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WO2005113069A3 - Utilisation de curcumine et d'analogues de curcumine comme inhibiteurs de l'acc2 - Google Patents

Utilisation de curcumine et d'analogues de curcumine comme inhibiteurs de l'acc2 Download PDF

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Publication number
WO2005113069A3
WO2005113069A3 PCT/US2005/016896 US2005016896W WO2005113069A3 WO 2005113069 A3 WO2005113069 A3 WO 2005113069A3 US 2005016896 W US2005016896 W US 2005016896W WO 2005113069 A3 WO2005113069 A3 WO 2005113069A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
acc2
curcumin
fatty acid
acid oxidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/016896
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English (en)
Other versions
WO2005113069A2 (fr
Inventor
C W Wellen
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Research Development Foundation
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Research Development Foundation
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Filing date
Publication date
Application filed by Research Development Foundation filed Critical Research Development Foundation
Publication of WO2005113069A2 publication Critical patent/WO2005113069A2/fr
Publication of WO2005113069A3 publication Critical patent/WO2005113069A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne l'utilisation de curcumine ou d'analogues de curcumine comme modulateurs de l'oxydation mitochondriale des acides gras. L'invention concerne plus précisément des compositions de curcumine ou d'analogues de curcumines qui peuvent être utilisées pour inhiber l'acétyl-CoA carboxylase 2 (ACC2) et ainsi promouvoir l'oxydation des acides gras. L'invention concerne également l'utilisation de curcumine et d'analogues de curcumine pour augmenter l'oxydation mitochondriale des acides gras et ainsi promouvoir la perte de poids et/ou réduire l'accumulation de lipides.
PCT/US2005/016896 2004-05-14 2005-05-13 Utilisation de curcumine et d'analogues de curcumine comme inhibiteurs de l'acc2 Ceased WO2005113069A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57146704P 2004-05-14 2004-05-14
US60/571,467 2004-05-14

Publications (2)

Publication Number Publication Date
WO2005113069A2 WO2005113069A2 (fr) 2005-12-01
WO2005113069A3 true WO2005113069A3 (fr) 2006-03-23

Family

ID=34979669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016896 Ceased WO2005113069A2 (fr) 2004-05-14 2005-05-13 Utilisation de curcumine et d'analogues de curcumine comme inhibiteurs de l'acc2

Country Status (2)

Country Link
US (1) US20050267221A1 (fr)
WO (1) WO2005113069A2 (fr)

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US8735595B2 (en) 2006-02-15 2014-05-27 Abbvie Inc. Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
WO2007095601A2 (fr) 2006-02-15 2007-08-23 Abbott Laboratories Nouveaux inhibiteurs de l'acetyl-coa carboxylase (acc) et leur utilisation dans les traitements du diabete, de l'obesite et d'un syndrome metabolique
US8748627B2 (en) 2006-02-15 2014-06-10 Abbvie Inc. Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
US8383865B2 (en) 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
EP2136797A4 (fr) 2007-04-17 2013-08-21 Codman & Shurtleff Administration intranasale de curcumine en bolus de gaz d'hélium pour traiter la maladie d'alzheimer
ATE520443T1 (de) * 2007-06-12 2011-09-15 Softslim Gmbh Funktionelles nahrungsprodukt
WO2009066303A2 (fr) * 2007-11-22 2009-05-28 Ganga Raju Gokaraju Nouvelle composition phytochimique synergique pour le traitement de l'obésité
US20110117008A1 (en) * 2007-11-26 2011-05-19 Research Development Foundation Use of avicins to deliver therapeutic and diagnostic agents
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US9242010B2 (en) 2008-05-16 2016-01-26 Research Foundation Of The City University Of New York Living copolymer-protein/peptide hybrids for biomedical applications
ES2545231T3 (es) 2008-05-28 2015-09-09 Pfizer Inc. Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa
US7985776B2 (en) 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
EP2348868A4 (fr) * 2008-10-22 2013-06-12 Metaproteomics Llc Nouveaux procédés de découplage mitochondrial et compositions pour augmenter la thermogenèse des adipocytes
US7723515B1 (en) 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100286585A1 (en) 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
WO2010132815A1 (fr) 2009-05-15 2010-11-18 The Research Foundation Of State University Of New York Analogues de curcumine utilisés en tant que chélateurs du zinc et leurs utilisations
CA2778886C (fr) 2009-11-10 2014-01-07 Pfizer Inc. Inhibiteurs de n1-pyrazolospirocetone acetyl-coa carboxylase
WO2011082290A2 (fr) 2009-12-31 2011-07-07 Organomed Corporation Formulations formées à partir de produits naturels, de curcuma et d'aspirine
RS55224B1 (sr) 2010-09-30 2017-02-28 Pfizer N1-pirazolospiroketon acetil-coa karboksilaza inhibitori
JP5647356B2 (ja) 2010-10-29 2014-12-24 ファイザー・インク Ｎ１／Ｎ２−ラクタムアセチル−ＣｏＡカルボキシラーゼ阻害剤
EP2699576B1 (fr) 2011-04-22 2015-12-09 Pfizer Inc Dérivés de pyrazolospirocétone destinés à être utilisés comme inhibiteurs d'acétyl-coa carboxylase
WO2014005089A2 (fr) 2012-06-29 2014-01-03 The Research Foundation Of State University Of New York Agents poly-énoliques de liaison au zinc (pezbin) favorisant activement l'inactivation de cellules souches cancéreuses et potentialisant des substances médicamenteuses anti-tumorales cytotoxiques
WO2014138426A2 (fr) * 2013-03-07 2014-09-12 Topokine Therapeutics, Inc. Procédés et compositions pour la réduction de la graisse corporelle et des adipocytes
KR102356390B1 (ko) * 2015-08-28 2022-02-08 칼리웨이 바이오파마슈티칼스 코., 엘티디. 국부 지방을 감소시키기 위해 사용되는 제약 조성물 및 그의 용도
US11318110B2 (en) 2015-08-28 2022-05-03 Caliway Biopharmaceuticals Co., Ltd. Pharmaceutical composition for reducing local fat and uses thereof
CA3033041A1 (fr) * 2016-08-26 2018-03-01 Caliway Biopharmaceuticals Co., Ltd. Injection sous-cutanee pour reduire le poids corporel et application associee
US10300000B2 (en) 2016-09-12 2019-05-28 The Research Foundation For The State University Of New York Inhibition of melanogenesis by chemically modified curcumins
FR3061658A1 (fr) * 2017-01-07 2018-07-13 Guy Faustin Monkam Nitcheu Composition pharmaceutique comprenant en tant que principe actif une combinaison de d-limoneme, de lupeol et du cinnamaldehyde et/ou du methylhydroxychalcone polymere et/ou du beta-sitosterol et/ou de
CN120130644A (zh) * 2018-05-09 2025-06-13 多马利纳股份有限公司Atf多马利纳单位信托 一种用于健康成分的可食用凝胶递送方法
CN112772558B (zh) * 2021-01-05 2022-05-03 南京农业大学 一种应用蛋白乙酰化抑制剂来改善生猪应激和肉品品质的方法
WO2023213813A1 (fr) * 2022-05-03 2023-11-09 Universiteit Maastricht Composé destiné à être utilisé dans la régulation de l'absorption de saccharide par l'intermédiaire du tractus gastro-intestinal et compositions associées

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CN1156601A (zh) * 1996-02-08 1997-08-13 袁克兴 降脂药及其制备方法
WO1999022728A1 (fr) * 1997-10-31 1999-05-14 Arch Development Corporation Procedes et compositions pour reguler l'activite de la 5-alpha-reductase
JP2002173435A (ja) * 2000-09-26 2002-06-21 Ryuei Soken:Kk 抗肥満剤および当該抗肥満剤の投与方法
US6475530B1 (en) * 2000-05-31 2002-11-05 Eric H. Kuhrts Methods and compositions for producing weight loss
US20030147979A1 (en) * 2001-10-23 2003-08-07 Tatsumasa Mae Ligand for peroxisome proliferator-activated receptor

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DE4137540A1 (de) * 1991-11-14 1993-05-19 Steigerwald Arzneimittelwerk Verwendung von praeparaten der curcuma-pflanzen
US5605929A (en) * 1992-05-27 1997-02-25 Arch Development Corp. Methods and compositions for inhibiting 5α-reductase activity
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US6664272B2 (en) * 1999-12-03 2003-12-16 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties
US6599522B2 (en) * 2000-12-01 2003-07-29 Lakshminarayan Rao V. Mokshagundam Triglyceride reducing agent
TWI329516B (en) * 2000-12-12 2010-09-01 Kaneka Corp Composition for preventing or ameliorating multiple risk factor syndromes and visceral fat-type obesity
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EP1478437B1 (fr) * 2002-02-27 2005-08-31 Pfizer Products Inc. Inhibiteurs de l'acetyl-coa-carboxylase
US20040029941A1 (en) * 2002-05-06 2004-02-12 Jennings Julianne E. Zonisamide use in obesity and eating disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156601A (zh) * 1996-02-08 1997-08-13 袁克兴 降脂药及其制备方法
WO1999022728A1 (fr) * 1997-10-31 1999-05-14 Arch Development Corporation Procedes et compositions pour reguler l'activite de la 5-alpha-reductase
US6475530B1 (en) * 2000-05-31 2002-11-05 Eric H. Kuhrts Methods and compositions for producing weight loss
JP2002173435A (ja) * 2000-09-26 2002-06-21 Ryuei Soken:Kk 抗肥満剤および当該抗肥満剤の投与方法
US20030147979A1 (en) * 2001-10-23 2003-08-07 Tatsumasa Mae Ligand for peroxisome proliferator-activated receptor

Non-Patent Citations (2)

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Title
DATABASE WPI Section Ch Week 200137, Derwent World Patents Index; Class B04, AN 2001-344348, XP002364055 *
DATABASE WPI Section Ch Week 200265, Derwent World Patents Index; Class B04, AN 2002-603049, XP002364056 *

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WO2005113069A2 (fr) 2005-12-01
US20050267221A1 (en) 2005-12-01

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