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WO2006127040A3 - Squelettes proteiques et leurs utilisations - Google Patents

Squelettes proteiques et leurs utilisations Download PDF

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Publication number
WO2006127040A3
WO2006127040A3 PCT/US2005/041639 US2005041639W WO2006127040A3 WO 2006127040 A3 WO2006127040 A3 WO 2006127040A3 US 2005041639 W US2005041639 W US 2005041639W WO 2006127040 A3 WO2006127040 A3 WO 2006127040A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein scaffolds
uses therof
present
monomer domains
therof
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/041639
Other languages
English (en)
Other versions
WO2006127040A2 (fr
Inventor
Willem P C Stemmer
Josh Silverman
Joost A Kolkman
Martin Vogt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Mountain View Inc
Original Assignee
Avidia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidia Inc filed Critical Avidia Inc
Priority to CA002587463A priority Critical patent/CA2587463A1/fr
Priority to EP05857979A priority patent/EP1817444A4/fr
Priority to JP2007541485A priority patent/JP2008520208A/ja
Priority to MX2007005865A priority patent/MX2007005865A/es
Priority to AU2005332022A priority patent/AU2005332022A1/en
Publication of WO2006127040A2 publication Critical patent/WO2006127040A2/fr
Anticipated expiration legal-status Critical
Publication of WO2006127040A3 publication Critical patent/WO2006127040A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des domaines monomères de thrombospondine, de thyroglobuline et de trfoil/PD, et des multimères comprenant lesdits domaines monomères. Elle concerne également des méthodes, des compositions, des bibliothèques et des cellules qui expriment un ou plusieurs éléments des bibliothèques, ainsi que des trousses et des systèmes intégrés.
PCT/US2005/041639 2004-11-16 2005-11-16 Squelettes proteiques et leurs utilisations Ceased WO2006127040A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002587463A CA2587463A1 (fr) 2004-11-16 2005-11-16 Squelettes proteiques et leurs utilisations
EP05857979A EP1817444A4 (fr) 2004-11-16 2005-11-16 Squelettes proteiques et leurs utilisations
JP2007541485A JP2008520208A (ja) 2004-11-16 2005-11-16 タンパク質骨格およびその使用
MX2007005865A MX2007005865A (es) 2004-11-16 2005-11-16 Adamios de proteina y usos de los mismos.
AU2005332022A AU2005332022A1 (en) 2004-11-16 2005-11-16 Protein scaffolds and uses therof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62859604P 2004-11-16 2004-11-16
US60/628,596 2004-11-16

Publications (2)

Publication Number Publication Date
WO2006127040A2 WO2006127040A2 (fr) 2006-11-30
WO2006127040A3 true WO2006127040A3 (fr) 2009-04-09

Family

ID=37452497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/041639 Ceased WO2006127040A2 (fr) 2004-11-16 2005-11-16 Squelettes proteiques et leurs utilisations

Country Status (6)

Country Link
EP (1) EP1817444A4 (fr)
JP (1) JP2008520208A (fr)
AU (1) AU2005332022A1 (fr)
CA (1) CA2587463A1 (fr)
MX (1) MX2007005865A (fr)
WO (1) WO2006127040A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
ATE439437T1 (de) 1999-01-05 2009-08-15 Univ Boston Verbessertes klonierungsverfahren
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
ATE540110T1 (de) 2004-11-11 2012-01-15 Modular Genetics Inc Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt
AU2010226391C1 (en) 2009-03-20 2016-11-24 Amgen Inc. Carrier immunoglobulins and uses thereof
KR20130110169A (ko) 2010-09-22 2013-10-08 암젠 인크 담체 면역글로뷸린 및 이것의 용도
AU2017366709A1 (en) 2016-12-02 2019-07-18 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
SG11202010767SA (en) 2018-05-18 2020-11-27 Bioverativ Therapeutics Inc Methods of treating hemophilia a

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088171A2 (fr) * 2001-04-26 2002-11-07 Avidia Research Institute Banques combinatoires de domaines monomeres

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030157561A1 (en) * 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
US7655411B2 (en) * 2002-08-23 2010-02-02 W2 Holdings, Inc. Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088171A2 (fr) * 2001-04-26 2002-11-07 Avidia Research Institute Banques combinatoires de domaines monomeres

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOBRON ET AL.: "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation.", JOURNAL OF CELL SCIENCE., vol. 109, 1996, pages 1053 - 1061, XP000205006 *
See also references of EP1817444A4 *

Also Published As

Publication number Publication date
CA2587463A1 (fr) 2006-11-30
EP1817444A2 (fr) 2007-08-15
EP1817444A4 (fr) 2010-02-17
MX2007005865A (es) 2008-02-25
WO2006127040A2 (fr) 2006-11-30
JP2008520208A (ja) 2008-06-19
AU2005332022A1 (en) 2006-11-30

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