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WO2006121552A3 - Abuse-resistant amphetamine prodrugs - Google Patents

Abuse-resistant amphetamine prodrugs Download PDF

Info

Publication number
WO2006121552A3
WO2006121552A3 PCT/US2006/013221 US2006013221W WO2006121552A3 WO 2006121552 A3 WO2006121552 A3 WO 2006121552A3 US 2006013221 W US2006013221 W US 2006013221W WO 2006121552 A3 WO2006121552 A3 WO 2006121552A3
Authority
WO
WIPO (PCT)
Prior art keywords
abuse
amphetamine
compositions
compounds
bioavailability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/013221
Other languages
French (fr)
Other versions
WO2006121552A2 (en
WO2006121552A9 (en
Inventor
Travis Mickle
Suma Krishnan
Barney Bishop
James Scott Moncrief
Christopher Lauderback
Rob Oberlender
Thomas Piccariello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New River Pharmaceuticals Inc
Original Assignee
New River Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP06769808A priority Critical patent/EP1865980A4/en
Priority to JP2008505617A priority patent/JP2008535860A/en
Priority to US11/400,304 priority patent/US7700561B2/en
Priority to BRPI0612440-2A priority patent/BRPI0612440A2/en
Priority to CA002603873A priority patent/CA2603873A1/en
Priority to MX2007012507A priority patent/MX2007012507A/en
Application filed by New River Pharmaceuticals Inc filed Critical New River Pharmaceuticals Inc
Publication of WO2006121552A2 publication Critical patent/WO2006121552A2/en
Publication of WO2006121552A9 publication Critical patent/WO2006121552A9/en
Publication of WO2006121552A3 publication Critical patent/WO2006121552A3/en
Anticipated expiration legal-status Critical
Priority to US12/202,067 priority patent/US7687467B2/en
Priority to US12/239,180 priority patent/US20090186825A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and compositions find particular use in providing an abuse-resistant alternative treatment for certain disorders, such as attention deficit hyperactivity disorder (ADHD), ADD, narcolepsy, and obesity. Oral bioavailability of amphetamine is maintained at therapeutically useful doses. At higher doses bioavailability is substantially reduced, thereby providing a method of reducing oral abuse liability. Further, compounds and compositions of the invention decrease the bioavailability of amphetamine by parenteral routes, such as intravenous or intranasal administration, further limiting their abuse liability.
PCT/US2006/013221 2002-02-22 2006-04-10 Abuse-resistant amphetamine prodrugs Ceased WO2006121552A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2008505617A JP2008535860A (en) 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrug
US11/400,304 US7700561B2 (en) 2002-02-22 2006-04-10 Abuse-resistant amphetamine prodrugs
BRPI0612440-2A BRPI0612440A2 (en) 2005-04-08 2006-04-10 pharmaceutical composition and use of an amphetamine prodrug
CA002603873A CA2603873A1 (en) 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrugs
MX2007012507A MX2007012507A (en) 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrugs.
EP06769808A EP1865980A4 (en) 2005-04-08 2006-04-10 Abuse-resistant amphetamine prodrugs
US12/202,067 US7687467B2 (en) 2002-02-22 2008-08-29 Abuse-resistant amphetamine prodrugs
US12/239,180 US20090186825A1 (en) 2002-02-22 2008-09-26 Abuse-resistant amphetamine prodrugs

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US66938505P 2005-04-08 2005-04-08
US66938605P 2005-04-08 2005-04-08
US60/669,385 2005-04-08
US60/669,386 2005-04-08
US68117005P 2005-05-16 2005-05-16
US60/681,170 2005-05-16
US75654806P 2006-01-06 2006-01-06
US60/756,548 2006-01-06
US75995806P 2006-01-19 2006-01-19
US60/759,958 2006-01-19
US11/400,304 2006-04-10

Publications (3)

Publication Number Publication Date
WO2006121552A2 WO2006121552A2 (en) 2006-11-16
WO2006121552A9 WO2006121552A9 (en) 2007-03-08
WO2006121552A3 true WO2006121552A3 (en) 2007-07-05

Family

ID=37397039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/013221 Ceased WO2006121552A2 (en) 2002-02-22 2006-04-10 Abuse-resistant amphetamine prodrugs

Country Status (6)

Country Link
EP (1) EP1865980A4 (en)
JP (1) JP2008535860A (en)
BR (1) BRPI0612440A2 (en)
CA (1) CA2603873A1 (en)
MX (1) MX2007012507A (en)
WO (1) WO2006121552A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009035473A2 (en) * 2007-09-13 2009-03-19 Sanfilippo Louis C Method of treating binge eating disorder, obesity resulting from binge eating behavior and depressive disorders
WO2010042120A1 (en) 2008-10-09 2010-04-15 Archimica, Inc. Process for the synthesis of amphetamine derivatives
GB201002612D0 (en) * 2010-02-16 2010-03-31 Jagotec Ag Improvements in or relating to organic compounds
US20140073589A1 (en) * 2012-06-27 2014-03-13 Shire Ag Amphetamine Prodrugs
EP3555280A4 (en) 2016-12-19 2020-09-09 The Regents of The University of California DUAL ENZYME-RESPONDING PEPTIDES
EP3554548A4 (en) 2016-12-19 2020-08-19 The Regents of The University of California NON-BREAKABLE TABLET FORMULATIONS
EP3459538B1 (en) 2017-09-20 2020-05-06 Sandoz AG Crystalline salts of a dextroamphetamine prodrug
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
CN113993522A (en) 2019-04-17 2022-01-28 指南针探路者有限公司 Method for treating anxiety disorders, headache disorders and eating disorders with siloxibin
LT3845215T (en) 2019-12-30 2022-11-10 Labomed Pharmaceutical Company S.A. Oral solutions comprising lisdexamfetamine salts
WO2022106947A1 (en) 2020-11-18 2022-05-27 Liechti Matthias Emanuel Mdma prodrugs to assist psychotherapy
EP4447891B1 (en) 2021-12-16 2025-10-01 Labomed Pharmaceutical Company S.A. Container comprising a lisdexamfetamine containing oral solution
WO2024023367A1 (en) 2022-07-29 2024-02-01 Labomed Pharmaceutical Company S.A. Lisdexamfetamine containing oral solution

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878187A (en) * 1972-09-11 1975-04-15 Syva Co Polypeptide derivatives of amphetamine and analogs for immunoassays
US20050054561A1 (en) * 2002-02-22 2005-03-10 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6384020B1 (en) * 1999-07-14 2002-05-07 Shire Laboratories, Inc. Rapid immediate release oral dosage form
ES2281527T3 (en) * 2001-05-25 2007-10-01 Cephalon, Inc. SOLID PHARMACEUTICAL FORMULATIONS THAT INCLUDE MODAFINILO.
CA2540678C (en) * 2003-09-30 2011-02-22 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878187A (en) * 1972-09-11 1975-04-15 Syva Co Polypeptide derivatives of amphetamine and analogs for immunoassays
US20050054561A1 (en) * 2002-02-22 2005-03-10 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1865980A4 *

Also Published As

Publication number Publication date
EP1865980A2 (en) 2007-12-19
MX2007012507A (en) 2008-03-11
WO2006121552A2 (en) 2006-11-16
WO2006121552A9 (en) 2007-03-08
EP1865980A4 (en) 2009-11-11
CA2603873A1 (en) 2006-11-16
JP2008535860A (en) 2008-09-04
BRPI0612440A2 (en) 2010-11-23

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