[go: up one dir, main page]

WO2006044793A3 - Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes - Google Patents

Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes Download PDF

Info

Publication number
WO2006044793A3
WO2006044793A3 PCT/US2005/037246 US2005037246W WO2006044793A3 WO 2006044793 A3 WO2006044793 A3 WO 2006044793A3 US 2005037246 W US2005037246 W US 2005037246W WO 2006044793 A3 WO2006044793 A3 WO 2006044793A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
disorder
methods
prevention
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/037246
Other languages
English (en)
Other versions
WO2006044793A2 (fr
Inventor
Ravish V Patwardhan
Mohammed Fasiuddin
Walter G Besio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Louisiana Tech University Foundation Inc
Louisiana State University
Original Assignee
Louisiana Tech University Foundation Inc
Louisiana State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana Tech University Foundation Inc, Louisiana State University filed Critical Louisiana Tech University Foundation Inc
Priority to EP05808963A priority Critical patent/EP1809369A4/fr
Priority to JP2007536997A priority patent/JP2008516696A/ja
Priority to CA002626691A priority patent/CA2626691A1/fr
Publication of WO2006044793A2 publication Critical patent/WO2006044793A2/fr
Anticipated expiration legal-status Critical
Publication of WO2006044793A3 publication Critical patent/WO2006044793A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/375—Electroencephalography [EEG] using biofeedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Neurosurgery (AREA)
  • Social Psychology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physiology (AREA)
  • Electrotherapy Devices (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

La présente invention a trait à des dispositifs et des procédés pour la détection, la prévention et/ou le traitement de troubles neurologiques. Ces dispositifs et procédés utilisent la stimulation électrique, et comportent un composant d'électrodes annulaire concentrique unique. Les procédés de l'invention comprennent le positionnement d'une pluralité d'électrodes sur le cuir chevelu d'un mammifère; le suivi des motifs électriques du cerveau du mammifère en vue de l'identification de l'apparition d'un événement neurologique; l'identification de l'emplacement des motifs électriques du cerveau indiquant un événement neurologique; et l'application d'une stimulation électrique transcutanée ou transcrânienne à l'emplacement de l'événement neurologique pour la modification bénéfique des motifs électriques. Les procédés de l'invention peuvent être utiles dans la détection, la prévention et/ou le traitement de diverses indications telles que l'épilepsie, la maladie de Parkinson, la maladie de Huntington, la maladie d'Alzheimer, la dépression, le trouble bipolaire, la phobie, la schizophrénie, le trouble de personnalité multiple, la migraine ou le mal de tête, la commotion, l'hyperactivité avec déficit de l'attention, le trouble alimentaire, la toxicomanie, et l'anxiété. Les procédés de l'invention peuvent également être utilisés en combinaison avec d'autres techniques de stimulation périphérique.
PCT/US2005/037246 2004-10-18 2005-10-17 Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes Ceased WO2006044793A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05808963A EP1809369A4 (fr) 2004-10-18 2005-10-17 Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes
JP2007536997A JP2008516696A (ja) 2004-10-18 2005-10-17 神経障害の検出、予防および／または治療のための医療装置ならびにその医療装置に関連する方法
CA002626691A CA2626691A1 (fr) 2004-10-18 2005-10-17 Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96789104A 2004-10-18 2004-10-18
US10/967,891 2004-10-18

Publications (2)

Publication Number Publication Date
WO2006044793A2 WO2006044793A2 (fr) 2006-04-27
WO2006044793A3 true WO2006044793A3 (fr) 2007-08-23

Family

ID=36203623

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/037246 Ceased WO2006044793A2 (fr) 2004-10-18 2005-10-17 Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes

Country Status (4)

Country Link
EP (1) EP1809369A4 (fr)
JP (1) JP2008516696A (fr)
CA (1) CA2626691A1 (fr)
WO (1) WO2006044793A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060058853A1 (en) 2004-09-13 2006-03-16 Jonathan Bentwich Integrated system and method for treating disease using cognitive-training and brain stimulation and computerized magnetic photo-electric stimulator (cmpes)
US8095209B2 (en) 2005-01-06 2012-01-10 Braingate Co., Llc Biological interface system with gated control signal
US7901368B2 (en) 2005-01-06 2011-03-08 Braingate Co., Llc Neurally controlled patient ambulation system
WO2006073915A2 (fr) 2005-01-06 2006-07-13 Cyberkinetics Neurotechnology Systems, Inc. Routine d'entrainement d'un patient destinee a un systeme d'interface biologique
WO2006076175A2 (fr) 2005-01-10 2006-07-20 Cyberkinetics Neurotechnology Systems, Inc. Systeme d'interface biologique pour appareil de reeducation de patients
WO2006078432A2 (fr) 2005-01-18 2006-07-27 Cyberkinetics Neurotechnology Systems, Inc. Systeme d'interface biologique a configuration automatisee
WO2008005478A2 (fr) * 2006-07-05 2008-01-10 Brainvital Corporation Traitement de troubles neurologiques par stimulation électrique et procédés correspondants
US8103341B2 (en) 2006-08-25 2012-01-24 Cardiac Pacemakers, Inc. System for abating neural stimulation side effects
JP4992034B2 (ja) * 2006-10-13 2012-08-08 岡山県 生体計測装置及び生体刺激装置
RU2355439C2 (ru) * 2007-07-04 2009-05-20 Федеральное государственное учреждение "Российский научный центр восстановительной медицины и курортологии Федерального агентства по здравоохранению и социальному развитию РФ" (ФГУ "РНЦВМиК Росздрава") Способ лечения больных с неврологическими проявлениями дорсопатии
US8694105B2 (en) 2007-07-10 2014-04-08 Sapiens Steering Brain Stimulation B.V. Neurostimulation system having a controller for controlling the supply of electrical pulses
WO2009044270A2 (fr) * 2007-10-04 2009-04-09 Neuronix Ltd. Systèmes et procédés permettant d'évaluer et traiter des états médicaux liés au système nerveux central et d'améliorer les fonctions cognitives
JP2011517962A (ja) * 2007-10-04 2011-06-23 ニューロニクス エルティーディー． 中枢神経系に関連する医学的状態の治療のための、および認知機能の向上のためのシステムならびに方法
KR101152282B1 (ko) 2007-10-24 2012-06-08 연세대학교 산학협력단 신경 소자
WO2009122485A1 (fr) 2008-03-31 2009-10-08 岡山県 Système de mesure biologique et système de stimulation biologique
DE102008043973B4 (de) * 2008-11-21 2011-12-01 Burkhard Brocke Vorrichtung zur transkraniellen Neurostimulation
MX2012004051A (es) 2009-10-05 2012-08-08 Univ California Dispositivos de implante extracranial, sistemas y metodos para el tratamiento de alteraciones neurologicas.
US8665101B2 (en) 2009-11-16 2014-03-04 Aquarius Spectrum Ltd. System method and device for leak detection and localization in a pipe network
CA2819346C (fr) 2010-11-30 2020-01-21 Ian A. Cook Generateur d'impulsions pour stimulation de nerf cranien
EP2651497B1 (fr) 2010-12-14 2019-02-20 The Regents of The University of California Systèmes implantables extra-crâniens destinés au traitement de troubles médicaux
KR20140037803A (ko) * 2010-12-14 2014-03-27 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 의료 질환 치료용 장치, 시스템 및 방법
JP5780432B2 (ja) * 2012-03-12 2015-09-16 医療法人社団ブックス 脳疲労及び／又はうつ治療装置の作動方法
US9399133B2 (en) * 2012-04-27 2016-07-26 Rhode Island Board Of Education, State Of Rhode Island And Providence Plantations Non-invasive automated electrical control systems and methods for monitoring animal conditions
WO2013166300A1 (fr) 2012-05-03 2013-11-07 Skaribas Ioannis Mihail Stimulateur électrique externe porté sur la tête permettant de traiter les conditions de mal de tête
FR2990137B1 (fr) * 2012-05-07 2019-12-20 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositifs de stimulation electrique d'un tissu biologique et son procede de calibrage.
ES2622359T3 (es) 2012-06-29 2017-07-06 Boston Scientific Neuromodulation Corporation Sistema de neuromodulación a alta frecuencia para reducir los requisitos energéticos
US12453853B2 (en) 2013-01-21 2025-10-28 Cala Health, Inc. Multi-modal stimulation for treating tremor
MX364276B (es) * 2014-08-26 2019-04-22 Avent Inc Método y sistema para la identificación de fuentes de dolor crónico y su tratamiento.
KR20230151068A (ko) 2015-03-30 2023-10-31 세팔리 테크놀로지 에스피알엘 삼차 신경의 경피 전기 자극을 위한 장치
WO2018119454A1 (fr) * 2016-12-23 2018-06-28 Icahn School Of Medicine At Mount Sinai Procédé et système d'évaluation de l'intégrité du nerf laryngé et du nerf vague chez des patients sous anesthésie générale
US11420071B2 (en) 2017-04-11 2022-08-23 Peaklogic, Inc. Minimum neuronal activation threshold transcranial magnetic stimulation at personalized resonant frequency
WO2019211845A1 (fr) 2018-05-01 2019-11-07 Brainsway Ltd. Dispositif et procédé pour la stimulation cérébrale en boucle fermée en temps réel
EP3639883A1 (fr) * 2018-10-18 2020-04-22 CEFALY Technology Sprl Stimulation e-tns kilohertz
WO2020252428A1 (fr) * 2019-06-14 2020-12-17 The Trustees Of Columbia University In The City Of New York Méthodes et dispositifs pour améliorer la perception sensorielle par stimulation tonique du nerf vague
CN110487996B (zh) * 2019-08-05 2020-11-24 汕头大学医学院 神经干单-双相动作电位同时记录研究实验方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850161A (en) * 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US5792186A (en) * 1996-04-25 1998-08-11 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5873898A (en) * 1997-04-29 1999-02-23 Medtronic, Inc. Microprocessor capture detection circuit and method
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US20040199237A1 (en) * 2001-09-07 2004-10-07 Mills Desmond Bryan Contact electrode

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3809502A (en) 1973-04-06 1974-05-07 Bertea Corp Pressure transformer
AU776786B2 (en) * 2000-01-07 2004-09-23 Biowave Corporation Electro therapy method and apparatus
JP2001271203A (ja) * 2000-03-24 2001-10-02 Ya Man Ltd パルス健康器
US7010351B2 (en) * 2000-07-13 2006-03-07 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7305268B2 (en) 2000-07-13 2007-12-04 Northstar Neurscience, Inc. Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7221981B2 (en) * 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US6882882B2 (en) * 2002-04-22 2005-04-19 Medtronic, Inc. Atrioventricular delay adjustment
US7302298B2 (en) * 2002-11-27 2007-11-27 Northstar Neuroscience, Inc Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography
RU2494545C2 (ru) 2009-07-27 2013-09-27 Хуавэй Текнолоджиз Ко., Лтд. Способ и устройство обработки передачи сигнала и распределенная базовая станция

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850161A (en) * 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US5792186A (en) * 1996-04-25 1998-08-11 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5873898A (en) * 1997-04-29 1999-02-23 Medtronic, Inc. Microprocessor capture detection circuit and method
US6248080B1 (en) * 1997-09-03 2001-06-19 Medtronic, Inc. Intracranial monitoring and therapy delivery control device, system and method
US20040199237A1 (en) * 2001-09-07 2004-10-07 Mills Desmond Bryan Contact electrode

Also Published As

Publication number Publication date
EP1809369A2 (fr) 2007-07-25
EP1809369A4 (fr) 2010-06-09
CA2626691A1 (fr) 2006-04-27
JP2008516696A (ja) 2008-05-22
WO2006044793A2 (fr) 2006-04-27

Similar Documents

Publication Publication Date Title
WO2006044793A3 (fr) Dispositif medicaux pour la detection, la prevention et/ou le traitement de troubles neurologiques, et procedes associes
Blumberger et al. A randomized double-blind sham-controlled study of transcranial direct current stimulation for treatment-resistant major depression
WO2007047853A3 (fr) Methodes et systemes visant a ameliorer le fonctionnement neural, tel que le fonctionnement cognitif et les troubles de la negligence
US8718778B2 (en) Apparatus and method for neurocranial electrostimulation
Li et al. Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex
WO2007018787A3 (fr) Dispositif de neurostimulation pour traiter des troubles de l'humeur
Makkos et al. High-frequency repetitive transcranial magnetic stimulation can improve depression in Parkinson's disease: a randomized, double-blind, placebo-controlled study
WO2007117344A3 (fr) systemes et procedes de differenciation et/ou d'identification de regionS tissulaires innervees par des nerfs cibles a des fins diagnostiques et/ou therapeutiques
Hallett Pathophysiology of dystonia
EP2698166A3 (fr) Inhibition du complément pour la régénération nerveuse améliorée
WO2008046032A3 (fr) Techniques de traitement par champ magnétique
Park et al. The effect of computer-assisted cognitive rehabilitation and repetitive transcranial magnetic stimulation on cognitive function for stroke patients
WO2008041129A3 (fr) Systemes et methodes permettant d'ameliorer une fonction cognitive
CA2440260A1 (fr) Procedes et appareil destines a apporter une modification durable dans une fonction neurale d'un patient
Najib et al. Transcranial magnetic stimulation (TMS) safety considerations and recommendations
WO2006002262A3 (fr) Genes et voies exprimes de maniere differentielle dans des troubles bipolaires et/ou troubles depressifs majeurs
JP2009506069A5 (fr)
WO2010100643A3 (fr) Configuration magnétique et schéma de temporisation pour stimulation magnétique transcrânienne
DE60027459D1 (de) Adaptive modulation von einem elektrischen feld für neuronale systeme
WO2006134598A3 (fr) Systeme et procedes de stimulation magnetique transcranienne
DK1355669T3 (da) Forbedret kognitiv træning
WO2013025997A3 (fr) Procédés de stimulation du cerveau pour le traitement d'une sensibilité centrale
Fisicaro et al. “Self-neuroenhancement”: the last frontier of noninvasive brain stimulation?
Mattoo et al. Repetitive transcranial magnetic stimulation in chronic tension-type headache: a pilot study
Brown et al. Use of transcranial magnetic stimulation in the treatment of selected movement disorders

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2007536997

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2005808963

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005808963

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005808963

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2626691

Country of ref document: CA