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WO2006116601A3 - Epithelial delaminating device (v) and blades useful in that device - Google Patents

Epithelial delaminating device (v) and blades useful in that device Download PDF

Info

Publication number
WO2006116601A3
WO2006116601A3 PCT/US2006/016034 US2006016034W WO2006116601A3 WO 2006116601 A3 WO2006116601 A3 WO 2006116601A3 US 2006016034 W US2006016034 W US 2006016034W WO 2006116601 A3 WO2006116601 A3 WO 2006116601A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelium
cornea
edge
eye
blade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/016034
Other languages
French (fr)
Other versions
WO2006116601A2 (en
WO2006116601A8 (en
Inventor
Edward Perez
Jay Daulton
Paul Hsei
Matthew Mcdonaold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TISSUE ENGINEERING REFRACTION Inc
TISSUE ENG REFRACTION Inc
Original Assignee
TISSUE ENGINEERING REFRACTION Inc
TISSUE ENG REFRACTION Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0609858-4A priority Critical patent/BRPI0609858A2/en
Priority to CA002606433A priority patent/CA2606433A1/en
Priority to MX2007013423A priority patent/MX2007013423A/en
Priority to EP06751645A priority patent/EP1898853A2/en
Priority to AU2006239287A priority patent/AU2006239287A1/en
Priority to JP2008509121A priority patent/JP2008539033A/en
Application filed by TISSUE ENGINEERING REFRACTION Inc, TISSUE ENG REFRACTION Inc filed Critical TISSUE ENGINEERING REFRACTION Inc
Publication of WO2006116601A2 publication Critical patent/WO2006116601A2/en
Publication of WO2006116601A3 publication Critical patent/WO2006116601A3/en
Priority to IL186938A priority patent/IL186938A0/en
Anticipated expiration legal-status Critical
Publication of WO2006116601A8 publication Critical patent/WO2006116601A8/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
    • A61F9/0133—Knives or scalpels specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

The described device is useful in the field of ophthalmology. The blades, devices, and methods for using them involve separating or lifting corneal epithelium from the eye in a substantially continuous layer to form an epithelial tissue member typically still attached to the cornea. The epithelial tissue member often is in the form of a flap or pocket. In particular, the devices utilize a non-cornea-cutting, oscillating blade that operates as a separator or dissector that is configured for example, by structure and lubricity, to separate the epithelium at naturally occurring cleavage surfaces in the eye, particularly between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina hicida. The blade may be blunt and have an open region away from the dissector edge for providing lower frictional forces against the separated epithelium. The blade may have a blunt dissecting edge possibly made by first forming an edge sufficiently sharp cut epithelium and then electropolishing that edge to a substantially blunt edge appropriate for separating the epithelium from the cornea without cutting the cornea. The blade may be at least partially coated with one or more lubricious materials, preferably on the surfaces adjacent the epithelium during use. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or pocket. The epithelium may then be replaced on the cornea after a refractive procedure or replaced onto an ocular lens after placement of that ocular lens on the eye.
PCT/US2006/016034 2005-04-27 2006-04-27 Epithelial delaminating device (v) and blades useful in that device Ceased WO2006116601A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002606433A CA2606433A1 (en) 2005-04-27 2006-04-27 Epithelial delaminating device (v) and blades useful in that device
MX2007013423A MX2007013423A (en) 2005-04-27 2006-04-27 Epithelial delaminating device (v) and blades useful in that device.
EP06751645A EP1898853A2 (en) 2005-04-27 2006-04-27 Epithelial delaminating device (v) and blades useful in that device
AU2006239287A AU2006239287A1 (en) 2005-04-27 2006-04-27 Epithelial delaminating device (v) and blades useful in that device
JP2008509121A JP2008539033A (en) 2005-04-27 2006-04-27 Epithelial stripping device (V) and blade useful in the device
BRPI0609858-4A BRPI0609858A2 (en) 2005-04-27 2006-04-27 epithelial delamination device (v) and slides useful in this device
IL186938A IL186938A0 (en) 2005-04-27 2007-10-25 Epithelial delaminating device (v) and blades useful in that device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67550605P 2005-04-27 2005-04-27
US60/675,506 2005-04-27
US78710206P 2006-03-28 2006-03-28
US60/787,102 2006-03-28

Publications (3)

Publication Number Publication Date
WO2006116601A2 WO2006116601A2 (en) 2006-11-02
WO2006116601A3 true WO2006116601A3 (en) 2006-12-07
WO2006116601A8 WO2006116601A8 (en) 2007-12-13

Family

ID=36973029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/016034 Ceased WO2006116601A2 (en) 2005-04-27 2006-04-27 Epithelial delaminating device (v) and blades useful in that device

Country Status (10)

Country Link
EP (1) EP1898853A2 (en)
JP (1) JP2008539033A (en)
KR (1) KR20080018988A (en)
AU (1) AU2006239287A1 (en)
BR (1) BRPI0609858A2 (en)
CA (1) CA2606433A1 (en)
IL (1) IL186938A0 (en)
MX (1) MX2007013423A (en)
TW (1) TW200716072A (en)
WO (1) WO2006116601A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05002669A (en) 2002-09-13 2005-08-19 Ocular Sciences Inc Devices and methods for improving vision.
MXPA06013343A (en) 2004-05-20 2007-05-08 Coopervision Inc Corneal onlays and wavefront aberration correction to enhance vision.
US7883520B2 (en) 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
WO2008096821A1 (en) * 2007-02-08 2008-08-14 Kaneka Corporation Injector for eye
US8162953B2 (en) * 2007-03-28 2012-04-24 Revision Optics, Inc. Insertion system for corneal implants
CN101932289B (en) * 2008-01-31 2014-02-19 兴和株式会社 Manufacturing method of medical tool
US9186245B2 (en) * 2011-09-07 2015-11-17 Vladimir Feingold Lens injector apparatus and method
CN110772709B (en) * 2019-11-28 2021-08-31 原子高科股份有限公司 Method for arranging radioactive particles in applicator for treating intraocular malignant tumors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0956841A2 (en) * 1998-03-31 1999-11-17 Nidek Co., Ltd. Corneal surgical apparatus
US6099543A (en) * 1998-03-18 2000-08-08 Smith; Thomas C. Ophthalmic surgical blade
EP1199055A1 (en) * 2000-10-16 2002-04-24 Gebauer GmbH Blade with amorphous cutting edge
WO2003034958A2 (en) * 2001-10-25 2003-05-01 Carl Zeiss Meditec Ag Cutting device
US20040260320A1 (en) * 2002-12-10 2004-12-23 Lisk James R. Disposable separator for separating the epithelium layer from the cornea of an eye
WO2005023159A1 (en) * 2003-09-05 2005-03-17 Sightrate B.V. Device for separation of corneal epithelium

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099543A (en) * 1998-03-18 2000-08-08 Smith; Thomas C. Ophthalmic surgical blade
EP0956841A2 (en) * 1998-03-31 1999-11-17 Nidek Co., Ltd. Corneal surgical apparatus
EP1199055A1 (en) * 2000-10-16 2002-04-24 Gebauer GmbH Blade with amorphous cutting edge
WO2003034958A2 (en) * 2001-10-25 2003-05-01 Carl Zeiss Meditec Ag Cutting device
US20040260320A1 (en) * 2002-12-10 2004-12-23 Lisk James R. Disposable separator for separating the epithelium layer from the cornea of an eye
WO2005023159A1 (en) * 2003-09-05 2005-03-17 Sightrate B.V. Device for separation of corneal epithelium

Also Published As

Publication number Publication date
WO2006116601A2 (en) 2006-11-02
AU2006239287A1 (en) 2006-11-02
JP2008539033A (en) 2008-11-13
TW200716072A (en) 2007-05-01
IL186938A0 (en) 2008-02-09
KR20080018988A (en) 2008-02-29
EP1898853A2 (en) 2008-03-19
AU2006239287A8 (en) 2008-12-18
CA2606433A1 (en) 2006-11-02
MX2007013423A (en) 2008-01-18
BRPI0609858A2 (en) 2010-05-11
WO2006116601A8 (en) 2007-12-13

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