WO2005115090A2 - A herbal composition having potent antimicrobial and wound healing properties - Google Patents
A herbal composition having potent antimicrobial and wound healing properties Download PDFInfo
- Publication number
- WO2005115090A2 WO2005115090A2 PCT/IN2005/000146 IN2005000146W WO2005115090A2 WO 2005115090 A2 WO2005115090 A2 WO 2005115090A2 IN 2005000146 W IN2005000146 W IN 2005000146W WO 2005115090 A2 WO2005115090 A2 WO 2005115090A2
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- WO
- WIPO (PCT)
- Prior art keywords
- extracts
- ficus
- composition
- excipients
- adjuants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- This invention relates to a herbal composition having potent anti-microbial and wound healing properties.
- This composition is particularly useful for effective treatment of wounds including diabetic wounds, bums and ulcerative wounds.
- This composition exhibits significant activity against microbes and fungi and exhibits broad spectrum anti-microbial and anti-fungal action.
- the composition according to this invention brings about immediate pain relief and brings down inflammation through its analgesic and anti-inflammatory properties. Microbial material adherent to wounds and bums are removed through effective debridement action.
- the composition also exhibits cooling and soothing properties, thus bringing down the burning sensation associated with bums. Keloid formation is also found to be considerably reduced on application of the composition which in rum reduces the formation of scar tissue.
- Bum injury destroys the skin functions leaving behind a large raw area bare with its exudates of serum and nacrotic tissue, which serve as an excellent culture medium for the growth of organisms.
- infection of bums not only causes conversion of a second degree bum to a third degree bum and is found to be the fundamental cause for wound sepsis and septicemia.
- Introduction of clinically effective anti-microbial agents has resulted in the rapid emergence of strains of bacteria resistant to such agents.
- Ayurvedic medicines include treatment and cure for many ailments through extracts of plant materials.
- Various combinations have been found effective in treating and curing diseases affecting civilization.
- Ficus bengalensis commonly known as Banyan 2. Ficus religiosa - commonly known as peepal tree 3. Ficus infectoria known in Sanskrit as Plaksha 4. Ficus racemosa known as country fig and 5. Azadirachta indica known as neem tree.
- Extracts of the whole plant material or parts thereof may be prepared by treating them with solvents like water, alcohols, acetone, toluene, ethyl acetate, butyl acetate and the like. Conventional solvents or mixtures thereof. Preferred solvents are ethyl or methyl alcohol. Extraction may be carried out in any conventional manner such as soxhlet solvent extraction, agitating with solvents, and recycling the solvent using- a pump. The most effective extracts are found to be extracts from the barks of these plant material.
- TDS total dissolved solids
- This invention relates to a herbal composition having potent anti-microbial and wound healing properties which comprises a mixture of extracts obtained from Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica in pharmaceutically acceptable carriers, excipients and adjuants.
- extracts of the bark of each of the above plants in the range of 0.05 to 5 w/w parts are admixed, the balance being one or more pharmaceutically acceptable adjuants or carriers.
- composition contains 0.4 w/w of each extract from the above mentioned extracts.
- Solvents after extraction of these plant materials are removed under vacuum and the concentrates obtained are admixed in the above specified range with adjuants.
- This invention relates to a herbal composition with potent anti-microbial and wound healing properties which comprises extracts of Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica in admixture with pharmaceutically acceptable carriers and adjuants. Potency and increased anti-microbial action of the composition is due to the synergistic nature of the admixture of the above plant extracts.
- composition may be in any form suitable for local application including suppositories, jellys, creams and lotions. Tablets with reduced strength may also be taken internally in admixture with dicalcium phosphate or any such known solid pharmaceutically acceptable carriers.
- This invention also includes a process of preparing a herbal composition with potent antimicrobial and wound healing properties comprising solvent extracting plant materials of Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica separately removing solvents therefrom and admixing the extracts with pharmaceutically acceptable carriers and adjuants.
- Preferred solvents are ethyl and methyl alcohols though water and other organic solvents may be effectively used for extraction.
- Each of the plant extract may be added in the concentration of 0.05 to 5 parts w/w, the balance being carriers and excipients. 0.4 w/w of each of the plant extract is a preferred composition.
- This invention also includes a method of treating injuries such as bums diabetic wounds and the like which comprises the steps of applying the composition as described above.
- Extracts may also be in the form of a gel paste using carbopol type of thickening agents. Anti-biotic efficacy has been evaluated by ditch plate
- the composition is found to achieve control of infection and inflammation improving wound condition to make them ready for graft and reducing the duration of wound improvement and healing.
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
This invention relates to a herbal composition which has potent antimicrobial and wound healing properties. The composition consists of extracts of Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica with pharmaceutically acceptable carriers and excipients. This invention also includes a process of preparing the composition by extracting each plant material separately with water organic solvents or admixtures thereof removing the solvents and admixing the solids obtained in a range of 0.05 to 4 parts w/w with pharmaceutically acceptable carriers.
Description
A HERBAL COMPOSITION HAVING POTENT ANTIMICROBIAL AND WOUND HEALING PROPERTIES
TECHNICAL FIELD OF THE INVENTION
This invention relates to a herbal composition having potent anti-microbial and wound healing properties. This composition is particularly useful for effective treatment of wounds including diabetic wounds, bums and ulcerative wounds. This composition exhibits significant activity against microbes and fungi and exhibits broad spectrum anti-microbial and anti-fungal action. The composition according to this invention brings about immediate pain relief and brings down inflammation through its analgesic and anti-inflammatory properties. Microbial material adherent to wounds and bums are removed through effective debridement action. The composition also exhibits cooling and soothing properties, thus bringing down the burning sensation associated with bums. Keloid formation is also found to be considerably reduced on application of the composition which in rum reduces the formation of scar tissue.
BACKGROUND OF THE INVENTION:
Despite the relatively efficacious anti-microbial treatment and improved supportive measures, treatment and cure for invasive infections, bums, wounds, chemical radiation, electrical bums, blunt injury and the like presently available are not as effective. Survival of patients who have suffered from one or more of the above continues to be a threat.
Bum injury destroys the skin functions leaving behind a large raw area bare with its exudates of serum and nacrotic tissue, which serve as an excellent culture medium for the growth of organisms. Thus infection of bums not only causes conversion of a second degree bum to a third degree bum and is found to be the fundamental cause for wound sepsis and septicemia.
Introduction of clinically effective anti-microbial agents has resulted in the rapid emergence of strains of bacteria resistant to such agents.
OBJECTS OF THE INVENTION:
To satisfy our quest for alternate sources of anti-bacterials which are non effective and which do not have side effects many hitherto known locally applicable antibiotics, antimicrobics and healants we turned to Ayurveda, the ancient system of Indian medicines. Ayurvedic medicines include treatment and cure for many ailments through extracts of plant materials. Various combinations have been found effective in treating and curing diseases affecting mankind.
A meticulous study was undertaken by the inventors to find the most effective and active combination of plant extracts having wide range of therapeutic effects. A composition of extracts of the following plants is found to be most effective in the management of the above discussed symptoms with no or minimal side effects.
1. Ficus bengalensis — commonly known as Banyan 2. Ficus religiosa - commonly known as peepal tree 3. Ficus infectoria known in Sanskrit as Plaksha 4. Ficus racemosa known as country fig and 5. Azadirachta indica known as neem tree.
Extracts of the whole plant material or parts thereof may be prepared by treating them with solvents like water, alcohols, acetone, toluene, ethyl acetate, butyl acetate and the like. Conventional solvents or mixtures thereof. Preferred solvents are ethyl or methyl alcohol. Extraction may be carried out in any conventional manner such as soxhlet solvent extraction, agitating with solvents, and recycling the solvent using- a pump.
The most effective extracts are found to be extracts from the barks of these plant material.
After extraction total dissolved solids (TDS) is estimated and a composition of the extracts are made using known pharmaceutically acceptable adjutants like petroleum jelly. Other biologically acceptable carriers and creams such as oil in water or water in oil emulsions may also be made.
This invention relates to a herbal composition having potent anti-microbial and wound healing properties which comprises a mixture of extracts obtained from Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica in pharmaceutically acceptable carriers, excipients and adjuants.
Preferably extracts of the bark of each of the above plants in the range of 0.05 to 5 w/w parts are admixed, the balance being one or more pharmaceutically acceptable adjuants or carriers.
Most preferred composition contains 0.4 w/w of each extract from the above mentioned extracts.
Solvents after extraction of these plant materials are removed under vacuum and the concentrates obtained are admixed in the above specified range with adjuants.
SUMMARY OF THE INVENTION:
This invention relates to a herbal composition with potent anti-microbial and wound healing properties which comprises extracts of Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica in admixture with pharmaceutically acceptable carriers and adjuants.
Potency and increased anti-microbial action of the composition is due to the synergistic nature of the admixture of the above plant extracts.
The composition may be in any form suitable for local application including suppositories, jellys, creams and lotions. Tablets with reduced strength may also be taken internally in admixture with dicalcium phosphate or any such known solid pharmaceutically acceptable carriers.
This invention also includes a process of preparing a herbal composition with potent antimicrobial and wound healing properties comprising solvent extracting plant materials of Ficus bengalensis, Ficus religiosa, Ficus infectoria, Ficus racemosa and Azadirachta indica separately removing solvents therefrom and admixing the extracts with pharmaceutically acceptable carriers and adjuants.
Preferred solvents are ethyl and methyl alcohols though water and other organic solvents may be effectively used for extraction.
Each of the plant extract may be added in the concentration of 0.05 to 5 parts w/w, the balance being carriers and excipients. 0.4 w/w of each of the plant extract is a preferred composition.
This invention also includes a method of treating injuries such as bums diabetic wounds and the like which comprises the steps of applying the composition as described above.
BRIEF DESCRIPTION AND PREFERRED EMBODIMENTS:
Preparation of tropical formulation is effected by admixing the extract components with biologically acceptable carriers. Extracts may also be in the form of a gel paste using carbopol type of thickening agents. Anti-biotic efficacy has been evaluated by ditch plate
TfiHtWHrt! T^ riltn WKttwtøliFitifciςi thftt the porormflition is effective against the following gram positive, gram negative and microorganisms.
Gram Positive (i) B.s. subtilis (n) Staphylococcus aureus ATCC 6538 P (Hi) Methicillin Resistant Staph Aureus (iv) Sareina lutea (v) Strep pyogenes (vi) Strep pneumoniae (vii) Vancomycin resistant enterococci
Gram Negative (i) E.coli (ii) Ps. acruginosa (Hi) S. typhi (iv) E.coli (MDR) (v) Acinetobacter (vi) Proteus Mirabilis
Microorganisms
(0 Candida spp
(«) Saccharomyces spp
Fungi
(i) Aspergillus niger
(ϋ) Pencillium spp
Animal and clinical studies have been carried out to evaluate the efficacy of the composition. The composition is found to achieve control of infection and inflammation improving wound condition to make them ready for graft and reducing the duration of wound improvement and healing.
Claims
1. A herbal composition having anti-microbial and wound healing properties which comprises extracts of Ficus religiosa, Ficus infectoria and Azadirachta indica in admixture with pharmaceutically acceptable carriers, excipients and adjuants.
2. The composition as claimed in claim 1 containing 0.05 parts w/w to 5 parts w/w of extracts of each of said extract, the balance being pharmaceutically acceptable carriers, excipients and adjuants.
3. The composition as claimed in claim 1 containing 0.4 parts w/w of each of said extract in combination, the balance being pharmaceutically acceptable carriers, excipients and adjuants.
4. The composition as claimed in claims 1 to 4, wherein extracts obtained from the bark of said plants are admixed after drying and determining the total solid weight content of each of said extract.
5. A process for producing a herbal composition having patient antimicrobial and wound healing properties comprising the steps of extracting plant materials of Ficus religiosa, Ficus infectoria and Azadirachta indica with one or more solvents, removing the solvents under vacuum and admixing the extracts after removal of solvents therefrom with pharmaceutically acceptable carriers, excipients and adjuants.
6. The process as claimed in claim 5, wherein said extraction is carried out with water, organic solvents such as alcohols, acetone, toluene, ethyl and butyl acetate either alone or in combination with one another, said extraction being carried out by soxhlet extraction or under agitation, said solvents are removed by distillation under vacuum.
7. The process as claimed in claims 5 and 6, wherein the plant materials as a whole or only tltβ barks of snid plnnta are subjected to extradtion.
8. The process as claimed in claims 5 to 7, wherein 0.05 parts w/w to 5 parts w/w of each of said extracts are admixed with said carriers excipients and adjuants.
9. The process as claimed in claims 5 to 7, wherein 0.4 parts w/w of each of said plant extracts are admixed with said carriers, excipients and adjuants.
10. A method of treating and curing bums including chemical, radiation and electrical bums and wounds including blunt injury and wounds including blunt injury by applying topically a composition consisting of extracts of Ficus religiosa, Ficus infectoria and Azadirachta indica in admixture with one or more pharmaceutically acceptable carriers, excipients and adjuants.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN513MU2004 | 2004-05-05 | ||
| IN513/MUM/2004 | 2004-05-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2005115090A2 true WO2005115090A2 (en) | 2005-12-08 |
| WO2005115090A3 WO2005115090A3 (en) | 2006-04-27 |
Family
ID=35451319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2005/000146 Ceased WO2005115090A2 (en) | 2004-05-05 | 2005-05-04 | A herbal composition having potent antimicrobial and wound healing properties |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2005115090A2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008104941A3 (en) * | 2007-02-28 | 2008-11-06 | Procter & Gamble | Personalcare composition comprising botanical extract of ficus benghalensis |
| WO2012110674A1 (en) | 2011-02-16 | 2012-08-23 | Sainz Prestel Valeria Lucila | Use of a vegetable extract as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining said extract |
| WO2012123962A2 (en) | 2011-02-17 | 2012-09-20 | Patankar Suresh Balkrishna | A novel herbal composition for the treatment of wound healing, a regenerative medicine |
| US9056117B2 (en) | 2006-12-12 | 2015-06-16 | Sunev Pharma Solutions Ltd. | Herbal formulation for wound healing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5906825A (en) * | 1997-10-20 | 1999-05-25 | Magellan Companies, Inc. | Polymers containing antimicrobial agents and methods for making and using same |
| US6218183B1 (en) * | 1998-03-31 | 2001-04-17 | Council Of Scientific & Industrial Research | Screening method for the identification of plants possessing anti-microbial activity and tolerance to abiotic stresses |
-
2005
- 2005-05-04 WO PCT/IN2005/000146 patent/WO2005115090A2/en not_active Ceased
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9056117B2 (en) | 2006-12-12 | 2015-06-16 | Sunev Pharma Solutions Ltd. | Herbal formulation for wound healing |
| WO2008104941A3 (en) * | 2007-02-28 | 2008-11-06 | Procter & Gamble | Personalcare composition comprising botanical extract of ficus benghalensis |
| US9358263B2 (en) | 2007-02-28 | 2016-06-07 | The Procter & Gamble Company | Personal care composition comprising botanical extract |
| WO2012110674A1 (en) | 2011-02-16 | 2012-08-23 | Sainz Prestel Valeria Lucila | Use of a vegetable extract as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining said extract |
| ES2387057A1 (en) * | 2011-02-16 | 2012-09-12 | Valeria Lucila Sainz Prestel | Use of a vegetable extract as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining said extract |
| CN103402529A (en) * | 2011-02-16 | 2013-11-20 | 瓦莱里娅·卢西拉·塞恩斯帕莱斯特 | Use of plant extracts as active ingredients for the production of pharmacologically active products for the treatment of tissue lesions, and methods for obtaining said extracts |
| US8715750B2 (en) | 2011-02-16 | 2014-05-06 | Valeria Lucila Sainz Prestel | Vegetable extract and method of use as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining the extract |
| US8877262B2 (en) | 2011-02-16 | 2014-11-04 | Valeria Lucila Sainz Prestel | Vegetable extract and method of use as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining the extract |
| US9155771B2 (en) | 2011-02-16 | 2015-10-13 | Valeria Lucila Sainz Prestel | Vegetable extract and method of use as an active principle in the production of a pharmacologically active product for the treatment of tissue lesions, and method for obtaining the extract |
| WO2012123962A2 (en) | 2011-02-17 | 2012-09-20 | Patankar Suresh Balkrishna | A novel herbal composition for the treatment of wound healing, a regenerative medicine |
| WO2012123962A3 (en) * | 2011-02-17 | 2012-11-08 | Patankar Suresh Balkrishna | A novel herbal composition for the treatment of wound healing, a regenerative medicine |
| US8709509B2 (en) | 2011-02-17 | 2014-04-29 | Suresh Balkrishna Patankar | Herbal composition for the treatment of wound healing, a regenerative medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005115090A3 (en) | 2006-04-27 |
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