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WO2006019673A3 - Analogues de jiadifenine et utilisations - Google Patents

Analogues de jiadifenine et utilisations Download PDF

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Publication number
WO2006019673A3
WO2006019673A3 PCT/US2005/024483 US2005024483W WO2006019673A3 WO 2006019673 A3 WO2006019673 A3 WO 2006019673A3 US 2005024483 W US2005024483 W US 2005024483W WO 2006019673 A3 WO2006019673 A3 WO 2006019673A3
Authority
WO
WIPO (PCT)
Prior art keywords
jiadifenin
analogs
methods
synthesis
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/024483
Other languages
English (en)
Other versions
WO2006019673A2 (fr
Inventor
Samuel J Danishefsky
Young Shin Cho
David A Carcache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of WO2006019673A2 publication Critical patent/WO2006019673A2/fr
Publication of WO2006019673A3 publication Critical patent/WO2006019673A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I) et des procédés relatifs à leur synthèse, des compositions correspondantes, et des procédés d'utilisation correspondants pour le traitement de troubles neurodégénérescents, sachant que R1-R6, m et n sont tels que définis dans la description.
PCT/US2005/024483 2004-07-08 2005-07-08 Analogues de jiadifenine et utilisations Ceased WO2006019673A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58630204P 2004-07-08 2004-07-08
US60/586,302 2004-07-08

Publications (2)

Publication Number Publication Date
WO2006019673A2 WO2006019673A2 (fr) 2006-02-23
WO2006019673A3 true WO2006019673A3 (fr) 2006-11-09

Family

ID=35602424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024483 Ceased WO2006019673A2 (fr) 2004-07-08 2005-07-08 Analogues de jiadifenine et utilisations

Country Status (1)

Country Link
WO (1) WO2006019673A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105732654B (zh) * 2016-01-29 2017-12-12 暨南大学 二氢青蒿素‑美金刚二联体化合物及其合成方法和用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
I. KOUNO ET AL: "Sesquiterpene Lactones from the Pericarps of Illicium majus; 2-Oxy Derivatives of Neomajucin and 3,4-Dehydroxyneomajucin", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 2, 1990, pages 422 - 5, XP008066830 *
R. YOKOYAMA ET AL: "New seco-Prezizaane-Type Sesquiterpenes, Jiadifenin with Neurotropic Activity and 1,2-Dehydroneomajucin from Illicium jiadifengpi", JOURNAL OF NATURAL PRODUCTS, vol. 65, no. 4, 2002, pages 527 - 531, XP002391240 *
YOUNG SHIN CHO ET AL: "Total Synthesis of (+-)-Jiadifenin, a Non-peptidyl Neurotrophic Modulator", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 44, 16 October 2004 (2004-10-16), pages 14358 - 14359, XP002391242 *

Also Published As

Publication number Publication date
WO2006019673A2 (fr) 2006-02-23

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