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WO2006014089A1 - Composition cosmétique contenant de la kératinocyte et/ou de la fibrocytes - Google Patents

Composition cosmétique contenant de la kératinocyte et/ou de la fibrocytes Download PDF

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Publication number
WO2006014089A1
WO2006014089A1 PCT/KR2005/002555 KR2005002555W WO2006014089A1 WO 2006014089 A1 WO2006014089 A1 WO 2006014089A1 KR 2005002555 W KR2005002555 W KR 2005002555W WO 2006014089 A1 WO2006014089 A1 WO 2006014089A1
Authority
WO
WIPO (PCT)
Prior art keywords
keratinocytes
fibroblasts
cosmetic composition
skin
growth factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2005/002555
Other languages
English (en)
Inventor
Sae-Wha Jeon
Dong-Il Jang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tegoscience Inc
Original Assignee
Tegoscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tegoscience Inc filed Critical Tegoscience Inc
Publication of WO2006014089A1 publication Critical patent/WO2006014089A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

Definitions

  • the keratinocyte- or fibroblast-produced cytokines that may act to promote skin regeneration include basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), keratinocyte growth iactor (KGF), transforming growth iactor alpha (TGF ⁇ ), transferming growth factor beta-1 (TGF ⁇ ), granulocyte colony stimulating factor (GCSF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), tumor necrosis iactor (TNF), interleukins such as IL-I, IL-6, EL-8, DL-Il, etc., but are not limited thereto.
  • bFGF basic fibroblast growth factor
  • EGF epidermal growth factor
  • KGF keratinocyte growth iactor
  • TGF ⁇ transforming growth iactor alpha
  • TGF ⁇ transferming growth factor beta-1
  • GCSF granulocyte colony stimulating factor
  • IGF insulin-like growth factor
  • VEGF
  • Fibroblasts another or an alternative constituent of the cosmetic composition according to the present invention, may be taken from animals, preferably from mammal, and more preferably from humans.
  • the disaggregation of differentiated skin tissues and/or the differentiation of embryonic stem cells can yield fibroblasts.
  • Disaggregation is well known in the art and includes physical disaggregation and/or treatment with digestive enzymes and/or chelating agents that weaken the junction between adjacent cells.
  • the disaggregation methods can disperse skin tissues to yield single cells without causing cell rupture. Particularly, enzymatic disaggregation can be readily achieved by mincing tissues and treating them with single or combinations of digestive enzymes.
  • the lyophilization of keratinocytes or fibroblasts is conducted as follows: (1) cells are suspended in a buffer in a suitable vessel, followed by freezing the cell suspension at -70 to -80°C for about 12 hours or longer in a deep freezer; (2) the vessel is put in a sample container in a lyophilizer and the inner pressure of the sample container is slowly reduced to about 1x10 '3 torr; (3) while the lyophilizer chamber is maintained at about -50 0 C 9 the inner pressure of the sample container is further controlled to about 2xlO 4 torr and kept thereat for 12 hours or longer to complete the lyophilization; and (4) the vessel is withdrawn from the lyophilizer, sealed with a cap, and stored at 2 to 8 0 C.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Composition cosmétique comprenant des kératinocytes lyophilisées et/ou des fibrocytes et méthode de préparation de la composition cosmétique comprenant (1) la culture de kératinocytes ou de fibrocytes ; (2) lyophilisation des kératinocytes ou des fibrocytes cultivées ; (3) incorporation des kératinocytes et/ou des fibrocytes lyophilisées dans un support cosmétiquement acceptable. Lors de l’application sur la peau, les kératinocytes et/ou les fibrocytes contenues dans la composition cosmétique libèrent des cytokines déjà émises permettant la regénération de la peau.
PCT/KR2005/002555 2004-08-06 2005-08-05 Composition cosmétique contenant de la kératinocyte et/ou de la fibrocytes Ceased WO2006014089A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040062079A KR100614903B1 (ko) 2004-08-06 2004-08-06 케라티노사이트 및/또는 섬유아세포를 함유하는 화장용조성물
KR10-2004-0062079 2004-08-06

Publications (1)

Publication Number Publication Date
WO2006014089A1 true WO2006014089A1 (fr) 2006-02-09

Family

ID=35787351

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2005/002555 Ceased WO2006014089A1 (fr) 2004-08-06 2005-08-05 Composition cosmétique contenant de la kératinocyte et/ou de la fibrocytes

Country Status (3)

Country Link
JP (1) JP2006045175A (fr)
KR (1) KR100614903B1 (fr)
WO (1) WO2006014089A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008116116A3 (fr) * 2007-03-20 2008-12-18 Harold Brem Compositions gm-csf cosméceuticales et leurs procédés d'utilisation
WO2008116111A3 (fr) * 2007-03-20 2009-05-22 Harold Brem Produits cosméceutiques induits par le facteur de croissance et leur utilisation pour l'amélioration de la qualité de la peau
CN104611289A (zh) * 2015-01-13 2015-05-13 广州赛奕德生物技术有限公司 自体表皮细胞和成纤维细胞同时制备方法及其生物美容产品
CN104662532A (zh) * 2011-03-28 2015-05-27 约翰·S·阿诺尼 用于从所获得的基于干细胞的生物材料收集、低温存储和分配化妆配制品的商业方法、过程和系统
CN106540246A (zh) * 2015-09-21 2017-03-29 四川大学 成纤维细胞疫苗及其制备方法和用途
US9907745B2 (en) 2014-01-15 2018-03-06 Serucell Corporation Cosmetic compositions and method of making the same
US9974813B1 (en) 2014-01-15 2018-05-22 Serucell Corporation Therapeutic serum obtained from co-cultured cells
CN109481389A (zh) * 2018-11-16 2019-03-19 深圳中旭细胞再生医学研究有限公司 一种用于美容护肤的干细胞激活素及其制备方法和应用
US10253334B2 (en) 2014-01-15 2019-04-09 Serucell Corporation Therapeutic serum obtained from co-cultured cells

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070000005A (ko) * 2005-06-24 2007-01-02 주식회사 아디포랩 섬유아세포성장인자를 함유한 화장료 조성물
JP2014058459A (ja) * 2012-09-14 2014-04-03 ▲高▼野 友梨 コラーゲン産生促進懸濁液の製造方法
KR102588627B1 (ko) * 2017-03-08 2023-10-16 김성진 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법
CN108578266B (zh) * 2018-07-27 2020-08-14 北京化工大学 一种抗氧化组合物及其在面膜液中的应用
KR102257532B1 (ko) * 2019-10-17 2021-05-31 더마몰 주식회사 성장인자 복합체를 포함하는 레이저 치료 후 피부 재생용 조성물

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784854A (en) * 1985-08-01 1988-11-15 Seguin Marie Christine Cosmetic composition obtained from cellular cultures of conjunctive tissue
EP0396442B1 (fr) * 1989-04-21 1992-11-11 L'oreal Composition cosmétique contenant des composés obtenus par culture de cellules, notamment de fibroblastes ou de kératinocytes
WO2001014527A1 (fr) * 1999-08-23 2001-03-01 Organogenesis Inc. Compositions et traitements pour soins cutanes
US6585969B1 (en) * 1991-11-20 2003-07-01 N. V. Innogenetics S.A. Non-viable keratinocyte cell composition or lysate for promoting wound healing
KR20030083824A (ko) * 2002-04-22 2003-11-01 동아제약 주식회사 인공피부 배양물 및 그 제조방법
EP1358857A1 (fr) * 1995-07-28 2003-11-05 Isolagen International S.A. Utilisation de fibroblastes dermiques autologués pour la réparation de la peau et des legers défauts cutanés

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784854A (en) * 1985-08-01 1988-11-15 Seguin Marie Christine Cosmetic composition obtained from cellular cultures of conjunctive tissue
EP0396442B1 (fr) * 1989-04-21 1992-11-11 L'oreal Composition cosmétique contenant des composés obtenus par culture de cellules, notamment de fibroblastes ou de kératinocytes
US6585969B1 (en) * 1991-11-20 2003-07-01 N. V. Innogenetics S.A. Non-viable keratinocyte cell composition or lysate for promoting wound healing
EP1358857A1 (fr) * 1995-07-28 2003-11-05 Isolagen International S.A. Utilisation de fibroblastes dermiques autologués pour la réparation de la peau et des legers défauts cutanés
WO2001014527A1 (fr) * 1999-08-23 2001-03-01 Organogenesis Inc. Compositions et traitements pour soins cutanes
KR20030083824A (ko) * 2002-04-22 2003-11-01 동아제약 주식회사 인공피부 배양물 및 그 제조방법

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008116111A3 (fr) * 2007-03-20 2009-05-22 Harold Brem Produits cosméceutiques induits par le facteur de croissance et leur utilisation pour l'amélioration de la qualité de la peau
US8673859B2 (en) 2007-03-20 2014-03-18 New York University GM-CSF cosmeceutical compositions and methods of use thereof
US9168214B2 (en) 2007-03-20 2015-10-27 New York University Methods of increasing collagen formation and cellular migration in intact skin
WO2008116116A3 (fr) * 2007-03-20 2008-12-18 Harold Brem Compositions gm-csf cosméceuticales et leurs procédés d'utilisation
CN104662532A (zh) * 2011-03-28 2015-05-27 约翰·S·阿诺尼 用于从所获得的基于干细胞的生物材料收集、低温存储和分配化妆配制品的商业方法、过程和系统
US10533191B2 (en) 2014-01-15 2020-01-14 Serucell Corporation Therapeutic serum obtained from co-cultured cells
US9907745B2 (en) 2014-01-15 2018-03-06 Serucell Corporation Cosmetic compositions and method of making the same
US9974813B1 (en) 2014-01-15 2018-05-22 Serucell Corporation Therapeutic serum obtained from co-cultured cells
US11299756B2 (en) 2014-01-15 2022-04-12 Serucell Corporation Therapeutic serum obtained from co-cultured cells
US10253334B2 (en) 2014-01-15 2019-04-09 Serucell Corporation Therapeutic serum obtained from co-cultured cells
CN104611289A (zh) * 2015-01-13 2015-05-13 广州赛奕德生物技术有限公司 自体表皮细胞和成纤维细胞同时制备方法及其生物美容产品
CN106540246A (zh) * 2015-09-21 2017-03-29 四川大学 成纤维细胞疫苗及其制备方法和用途
CN109481389A (zh) * 2018-11-16 2019-03-19 深圳中旭细胞再生医学研究有限公司 一种用于美容护肤的干细胞激活素及其制备方法和应用

Also Published As

Publication number Publication date
KR100614903B1 (ko) 2006-08-25
KR20060013207A (ko) 2006-02-09
JP2006045175A (ja) 2006-02-16

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