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WO2006116781A1 - Dispositif pour realiser des traitements photodynamiques - Google Patents

Dispositif pour realiser des traitements photodynamiques Download PDF

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Publication number
WO2006116781A1
WO2006116781A1 PCT/AT2006/000170 AT2006000170W WO2006116781A1 WO 2006116781 A1 WO2006116781 A1 WO 2006116781A1 AT 2006000170 W AT2006000170 W AT 2006000170W WO 2006116781 A1 WO2006116781 A1 WO 2006116781A1
Authority
WO
WIPO (PCT)
Prior art keywords
emitting diodes
light
object plane
radiation
plane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AT2006/000170
Other languages
German (de)
English (en)
Inventor
Kristjan PLÄTZER
Tobias Kiesslich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PARIS-LODRON-UNIVERSITAT SALZBURG
Original Assignee
PARIS-LODRON-UNIVERSITAT SALZBURG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PARIS-LODRON-UNIVERSITAT SALZBURG filed Critical PARIS-LODRON-UNIVERSITAT SALZBURG
Publication of WO2006116781A1 publication Critical patent/WO2006116781A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03—Automatic limiting or abutting means, e.g. for safety
    • A61B2090/033—Abutting means, stops, e.g. abutting on tissue or skin
    • A61B2090/036—Abutting means, stops, e.g. abutting on tissue or skin abutting on tissue or skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644—Handheld applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes

Definitions

  • the invention relates to a device for carrying out photodynamic treatments with a plurality of light-emitting diodes, which are arranged in a common plane on a circuit board, wherein in front of the light-emitting diodes a peripheral to the circuit board spacer is provided.
  • photodynamic therapy can be used for the treatment of various cancers, skin diseases and wound healing disorders.
  • the photodynamic treatment consists in bringing a photosensitive agent into the cells to be treated and then irradiating these cells with light of suitable wavelength. This places the photosensitive agent in an excited state in which it releases intracellular reactive oxygen species (ROS), i. free oxygen radicals produced. Overproduction of these reactive molecules results in damage to the cell and ultimately death of the cells in the target tissue.
  • ROS reactive oxygen species
  • Photodynamic therapy has proven to be an attractive therapeutic option as it is efficient and provides good cosmetic results.
  • the photodynamic theory has little side effects as long as the radiation is not overdosed. This is the reason why stable and reproducible light sources are essential.
  • Laser light sources meet some of the requirements, but are complex and suitable only for the irradiation relatively small treatment area.
  • non-coherent light sources such as halogen lamps, xenon arc lamps or the like are in use. Such light sources partially radiate in a large spectral range, resulting in a relatively high heating of the tissue.
  • Other commercially available light sources use halogen lamps with optical filters to filter out ultraviolet and infrared wavelengths.
  • the radiation profile of such lamps is asymmetric with a crater-like profile of irradiance.
  • Essential in the photodynamic treatment is thus the production of a reproducible illumination, ie that both wavelength and intensity of the applied light can be controlled within narrow limits.
  • a particularly uniform intensity distribution is also essential here.
  • Another requirement is to provide high light intensities with relatively low heat input.
  • the above requirements are very well met by light-emitting diodes, since they have a high light output at a defined wavelength, are relatively inexpensive and have a long life. Due to the minimal heating of the LEDs consuming cooling devices are not required, resulting in a further simplification of the corresponding irradiation devices.
  • the problem with LEDs is that a uniform light intensity over the area to be irradiated can not be readily ensured.
  • No. 5,420,768 A shows a device for photodynamic treatment with light-emitting diodes, in front of which an optical waveguide arrangement is arranged.
  • the light guide arrangement seems to focus the radiation of the LEDs on a smaller area.
  • a uniform intensity of irradiation can be achieved with the pre-published solution or even desired, is not apparent from the document, since this is not relevant here.
  • WO 02/098508 A a solution is proposed in which an arrangement of light-emitting diodes is provided, which are each preceded by a lens element in order to focus the radiation. With appropriate design of the lenses, a substantially uniform illumination intensity can be achieved.
  • the production of light-emitting diodes and lenses arrangement is very complex and error-prone.
  • the object of the present invention is to further develop the device described above so that a simplification is achieved without impairing the quality of treatment. In particular, a uniform irradiation intensity should be ensured.
  • Another object of the invention is to provide a device which is particularly easy to handle and particularly suitable for practical use.
  • the spacer surrounds the radiation cone of the light-emitting diodes and has a front edge region lying in an object plane which is arranged parallel to the common plane.
  • Essential to the present invention is the realization that even with conventional light emitting diodes a uniform and reproducible radiation intensity can be achieved, provided that the distance of the light emitting diodes to the object to be irradiated is defined within narrow limits. With conventional devices, this can only be achieved by precise and careful adjustment and is only possible if the area to be irradiated is essentially flat.
  • compliance with the required distance is ensured by the spacer and at the same time, by applying a certain pressure, even when the coating is not even A certain smoothing can be achieved areas of action, so that the required light intensity is actually achieved within relatively narrow limits.
  • a particularly favorable embodiment variant of the device according to the invention provides that a transparent plate is arranged in the object plane. In this way, it is achieved within the anatomical and physiological possibilities that the skin areas to be irradiated lie directly against the transparent plate, so that a completely flat irradiation area is achieved.
  • the transparent plate may be made of glass or Plexiglas.
  • a thin transparent grid structure is arranged in the object plane.
  • a particularly favorable embodiment variant of the present invention provides that the light-emitting diodes are placed directly on the circuit board. In this way it is possible to ensure with relatively little technical effort that the individual LEDs are positioned exactly in one plane and aligned parallel to each other.
  • a particularly uniform radiation field in the object plane can be achieved in that the light-emitting diodes have radiation cones and that the boundaries of the radiation cones of adjacent light-emitting diodes touch one another in the object plane. It is particularly advantageous if the LEDs or their radiation cone are arranged substantially in a tightest packing. Normally, i. then, when the object plane intersects the radiation cones in circles, this is an arrangement at the vertices of equilateral triangles. In this way, the ripple of the radiation intensity in the object plane is minimized.
  • a particularly simple construction of the circuit board can be achieved by arranging the light-emitting diodes substantially in a square grid.
  • a particularly easily applicable and practicable embodiment of the present invention is characterized in that the device is designed as a handheld device with integrated power supply. In this way, all body regions can be irradiated with little load on the patient.
  • FIG. 1 shows schematically a device according to the invention
  • Fig. Ia shows a detail of Fig. 1;
  • Figs. 2 and 3 are diagrams explaining the effect of the invention.
  • Fig. 4 is a schematic representation of the arrangement of the LEDs.
  • the device according to the invention consists of a housing 1, which has a handle 2 and a radiation head 3.
  • a circuit board 4 is provided, on which a plurality of light-emitting diodes 5 are fixed in a regular triangular arrangement, so that there is a densest arrangement of the radiation cone sections in the object plane.
  • the axes 5a of the individual LEDs 5 are aligned parallel to each other and perpendicular to the plane formed by the board 4 common plane 4a, on which the light-emitting diodes 5 are placed.
  • an object plane 6a is arranged, in which a transparent plate 6 is provided.
  • the transparent plate 6 is held by a circumferential spacer 7 fixed to the irradiation head 3, the transparent plate 6 being fixed to a front edge portion 8 of the spacer 7.
  • a controller 9 is used to adjust the current intensity and thus the light intensity, which is displayed on a display 10.
  • An on-off switch 11 is arranged in the region of the transition from the handle 2 in the irradiation head 3 and inside the handle 2 are rechargeable batteries 12 for power supply.
  • the light emitting diodes 5 are, as shown in FIG. Ia, arranged at a distance d from each other.
  • the radiation cone 13 of the light-emitting diodes 5 has an opening angle 2 ⁇ of, for example, 20 °.
  • a distance a between the plane 4a of the light-emitting diodes 5 and the object plane 6a results in a diameter 2b of the radiation cone 13 in the object plane 6a for which the following applies:
  • the distance a between the planes 4a and 6a is chosen so that
  • Fig. 2 shows the linearity of the illuminance which is applied in mWcrn "2 on the ordinate, to the applied current, which listed in A on the abscissa at a given distance to the diode plane (common plane 4a) for three types of light emitting diodes 5, namely for 660 nm diodes (L53SRC-F) through the data points 20, for 630 nm diodes (L53SRC-M) through the data points 21 and 16 610 nm diodes (L53SRC) through the data points 22.
  • L53SRC-F 660 nm diodes
  • L53SRC-M 630 nm diodes
  • L53SRC 16 610 nm diodes
  • Fig. 3 the cytotoxic effect, measured as relative cytotoxicity with respect to an untreated control in%, plotted on the ordinate, of photodynamic therapy using a diode array for three different photosensitizers as a function of illuminance is shown. This is plotted on the abscissa in Jcm '2 on the upper axis 23 for L53SEC-F (660 nm) and L53SEC-M (630 nm), and on the lower axis 24 for L53SEC (610 nm).
  • Cytotoxicity was measured by conversion of 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyl-2H-tetrazolium bromide into the dye formazan only in living cells. This demonstrates that photodynamic therapy with various photosensitizers using the device with corresponding diode types is cytotoxic.
  • Data points 25 were obtained with mTHPC and L53SEC-F (660 nm), data points 26 were determined with Photofrin and L53SEC-M (630 nm), and data points 27 were determined with hypericin and L53SEC (610 nm).
  • Fig. 4 shows the arrangement of LEDs 5 at the vertices of equilateral triangles 28 with the side length a, so that the radiation cone of the LEDs, the object plane 4a intersect in circles 29 which touch each other or overlap slightly.

Landscapes

  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un dispositif pour réaliser des traitements photodynamiques, comprenant une pluralité de photodiodes (5) qui sont disposées dans un plan commun (4a) sur une platine (4), un élément d'espacement (7) qui entoure la platine (4), se trouvant en amont des photodiodes (5). On obtient un rayonnement particulièrement homogène grâce au fait que l'élément d'espacement (7) entoure le cône de rayonnement (13) des photodiodes (5), et présente une zone marginale avant (8) qui se trouve dans un plan objet (6a) qui est parallèle au plan commun (4a).
PCT/AT2006/000170 2005-04-29 2006-04-26 Dispositif pour realiser des traitements photodynamiques Ceased WO2006116781A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0074405A AT503079B1 (de) 2005-04-29 2005-04-29 Vorrichtung zur durchführung photodynamischer behandlungen
ATA744/2005 2005-04-29

Publications (1)

Publication Number Publication Date
WO2006116781A1 true WO2006116781A1 (fr) 2006-11-09

Family

ID=36790816

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2006/000170 Ceased WO2006116781A1 (fr) 2005-04-29 2006-04-26 Dispositif pour realiser des traitements photodynamiques

Country Status (2)

Country Link
AT (1) AT503079B1 (fr)
WO (1) WO2006116781A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133385A1 (fr) * 2008-04-30 2009-11-05 Photopharmica Limited Dispositif de traitement destiné à administrer des radiations à une zone externe du corps humain

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934759A1 (fr) * 1995-05-16 1999-08-11 Lutz Wilden Appareillage stimulant le système nerveux central
WO2000043067A1 (fr) * 1999-01-20 2000-07-27 Biolight Patent Holding Ab Moyens d'emission de lumiere pour traitement medical externe utilisant de la lumiere
EP1238683A1 (fr) * 1999-12-08 2002-09-11 Yaman Ltd. Dispositif d'irradiation par faisceau laser
US20030004499A1 (en) * 2000-01-13 2003-01-02 Mcdaniel David H. Method and apparatus for the photomodulation of living cells
WO2005011801A2 (fr) * 2003-07-30 2005-02-10 Tru-Light Corporation Application modularisee de rayonnement lumineux sur des parties du corps a des fins de traitement
US20050085875A1 (en) * 2003-08-19 2005-04-21 Jeffrey Van Zuylen Photon therapy method and apparatus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420768A (en) * 1993-09-13 1995-05-30 Kennedy; John Portable led photocuring device
GB2360459B (en) * 2000-03-23 2002-08-07 Photo Therapeutics Ltd Therapeutic light source and method
GB0113899D0 (en) * 2001-06-07 2001-08-01 Photocure Asa Photodynamic therapy lamp
BR8302354U (pt) * 2003-09-17 2004-05-18 Orlando Rossi Jr Aperfeiçoamento introduzido em fonte de luz fototerápica para tratamento da hiperbilirrubinemia

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934759A1 (fr) * 1995-05-16 1999-08-11 Lutz Wilden Appareillage stimulant le système nerveux central
WO2000043067A1 (fr) * 1999-01-20 2000-07-27 Biolight Patent Holding Ab Moyens d'emission de lumiere pour traitement medical externe utilisant de la lumiere
EP1238683A1 (fr) * 1999-12-08 2002-09-11 Yaman Ltd. Dispositif d'irradiation par faisceau laser
US20030004499A1 (en) * 2000-01-13 2003-01-02 Mcdaniel David H. Method and apparatus for the photomodulation of living cells
WO2005011801A2 (fr) * 2003-07-30 2005-02-10 Tru-Light Corporation Application modularisee de rayonnement lumineux sur des parties du corps a des fins de traitement
US20050085875A1 (en) * 2003-08-19 2005-04-21 Jeffrey Van Zuylen Photon therapy method and apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009133385A1 (fr) * 2008-04-30 2009-11-05 Photopharmica Limited Dispositif de traitement destiné à administrer des radiations à une zone externe du corps humain

Also Published As

Publication number Publication date
AT503079B1 (de) 2008-03-15
AT503079A1 (de) 2007-07-15

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