WO2006065163A1 - Device for medicamentally testing a patient - Google Patents

Abstract

The invention relates to medicine. The inventive device for medicamentally testing a patient comprises an instrument for measuring the patient tissue light absorption by means of light sources whose wavelength is equal to or greater than a red range and optoelectronic sensors in at least two areas of the patient body, a patient loading source in the form of a medicamental selector containing at least one preparation and a computer unit connected to said selector and measuring instrument. The computing unit is connected to said instrument through a digital-to-analog converter and the amplifier of optoelectronic sensor signals and is embodied such that it makes it possible to evaluate the patient reaction to the medicamental loading according to the received signals and to control the selector for selecting load for a subsequent testing step. The computer unit makes it possible to compare the signals recorded during the patient testing therebetween, to determine an amplitude and/or phase variability and/or a form variability and/or the periodicity of said signals and to compute numerical characteristics corresponding to the different aspects of the patient reaction.

Description

 Patient drug testing device

The invention relates to medicine, namely to medical equipment and can be used for individual selection of a drug without ingestion during reflexology, electropuncture, heat and drug therapy.

Known drug testing according to the method of R. Voll [1], which consists in the selection of the necessary drug for the patient without introducing it into the body based on electro-puncture diagnostics, carried out by measuring the current flowing in the measuring circuit electrodes - acupuncture point (AT) at constant pressure electrode on the skin with a device for measuring the electrical characteristics of AT for some time. It is enough for the patient to touch the medicine with his hand, and, on the basis of the long-range phenomenon, the effectiveness of its action on the patient is determined not only with molecular contact, but also at a distance. The effect of the drug is measured indirectly by the reaction of the body, and the indicator is the acupuncture system of a person, which allows to differentiate and evaluate the direction of the reaction of the body. In this case, the normalized current values measured in the presence and absence of the drug are compared. Deviations from normalized values are the basis for the conclusion that there is an improvement or deterioration in the functioning of an organ or system of an organism.

Also known is a device for non-invasive express diagnostics [2], containing a power source, a measuring unit with a display device and electrodes with a testing microresonant circuit.

The device allows to assess the response of the body to the effects of various substances by changing the skin conductivity.

A disadvantage of the known devices is the significant duration of the diagnostic process, which is associated with the need to determine the optimal acupuncture points on the patient and low diagnostic accuracy due to effects of external electromagnetic fields on acupuncture points.

A device for conducting medical testing [3], containing a block of influence on the object of study (AT) in the form of a constant current source and electrodes installed in contact with the patient’s body, a testing block, including several microresonant circuits and their switching elements, a program registration unit and information processing, consisting of an AT conductivity meter with an amplifier, an analog-to-digital converter (ADC) and a computing device with a display device.

The known device does not actually use information related to the dynamics of measuring the characteristics of the study for one or another selected test effect, which reduces the effectiveness of testing and the accuracy of the selection of the drug.

In addition, a common significant drawback of all of these known devices is that they all conduct testing of a drug for a patient by measuring conductivity in AT. Clinical patients can also have multiple and concomitant underlying disease disorders that affect the electrical conductive properties of the AT tissue under investigation and do not allow supporting information about the parameters of “normal tissue”.

The present invention aims to eliminate the above disadvantages. The technical result achieved by its implementation is to increase the effectiveness of drug testing by selecting a drug using a device that is not affected by external electromagnetic fields. At the same time, monitoring the dynamics of the study and the software processing of the data obtained allows us to additionally obtain conclusions about the effectiveness of a particular drug that is adequate to the current condition of the patient. The device allows to increase the accuracy of measurements, because It works without measuring the electrical conductivity and the skin is not affected by the indications and the presence of a pacemaker in the patient. Fatigue errors of the operator conducting the study are also excluded, and research is automated.

The essence of the invention lies in the fact that the apparatus for drug testing of a patient includes a device for measuring light absorption by patient tissues using light sources with a length of waves not lower than the red range and optoelectronic sensors in at least two parts of the patient’s body, the patient’s load source in the form of a drug selector containing at least one drug, and a computing device associated with a selector and a measurement device, while the computing device It is connected to the device through a digital-to-analog converter and amplifiers of signals of optoelectronic sensors and is made with the possibility of evaluating, based on the received signals, the patient’s response to the drug load Control selector for selecting the load for the next stage of testing. The computing device is capable of comparing with each other the signals of each optoelectronic sensor recorded during patient testing, determining the amplitude and / or phase variability and / or variability of the shape and / or frequency of these signals and calculating numerical characteristics corresponding to various aspects of the patient's reactions. In a person at rest, the activity of metabolic processes of various organs can dynamically change. At the same time, the volume of blood entering these organs dynamically changes. The redistribution of the amount of blood in different parts of the body is provided by a change in the conductivity of the autonomic nerve and, thus, a change in the value of the cardio pulse, which provides maximum pressure in the innervated blood vessels. A change in the value of the cardiac pulse leads to a change in both the maximum pressure and the speed of blood flow in the vessel. These changes characterize the intensity of the patient’s functioning and can be recorded by measuring the amount of light absorbed by the patient’s tissues. The method is based on the measurement data of blood flow parameters in the peripheral parts of the cardiovascular system. Accordingly, it is these data that contain all the possible signs of optimal functioning and the intensity of the functioning of the patient's body. Monitoring the functioning of the cardiovascular system makes it possible to observe various parameters of the blood flow: the relative change in the amount of hemoglobin and oxyhemoglobin in the blood, the pulse intervals in different leads, the change in the amplitude or phase of light absorption by hemoglobin, the gravitational parameters of the vertical blood flow, and many others. The most effective use of these methods is to evaluate various kinds of drug loads with the goal, for example, of predicting the patient’s response to the prescription of a particular drug.

The apparatus for drug testing of a patient includes, in addition to the selector, a device for measuring light absorption by the patient’s tissues. The device consists of light sources with a wavelength of at least the wavelength of the red range and optoelectronic sensors installed in at least two parts of the patient’s body. Depending on the test task, the dynamics of light absorption by hemoglobin or oxyhemoglobin of the blood (red or infrared radiation ranges) is determined.

For each of the photoplezograms, i.e. curve of light absorption by hemoglobin or oxyhemoglobin, calculated ((the distance between its minima)) - this is the pulse intervals.

As already noted, a change in the value of the cardio pulse leads to a change in both the maximum pressure and the speed of blood flow in the vessel. When testing this effect is observed as the variability of the lengths of pulse intervals in different parts of the body, i.e. pulse intervals successively measured in different parts of the patient’s body have different lengths, this mutual difference is called pulse variability.

The functioning of various vessels in the optimal mode should have many common characteristics. With lesions of both the vessels themselves and the cells supplied with blood, non-optimal functioning of the vessels occurs. A description of how much in phase the light absorption curves of hemoglobin or oxyhemoglobin of the blood taken in different parts of the patient’s body coincide are called phase variability. The smaller the differences in phase, the correspondingly smaller the value of phase variability, and therefore the smaller the differences in blood flow characteristics in different parts of the patient’s body, and the closer the functioning of the test blood vessels to normal.

Vegetative variability is understood as the mutual difference between pulse intervals or phase deviations of the light absorption curves when measuring blood flow parameters in the peripheral parts of the cardiovascular system. As one of the most sensitive to drug testing, the variable value of the optimal functioning of the patient’s body usually uses the value of its average and amplitude deviation of blood flow from the optimum. In an organism oriented towards optimal functioning, the amount of blood supplied to the cells should be consistent with the need for the cells provided with blood. In a healthy person, the functioning of the blood vessel supplying the cells is also optimal: the capacity of the vessel, its elasticity and resilience, the adequacy of its reactions to the cardiac impulse (if the vessel is innervated) and other parameters allow the amount of blood required for the cells to pass through with minimal resources.

The similarity to the optimal functioning of the vessel in different leads of the patient's cardiovascular system using the light absorption curve of hemoglobin or oxyhemoglobin is set by indicators of the average and amplitude deviation of blood flow from the optimum (shape variability). The smaller the value of these indicators, the less discrepancies between the recorded curves and the theoretical optimum. Consequently, less deviations from the optimum in the functioning of the test blood vessels are observed.

The work of the proposed device is as follows.

The sensors are fixed on the studied surface, for example, earlobes, fingers or toes, while the nail phalanx of the finger is fixed in the sensor between its elements so that the nail is facing the emitter.

Next, the patient is tested in the absence of any drug exposure. In this case, the light from each radiation source propagates through the corresponding test medium, partially absorbed in it, and is received by a photodetector generating an electric current, indicating the intensity of the incident light radiation. This signal is fed to the corresponding amplifier and through a multi-channel ADC in digital form is analyzed in a computing device to determine information related to the medium through which the light energy was transmitted, and determine it characteristics.

Repeated testing of the patient is carried out during a drug exposure, which can include not only the use of a drug applied to the skin surface, but also allows you to analyze the patient's reactions to drugs of viruses, microbes and toxins, various organ preparations, electromagnetic, thermal and other effects.

The data obtained as a result of this study will have different values for the same sensors.

As a result of comparing the measured values with and without load, we can conclude that the patient has a positive or negative reaction to the test load. The information obtained can be used for diagnostic purposes or to identify the most effective therapeutic drug.

Comparison of indicators among themselves is illustrated by table N ° l. All measurements at each stage of testing are processed in a computing device that evaluates the response of the patient and controls the selector to select the load for the next stage of testing.

Sources of information: [1] Lupichev H. JT. Electropuncture diagnostics, homeopathy and the phenomenon of long-range action. M., Irius, 1990. [2] SU 1600696, 1990. [3] SU 1787016, 1993.

TABLES 1

Interpretation of indicators of drug testing of a patient without load and with load

Claims

Claim 1. A device for medical testing of a patient, including a device for measuring light absorption by patient’s tissues using light sources with a wavelength of at least the wavelength of the red range and optoelectronic sensors in at least two parts of the patient’s body, the patient’s load source in the form of a drug a selector containing at least one drug, and a computing device associated with the selector and the device for taking measurements, while the computing device is connected to the device through of digital-to-analog converter and amplifiers optoelectronic sensor signals and adapted to evaluation of patient response signals received on the pill burden and the selector control to select the load for the next stage of testing. 2. The device according to claim 1, characterized in that the computing device is configured to compare each signal of each optoelectronic sensor recorded during patient testing, determine the amplitude and / or phase variability and / or variability of the shape and / or frequency of these signals and calculate numerical characteristics corresponding to various aspects of the patient's reactions.