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WO2006017217A3 - Lc-esi integre sur puce - Google Patents

Lc-esi integre sur puce Download PDF

Info

Publication number
WO2006017217A3
WO2006017217A3 PCT/US2005/024518 US2005024518W WO2006017217A3 WO 2006017217 A3 WO2006017217 A3 WO 2006017217A3 US 2005024518 W US2005024518 W US 2005024518W WO 2006017217 A3 WO2006017217 A3 WO 2006017217A3
Authority
WO
WIPO (PCT)
Prior art keywords
chip
inlet
outlet
substrate
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/024518
Other languages
English (en)
Other versions
WO2006017217A2 (fr
Inventor
Yu-Chong Tai
Jun Xie
Jason Shih
Terry Lee
Yunan Miao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
City of Hope
Original Assignee
California Institute of Technology
City of Hope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology, City of Hope filed Critical California Institute of Technology
Publication of WO2006017217A2 publication Critical patent/WO2006017217A2/fr
Publication of WO2006017217A3 publication Critical patent/WO2006017217A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Système microfluidique associé à un pompage sur la puce et pouvant être utilisé en chromatographie liquide et également en spectrométrie de masse à ionisation par électropulvérisation, tout en permettant d'obtenir une efficacité améliorée, une intégration accrue avec des capteurs, une portabilité augmentée, une consommation électrique limitée et un coût diminué. Ce système peut comprendre (A) une puce principale composée d'une substrat présentant une face avant et une face arrière, d'une colonne chromatographique sur la face avant dudit substrat, ladite colonne possédant une entrée et une sortie, d'un ajutage d'ionisation par électropulvérisation (ESI) sur la face avant dudit substrat, ledit ajutage possédant une entrée et une sortie, l'entrée de l'ajutage étant couplée de façon microfluidique à la sortie de la colonne, d'un ou de plusieurs systèmes de pompage sur la face avant dudit substrat comportant une chambre de pompage, une ou plusieurs électrodes et une sortie couplée de façon microfluidique à l'entrée de ladite colonne. Ce système peut également comporter (B) une puce réservoir présentant une surface avant et une surface arrière et dont la surface arrière est pourvue d'une ou de plusieurs cavités qui, quand elles sont placées à côté de la surface avant de la puce principale, augmentent le volume de la chambre de pompage d'un des systèmes de pompage. On peut mettre en application des techniques de microfabrication afin de préparer ces puces qu'on peut ensuite monter avec un couvercle et insérer dans un gabarit de contrôle électronique et d'analyse spectrale de masse. Ce système permet d'effectuer des séparations de peptides pouvant être mises en concurrence avec des systèmes de l'état actuel de la technique.
PCT/US2005/024518 2004-07-09 2005-07-11 Lc-esi integre sur puce Ceased WO2006017217A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58657604P 2004-07-09 2004-07-09
US60/586,576 2004-07-09

Publications (2)

Publication Number Publication Date
WO2006017217A2 WO2006017217A2 (fr) 2006-02-16
WO2006017217A3 true WO2006017217A3 (fr) 2006-04-06

Family

ID=35839761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024518 Ceased WO2006017217A2 (fr) 2004-07-09 2005-07-11 Lc-esi integre sur puce

Country Status (1)

Country Link
WO (1) WO2006017217A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2534936B (en) * 2015-02-06 2021-09-08 Agilent Technologies Inc Liquid chromatography analysis unit
AU2021400841A1 (en) * 2020-12-15 2023-07-13 Proteas Bioanalytics, Inc. Mass spectrometry sample processing methods, chromatography devices, and data analysis techniques for biomarker analysis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing

Also Published As

Publication number Publication date
WO2006017217A2 (fr) 2006-02-16

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