed domestic animals such as Korean native cows (Hanwoo), dairy cows and the like may suffer from or may be susceptible to significant hoof disorders caused by inhabitation and growth of a variety of harmful bacteria and fungi in the open volume defined broadly by the hoof bottom wall. Due to a large body frame and heavy weight of Korean native cows and dairy cows, there would be the heavy weight load imposed on the hooves and legs thereof. Therefore, hoof disorders may be fatal to survival of cows which usually keep standing all day long.
  • dairy farmers have taken a step to treat the animals by a method involving applying antibiotic ointments to the affected areas of the animal and then applying a bandage thereto, or a method of spraying a copper sulfate (CuSO 4 ) solution to the affected lesions, upon incidence of such diseases.
  • the copper sulfate solution or a chemical substance such as formalin has also been employed as a hoof cleaning solution for use in a hoof bath or hoof-cleaning room.
  • the present invention has been made in view of the above problems, and it is an aspect of the present invention to provide a hoof cleaning agent for prevention of cow's hoof disorders, and use and preparation thereof, which are capable of simultaneously achieving cleaning and sterilizing effects of cow's hooves, thus allowing for sterilization of affected animal hooves under cleaned conditions of the contaminated area and consequently resulting in early prevention of the productivity decrease such as a low milk yield and a low breeding coefficient via prophylaxis of cow's hoof disorders and avoidance of extreme situations such as culling, and are also capable of making great contributions to the promotion of cow's welfare.
  • a hoof cleaning agent for prevention of cow's hoof disorders simultaneously contains cleaning components and sterilizing components. Therefore, when the hoof cleaning agent is diluted in water to form a hoof cleaning solution for use in a hoof bath and is then applied to hooves of the cow through the hoof bath, the cleaning components of the hoof cleaning solution first removes foreign materials adhered to interstices between cloven hooves of the animal while harmful bacteria adhered to the animal hooves are completely exposed to the hoof cleaning solution, and under such conditions, the adhered bacteria are thoroughly sterilized by sodium hypochlorite contained in the hoof cleaning solution.
  • hoof cleaning solution utilizing the hoof cleaning agent of the present invention enables effective prevention and treatment of cow's hoof disorders, which in turn results in early prevention of productivity reduction such as a low milk yield and a low breeding coefficient and avoidance of potential extreme situations such as cow culling, as well as achievement of great contributions to the promotion of cow's health and comfort.
  • a hoof cleaning agent for prevention of cow's hoof disorders comprising a wash liquid prepared by mixing a solid mixture of tartaric acid, citric acid, zinc sulfate, sodium molybdate and potassium nitrate with water, in order to remove foreign materials from cow's hooves, and a sodium hypochlorite for sterilizing harmful bacteria of cow's hooves from which foreign materials were removed.
  • a hoof cleaning agent for prevention of cow's hoof disorders which is prepared by mixing solids of 15 to 25% by weight of tartaric acid, 15 to 25% by weight of citric acid, 15 to 25% by weight of zinc sulfate, 15 to 25% by weight of sodium molybdate and 15 to 25 % by weight of potassium nitrate; mixing and liquefying 50% by weight of the resulting mixture and 50% by weight of water to prepare a wash liquid; and mixing 50% by weight of the wash liquid and 50% by weight of sodium hypochlorite.
  • a hoof cleaning agent as a hoof cleaning solution of a hoof bath for cow's hooves, wherein the hoof cleaning agent is diluted with water and a concentration of the hoof cleaning agent in the hoof cleaning solution is in a range of 5 to 16% by weight.
  • a method of preparing a hoof cleaning agent for prevention of cow's hoof disorders comprising mixing solids of 15 to 25% by weight of tartaric acid, 15 to 25% by weight of citric acid, 15 to 25% by weight of zinc sulfate, 15 to 25% by weight of sodium molybdate and 15 to 25% by weight of potassium nitrate; mixing and liquefying 50% by weight of the mixture and 50% by weight of water to prepare a wash liquid; providing a stock solution of sodium hypochlorite; and mixing 50% by weight of the wash liquid and 50% by weight of the sodium hypochlorite stock solution.
  • a hoof cleaning agent according to the present invention is used as a raw material which forms a hoof cleaning solution to be used in a hoof bath for cow's hooves, via dilution of the agent with water, and is provided by mixing a wash liquid, composed of a mixture of solids of 15 to 25% by weight of tartaric acid, 15 to 25% by weight of citric acid, 15 to 25% by weight of zinc sulfate, 15 to 25% by weight of sodium molybdate and 15 to 25% by weight of potassium nitrate and water, with a stock solution of sodium hypochlorite.
  • the hoof cleaning agent is prepared by a process of mixing solids of 15 to 25% by weight of tartaric acid, 15 to 25% by weight of citric acid, 15 to 25% by weight of zinc sulfate, 15 to 25% by weight of sodium molybdate and 15 to 25% by weight of potassium nitrate; mixing and liquefying 50% by weight of the resulting mixture and 50% by weight of water to prepare a wash liquid; and mixing 50% by weight of the resulting wash liquid and 50% by weight of the sodium hypochlorite stock solution.
  • the agent is preferably mixed again with water to form the hoof cleaning solution containing a 5% to 16% by weight of the agent (which will be demonstrated by the following experimental values hereinafter).
  • the thus-prepared hoof cleaning solution is poured in a hoof bath through which cows are then allowed to pass, cow's hooves are dipped in the hoof cleaning solution during passage of the cows and bacteria inhabiting in cow's hooves are thoroughly removed by the washing action of the wash liquid and the sterilizing action of the sodium hypochlorite stock solution.
  • tartaric acid, citric acid and zinc sulfate among components constituting the wash liquid are materials exerting excellent detergency, and a mixture thereof separates and removes foreign materials and contaminants adhered to cow's hooves during a short period of time at which cows pass through the hoof bath.
  • sodium molybdate and potassium nitrate prevent deterioration in the intrinsic detergency of individual components which may occur upon intermixing of tartaric acid, citric acid and zinc sulfate.
  • Table 1 shows a Minimal Inhibition Concentration (MIC) and a Minimal Bactericidal Concentration (MBC) of the hoof cleaning agent on isolated bacteria.
  • test bacteria were grown in a broth tube made of transparent glass, containing Muller-Hinton broth, with addition of a commercial copper sulfate solution and dilute solutions thereof having different copper sulfate concentrations of 5.00%, 2.50%, 1.25%, 0.63%, 0.31%, 0.15% and 0.08%, respectively.
  • the Minimal Inhibition Concentration (MIC) and Minimal Bactericidal Concentration (MBC) of copper sulfate solutions were determined.
  • the MIC and MBC of the copper sulfate solution on Bacteria A and Bacteria B were 0.31%, respectively.
  • the hoof cleaning solution of the present invention exhibited MBC of 5% for Bacteria A (E. coli). It was determined that the hoof cleaning solution shows a higher MBC as compared to the copper sulfate, but exhibits bactericidal effects on most species of bacteria isolated from cow's hooves, at a concentration of 5% or higher.
  • Table 2 below shows the MIC and MBC of the hoof cleaning solution on Bacteria A (E. coli).
  • the concentration of the hoof cleaning solution was set to 5.00%, 2.50%, 1.25%, 0.63%, 0.31%, 0.15% and 0.08%, respectively.
  • the MIC and MBC of the hoof cleaning solution on E. coli were measured to be 1.25% and 5%, respectively, as shown in Table 2.
  • CFU colony forming units
  • a reduction in bacterial number exhibited a high rate of 95% or higher at the MBC concentration as well as at an in situ application concentration of the hoof cleaning agent for the hoof cleaning solution. That is, it was confirmed that the hoof cleaning solution containing the hoof cleaning agent in a concentration of 5% to 16% by weight exhibits a significant reduction of bacterial number.
  • Table 4 shows the comparison results of bacterial number present in cloven hooves of cows, before and after treatment of animals with tap water, the copper sulfate solution and the hoof cleaning solution of the present invention, respectively.
  • cows treated with the hoof cleaning solution of the present invention exhibited a significant reduction of the bacterial number from animal hooves, as compared to treatment of tap water or the copper sulfate solution.
  • Table 5 below shows an incidence rate of hoof disorders in dairy cows which were raised in common cowshed.
  • Table 6 shows a recovery rate of cows from a walking behavior index of 2-3 to a normal level (a value of 1), after treatment of animals with the copper sulfate solution and the hoof cleaning solution of the present invention, respectively.
  • copper sulfate solution and the hoof cleaning solution used in this study copper sulfate and the hoof cleaning agent were respectively diluted to a concentration of 16% by weight.
  • the copper sulfate solution and the hoof cleaning solution were replaced every 7 days.
  • the tests were performed in 4 places (4 different cowsheds).
  • Table 7 shows a recovery rate of cows from a walking behavior index of 4-5 to a normal level (a value of 1), after treatment of animals with the copper sulfate solution and the hoof cleaning solution of the present invention, respectively.
  • copper sulfate solution and the hoof cleaning solution used in this study copper sulfate and the hoof cleaning agent were respectively diluted to a concentration of 16% by weight.
  • the copper sulfate solution and the hoof cleaning solution were replaced every 7 days.
  • Table 8 below shows an incidence rate of hoof disorders in dairy cows during application of the hoof cleaning solution.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un agent de nettoyage de sabot pour la prévention de troubles du sabot de vache. Spécifiquement, la présente invention concerne un agent de nettoyage de sabot pour la prévention de troubles du sabot de vache, et l'utilisation et la préparation de celui-ci, permettant de produire simultanément des effets de nettoyage et de stérilisation de sabots de vache, de manière à permettre la stérilisation de sabots d'animaux affectés dans des conditions propres de la zone contaminée et permettant ainsi de prévenir de manière précoce une diminution de productivité telle qu'un faible rendement en lait et un faible coefficient de reproduction par prophylaxie des troubles du sabot de vache et d'éviter des situations extrêmes telles que l'élimination sélective de vaches, et permettant également d'apporter des contributions importantes à la promotion de la santé et du bien-être des vaches. A cette fin, l'agent de nettoyage de sabot comprend un liquide de lavage préparé en mélangeant un mélange solide d'acide tartrique, d'acide citrique, de sulfate de zinc, de molybdate de sodium et de nitrate de potassium avec de l'eau, afin d'éliminer les matières étrangères des sabots de vache, et de l'hypochlorite de sodium pour stériliser des bactéries nuisibles de sabots de vache depuis lesquels les matières étrangères sont éliminées.
PCT/KR2006/004950 2005-11-23 2006-11-23 Nettoyant pour les soins preventifs de sabot de vache, procede de fabrication de celui-ci, et procede d'utilisation de celui-ci Ceased WO2007061236A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008539942A JP4843680B2 (ja) 2005-11-23 2006-11-23 牛のひづめ障害予防用の洗足剤及びその使用方法とその製造方法
KR1020087012344A KR100997709B1 (ko) 2005-11-23 2006-11-23 소의 발굽장애 예방용 세족제 및 그 사용방법과 그제조방법
CN2006800427462A CN101309677B (zh) 2005-11-23 2006-11-23 用于预防牛蹄障碍的清洗剂及其制造方法和使用方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2005-0112210 2005-11-23
KR20050112210 2005-11-23

Publications (1)

Publication Number Publication Date
WO2007061236A1 true WO2007061236A1 (fr) 2007-05-31

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Application Number Title Priority Date Filing Date
PCT/KR2006/004950 Ceased WO2007061236A1 (fr) 2005-11-23 2006-11-23 Nettoyant pour les soins preventifs de sabot de vache, procede de fabrication de celui-ci, et procede d'utilisation de celui-ci

Country Status (4)

Country Link
JP (1) JP4843680B2 (fr)
KR (1) KR100997709B1 (fr)
CN (1) CN101309677B (fr)
WO (1) WO2007061236A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008031087A1 (fr) * 2006-09-08 2008-03-13 Delaval Holdings Ab Compositions comprenant un acide carboxylique en c2-c14 et à tensioactifs pour le traitement des maladies du sabot

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1105614A2 (pt) * 2011-12-06 2013-11-12 I.C.F. S.R.L. Composição em pó para banhos de desinfecção de cascos
KR101839773B1 (ko) 2016-12-07 2018-03-19 (주)대명산업 해초제거제
KR101960268B1 (ko) * 2017-01-04 2019-03-21 어업회사법인 블루오션(주) 녹조류 제거제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472715A (en) * 1992-12-11 1995-12-05 Japan Lotion Company Antifungal agent for the treatment of skin disease caused by trichophyton, eczema or various fungi, and also for activating the recovery of the skin and burns
KR20020050459A (ko) * 2000-12-21 2002-06-27 성재갑 살균, 소독력을 갖는 오염물질 제거용 부착제
JP3554749B2 (ja) * 2001-02-22 2004-08-18 株式会社アクシス 殺菌消毒剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203027A1 (en) 2002-04-26 2003-10-30 Ethicon, Inc. Coating technique for deposition of drug substance on a substrate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472715A (en) * 1992-12-11 1995-12-05 Japan Lotion Company Antifungal agent for the treatment of skin disease caused by trichophyton, eczema or various fungi, and also for activating the recovery of the skin and burns
KR20020050459A (ko) * 2000-12-21 2002-06-27 성재갑 살균, 소독력을 갖는 오염물질 제거용 부착제
JP3554749B2 (ja) * 2001-02-22 2004-08-18 株式会社アクシス 殺菌消毒剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008031087A1 (fr) * 2006-09-08 2008-03-13 Delaval Holdings Ab Compositions comprenant un acide carboxylique en c2-c14 et à tensioactifs pour le traitement des maladies du sabot

Also Published As

Publication number Publication date
KR20080069206A (ko) 2008-07-25
KR100997709B1 (ko) 2010-12-02
CN101309677B (zh) 2011-03-09
CN101309677A (zh) 2008-11-19
JP4843680B2 (ja) 2011-12-21
JP2009519217A (ja) 2009-05-14

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