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WO2005118797A3 - Biosynthetic gene cluster for tautomycetin - Google Patents

Biosynthetic gene cluster for tautomycetin Download PDF

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Publication number
WO2005118797A3
WO2005118797A3 PCT/US2005/019627 US2005019627W WO2005118797A3 WO 2005118797 A3 WO2005118797 A3 WO 2005118797A3 US 2005019627 W US2005019627 W US 2005019627W WO 2005118797 A3 WO2005118797 A3 WO 2005118797A3
Authority
WO
WIPO (PCT)
Prior art keywords
tautomycetin
gene cluster
biosynthetic gene
prepare
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/019627
Other languages
French (fr)
Other versions
WO2005118797A2 (en
Inventor
Ralph Reid
Li Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of WO2005118797A2 publication Critical patent/WO2005118797A2/en
Anticipated expiration legal-status Critical
Publication of WO2005118797A3 publication Critical patent/WO2005118797A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Domains of tautomycetin polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare tautomycetin in pharmaceutically useful quantities are described, as are methods to prepare tautomycetin analogs and other polyketides using the polynucleotides encoding tautomycetin synthase domains or modifying enzymes.
PCT/US2005/019627 2004-06-03 2005-06-03 Biosynthetic gene cluster for tautomycetin Ceased WO2005118797A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57734304P 2004-06-03 2004-06-03
US60/577,343 2004-06-03
US59142804P 2004-07-26 2004-07-26
US60/591,428 2004-07-26

Publications (2)

Publication Number Publication Date
WO2005118797A2 WO2005118797A2 (en) 2005-12-15
WO2005118797A3 true WO2005118797A3 (en) 2009-04-02

Family

ID=35463450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/019627 Ceased WO2005118797A2 (en) 2004-06-03 2005-06-03 Biosynthetic gene cluster for tautomycetin

Country Status (1)

Country Link
WO (1) WO2005118797A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608045B2 (en) * 1998-03-27 2003-08-19 Chong Kun Dang Corporation Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608045B2 (en) * 1998-03-27 2003-08-19 Chong Kun Dang Corporation Streptomyces sp producing tautomycetin and immunosuppressant comprising tautomycetin as active ingredient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UBUKATA, M. ET AL.: "Biosynthesis of the Dialkylmaleic Anhydride-containing Antibiotics, Tautomycin and Tautomycetin.", J. CHEM. SOC. PERKIN TRANS., vol. 19, 1 July 1995 (1995-07-01), pages 2399 - 2404 *

Also Published As

Publication number Publication date
WO2005118797A2 (en) 2005-12-15

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