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WO2006010838A3 - Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant - Google Patents

Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant Download PDF

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Publication number
WO2006010838A3
WO2006010838A3 PCT/FR2005/001612 FR2005001612W WO2006010838A3 WO 2006010838 A3 WO2006010838 A3 WO 2006010838A3 FR 2005001612 W FR2005001612 W FR 2005001612W WO 2006010838 A3 WO2006010838 A3 WO 2006010838A3
Authority
WO
WIPO (PCT)
Prior art keywords
active principle
immunostimulatory
low diffusion
products containing
anticancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2005/001612
Other languages
English (en)
Other versions
WO2006010838A2 (fr
Inventor
Caroline Robert
Lluis Mir
Antoine Carpentier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Universite Paris Descartes
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Universite Paris Descartes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04292515A external-priority patent/EP1649859A1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Gustave Roussy (IGR), Universite Paris Descartes filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP05783840A priority Critical patent/EP1765361A2/fr
Priority to AU2005266225A priority patent/AU2005266225A1/en
Publication of WO2006010838A2 publication Critical patent/WO2006010838A2/fr
Publication of WO2006010838A3 publication Critical patent/WO2006010838A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Produits utilisés en combinaison, en vue d'un traitement efficace des tumeurs et plus particulièrement des métastases. Lesdits produits contiennent au moins un principe actif anticancéreux peu diffusible et un principe actif immunostimulant sélectionné dans le groupe constitué par des ligands de TLR en tant que préparation combinée pour une utilisation simultanée, séparée ou étalée dans le temps, pour le traitement des tumeurs bénignes ou malignes et plus particulièrement des métastases, chez un sujet atteint d'une tumeur et soumis à une électroperméabilisation au niveau de ladite tumeur ou au niveau d'un tissu sain approprié.
PCT/FR2005/001612 2004-06-25 2005-06-24 Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant Ceased WO2006010838A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05783840A EP1765361A2 (fr) 2004-06-25 2005-06-24 Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant
AU2005266225A AU2005266225A1 (en) 2004-06-25 2005-06-24 Products containing at least one anticancer active principle with low diffusion and an immunostimulatory active principle

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04291615.5 2004-06-25
EP04291615 2004-06-25
EP04292515A EP1649859A1 (fr) 2004-10-22 2004-10-22 Produits pharmaceutiques contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant sous forme d'oligodésoxynucléotide
EP04292515.6 2004-10-22

Publications (2)

Publication Number Publication Date
WO2006010838A2 WO2006010838A2 (fr) 2006-02-02
WO2006010838A3 true WO2006010838A3 (fr) 2006-06-15

Family

ID=35515626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/001612 Ceased WO2006010838A2 (fr) 2004-06-25 2005-06-24 Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant

Country Status (3)

Country Link
EP (1) EP1765361A2 (fr)
AU (1) AU2005266225A1 (fr)
WO (1) WO2006010838A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006054129A1 (fr) 2004-11-19 2006-05-26 Institut Gustave Roussy Traitement ameliore du cancer par arn double brin
FR2975600B1 (fr) * 2011-05-24 2013-07-05 Assist Publ Hopitaux De Paris Agents pour le traitement de tumeurs
GB201408119D0 (en) 2014-05-08 2014-06-25 Univ Cork Method
JP7409773B2 (ja) 2015-07-31 2024-01-09 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 改変された細胞および治療の方法
US20200208111A1 (en) * 2016-06-09 2020-07-02 Branden S. Moriarity Genome-edited nk cell and methods of making and using

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051259A2 (fr) * 1998-04-03 1999-10-14 University Of Iowa Research Foundation Procedes et produits servant a stimuler le systeme immunitaire au moyen d'oligonucleotides et de cytokines immunotherapeutiques
US20020192184A1 (en) * 1999-03-19 2002-12-19 Carpentier Antoine F. Use of stabilized oligonucleotides for preparing a medicament with antitumor activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051259A2 (fr) * 1998-04-03 1999-10-14 University Of Iowa Research Foundation Procedes et produits servant a stimuler le systeme immunitaire au moyen d'oligonucleotides et de cytokines immunotherapeutiques
US20020192184A1 (en) * 1999-03-19 2002-12-19 Carpentier Antoine F. Use of stabilized oligonucleotides for preparing a medicament with antitumor activity

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CARPENTIER A F ET AL: "Successful treatment of intracranial gliomas in rat by oligodeoxynucleotides containing CpG motifs.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. JUN 2000, vol. 6, no. 6, June 2000 (2000-06-01), pages 2469 - 2473, XP002366692, ISSN: 1078-0432 *
CONNELL Y S ET AL: "ANTI-TUMOR ACTIVITY OF A CPG-CONTAINING OLIGODEOXYNUCLEOTIDE (ODN) IN ATHYMIC MICE", PROCEEDINGS OF THE 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. PHILADELPHIA, PA, APRIL 10 - 14, 1999, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, vol. VOL. 40, April 1999 (1999-04-01), pages 299, XP000857678 *
HECKELSMILLER K ET AL: "Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 32, no. 11, November 2002 (2002-11-01), pages 3235 - 3245, XP002322319, ISSN: 0014-2980 *
HECKELSMILLER K ET AL: "Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 169, no. 7, 1 October 2002 (2002-10-01), pages 3892 - 3899, XP002322318, ISSN: 0022-1767 *
MIR L M ET AL: "ELECTROCHEMOTHERAPY POTENTIATION OF ANTITUMOUR EFFECT OF BLEOMYCIN BY LOCAL ELECTRIC PULSES", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 27, no. 1, 1991, pages 68 - 72, XP000575541, ISSN: 0959-8049 *
WEIGEL BRENDA J ET AL: "CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 1 AUG 2003, vol. 9, no. 8, 1 August 2003 (2003-08-01), pages 3105 - 3114, XP002990544, ISSN: 1078-0432 *

Also Published As

Publication number Publication date
WO2006010838A2 (fr) 2006-02-02
AU2005266225A1 (en) 2006-02-02
EP1765361A2 (fr) 2007-03-28

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