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WO2005105840A3 - Cd40 variants and uses thereof - Google Patents

Cd40 variants and uses thereof Download PDF

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Publication number
WO2005105840A3
WO2005105840A3 PCT/US2005/010760 US2005010760W WO2005105840A3 WO 2005105840 A3 WO2005105840 A3 WO 2005105840A3 US 2005010760 W US2005010760 W US 2005010760W WO 2005105840 A3 WO2005105840 A3 WO 2005105840A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
polypeptides
disclosed
polypeptide sequences
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/010760
Other languages
French (fr)
Other versions
WO2005105840A2 (en
Inventor
Shannon A Marshall
Thomas Linnemann
Lorianne Masuoka
Ernestine A Lee
Kevin F Hestir
Keting Chu
Elizabeth Bosch
Robert Hallenbeck
Lewis T Williams
Haishan Lin
Dirk Behrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Five Prime Therapeutics Inc
Original Assignee
Five Prime Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Prime Therapeutics Inc filed Critical Five Prime Therapeutics Inc
Publication of WO2005105840A2 publication Critical patent/WO2005105840A2/en
Anticipated expiration legal-status Critical
Publication of WO2005105840A3 publication Critical patent/WO2005105840A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Disclosed are newly discovered CD40 variant molecules, their polypeptide sequences, and the polynucleotides encoding the polypeptide sequences. Also provided are procedures for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
PCT/US2005/010760 2004-03-26 2005-03-28 Cd40 variants and uses thereof Ceased WO2005105840A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55709204P 2004-03-26 2004-03-26
US60/557,092 2004-03-26

Publications (2)

Publication Number Publication Date
WO2005105840A2 WO2005105840A2 (en) 2005-11-10
WO2005105840A3 true WO2005105840A3 (en) 2008-03-20

Family

ID=35058742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/010760 Ceased WO2005105840A2 (en) 2004-03-26 2005-03-28 Cd40 variants and uses thereof

Country Status (1)

Country Link
WO (1) WO2005105840A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009237577B2 (en) * 2008-04-18 2014-06-05 Baxter Healthcare Sa Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
EP2621514B1 (en) 2010-09-28 2016-09-21 KAHR Medical (2005) Ltd Compositions and methods for treatment of hematological malignancies
CR20170592A (en) 2015-05-29 2018-02-13 Abbvie Inc ANTI-CD40 ANTIBODIES AND THEIR USES
WO2017137477A1 (en) 2016-02-09 2017-08-17 Bracco Suisse Sa A recombinant chimeric protein for selectins targeting
CN109456989B (en) * 2018-10-31 2022-03-29 陕西慧康生物科技有限责任公司 Construction method of vector for improving secretion expression of pichia pastoris

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070768A2 (en) * 2002-02-22 2003-08-28 Compugen Ltd. Cd40 splice variants,method of detection thereof, compositions comprising said variant(s) or nucleic acid encoding the same and use thereof
WO2004020593A2 (en) * 2002-08-30 2004-03-11 Incyte Corporation Immune response associated proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070768A2 (en) * 2002-02-22 2003-08-28 Compugen Ltd. Cd40 splice variants,method of detection thereof, compositions comprising said variant(s) or nucleic acid encoding the same and use thereof
WO2004020593A2 (en) * 2002-08-30 2004-03-11 Incyte Corporation Immune response associated proteins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CONTIN CECILE ET AL: "Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 35, 29 August 2003 (2003-08-29), pages 32801 - 32809, XP002355715, ISSN: 0021-9258 *
DATABASE Geneseq [online] 3 June 2004 (2004-06-03), "Human immune response associated protein IRAP-31 protein.", XP002370167, retrieved from EBI accession no. GSP:ADK98568 Database accession no. ADK98568 *
SIWKOWSKI ANDREW M ET AL: "Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing.", NUCLEIC ACIDS RESEARCH. 2004, vol. 32, no. 9, 2004, pages 2695 - 2706, XP002355716, ISSN: 1362-4962 *
TONE M ET AL: "Regulation of CD40 function by its isoforms generated through alternative splicing", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 4, 13 February 2001 (2001-02-13), pages 1751 - 1756, XP002262482, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2005105840A2 (en) 2005-11-10

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