WO2006116781A1 - Device for carrying out photodynamic treatments - Google Patents
Device for carrying out photodynamic treatments Download PDFInfo
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- WO2006116781A1 WO2006116781A1 PCT/AT2006/000170 AT2006000170W WO2006116781A1 WO 2006116781 A1 WO2006116781 A1 WO 2006116781A1 AT 2006000170 W AT2006000170 W AT 2006000170W WO 2006116781 A1 WO2006116781 A1 WO 2006116781A1
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- emitting diodes
- light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/03—Automatic limiting or abutting means, e.g. for safety
- A61B2090/033—Abutting means, stops, e.g. abutting on tissue or skin
- A61B2090/036—Abutting means, stops, e.g. abutting on tissue or skin abutting on tissue or skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
Definitions
- the invention relates to a device for carrying out photodynamic treatments with a plurality of light-emitting diodes, which are arranged in a common plane on a circuit board, wherein in front of the light-emitting diodes a peripheral to the circuit board spacer is provided.
- photodynamic therapy can be used for the treatment of various cancers, skin diseases and wound healing disorders.
- the photodynamic treatment consists in bringing a photosensitive agent into the cells to be treated and then irradiating these cells with light of suitable wavelength. This places the photosensitive agent in an excited state in which it releases intracellular reactive oxygen species (ROS), i. free oxygen radicals produced. Overproduction of these reactive molecules results in damage to the cell and ultimately death of the cells in the target tissue.
- ROS reactive oxygen species
- Photodynamic therapy has proven to be an attractive therapeutic option as it is efficient and provides good cosmetic results.
- the photodynamic theory has little side effects as long as the radiation is not overdosed. This is the reason why stable and reproducible light sources are essential.
- Laser light sources meet some of the requirements, but are complex and suitable only for the irradiation relatively small treatment area.
- non-coherent light sources such as halogen lamps, xenon arc lamps or the like are in use. Such light sources partially radiate in a large spectral range, resulting in a relatively high heating of the tissue.
- Other commercially available light sources use halogen lamps with optical filters to filter out ultraviolet and infrared wavelengths.
- the radiation profile of such lamps is asymmetric with a crater-like profile of irradiance.
- Essential in the photodynamic treatment is thus the production of a reproducible illumination, ie that both wavelength and intensity of the applied light can be controlled within narrow limits.
- a particularly uniform intensity distribution is also essential here.
- Another requirement is to provide high light intensities with relatively low heat input.
- the above requirements are very well met by light-emitting diodes, since they have a high light output at a defined wavelength, are relatively inexpensive and have a long life. Due to the minimal heating of the LEDs consuming cooling devices are not required, resulting in a further simplification of the corresponding irradiation devices.
- the problem with LEDs is that a uniform light intensity over the area to be irradiated can not be readily ensured.
- No. 5,420,768 A shows a device for photodynamic treatment with light-emitting diodes, in front of which an optical waveguide arrangement is arranged.
- the light guide arrangement seems to focus the radiation of the LEDs on a smaller area.
- a uniform intensity of irradiation can be achieved with the pre-published solution or even desired, is not apparent from the document, since this is not relevant here.
- WO 02/098508 A a solution is proposed in which an arrangement of light-emitting diodes is provided, which are each preceded by a lens element in order to focus the radiation. With appropriate design of the lenses, a substantially uniform illumination intensity can be achieved.
- the production of light-emitting diodes and lenses arrangement is very complex and error-prone.
- the object of the present invention is to further develop the device described above so that a simplification is achieved without impairing the quality of treatment. In particular, a uniform irradiation intensity should be ensured.
- Another object of the invention is to provide a device which is particularly easy to handle and particularly suitable for practical use.
- the spacer surrounds the radiation cone of the light-emitting diodes and has a front edge region lying in an object plane which is arranged parallel to the common plane.
- Essential to the present invention is the realization that even with conventional light emitting diodes a uniform and reproducible radiation intensity can be achieved, provided that the distance of the light emitting diodes to the object to be irradiated is defined within narrow limits. With conventional devices, this can only be achieved by precise and careful adjustment and is only possible if the area to be irradiated is essentially flat.
- compliance with the required distance is ensured by the spacer and at the same time, by applying a certain pressure, even when the coating is not even A certain smoothing can be achieved areas of action, so that the required light intensity is actually achieved within relatively narrow limits.
- a particularly favorable embodiment variant of the device according to the invention provides that a transparent plate is arranged in the object plane. In this way, it is achieved within the anatomical and physiological possibilities that the skin areas to be irradiated lie directly against the transparent plate, so that a completely flat irradiation area is achieved.
- the transparent plate may be made of glass or Plexiglas.
- a thin transparent grid structure is arranged in the object plane.
- a particularly favorable embodiment variant of the present invention provides that the light-emitting diodes are placed directly on the circuit board. In this way it is possible to ensure with relatively little technical effort that the individual LEDs are positioned exactly in one plane and aligned parallel to each other.
- a particularly uniform radiation field in the object plane can be achieved in that the light-emitting diodes have radiation cones and that the boundaries of the radiation cones of adjacent light-emitting diodes touch one another in the object plane. It is particularly advantageous if the LEDs or their radiation cone are arranged substantially in a tightest packing. Normally, i. then, when the object plane intersects the radiation cones in circles, this is an arrangement at the vertices of equilateral triangles. In this way, the ripple of the radiation intensity in the object plane is minimized.
- a particularly simple construction of the circuit board can be achieved by arranging the light-emitting diodes substantially in a square grid.
- a particularly easily applicable and practicable embodiment of the present invention is characterized in that the device is designed as a handheld device with integrated power supply. In this way, all body regions can be irradiated with little load on the patient.
- FIG. 1 shows schematically a device according to the invention
- Fig. Ia shows a detail of Fig. 1;
- Figs. 2 and 3 are diagrams explaining the effect of the invention.
- Fig. 4 is a schematic representation of the arrangement of the LEDs.
- the device according to the invention consists of a housing 1, which has a handle 2 and a radiation head 3.
- a circuit board 4 is provided, on which a plurality of light-emitting diodes 5 are fixed in a regular triangular arrangement, so that there is a densest arrangement of the radiation cone sections in the object plane.
- the axes 5a of the individual LEDs 5 are aligned parallel to each other and perpendicular to the plane formed by the board 4 common plane 4a, on which the light-emitting diodes 5 are placed.
- an object plane 6a is arranged, in which a transparent plate 6 is provided.
- the transparent plate 6 is held by a circumferential spacer 7 fixed to the irradiation head 3, the transparent plate 6 being fixed to a front edge portion 8 of the spacer 7.
- a controller 9 is used to adjust the current intensity and thus the light intensity, which is displayed on a display 10.
- An on-off switch 11 is arranged in the region of the transition from the handle 2 in the irradiation head 3 and inside the handle 2 are rechargeable batteries 12 for power supply.
- the light emitting diodes 5 are, as shown in FIG. Ia, arranged at a distance d from each other.
- the radiation cone 13 of the light-emitting diodes 5 has an opening angle 2 ⁇ of, for example, 20 °.
- a distance a between the plane 4a of the light-emitting diodes 5 and the object plane 6a results in a diameter 2b of the radiation cone 13 in the object plane 6a for which the following applies:
- the distance a between the planes 4a and 6a is chosen so that
- Fig. 2 shows the linearity of the illuminance which is applied in mWcrn "2 on the ordinate, to the applied current, which listed in A on the abscissa at a given distance to the diode plane (common plane 4a) for three types of light emitting diodes 5, namely for 660 nm diodes (L53SRC-F) through the data points 20, for 630 nm diodes (L53SRC-M) through the data points 21 and 16 610 nm diodes (L53SRC) through the data points 22.
- L53SRC-F 660 nm diodes
- L53SRC-M 630 nm diodes
- L53SRC 16 610 nm diodes
- Fig. 3 the cytotoxic effect, measured as relative cytotoxicity with respect to an untreated control in%, plotted on the ordinate, of photodynamic therapy using a diode array for three different photosensitizers as a function of illuminance is shown. This is plotted on the abscissa in Jcm '2 on the upper axis 23 for L53SEC-F (660 nm) and L53SEC-M (630 nm), and on the lower axis 24 for L53SEC (610 nm).
- Cytotoxicity was measured by conversion of 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyl-2H-tetrazolium bromide into the dye formazan only in living cells. This demonstrates that photodynamic therapy with various photosensitizers using the device with corresponding diode types is cytotoxic.
- Data points 25 were obtained with mTHPC and L53SEC-F (660 nm), data points 26 were determined with Photofrin and L53SEC-M (630 nm), and data points 27 were determined with hypericin and L53SEC (610 nm).
- Fig. 4 shows the arrangement of LEDs 5 at the vertices of equilateral triangles 28 with the side length a, so that the radiation cone of the LEDs, the object plane 4a intersect in circles 29 which touch each other or overlap slightly.
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
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Abstract
Description
Vorrichtung zur Durchführung photodynamischer BehandlungenDevice for carrying out photodynamic treatments
Die Erfindung betrifft eine Vorrichtung zur Durchführung photodynamischer Behandlungen mit einer Mehrzahl von Leuchtdioden, die in einer gemeinsamen Ebene auf einer Platine angeordnet sind, wobei vor den Leuchtdioden ein um die Platine umlaufender Abstandhalter vorgesehen ist.The invention relates to a device for carrying out photodynamic treatments with a plurality of light-emitting diodes, which are arranged in a common plane on a circuit board, wherein in front of the light-emitting diodes a peripheral to the circuit board spacer is provided.
Es ist bekannt, dass die photodynamische Therapie zur Behandlung bei verschiedenen Krebsarten, Hautkrankheiten und Wundheilungsstörungen eingesetzt werden kann. Die photodynamische Behandlung besteht darin, einen photosensitiven Wirkstoff in die zu behandelnden Zellen zu bringen und diese Zellen danach mit Licht von geeigneter Wellenlänge zu bestrahlen. Dadurch wird der photosensitive Wirkstoff in einen angeregten Zustand gebracht, in dem er intrazelluläre reaktive Sauerstoff-Spezies (ROS), d.h. freie Sauerstoffradikale, produziert. Eine Überproduktion dieser reaktiven Moleküle führt zu einer Beschädigung der Zelle und letztlich zum Tod der Zellen im Zielgewebe. Die photodynamische Therapie hat sich als attraktive therapeutische Option herausgestellt, da sie effizient ist und gute kosmetische Resultate liefert. Darüber hinaus weist die photodynamische Theorie geringe Nebenwirkungen auf, solange die Bestrahlung nicht überdosiert wird. Dies ist der Grund, warum stabile und reproduzierbare Lichtquellen wesentlich sind. Laserlichtquellen erfüllen manche der Anforderungen, sind jedoch aufwändig und nur für die Bestrahlung relativ kleiner Behandlungsbereich geeignet. Für die Bestrahlung größerer Bereiche sind nichtkohärente Lichtquellen, wie etwa Halogenlampen, Xenonbogenlampen oder dergleichen, in Verwendung. Solche Lichtquellen strahlen teilweise in einem großen Spektralbereich, so dass eine relativ starke Erwärmung des Gewebes resultiert. Weitere kommerziell erhältliche Lichtquellen verwenden Halogenlampen mit optischen Filtern, um ultraviolette und Infrarotwellenlängen auszufiltern. Das Strahlungsprofil solcher Lampen ist jedoch asymmetrisch mit einem kraterartigen Profil der Bestrahlungsleistung. Darüber hinaus ist es zumeist nicht möglich, den Wellenlängenbereich dieser Lampen einzuschränken oder den Erfordernissen anzupassen.It is known that photodynamic therapy can be used for the treatment of various cancers, skin diseases and wound healing disorders. The photodynamic treatment consists in bringing a photosensitive agent into the cells to be treated and then irradiating these cells with light of suitable wavelength. This places the photosensitive agent in an excited state in which it releases intracellular reactive oxygen species (ROS), i. free oxygen radicals produced. Overproduction of these reactive molecules results in damage to the cell and ultimately death of the cells in the target tissue. Photodynamic therapy has proven to be an attractive therapeutic option as it is efficient and provides good cosmetic results. In addition, the photodynamic theory has little side effects as long as the radiation is not overdosed. This is the reason why stable and reproducible light sources are essential. Laser light sources meet some of the requirements, but are complex and suitable only for the irradiation relatively small treatment area. For the irradiation of larger areas, non-coherent light sources such as halogen lamps, xenon arc lamps or the like are in use. Such light sources partially radiate in a large spectral range, resulting in a relatively high heating of the tissue. Other commercially available light sources use halogen lamps with optical filters to filter out ultraviolet and infrared wavelengths. However, the radiation profile of such lamps is asymmetric with a crater-like profile of irradiance. In addition, it is usually not possible to limit the wavelength range of these lamps or adapt to the requirements.
Wesentlich bei der photodynamischen Behandlung ist somit die Herstellung einer reproduzierbaren Beleuchtung, d.h., dass sowohl Wellenlänge als auch Intensität des einwirkenden Lichtes innerhalb enger Grenzen steuerbar sind. Hinsichtlich der Intensität ist hier weiters auch eine besonders gleichmäßige Intensitätsverteilung wesentlich. Eine weitere Anforderung ist es, hohe Lichtintensitäten mit relativ geringem Wärmeeintrag zur Verfügung zu stellen. Die obigen Anforderungen werden sehr gut durch Leuchtdioden erfüllt, da diese eine hohe Lichtausbeute bei definierter Wellenlänge aufweisen, relativ kostengünstig sind und eine lange Lebensdauer haben. Aufgrund der minimalen Erwärmung der Leuchtdioden sind aufwändige Kühlvorrichtungen nicht erforderlich, was zu einer weiteren Vereinfachung der entsprechenden Bestrahlungsvorrichtungen führt. Problematisch bei Leuchtdioden ist jedoch, dass eine gleichmäßige Lichtintensität über den zu bestrahlenden Bereich nicht ohne weiteres gewährleistet werden kann.Essential in the photodynamic treatment is thus the production of a reproducible illumination, ie that both wavelength and intensity of the applied light can be controlled within narrow limits. With regard to the intensity, a particularly uniform intensity distribution is also essential here. Another requirement is to provide high light intensities with relatively low heat input. The above requirements are very well met by light-emitting diodes, since they have a high light output at a defined wavelength, are relatively inexpensive and have a long life. Due to the minimal heating of the LEDs consuming cooling devices are not required, resulting in a further simplification of the corresponding irradiation devices. The problem with LEDs, however, is that a uniform light intensity over the area to be irradiated can not be readily ensured.
Die US 5,420,768 A zeigt ein Gerät zur photodynamischen Behandlung mit Leuchtdioden, vor denen eine Lichtleiteranordnung angeordnet ist. Die Lichtleiteranordnung scheint die Strahlung der Leuchtdioden auf einen kleineren Bereich zu konzentrieren. Ob eine gleichmäßige Bestrahlungsintensität mit der vorveröffentlichten Lösung erreicht werden kann oder auch nur angestrebt wird, ist aus der Druckschrift nicht zu entnehmen, da dies hier nicht relevant ist. In der WO 02/098508 A wird eine Lösung vorgeschlagen, bei der eine Anordnung von Leuchtdioden vorgesehen ist, denen jeweils ein Linsenelement vorgeschaltet ist, um die Strahlung zu bündeln. Bei entsprechender Ausbildung der Linsen kann eine weitgehend gleichmäßige Beleuchtungsintensität erreicht werden. Die Herstellung der aus Leuchtdioden und Linsen bestehenden Anordnung ist jedoch sehr aufwändig und fehleranfällig.No. 5,420,768 A shows a device for photodynamic treatment with light-emitting diodes, in front of which an optical waveguide arrangement is arranged. The light guide arrangement seems to focus the radiation of the LEDs on a smaller area. Whether a uniform intensity of irradiation can be achieved with the pre-published solution or even desired, is not apparent from the document, since this is not relevant here. In WO 02/098508 A, a solution is proposed in which an arrangement of light-emitting diodes is provided, which are each preceded by a lens element in order to focus the radiation. With appropriate design of the lenses, a substantially uniform illumination intensity can be achieved. However, the production of light-emitting diodes and lenses arrangement is very complex and error-prone.
Aufgabe der vorliegenden Erfindung ist es, die oben beschriebene Vorrichtung so weiterzuentwickeln, dass eine Vereinfachung erzielt wird, ohne die Behandlungsqualität zu verschlechtern. Insbesondere soll eine gleichmäßige Bestrahlungsintensität sichergestellt werden. Eine weitere Aufgabe der Erfindung ist es, eine Vorrichtung anzugeben, die besonders leicht handhabbar und für den praktischen Einsatz besonders geeignet ist.The object of the present invention is to further develop the device described above so that a simplification is achieved without impairing the quality of treatment. In particular, a uniform irradiation intensity should be ensured. Another object of the invention is to provide a device which is particularly easy to handle and particularly suitable for practical use.
Erfindungsgemäß ist vorgesehen, dass der Abstandhalter die Strahlungskegel der Leuchtdioden umschließt und einen vorderen Randbereich aufweist, der in einer Objektebene liegt, die parallel zur gemeinsamen Ebene angeordnet ist.According to the invention, the spacer surrounds the radiation cone of the light-emitting diodes and has a front edge region lying in an object plane which is arranged parallel to the common plane.
Wesentlich an der vorliegenden Erfindung ist die Erkenntnis, dass auch mit herkömmlichen Leuchtdioden eine gleichmäßige und reproduzierbare Strahlungsintensität erreichbar ist, sofern der Abstand der Leuchtdioden zum bestrahlten Objekt innerhalb enger Grenzen festgelegt ist. Mit herkömmlichen Vorrichtungen kann dies nur durch eine genaue und sorgfältige Justierung erreicht werden und ist überhaupt nur dann möglich, wenn der zu bestrahlende Bereich im Wesentlichen eben ist. Bei der erfindungsgemäßen Lösung wird durch den Abstandhalter die Einhaltung des erforderlichen Abstandes sichergestellt und gleichzeitig kann durch Anwendung eines gewissen Druckes auch bei an sich nicht ebenen Be- handlungsbereichen eine gewisse Glättung erreicht werden, so dass die erforderliche Lichtintensität innerhalb relativ enger Grenzen tatsächlich erreicht wird.Essential to the present invention is the realization that even with conventional light emitting diodes a uniform and reproducible radiation intensity can be achieved, provided that the distance of the light emitting diodes to the object to be irradiated is defined within narrow limits. With conventional devices, this can only be achieved by precise and careful adjustment and is only possible if the area to be irradiated is essentially flat. In the solution according to the invention, compliance with the required distance is ensured by the spacer and at the same time, by applying a certain pressure, even when the coating is not even A certain smoothing can be achieved areas of action, so that the required light intensity is actually achieved within relatively narrow limits.
Eine besonders begünstigte Ausführungsvariante der erfindungsgemäßen Vorrichtung sieht vor, dass eine transparente Platte in der Objektebene angeordnet ist. Auf diese Weise wird im Rahmen der anatomischen und physiologischen Möglichkeiten erreicht, dass die zu bestrahlenden Hautareale direkt an der transparenten Platte anliegen, so dass eine völlig ebene Bestrahlungsfläche erreicht wird. Die transparente Platte kann aus Glas oder aus Plexiglas bestehen.A particularly favorable embodiment variant of the device according to the invention provides that a transparent plate is arranged in the object plane. In this way, it is achieved within the anatomical and physiological possibilities that the skin areas to be irradiated lie directly against the transparent plate, so that a completely flat irradiation area is achieved. The transparent plate may be made of glass or Plexiglas.
Alternativ zur obigen Ausführungsvariante ist es möglich, dass eine dünne transparente Gitterstruktur in der Objektebene angeordnet ist.As an alternative to the above embodiment, it is possible that a thin transparent grid structure is arranged in the object plane.
Eine besonders begünstigte Ausführungsvariante der vorliegenden Erfindung sieht vor, dass die Leuchtdioden direkt auf die Platine aufgesetzt sind. Auf diese Weise ist es möglich, mit relativ geringem technischen Aufwand sicherzustellen, dass die einzelnen Leuchtdioden exakt in einer Ebene positioniert und parallel zueinander ausgerichtet sind.A particularly favorable embodiment variant of the present invention provides that the light-emitting diodes are placed directly on the circuit board. In this way it is possible to ensure with relatively little technical effort that the individual LEDs are positioned exactly in one plane and aligned parallel to each other.
Ein besonders gleichmäßiges Strahlungsfeld in der Objektebene kann dadurch erreicht werden, dass die Leuchtdioden Strahlungskegel aufweisen und dass die Grenzen der Strahlungskegel benachbarter Leuchtdioden einander in der Objektebene berühren. Dabei ist es besonders günstig, wenn die Leuchtdioden bzw. deren Strahlungskegel im Wesentlichen in einer dichtesten Packung angeordnet sind. Im Normalfall, d.h. dann, wenn die Objektebene die Strahlungskegel in Kreisen schneidet, ist dies eine Anordnung an den Eckpunkten gleichseitiger Dreiecke. Auf diese Weise wird die Welligkeit der Strahlungsintensität in der Objektebene minimiert. Ein besonders einfacher Aufbau der Platine kann jedoch dadurch erreicht werden, dass die Leuchtdioden im Wesentlichen in einem Quadratgitter angeordnet sind.A particularly uniform radiation field in the object plane can be achieved in that the light-emitting diodes have radiation cones and that the boundaries of the radiation cones of adjacent light-emitting diodes touch one another in the object plane. It is particularly advantageous if the LEDs or their radiation cone are arranged substantially in a tightest packing. Normally, i. then, when the object plane intersects the radiation cones in circles, this is an arrangement at the vertices of equilateral triangles. In this way, the ripple of the radiation intensity in the object plane is minimized. However, a particularly simple construction of the circuit board can be achieved by arranging the light-emitting diodes substantially in a square grid.
Weiters trägt es zur Erzielung eines sehr gleichmäßigen Strahlungsfeldes bei, wenn die Leuchtdioden in einer Parallelschaltung mit Strom versorgt sind.Furthermore, it contributes to achieving a very uniform radiation field when the LEDs are powered in a parallel circuit with power.
Eine in der Praxis besonders leicht anwendbare und praktikable Ausführungsform der vorliegenden Erfindung ist dadurch gekennzeichnet, dass die Vorrichtung als Handgerät mit integrierter Stromversorgung ausgebildet ist. Auf diese Weise können alle Körperregionen mit geringer Belastung des Patienten bestrahlt werden.A particularly easily applicable and practicable embodiment of the present invention is characterized in that the device is designed as a handheld device with integrated power supply. In this way, all body regions can be irradiated with little load on the patient.
Je nach Art der Behandlung kann es erforderlich sein, Licht unterschiedlicher Wellenlängen zu verwenden. Eine leichte Anpassung der Wellenlänge an die je- weüs erforderliche Behandlung kann dadurch erreicht werden, dass die Platine austauschbar ausgeführt ist.Depending on the type of treatment, it may be necessary to use light of different wavelengths. A slight adaptation of the wavelength to the Necessary treatment can be achieved by making the board interchangeable.
In der Folge wird die vorliegende Erfindung anhand der in den Figuren darstellten Ausführungsvariante näher erläutert. Es zeigen:As a result, the present invention will be explained in more detail with reference to the embodiment shown in the figures. Show it:
Fig. 1 schematisch eine erfindungsgemäße Vorrichtung; Fig. Ia ein Detail von Fig. 1;Fig. 1 shows schematically a device according to the invention; Fig. Ia shows a detail of Fig. 1;
Fig. 2 und Fig. 3 Diagramme, die die Wirkung der Erfindung erklären; undFigs. 2 and 3 are diagrams explaining the effect of the invention; and
Fig. 4 eine schematische Darstellung der Anordnung der Leuchtdioden.Fig. 4 is a schematic representation of the arrangement of the LEDs.
Die erfindungsgemäße Vorrichtung besteht aus einem Gehäuse 1, das einen Griff 2 und einen Bestrahlungskopf 3 aufweist. Im Bestrahlungskopf 3 ist eine Platine 4 vorgesehen, auf der eine Mehrzahl von Leuchtdioden 5 in einer regelmäßigen Dreiecksanordnung befestigt sind, so dass sich in der Objektebene eine dichteste Anordnung der Strahlungskegelschnitte ergibt. Die Achsen 5a der einzelnen Leuchtdioden 5 sind parallel zueinander ausgerichtet und senkrecht auf die durch die Platine 4 gebildete gemeinsame Ebene 4a, auf der die Leuchtdioden 5 aufgesetzt sind. Parallel zur Ebene 4a ist eine Objektebene 6a angeordnet, in der eine transparente Platte 6 vorgesehen ist. Die transparente Platte 6 wird von einem umlaufenen Abstandhalter 7 gehalten, der am Bestrahlungskopf 3 befestigt ist, wobei die transparente Platte 6 an einem vorderen Randbereich 8 des Abstandhalters 7 befestigt ist. Ein Regler 9 dient zur Einstellung der Stromstärke und damit der Lichtintensität, die auf einer Anzeige 10 angezeigt wird. Ein Ein- und Ausschalter 11 ist im Bereich des Überganges vom Handgriff 2 in den Bestrahlungskopf 3 angeordnet und im Inneren des Handgriffes 2 sind wiederaufladbare Batterien 12 zur Stromversorgung.The device according to the invention consists of a housing 1, which has a handle 2 and a radiation head 3. In the irradiation head 3, a circuit board 4 is provided, on which a plurality of light-emitting diodes 5 are fixed in a regular triangular arrangement, so that there is a densest arrangement of the radiation cone sections in the object plane. The axes 5a of the individual LEDs 5 are aligned parallel to each other and perpendicular to the plane formed by the board 4 common plane 4a, on which the light-emitting diodes 5 are placed. Parallel to the plane 4a, an object plane 6a is arranged, in which a transparent plate 6 is provided. The transparent plate 6 is held by a circumferential spacer 7 fixed to the irradiation head 3, the transparent plate 6 being fixed to a front edge portion 8 of the spacer 7. A controller 9 is used to adjust the current intensity and thus the light intensity, which is displayed on a display 10. An on-off switch 11 is arranged in the region of the transition from the handle 2 in the irradiation head 3 and inside the handle 2 are rechargeable batteries 12 for power supply.
Die Leuchtdioden 5 sind, wie aus Fig. Ia ersichtlich ist, in einem Abstand d voneinander angeordnet. Der Strahlungskegel 13 der Leuchtdioden 5 besitzt einen Öffnungswinkel 2α von beispielsweise 20°. Einem Abstand a zwischen der Ebene 4a der Leuchtdioden 5 und der Objektebene 6a ergibt sich dabei ein Durchmesser 2b des Strahlungskegels 13 in der Objektebene 6a für den gilt:The light emitting diodes 5 are, as shown in FIG. Ia, arranged at a distance d from each other. The radiation cone 13 of the light-emitting diodes 5 has an opening angle 2α of, for example, 20 °. A distance a between the plane 4a of the light-emitting diodes 5 and the object plane 6a results in a diameter 2b of the radiation cone 13 in the object plane 6a for which the following applies:
b = a . tanαb = a. tanα
Der Abstand a zwischen den Ebenen 4a und 6a wird dabei so gewählt, dassThe distance a between the planes 4a and 6a is chosen so that
0,5 d < b < 0,6 d.0.5 d <b <0.6 d.
Fig. 2 zeigt die Linearität der Beleuchtungsstärke, die in mWcrn"2 auf der Ordinate aufgetragen ist, zum anliegenden Strom, der in A auf der Abszisse aufge- tragen ist, bei gegebenen Abstand zur Diodenebene (gemeinsame Ebene 4a) für drei Typen von Leuchtdioden 5, nämlich für 660 nm Dioden (L53SRC-F) durch die Datenpunkte 20, für 630 nm Dioden (L53SRC-M) durch die Datenpunkte 21 und für 610 nm Dioden (L53SRC) durch die Datenpunkte 22. Damit sei gezeigt, daß die Vorrichtung eine stufenlose Regulierung der Beleuchtungsstärke über die Variation des Stromes bei konstantem Abstand erlaubt.Fig. 2 shows the linearity of the illuminance which is applied in mWcrn "2 on the ordinate, to the applied current, which listed in A on the abscissa at a given distance to the diode plane (common plane 4a) for three types of light emitting diodes 5, namely for 660 nm diodes (L53SRC-F) through the data points 20, for 630 nm diodes (L53SRC-M) through the data points 21 and 16 610 nm diodes (L53SRC) through the data points 22. It should be noted that the device allows stepless regulation of the illuminance via the variation of the current at a constant distance.
In Fig. 3 ist die zytotoxische Wirkung, gemessen als relative Zytotoxizität in Bezug auf eine unbehandelte Kontrolle in %, aufgetragen auf der Ordinate, der photodynamischen Therapie unter Verwendung eines Diodenarrays für drei verschiedene Photosensibilisatoren als Funktion der Beleuchtungsstärke dargestellt. Diese ist auf der Abszisse in Jcm'2 auf der oberen Achse 23 für L53SEC-F (660 nm) und L53SEC-M (630 nm), sowie auf der unteren Achse 24 für L53SEC (610 nm) aufgetragen.In Fig. 3 the cytotoxic effect, measured as relative cytotoxicity with respect to an untreated control in%, plotted on the ordinate, of photodynamic therapy using a diode array for three different photosensitizers as a function of illuminance is shown. This is plotted on the abscissa in Jcm '2 on the upper axis 23 for L53SEC-F (660 nm) and L53SEC-M (630 nm), and on the lower axis 24 for L53SEC (610 nm).
Die Zytotoxizität wurde durch die nur in lebenden Zellen stattfindende Umwandlung von 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromid in den Farbstoff Formazan gemessen. Damit sei gezeigt, daß photodynamische Therapie mit verschiedenen Photosensibilatoren unter Verwendung der Vorrichtung mit entsprechenden Diodentypen zytotoxisch wirksam ist.Cytotoxicity was measured by conversion of 3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyl-2H-tetrazolium bromide into the dye formazan only in living cells. This demonstrates that photodynamic therapy with various photosensitizers using the device with corresponding diode types is cytotoxic.
Die Datenpunkte 25 sind mit mTHPC und L53SEC-F (660 nm) ermittelt worden, die Datenpunkte 26 sind mit Photofrin und L53SEC-M (630 nm) ermittelt worden, und die Datenpunkte 27 sind mit Hypericin und L53SEC (610 nm) ermittelt worden.Data points 25 were obtained with mTHPC and L53SEC-F (660 nm), data points 26 were determined with Photofrin and L53SEC-M (630 nm), and data points 27 were determined with hypericin and L53SEC (610 nm).
Fig. 4 zeigt die Anordnung von Leuchtdioden 5 an den Eckpunkten gleichseitiger Dreiecke 28 mit der Seitenlänge a, so dass die Strahlungskegel der Leuchtdioden, die Objektebene 4a in Kreisen 29 schneiden, die einander berühren oder geringfügig überlappen. Fig. 4 shows the arrangement of LEDs 5 at the vertices of equilateral triangles 28 with the side length a, so that the radiation cone of the LEDs, the object plane 4a intersect in circles 29 which touch each other or overlap slightly.
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA744/2005 | 2005-04-29 | ||
| AT0074405A AT503079B1 (en) | 2005-04-29 | 2005-04-29 | DEVICE FOR IMPLEMENTING PHOTODYNAMIC TREATMENTS |
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| Publication Number | Publication Date |
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| WO2006116781A1 true WO2006116781A1 (en) | 2006-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AT2006/000170 Ceased WO2006116781A1 (en) | 2005-04-29 | 2006-04-26 | Device for carrying out photodynamic treatments |
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| AT (1) | AT503079B1 (en) |
| WO (1) | WO2006116781A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009133385A1 (en) * | 2008-04-30 | 2009-11-05 | Photopharmica Limited | Treatment device for delivering radiation to an external area of the human body |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0934759A1 (en) * | 1995-05-16 | 1999-08-11 | Lutz Wilden | Device for stimulating the central nervous system |
| WO2000043067A1 (en) * | 1999-01-20 | 2000-07-27 | Biolight Patent Holding Ab | Light emitting means for external medical treatment with light |
| EP1238683A1 (en) * | 1999-12-08 | 2002-09-11 | Yaman Ltd. | Laser beam irradiation probe |
| US20030004499A1 (en) * | 2000-01-13 | 2003-01-02 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
| WO2005011801A2 (en) * | 2003-07-30 | 2005-02-10 | Tru-Light Corporation | Modularized light processing of body components |
| US20050085875A1 (en) * | 2003-08-19 | 2005-04-21 | Jeffrey Van Zuylen | Photon therapy method and apparatus |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420768A (en) * | 1993-09-13 | 1995-05-30 | Kennedy; John | Portable led photocuring device |
| GB2360459B (en) * | 2000-03-23 | 2002-08-07 | Photo Therapeutics Ltd | Therapeutic light source and method |
| GB0113899D0 (en) * | 2001-06-07 | 2001-08-01 | Photocure Asa | Photodynamic therapy lamp |
| BR8302354U (en) * | 2003-09-17 | 2004-05-18 | Orlando Rossi Jr | Improvement introduced in phototherapeutic light source for treatment of hyperbilirubinemia |
-
2005
- 2005-04-29 AT AT0074405A patent/AT503079B1/en active
-
2006
- 2006-04-26 WO PCT/AT2006/000170 patent/WO2006116781A1/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0934759A1 (en) * | 1995-05-16 | 1999-08-11 | Lutz Wilden | Device for stimulating the central nervous system |
| WO2000043067A1 (en) * | 1999-01-20 | 2000-07-27 | Biolight Patent Holding Ab | Light emitting means for external medical treatment with light |
| EP1238683A1 (en) * | 1999-12-08 | 2002-09-11 | Yaman Ltd. | Laser beam irradiation probe |
| US20030004499A1 (en) * | 2000-01-13 | 2003-01-02 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
| WO2005011801A2 (en) * | 2003-07-30 | 2005-02-10 | Tru-Light Corporation | Modularized light processing of body components |
| US20050085875A1 (en) * | 2003-08-19 | 2005-04-21 | Jeffrey Van Zuylen | Photon therapy method and apparatus |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009133385A1 (en) * | 2008-04-30 | 2009-11-05 | Photopharmica Limited | Treatment device for delivering radiation to an external area of the human body |
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| Publication number | Publication date |
|---|---|
| AT503079B1 (en) | 2008-03-15 |
| AT503079A1 (en) | 2007-07-15 |
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