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WO2006078811A3 - Preparations pharmaceutiques qui procedes d'utilisation - Google Patents

Preparations pharmaceutiques qui procedes d'utilisation Download PDF

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Publication number
WO2006078811A3
WO2006078811A3 PCT/US2006/001887 US2006001887W WO2006078811A3 WO 2006078811 A3 WO2006078811 A3 WO 2006078811A3 US 2006001887 W US2006001887 W US 2006001887W WO 2006078811 A3 WO2006078811 A3 WO 2006078811A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical formulations
release component
methods
component
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/001887
Other languages
English (en)
Other versions
WO2006078811A2 (fr
Inventor
Rodney A Brown
Stephen H Curry
Michael Rubenstein
Michael R Violante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quay Pharmaceuticals Ltd
Pharmanova Inc
Original Assignee
Quay Pharmaceuticals Ltd
Pharmanova Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36692870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006078811(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA002595470A priority Critical patent/CA2595470A1/fr
Priority to AU2006206423A priority patent/AU2006206423A1/en
Priority to MX2007008833A priority patent/MX2007008833A/es
Priority to JP2007552260A priority patent/JP2008528494A/ja
Priority to BRPI0614021-1A priority patent/BRPI0614021A2/pt
Application filed by Quay Pharmaceuticals Ltd, Pharmanova Inc filed Critical Quay Pharmaceuticals Ltd
Priority to EP06718892A priority patent/EP1838291A4/fr
Publication of WO2006078811A2 publication Critical patent/WO2006078811A2/fr
Publication of WO2006078811A3 publication Critical patent/WO2006078811A3/fr
Priority to IL184735A priority patent/IL184735A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne de nouvelles préparations pharmaceutiques et de nouvelles utilisations médicales de gabapentine et de pregabaline. Ces préparations peuvent comprendre jusqu'à trois composants comprenant un composant à libération immédiate, un composant à libération soutenue et un composant à libération retardée. La proportion de chaque composant dans cette préparation peut-être réglée de façon à obtenir l'AUC souhaité et l'effet thérapeutique suivant l'administration à une personne par voie orale.
PCT/US2006/001887 2005-01-21 2006-01-20 Preparations pharmaceutiques qui procedes d'utilisation Ceased WO2006078811A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP06718892A EP1838291A4 (fr) 2005-01-21 2006-01-20 Preparations pharmaceutiques qui procedes d'utilisation
AU2006206423A AU2006206423A1 (en) 2005-01-21 2006-01-20 Pharmaceutical formulations and methods of use
MX2007008833A MX2007008833A (es) 2005-01-21 2006-01-20 Formulaciones farmaceuticas y metodos de uso.
JP2007552260A JP2008528494A (ja) 2005-01-21 2006-01-20 医薬製剤および使用方法
BRPI0614021-1A BRPI0614021A2 (pt) 2005-01-21 2006-01-20 formulações farmacêuticas e métodos de uso
CA002595470A CA2595470A1 (fr) 2005-01-21 2006-01-20 Preparations pharmaceutiques qui procedes d'utilisation
IL184735A IL184735A0 (en) 2005-01-21 2007-07-19 Pharmaceutical formulations and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64585705P 2005-01-21 2005-01-21
US60/645,857 2005-01-21

Publications (2)

Publication Number Publication Date
WO2006078811A2 WO2006078811A2 (fr) 2006-07-27
WO2006078811A3 true WO2006078811A3 (fr) 2007-03-01

Family

ID=36692870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/001887 Ceased WO2006078811A2 (fr) 2005-01-21 2006-01-20 Preparations pharmaceutiques qui procedes d'utilisation

Country Status (12)

Country Link
EP (1) EP1838291A4 (fr)
JP (1) JP2008528494A (fr)
KR (1) KR20070116588A (fr)
CN (1) CN101137352A (fr)
AR (1) AR062647A1 (fr)
AU (1) AU2006206423A1 (fr)
BR (1) BRPI0614021A2 (fr)
CA (1) CA2595470A1 (fr)
IL (1) IL184735A0 (fr)
MX (1) MX2007008833A (fr)
TW (1) TW200640497A (fr)
WO (1) WO2006078811A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA017171B1 (ru) 2006-12-22 2012-10-30 Рекордати Айерленд Лимитед КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП)
EP2018854A1 (fr) * 2007-07-27 2009-01-28 Merz Pharma GmbH & Co. KGaA Nouvelles combinaisons de néramexane pour le traitement des troubles neuro-dégénératifs
JP2011504491A (ja) 2007-11-23 2011-02-10 ルピン・リミテッド プレガバリンの制御放出医薬組成物
WO2009067703A2 (fr) * 2007-11-23 2009-05-28 Nectid, Inc. Compositions de tapentadol
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
DK2661266T3 (da) 2011-01-07 2020-11-16 Anji Pharma Us Llc Kemosensoriske receptorligandbaserede terapier
US11974971B2 (en) 2011-01-07 2024-05-07 Anji Pharmaceuticals Inc. Compositions and methods for treating metabolic disorders
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
EP2704698B1 (fr) * 2011-05-05 2019-10-02 Hennig Arzneimittel GmbH&Co. Kg Forme galénique pour libération ciblée de principes actifs
KR101438546B1 (ko) * 2011-08-26 2014-09-17 근화제약주식회사 프레가발린을 포함하는 서방성 제제
WO2013100873A1 (fr) * 2011-12-19 2013-07-04 Mahmut Bilgic Formulation pharmaceutique de prégabaline (taille de particules 300-2500 micromètres)
SG10201901922VA (en) 2012-01-06 2019-04-29 Elcelyx Therapeutics Inc Compositions and methods for treating metabolic disorders
SG11201403839SA (en) 2012-01-06 2014-08-28 Elcelyx Therapeutics Inc Biguanide compositions and methods of treating metabolic disorders
KR102221846B1 (ko) * 2014-04-07 2021-02-26 영진약품 주식회사 안정성이 개선된 프레가발린을 함유하는 약제학적 조성물 및 이의 제조방법
JP6665099B2 (ja) * 2014-08-29 2020-03-13 わかもと製薬株式会社 乳酸菌含有組成物
CA2902911C (fr) 2014-10-31 2017-06-27 Purdue Pharma Methodes et compositions destinees au traitement du trouble de deficit d'attention
WO2016187718A1 (fr) 2015-05-26 2016-12-01 Isa Odidi Prégabaline à libération prolongée contrôlée
RU2738114C2 (ru) * 2016-04-19 2020-12-08 Конарис Рисёрч Инститьют Аг Пероральные фармацевтические композиции никотинамида
EP3484456A4 (fr) * 2016-07-17 2020-03-18 Mapi Pharma Limited Formes galéniques à libération prolongée de prégabaline
JP6919119B2 (ja) * 2017-01-23 2021-08-18 日新製薬株式会社 ３位が置換されたγ−アミノ酪酸誘導体を含有する圧縮固形医薬組成物。
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
CN112023032B (zh) * 2020-09-14 2022-03-18 广东鼎信医药科技有限公司 一种含有消化酶的药物组合物及其制备方法
WO2022119430A1 (fr) 2020-12-04 2022-06-09 Laboratorios Silanes S.A. De C.V. Composition pharmaceutique solide recouverte et stable d'un analgésique et d'un antiépileptique contre la douleur
CN116898819B (zh) * 2023-06-09 2024-02-06 则正(上海)生物科技有限公司 一种普瑞巴林缓释剂及其制备方法

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JP4625637B2 (ja) * 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US20060182805A1 (en) * 2005-02-15 2006-08-17 Jazz Pharmaceuticals Dosage form and method for sustained release of substituted pyrazine compound

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Non-Patent Citations (2)

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Title
CHOURASIA M.K. ET AL.: "Pharmaceutical approaches to colon targeted drug delivery systems", J. PHARM. PHARMACEUT. SCI., vol. 6, no. 1, 2003, pages 33 - 65, XP008078133 *
MAGNUS L.: "Nonepileptic Uses of Gabapentin", IPILEPSIA, vol. 40, no. SUPPL. 6, 1999, pages S66 - S72, XP000866519 *

Also Published As

Publication number Publication date
WO2006078811A2 (fr) 2006-07-27
IL184735A0 (en) 2007-12-03
BRPI0614021A2 (pt) 2011-03-01
KR20070116588A (ko) 2007-12-10
EP1838291A2 (fr) 2007-10-03
TW200640497A (en) 2006-12-01
AR062647A1 (es) 2008-11-26
AU2006206423A1 (en) 2006-07-27
MX2007008833A (es) 2008-03-25
EP1838291A4 (fr) 2008-12-03
JP2008528494A (ja) 2008-07-31
CN101137352A (zh) 2008-03-05
CA2595470A1 (fr) 2006-07-27

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