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WO2006043295A1 - Distributeur multidose destine a des preparations de liquides steriles - Google Patents

Distributeur multidose destine a des preparations de liquides steriles Download PDF

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Publication number
WO2006043295A1
WO2006043295A1 PCT/IT2005/000170 IT2005000170W WO2006043295A1 WO 2006043295 A1 WO2006043295 A1 WO 2006043295A1 IT 2005000170 W IT2005000170 W IT 2005000170W WO 2006043295 A1 WO2006043295 A1 WO 2006043295A1
Authority
WO
WIPO (PCT)
Prior art keywords
dropper
container
nozzle
container body
dispenser according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2005/000170
Other languages
English (en)
Inventor
Federigo Federighi
Mario Federighi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2006043295A1 publication Critical patent/WO2006043295A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2081—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers

Definitions

  • the present invention concerns a multidose bottle for dispensing liquid preparations without preservatives. More specifically, the invention con ⁇ cerns a container specially designed for the sterile conservation of liquid prod ⁇ ucts and their distribution in the form of drops, the sterility being maintained also after the first opening of the container, without the need to include pre ⁇ serving agents in the liquid product.
  • Many products, particularly but not exclusively in the medical field, are obtained and used in liquid form, such as solutions or mixtures of one or more liquid components with one or more dissolved solids. For their proper applica ⁇ tion, these liquids must be dispensed in the form of drops at the time of use.
  • Topical ophthalmic products such as eye ⁇ drops and artificial tears, also have the peculiarity that, besides needing to be administered in the form of drops, they must also be applied by the users on their own visual apparatus, and thus normally require the use of droppers with sufficiently elongated nozzles to facilitate as much as possible the actual ap ⁇ plication of the medication onto the surface of the cornea.
  • liquid products that may require storage in vials or bottles and distribution in the form of drops are particular detergents or addi- tives, also outside the pharmaceutical field, such as in the field of cosmetics or foodstuffs. These fields also have the problem of properly storing liquid prod ⁇ ucts in sterile conditions and without altering their quality from one use to the next. Particular applications in these fields may also need a drop by drop dispensing of the product which may be as uniform and easily controllable as possible.
  • the conventional way of preventing or combating the microbial growth in liquid products to be used several times over after the first opening of the relative container consists of adding suitable preserving agents, antioxidants and antibacterial agents in the liquid product itself.
  • suitable preserving agents, antioxidants and antibacterial agents in the liquid product itself.
  • the choice and concentra ⁇ tion of the agents used must in any case be such to guarantee the necessary sterility within the envisaged conditions and expiry date of the product life, and at the same time must not alter the intrinsic characteristics of the liquid prod ⁇ uct.
  • the initial sterilization of the product takes place during the bottling phase, after which the bottle is sealed and packaged, and arrives in the consumer's hands in sterile form.
  • the product is still in a sterile condition, also without the use of preserving agents.
  • On first use by gently squeezing the bottle some liquid is forced out and made to pass through the dropper nozzle to reach the user. When the gentle pressure exerted on the bottle ceases, the bottle stops distributing the liquid product.
  • preservatives to liquid products for ophthalmic use, although admitted in pharmacology and commonly accepted, is not devoid of a series of drawbacks, however. These include, in particular, the possibility of causing burning sensations or inflammatory or allergic reactions as well as, above all, the proven cytotoxicity of these products. For example, it is well- known that some preservatives used for ophthalmic products have a toxic effect on the goblet cells of the cornea, so that their prolonged use could cause more problems than the ones they can actually help to overcome.
  • One possible strategy to avoid using preservatives in multidose bot ⁇ tles of liquid products is to provide one or more antibacterial filters on the liquid pathway towards the exit point in the bottle.
  • filters with openings or pores of about 0.2 micron in diameter are provided, which me ⁇ chanically prevent any micro-organisms from getting into the bottle while not preventing the flow of liquid out.
  • WO 90/05110 Eye Research Institute of Retina Foundation
  • the filter closest to the bottle body is hydrophilic and has the characteristic of being easily wettable in order to facilitate the outward flow of the liquid product, while the filter located more downstream along the liquid path is of the hydrophobic or water-repellent kind so as not to retain the me- dicinal solution inside it after dispensing it. This results in preventing bacterial growth on the external surface of the filter assembly. It is obvious that, despite the adoption of an antibacterial filter, the external channel of the bottle lying downstream of the filter, including the dropper tip, is still exposed to contami ⁇ nation by the external environment.
  • U.S. patent No. 5,232,687 proposes adopting another, alterna ⁇ tive or complementary, device in order to guarantee the sterility of a liquid product for topical administration without resorting to preservatives: the use of a solid substance with a germicide action like silver.
  • the device proposed in this connection is not actually a drop dispenser, but a small reciprocating pump that supplies dosed quantities of liquid product in spray form. At each stroke of the pump a pre-fixed quantity of liquid passes into a dispensing chamber and, in order to exit into the outside environment, it must then come into close contact with a silver-based element with germicide functions.
  • the pump device is airtight and does not allow any air to come into the product container to replace the outflowing liquid. This safeguards against any possi ⁇ bility of contamination from the outside environment. It is evident that such a solution is not very economical, also due to the need to construct a completely airtight device of such solidity to withstand the creation of a depression inside the product container. Moreover, the type of liquid dispensing obtained is not actually in drop form but in jet form, and is not really suitable for applying prod ⁇ ucts to the eye.
  • a pad made of po ⁇ rous material that creates a head loss sufficient to make the product come out in the form of drops through the dropper nozzle, by manually squeezing the bellow-shaped container.
  • the necessary aseptic conditions are pro ⁇ vided by an antibacterial filter placed along the product outflow path down ⁇ stream of the porous pad but upstream of the dropper nozzle.
  • the inside channel of the dropper nozzle is exposed to bacterial contami- nation from the external environment.
  • EP-A-1319606 (Nihon Tenganyaku Co. and Taisei Kako Co.), which con ⁇ cerns a double-walled container with an external flexible wall and an internal collapsible one, in which the manually exerted pressure on the external con ⁇ tainer is transmitted to the internal wall thereby forcing the liquid out during administration. Then, due to a vent hole on the external container, the latter can elastically return to its original shape by sucking air into the gap between the external wall and internal collapsible wall. This air does not come into contact with the product enclosed inside the internal container, thus prevent ⁇ ing any possible contamination to the product itself.
  • the product flows out of the bottle through a check valve that does not allow the liquid to come back into the internal container. Downstream of this check valve the outflowing liquid still passes through a filter before leaving the container.
  • the device includes a space between the check valve and the dropper tip on which the filter is located, in which some stagnant liquid remains that is not excluded from contact with the outside air, even if the presence of the filter further downstream should at least prevent micro ⁇ organisms from entering the bottle spout.
  • a device for dispensing products drop by drop that should do without the addition of preservatives in the product, must be able to prevent the entry of contaminating air inside the dropper nozzle representing the terminal element of the dispenser device.
  • the said element normally ends with a more or less pronounced tip that facilitates product outflow.
  • an external cap provides for closure of the bottle. Said cap mechanically closes the tip of the dropper nozzle through suitable protuberances or internal projec ⁇ tions.
  • air has already entered the dropper nozzle because, by returning to its original shape, the bottle sucks in outside air to replace the volume of liquid used in the administration.
  • the known devices envisaging the presence of check valves on the liquid outflow duct still have sections downstream of the check valve - which may particularly include the dropper nozzle - where stagnant liquid remains after administration and where contaminating air can enter from the outside.
  • An object of the present invention is, thus, to provide a stable kind of closing mechanism operating on the dropper nozzle tip, which is operated automati- cally in a safe and continuative manner, without requiring any external action or the use of a potentially contaminating closing device (external cap).
  • a check valve directly on the bottle dropper nozzle tip.
  • This valve is configured with a truncated cone-shaped pin plug having a shape complementary to that of the nozzle, wherein, however, the valve element with the plugging function is fixed with respect to the bottle body, and the element that functions as the relative housing, i.e. the nozzle, is mobile.
  • annular mem ⁇ brane expansion chamber that is sufficiently flexible to allow the dropper noz ⁇ zle to extend forward with respect to the fixed plug when the pressure on the liquid contained in the bottle is increased by squeezing the bottle itself.
  • the slight advancement of the nozzle with respect to the fixed plug opens up a sufficient gap to enable the liquid to pass through to be dosed in drops from the nozzle tip.
  • the annular membrane contracts again automatically causing the nozzle to draw back with respect to the fixed pin plug.
  • the present invention specifically provides a dispenser for liquid preparations without preservatives, comprising a container body and a dropper assembly, which in turn comprises a container body closure element ending with an elongated dropper nozzle provided with a central port, and a pin plug of a complementary shape to the said dropper nozzle and cooperat ⁇ ing with it to intercept the outflow of a liquid preparation contained in said dispenser, the pin plug being located inside the dropper nozzle in a fixed posi ⁇ tion with respect to the container body, and said dropper nozzle being dis- placeabie outward from said pin plug in order to open up the port of the drop ⁇ per assembly as a result of a mechanical pressure applied to the exterior of the container body.
  • this movement of the dropper noz ⁇ zle with respect to the fixed pin plug is obtained by the distension of an elastic annular membrane housed in the dropper nozzle and such to establish an expansion annular chamber that dilates due to the pressure exerted on the exterior of the container body.
  • said closure element of the container body ending with a dropper nozzle is made up of a suitable polymeric material workable by mold ⁇ ing, and particularly a polyethylene.
  • the preferred shape for the dropper nozzle and the corre ⁇ sponding pin plug according to the present invention is a truncated cone shape, not only because the elongated shape of the dropper facilitates prod ⁇ uct administration in the eye, if the considered preparation is an ophthalmic product for topical application, but also because closure through the coopera- tion of two truncated cone-shaped coaxial surfaces is the easiest and most reliable form of blockage.
  • the container body of the bottle is of the double-wall type with a cavity in be ⁇ tween, with an elastic external body and an internal collapsible body inside it, that contains the liquid preparation and decreases in volume as the liquid flows out of the diospenser.
  • This type of construction provides the necessary solidity to the bottle, whose external body protects the internal collapsible container, and at the same time allows a gradual transfer of the external man ⁇ ual pressure applied to the bottle to the internal container, through the air cavity between the two walls. This avoids any excessive dosage dispensing or spraying of the product.
  • the said internal and external bodies of the dispenser are connected rigidly and in airtight manner to the closure element of the con ⁇ tainer, particularly via the interposition of a ring nut, to the closure device of the container body terminating with the dropper nozzle.
  • Each of said inner and outer container is made of with a polymeric material suitable for the mechani ⁇ cal characteristics it must have.
  • the internal container may be made of a thin polyethylene material so that it can collapse as it empties, without sucking in air from the outside. After dispensing the liquid dose, the volume of liquid product leaving the bottle is replaced by a corresponding volume of air sucked in from the outside, but this air fills the cavity between the two walls and does not come into contact with the liquid contained inside the bottle.
  • the external body of the container has a port that may also be fitted with a suitable valve.
  • the dispenser according to the present invention is also completed by an external closure capsule which engages the described dropper assembly to create a seal.
  • This closing device preferably consists of a screw cap that can protect the dropper nozzle tip and also a knurled overcap outside the screw cap but connected to it.
  • the combination of screw cap and overcap creates a safety closure system that prevents accidental opening of the bottle, like the kind of devices normally used on pharmaceutical bottles to avoid any improper use by children (child-proof devices).
  • the capsule envis ⁇ ages a frangible part only on first opening the bottle - a tamper-evident device also acting as a guarantee seal.
  • Figure 1 shows a longitudinal cross-section of a multidose dispenser for liquid preparations according to the present invention, particularly designed for dispensing pharmaceutical products drop by drop without using preserva- tives, and complete with all its closure elements;
  • Figure 2 shows a longitudinal cross-section of the same bottle of Fig ⁇ ure 1 , without the external closure capsule;
  • Figure 3 shows a longitudinal cross-section of the dropper nozzle of the aforesaid bottle
  • Figure 4 shows a longitudinal cross-section of the corresponding pin plug element for closing the dropper nozzle
  • Figure 5 is a perspective view of the said pin plug element shown in Figure 4.
  • Figure 6 shows a longitudinal cross-section of the ring nut connecting the internal container of the dispenser to the external body, and onto which the dropper nozzle is fixed;
  • Figure 7 is a perspective view of the said ring nut shown in Figure 6;
  • Figure 8 shows a longitudinal cross-section of the cap that constitutes an element of the bottle closure capsule shown in Figure 1 ;
  • Figure 9 is a perspective view of the said cap shown in Figure 8.
  • Figure 10 shows a longitudinal cross-section of the overcap constitut- ing an element of the bottle closure capsule shown in Figure 1 ;
  • Figure 11 is a perspective view of the said overcap shown in Figure 10.
  • Figures 12 a), b), c) and d) schematically show the functioning of the multidose dispenser bottle shown in the above Figures, with a schematic lon- gitudinal cross-section representation of four different operative phases of the bottle.
  • the illustrated embodiment of the dis ⁇ oral for liquid products according to the present invention is composed of a container body (1) that is closed off at the top with a dropper assembly (2) and completed with an external closure capsule (3).
  • the dropper assembly (2) which is also shown in more detail in Figures 3, 4 and 5, in turn includes a closure element (4), shown specifically in Figure 3, and consists of a single piece of moulded plastic material. This ends with a dropper nozzle (5) of a truncated cone shape, that has a central port (6) for channelling the drops of the liquid contained in the bottle.
  • the second fundamental element of the dropper assembly (2) is the pin plug (7), which is shown specifically in Figures 4 and 5, and which includes a truncated cone-shaped pin (8) complementary to the dropper nozzle (5), that fits into the latter to completely plug the port (6) of the dropper nozzle (5) with- out any loss of liquid.
  • the opening and closing of this assembly which creates a check valve for the liquid product dispensed, is obtained by the outward movement of the dropper nozzle (5) with respect to the pin plug (7), which is firmly anchored to the bottle body and is thus fixed.
  • the dropper nozzle (5) is connected to the closure element (4), of which it forms the terminal element, through an elastic annular membrane (9), and can thus slightly move forward (by some tenths of a millimetre, in the case of a dropper bottle for ophthalmic use), as will be shown in detail below, opening up the port (6) for the passage of the product in the form of drops.
  • the container body (1) of the bottle according to the present invention is of the double-wall type with an air cavity in between, and consists of an external elastic cylindrical body (10) and an internal collapsible body (11), also cylindrical but of a smaller diameter, which is the actual container of the liquid product.
  • Both the internal (11) and external (10) bodies are attached to one another by means of a cylindrical ring, specifi ⁇ cally shown in Figures 6 and 7.
  • the con ⁇ tainer body (1) is then attached - via the ring (12) - to the dropper assembly (2), with the pin plug (7) and closure element (4), in order to obtain the com ⁇ plete dispenser device shown in Figure 2. All this takes place according to the standard sterilisation procedures.
  • the dispenser When closed and in a resting state, the dispenser is as shown sche ⁇ matically in Figure 12 a): the port (6) of the dropper is closed by the pin (8) of the plug (7).
  • the dispenser For use as an eye-drop dispenser, the dispenser is held upside- down as shown in Figure 12 b) so that the dropper nozzle (5) points to the user's conjunctival sac, and then the external body (10) of the container (1) is gently squeezed, as shown in Figure 12 c).
  • the internal body (11) of the con ⁇ tainer (1) is manufactured using thin material and is collapsible, and air is sucked into the cavity between the internal body (11) and external body (10) of the container (1), the internal body (11) remains collapsed and no air comes into contact with the liquid product contained in the dispenser.
  • the dispenser according to the present invention is equipped with an external closure capsule (3) (visible in Figure 1) which, in the form illustrated, consists of two superimposed and combining elements. These elements are shown individually in Figures 8-10 and consist of a screw cap (14), whose internal thread (15) engages the thread (16) on the neck of the closure element (4) (see Figure 3), and also an externally knurled overcap (17) which, by fitting over the screw cap (14), creates a secure child-proof closure device.
  • the overcap (17) also includes a collar (18) that is broken and removed on first opening the dispenser and acts as a guarantee seal (tamper- evident device).
  • the dispenser ac ⁇ cording to the present invention can be used in the same way as with other normal dropper bottles for repeated administrations of the product and does not require any specific procedure for its use, but guarantees an immediate and automatic closure of the container when the user stops using the product.
  • This type of stable, safe, sterile and automatic closure occurs at the tip of the dropper nozzle, where the product drops out, and thus guarantees the com ⁇ plete sterility of the product, its proper storage without any oxidative phenom- ena, and its availability for repeated administrations up to the complete empty ⁇ ing of the bottle contents.
  • the device is easy to use also by the most inexperienced or elderly users and requires no strange preparatory movements before adminis- tering the liquid product; the dispenser is also easy to open and close.
  • the structure of the proposed device is such that it is not ex ⁇ cessively complex and is easy to produce from a manufacturing standpoint. It also offers the possibility of being tested during production in order to reduce the number of rejects to negligible levels during the product filling phase in sterile conditions.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)

Abstract

L'invention concerne un distributeur conçu pour stocker des produits liquides dans des conditions stériles et pour distribuer ces produits goutte par goutte, ce qui permet de maintenir la stérilité du produit même après la première ouverture de la bouteille, sans avoir à ajouter des conservateurs dans le produit liquide. Le distributeur comprend un corps de conteneur (1) et un ensemble compte-gouttes (2), qui à son tour comprend un élément de fermeture du corps de conteneur (1) se terminant avec une buse compte-gouttes oblongue (5) équipée d'un orifice central (6) et d'un bouchon expansible (7) coopérant avec la buse compte-gouttes (5) afin d'intercepter l'écoulement d'une préparation liquide contenue dans la bouteille. Le bouchon expansible (7) est placé dans la buse compte-gouttes (5) dans une position fixe par rapport au corps du conteneur (1), et la buse compte-gouttes (5) peut se déplacer hors du bouchon expansible (7) afin d'ouvrir l'orifice (6) suite à une pression mécanique appliquée à l'extérieur du corps du conteneur (1).
PCT/IT2005/000170 2004-10-22 2005-03-25 Distributeur multidose destine a des preparations de liquides steriles Ceased WO2006043295A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000524A ITRM20040524A1 (it) 2004-10-22 2004-10-22 Flacone erogatore multidose per preparati liquidi senza conservanti.
ITRM2004A000524 2004-10-22

Publications (1)

Publication Number Publication Date
WO2006043295A1 true WO2006043295A1 (fr) 2006-04-27

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PCT/IT2005/000170 Ceased WO2006043295A1 (fr) 2004-10-22 2005-03-25 Distributeur multidose destine a des preparations de liquides steriles

Country Status (2)

Country Link
IT (1) ITRM20040524A1 (fr)
WO (1) WO2006043295A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008142721A1 (fr) * 2007-05-17 2008-11-27 Federighi, Federigo Distributeur multidose pour des préparations liquides stériles
WO2009116850A1 (fr) * 2008-03-21 2009-09-24 Ipn Ip B.V. Embout buccal à valve actionnée par aspiration pour récipient de boisson
FR2929248A1 (fr) * 2008-03-27 2009-10-02 Rexam Pharma La Verpilliere Sa Dispositif de distribution de liquide sous forme de gouttes
WO2010013131A1 (fr) * 2008-07-31 2010-02-04 Laboratoires Thea Flacon de conditionnement de liquide à distribuer goutte à goutte à protection antibactérienne
DE102009021501A1 (de) * 2009-05-15 2010-12-02 F. Holzer Gmbh Vorratsbehälter sowie Verwendung des Vorratsbehälters
DE102012217338A1 (de) * 2012-09-25 2014-05-28 Aptar Radolfzell Gmbh Flüssigkeitsspender
ITUA20161615A1 (it) * 2016-03-14 2017-09-14 Trifarma S P A Dispositivo migliorato multi-dose dinamico per l’erogazione, in forma di gocce, di una soluzione medicinale o un farmaco, in particolare un collirio
EP2573005B1 (fr) * 2011-09-23 2017-11-01 Aptar Radolfzell GmbH Distributeur compte-gouttes
CN109370877A (zh) * 2018-12-18 2019-02-22 章毅 细胞悬液分装装置
WO2021162560A1 (fr) * 2020-02-11 2021-08-19 Gamboa Burgos Alejandro Dispositif distributeur de liquides à mécanisme antiretour de goutte et filtre à air
EP2877138B1 (fr) 2012-07-26 2023-06-28 Allergan, Inc. Système de bouchon double pour fermeture de récipient pour maintenir la stérilité de la pointe durant le stockage de conservation
EP3090957B1 (fr) 2009-09-11 2023-08-09 Nemera La Verpilliere Dispositif de distribution de liquide comprenant une surface d'appui pour un ressort

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US4420100A (en) * 1978-10-31 1983-12-13 Containaire, Inc. Dispensing apparatus
US4739906A (en) * 1986-07-14 1988-04-26 Blairex Laboratories, Inc. Storage bottle for contact lens cleaning solution having a self closing valve assembly
US5033647A (en) * 1990-03-09 1991-07-23 Allergan, Inc. Value controlled squeezable fluid dispenser
JP2002002755A (ja) * 2000-06-22 2002-01-09 Kitano Seisaku Kk 逆流防止容器

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420100A (en) * 1978-10-31 1983-12-13 Containaire, Inc. Dispensing apparatus
US4739906A (en) * 1986-07-14 1988-04-26 Blairex Laboratories, Inc. Storage bottle for contact lens cleaning solution having a self closing valve assembly
US5033647A (en) * 1990-03-09 1991-07-23 Allergan, Inc. Value controlled squeezable fluid dispenser
JP2002002755A (ja) * 2000-06-22 2002-01-09 Kitano Seisaku Kk 逆流防止容器

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Title
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 05 3 May 2002 (2002-05-03) *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008142721A1 (fr) * 2007-05-17 2008-11-27 Federighi, Federigo Distributeur multidose pour des préparations liquides stériles
WO2009116850A1 (fr) * 2008-03-21 2009-09-24 Ipn Ip B.V. Embout buccal à valve actionnée par aspiration pour récipient de boisson
FR2929248A1 (fr) * 2008-03-27 2009-10-02 Rexam Pharma La Verpilliere Sa Dispositif de distribution de liquide sous forme de gouttes
WO2009130411A1 (fr) * 2008-03-27 2009-10-29 Rexam Pharma La Verpilliere Dispositif de distribution de liquide sous forme de gouttes
US11524822B2 (en) 2008-03-27 2022-12-13 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US11155391B2 (en) 2008-03-27 2021-10-26 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US10640268B2 (en) 2008-03-27 2020-05-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
US10220988B2 (en) 2008-03-27 2019-03-05 Nemera La Verpillière Device for dispensing a liquid in the form of drops
CN101998925B (zh) * 2008-03-27 2012-05-09 雷盛医疗拉韦尔皮列尔公司 以滴剂的形式分发液体的装置
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