[go: up one dir, main page]

WO2006127040A3 - Protein scaffolds and uses therof - Google Patents

Protein scaffolds and uses therof Download PDF

Info

Publication number
WO2006127040A3
WO2006127040A3 PCT/US2005/041639 US2005041639W WO2006127040A3 WO 2006127040 A3 WO2006127040 A3 WO 2006127040A3 US 2005041639 W US2005041639 W US 2005041639W WO 2006127040 A3 WO2006127040 A3 WO 2006127040A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein scaffolds
uses therof
present
monomer domains
therof
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/041639
Other languages
French (fr)
Other versions
WO2006127040A2 (en
Inventor
Willem P C Stemmer
Josh Silverman
Joost A Kolkman
Martin Vogt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Mountain View Inc
Original Assignee
Avidia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidia Inc filed Critical Avidia Inc
Priority to JP2007541485A priority Critical patent/JP2008520208A/en
Priority to EP05857979A priority patent/EP1817444A4/en
Priority to CA002587463A priority patent/CA2587463A1/en
Priority to MX2007005865A priority patent/MX2007005865A/en
Priority to AU2005332022A priority patent/AU2005332022A1/en
Publication of WO2006127040A2 publication Critical patent/WO2006127040A2/en
Anticipated expiration legal-status Critical
Publication of WO2006127040A3 publication Critical patent/WO2006127040A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides thrombospondin, thyroglobulin and trfoil/PD monomer domains and multimers comprising the monomer domains are provided. Methods, compositions, libraries and cells that express one or more library member, along with kits and integrated systems, are also included in the present invention.
PCT/US2005/041639 2004-11-16 2005-11-16 Protein scaffolds and uses therof Ceased WO2006127040A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2007541485A JP2008520208A (en) 2004-11-16 2005-11-16 Protein backbone and uses thereof
EP05857979A EP1817444A4 (en) 2004-11-16 2005-11-16 Protein scaffolds and uses therof
CA002587463A CA2587463A1 (en) 2004-11-16 2005-11-16 Protein scaffolds and uses therof
MX2007005865A MX2007005865A (en) 2004-11-16 2005-11-16 Protein scaffolds and uses therof.
AU2005332022A AU2005332022A1 (en) 2004-11-16 2005-11-16 Protein scaffolds and uses therof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62859604P 2004-11-16 2004-11-16
US60/628,596 2004-11-16

Publications (2)

Publication Number Publication Date
WO2006127040A2 WO2006127040A2 (en) 2006-11-30
WO2006127040A3 true WO2006127040A3 (en) 2009-04-09

Family

ID=37452497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/041639 Ceased WO2006127040A2 (en) 2004-11-16 2005-11-16 Protein scaffolds and uses therof

Country Status (6)

Country Link
EP (1) EP1817444A4 (en)
JP (1) JP2008520208A (en)
AU (1) AU2005332022A1 (en)
CA (1) CA2587463A1 (en)
MX (1) MX2007005865A (en)
WO (1) WO2006127040A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE439437T1 (en) 1999-01-05 2009-08-15 Univ Boston IMPROVED CLONING PROCESS
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
CA2590245A1 (en) 2004-11-11 2006-05-18 Modular Genetics, Inc. Ladder assembly and system for generating diversity
WO2010108153A2 (en) 2009-03-20 2010-09-23 Amgen Inc. Carrier immunoglobulins and uses thereof
MX360946B (en) 2010-09-22 2018-10-29 Amgen Inc Star CARRYING IMMUNOGLOBULINS AND USES OF THE SAME.
AU2017366709A1 (en) 2016-12-02 2019-07-18 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
TW202015723A (en) 2018-05-18 2020-05-01 美商百歐維拉提夫治療公司 Methods of treating hemophilia a

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088171A2 (en) * 2001-04-26 2002-11-07 Avidia Research Institute Combinatorial libraries of monomer domains

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030157561A1 (en) * 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
US7655411B2 (en) * 2002-08-23 2010-02-02 W2 Holdings, Inc. Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088171A2 (en) * 2001-04-26 2002-11-07 Avidia Research Institute Combinatorial libraries of monomer domains

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOBRON ET AL.: "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation.", JOURNAL OF CELL SCIENCE., vol. 109, 1996, pages 1053 - 1061, XP000205006 *
See also references of EP1817444A4 *

Also Published As

Publication number Publication date
EP1817444A2 (en) 2007-08-15
CA2587463A1 (en) 2006-11-30
MX2007005865A (en) 2008-02-25
AU2005332022A1 (en) 2006-11-30
WO2006127040A2 (en) 2006-11-30
EP1817444A4 (en) 2010-02-17
JP2008520208A (en) 2008-06-19

Similar Documents

Publication Publication Date Title
WO2006055689A3 (en) Protein scaffolds and uses thereof
WO2005040229A3 (en) Ldl receptor class a and egf domain monomers and multimers
WO2007133290A3 (en) Anti-ox40l antibodies and methods using same
WO2006012507A3 (en) Methods and compositions for risk stratification
WO2010011944A3 (en) Protein screeing methods
WO2007136893A3 (en) Anti-fgf19 antibodies and methods using same
WO2009058379A3 (en) Protein scaffolds
WO2006137934A3 (en) Purposeful movement of human migratory cells away from an agent source
DK1409459T3 (en) ECL labels which have improved, non-specific binding properties, methods of using them, and kits containing the same.
WO2005111212A3 (en) Biological bar code
WO2007118222A3 (en) Compositions for the use in identification of fungi
WO2007061874A3 (en) Methods and compositions for use in treating cancer
WO2004011611A3 (en) Taci antibodies and uses thereof
WO2006044614A3 (en) Anti-angiogenic peptides and methods of use thereof
WO2006116127A3 (en) Compositions for use in identification of bacteria
WO2007130697A8 (en) Anti-ephb4 antibodies and methods using same
WO2008157697A3 (en) Copolymer assay
WO2005041896A3 (en) Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke
WO2007076370A3 (en) Block copolymer particles
WO2005087951A3 (en) Reagents, methods and kits for use in deactivating nucleic acids
WO2007076174A3 (en) Methods, systems, and apparatus for multi-domain markers
WO2005087793A3 (en) Immunostimulatory compositions and uses thereof
WO2005076908A3 (en) Anti-freeze protein enhanced nucleic acid amplification
WO2007010379A3 (en) Calorimetric assessment of microorganisms and use thereof
WO2006127040A3 (en) Protein scaffolds and uses therof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2587463

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/005865

Country of ref document: MX

Ref document number: 2007541485

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005857979

Country of ref document: EP

Ref document number: 2005332022

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2005332022

Country of ref document: AU

Date of ref document: 20051116

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005332022

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2005857979

Country of ref document: EP