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WO2006019673A3 - Jiadifenin analogs and uses thereof - Google Patents

Jiadifenin analogs and uses thereof Download PDF

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Publication number
WO2006019673A3
WO2006019673A3 PCT/US2005/024483 US2005024483W WO2006019673A3 WO 2006019673 A3 WO2006019673 A3 WO 2006019673A3 US 2005024483 W US2005024483 W US 2005024483W WO 2006019673 A3 WO2006019673 A3 WO 2006019673A3
Authority
WO
WIPO (PCT)
Prior art keywords
jiadifenin
analogs
methods
synthesis
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/024483
Other languages
French (fr)
Other versions
WO2006019673A2 (en
Inventor
Samuel J Danishefsky
Young Shin Cho
David A Carcache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of WO2006019673A2 publication Critical patent/WO2006019673A2/en
Publication of WO2006019673A3 publication Critical patent/WO2006019673A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides compounds having formula (I) and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of neurodegenerative disorders, wherein R1-R6, m and n are as defined herein.
PCT/US2005/024483 2004-07-08 2005-07-08 Jiadifenin analogs and uses thereof Ceased WO2006019673A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58630204P 2004-07-08 2004-07-08
US60/586,302 2004-07-08

Publications (2)

Publication Number Publication Date
WO2006019673A2 WO2006019673A2 (en) 2006-02-23
WO2006019673A3 true WO2006019673A3 (en) 2006-11-09

Family

ID=35602424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024483 Ceased WO2006019673A2 (en) 2004-07-08 2005-07-08 Jiadifenin analogs and uses thereof

Country Status (1)

Country Link
WO (1) WO2006019673A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105732654B (en) * 2016-01-29 2017-12-12 暨南大学 Dihydroartemisinine Memantine dyad compound and its preparation method and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
I. KOUNO ET AL: "Sesquiterpene Lactones from the Pericarps of Illicium majus; 2-Oxy Derivatives of Neomajucin and 3,4-Dehydroxyneomajucin", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 2, 1990, pages 422 - 5, XP008066830 *
R. YOKOYAMA ET AL: "New seco-Prezizaane-Type Sesquiterpenes, Jiadifenin with Neurotropic Activity and 1,2-Dehydroneomajucin from Illicium jiadifengpi", JOURNAL OF NATURAL PRODUCTS, vol. 65, no. 4, 2002, pages 527 - 531, XP002391240 *
YOUNG SHIN CHO ET AL: "Total Synthesis of (+-)-Jiadifenin, a Non-peptidyl Neurotrophic Modulator", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 44, 16 October 2004 (2004-10-16), pages 14358 - 14359, XP002391242 *

Also Published As

Publication number Publication date
WO2006019673A2 (en) 2006-02-23

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