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WO2005021504A3 - Nouvelles formes cristallines de carvedilol - Google Patents

Nouvelles formes cristallines de carvedilol Download PDF

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Publication number
WO2005021504A3
WO2005021504A3 PCT/SI2004/000029 SI2004000029W WO2005021504A3 WO 2005021504 A3 WO2005021504 A3 WO 2005021504A3 SI 2004000029 W SI2004000029 W SI 2004000029W WO 2005021504 A3 WO2005021504 A3 WO 2005021504A3
Authority
WO
WIPO (PCT)
Prior art keywords
carvedilol
new crystalline
crystalline forms
processes
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SI2004/000029
Other languages
English (en)
Other versions
WO2005021504A2 (fr
Inventor
Rok Zupet
Marija Grcman
Matej Smrkolj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KRKA dd
Original Assignee
KRKA Tovarna Zdravil dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KRKA Tovarna Zdravil dd filed Critical KRKA Tovarna Zdravil dd
Priority to EP04775682A priority Critical patent/EP1660451A2/fr
Publication of WO2005021504A2 publication Critical patent/WO2005021504A2/fr
Publication of WO2005021504A3 publication Critical patent/WO2005021504A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La présente invention concerne de nouvelles formes cristallines VII and IX de carvédilol et des processus de préparation de celle-ci. Cette invention concerne en particulier des processus d'isolation de carvédilol, via un acétate éthyle utilisé comme solvant.
PCT/SI2004/000029 2003-09-02 2004-09-01 Nouvelles formes cristallines de carvedilol Ceased WO2005021504A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04775682A EP1660451A2 (fr) 2003-09-02 2004-09-01 Nouvelles formes cristallines de carvedilol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200300218A SI21616A (sl) 2003-09-02 2003-09-02 Nove kristalne oblike karvedilola
SIP-200300218 2003-09-02

Publications (2)

Publication Number Publication Date
WO2005021504A2 WO2005021504A2 (fr) 2005-03-10
WO2005021504A3 true WO2005021504A3 (fr) 2005-06-02

Family

ID=34271325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2004/000029 Ceased WO2005021504A2 (fr) 2003-09-02 2004-09-01 Nouvelles formes cristallines de carvedilol

Country Status (3)

Country Link
EP (1) EP1660451A2 (fr)
SI (1) SI21616A (fr)
WO (1) WO2005021504A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030017569A (ko) 2000-06-28 2003-03-03 테바 파마슈티컬 인더스트리즈 리미티드 카르베딜올
MXPA04006909A (es) 2002-01-15 2005-04-19 Teva Pharma Solidos cristalinos de carvedilol y procesos para su preparacion.
US20070043099A1 (en) * 2005-06-09 2007-02-22 Igor Lifshitz Crystalline forms of carvedilol and processes for their preparation
WO2007043938A1 (fr) * 2005-10-07 2007-04-19 Astrazeneca Ab Nouvelle forme cristalline de 3,5-dibromo-n-[(2s)-2-(4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl]-n-methylbenzamide, modification b
WO2008002683A2 (fr) 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Carvédilol phosphate

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005105A1 (fr) * 1997-07-22 1999-02-04 Roche Diagnostics Gmbh Modification thermodynamiquement stable de 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, son procede de preparation et compositions pharmaceutiques le contenant
WO2002000216A1 (fr) * 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
WO2003005970A2 (fr) * 2001-07-13 2003-01-23 Smithkline Beecham Corporation Polymorphe de carvedilol
WO2003029214A1 (fr) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Formes pseudopolymorphes de carvedilol
WO2003059807A2 (fr) * 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Corps solides cristallins de carvedilol, et leurs procedes d'elaboration
WO2004041252A1 (fr) * 2002-11-08 2004-05-21 Egalet A/S Compositions de carvedilol a liberation commandee
WO2004041783A1 (fr) * 2002-11-08 2004-05-21 Zentiva, A.S. Procede pour preparer du carvedilol
WO2004113296A1 (fr) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited Procede de preparation de 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propane-2-ol

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005105A1 (fr) * 1997-07-22 1999-02-04 Roche Diagnostics Gmbh Modification thermodynamiquement stable de 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, son procede de preparation et compositions pharmaceutiques le contenant
WO2002000216A1 (fr) * 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
WO2003005970A2 (fr) * 2001-07-13 2003-01-23 Smithkline Beecham Corporation Polymorphe de carvedilol
WO2003029214A1 (fr) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Formes pseudopolymorphes de carvedilol
WO2003059807A2 (fr) * 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Corps solides cristallins de carvedilol, et leurs procedes d'elaboration
WO2004041252A1 (fr) * 2002-11-08 2004-05-21 Egalet A/S Compositions de carvedilol a liberation commandee
WO2004041783A1 (fr) * 2002-11-08 2004-05-21 Zentiva, A.S. Procede pour preparer du carvedilol
WO2004113296A1 (fr) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited Procede de preparation de 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propane-2-ol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VENKATESH, GOPI M. ET AL: "Detection of low levels of the amorphous phase in crystalline pharmaceutical materials by thermally stimulated current spectrometry", PHARMACEUTICAL RESEARCH , 18(1), 98-103 CODEN: PHREEB; ISSN: 0724-8741, 2001, XP002316351 *

Also Published As

Publication number Publication date
WO2005021504A2 (fr) 2005-03-10
EP1660451A2 (fr) 2006-05-31
SI21616A (sl) 2005-04-30

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