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WO2005020720A1 - Procede pour produire des pastilles substrat gonflantes comme forme d'administration par voie orale pour des fibres alimentaires et pastilles substrat gonflantes ainsi produites - Google Patents

Procede pour produire des pastilles substrat gonflantes comme forme d'administration par voie orale pour des fibres alimentaires et pastilles substrat gonflantes ainsi produites Download PDF

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Publication number
WO2005020720A1
WO2005020720A1 PCT/DE2004/001823 DE2004001823W WO2005020720A1 WO 2005020720 A1 WO2005020720 A1 WO 2005020720A1 DE 2004001823 W DE2004001823 W DE 2004001823W WO 2005020720 A1 WO2005020720 A1 WO 2005020720A1
Authority
WO
WIPO (PCT)
Prior art keywords
source substrate
substrate pellets
mass
pellets
carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2004/001823
Other languages
German (de)
English (en)
Inventor
Wolfgang Kempe
Axel Kuschk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IPC Process Center GmbH and Co KG
Original Assignee
IPC Process Center GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IPC Process Center GmbH and Co KG filed Critical IPC Process Center GmbH and Co KG
Publication of WO2005020720A1 publication Critical patent/WO2005020720A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/20—Shaping or working-up of animal feeding-stuffs by moulding, e.g. making cakes or briquettes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/24—Cellulose or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention relates to a method for producing source substrate pellets, as an oral dosage form for dietary fiber, as can be used in particular for dietetic applications, and to source substrate pellets produced using this method. Furthermore, with the swelling substrate pellets according to the invention, advantageous effects for the metabolism and prophylactic effects for living organisms can also be achieved.
  • Such fiber can be obtained from different plants or fruits, so that it does not have to be consumed orally as plant food.
  • pectins a wide variety of celluloses, algae from algae or oligofructose commonly referred to as inulin can be made available as food supplements from different plants.
  • this object is achieved with a ren, which has the features of claim 1, solved.
  • the features referred to in claim 11 relate to source substrate pellets produced in this way.
  • the source substrate pellets produced according to the invention therefore contain at least one carbonate and / or a bicarbonate with a minimum proportion of 0.1% by mass in addition to at least one fiber.
  • the proportion of carbonates or bicarbonates should advantageously be more than 1% by mass, but not more than 80% by mass, preferably not more than 50% by mass.
  • a fiber suitable for the invention and also a network formed therefrom should not be or only sparingly soluble, this particularly relating to the temperature range below 45 ° C.
  • Another parameter that can be taken into account for the volume increase that can be achieved is the respective grain size of source substrate pellets.
  • the latter parameter also influences the time behavior for the desired volume increase.
  • alginates, cellulose, hemicelluloses, lignin and / or oligofructoses can also be used as dietary fibers for source substrate pellets according to the invention.
  • dietary fiber mixtures can be advantageous to use in the form of pectin or cellulose-based dietary fibers in such a way that a mixture of pectin or cellulose obtained from different plant types can be used, which has an advantageous effect on the digestive process and can also have an impact on the more extensive prophylactic effects that can be achieved.
  • Suitable carbonates or hydrogen carbonates are, for example, calcium carbonate, magnesium carbonate, calcium hydrogen carbonate, sodium hydrogen carbonate.
  • Carbonates or hydrogen carbonates which have been found to be particularly advantageous are those which, in the chemical reaction already mentioned, under the Influence of hydrochloric acid in the stomach to release 2-valent cations, such as Ca ++ ions.
  • source substrate pellets according to the invention In addition to dietary fibers, carbonates and / or hydrogen carbonates, however, further additives can be used in source substrate pellets according to the invention or in combination with source substrate pellets, the latter still to be mentioned.
  • salts such as salts which can be dissociated in liquids, such as chlorides, phosphates, sulfides or sulfates, can also be present, which on the one hand can produce an advantageous taste-improving effect, but can also be of nutritional physiological importance in order to prevent this
  • Metabolism necessary elements or additional substances to be able to supply for the respective organism.
  • certain dyes can also be present, natural biological dyes being particularly suitable here because of their harmlessness.
  • the individual source substrate pellets can advantageously also be enclosed by a covering or a plurality of source substrate pellets can be embedded in a matrix.
  • these substances or mixtures of substances can also contain different aroma and / or flavoring substances in order to improve the appetite of the essentially tasteless and odorless fiber.
  • This effect can be achieved, for example, with different, preferably vegetable fats or waxes.
  • individual source substrate pellets with a coating made of natural or synthetic polymers e.g. Shellac or cellulose acetate are enclosed.
  • Cellulose derivatives e.g. HPMC, MC etc.
  • latex-like substances e.g. Eudragite
  • Envelopes can also be applied in multiple layers and then optionally with different consistency.
  • the source substrate pellets according to the invention can have been formed in a grain size range between 0.5 to 3 mm, the respective grain size fraction also taking into account the fiber contained in the source substrate pellets and, if appropriate, also the proportion of carbonates or bicarbonates present.
  • Source substrate pellets can be prepared for consumption in a narrowly limited grain size range, but also in a grain size range that extends beyond the specified dimensions.
  • the source substrate pellets according to the invention can be produced as follows.
  • the respective substances that is to say at least one fiber, a carbonate or a hydrogen carbonate, are mixed with one another in a wet mixing unit, it being possible for a certain proportion of water to be added in order to be able to set a dough-like extrudable consistency.
  • the dough-like mass obtained in this way is then fed to an extruder, for example a screw or rotary extruder, and rod-shaped pellets are produced after the extrusion.
  • an extruder for example a screw or rotary extruder
  • matrices designed according to the desired grain sizes can be used.
  • the pressures and forces acting during the extrusion and also the temperature of the mass to be extruded can also be taken into account.
  • cooling can also be provided in order to avoid certain maximum temperatures which can lead to an undesired influence on certain components contained in the extrudate.
  • rounding spheronization
  • at least rounded end faces can be achieved on cylindrical source substrate pellets. In extreme cases, rounding can also lead to a completely spherical shape of source substrate pellets.
  • the moisture can be reduced by drying.
  • corresponding coatings can then be formed around the individual source substrate pellets by spraying.
  • Drying and spraying can be carried out in a fluidized bed, for example.
  • the finished source substrate pellets can then already be consumed orally in this form.
  • a corresponding cereal preparation with source substrate pellets according to the invention can be prepared.
  • the substance forming a matrix or such a mixture of substances completely surrounds the source substrate pellets containing it, so that a desired protective effect can be achieved up to consumption.
  • the source substrate pellets according to the invention have several advantageous effects from a nutritional and therapeutic point of view.
  • the residence time in the stomach can be extended.
  • the indigestible fiber increases the stool volume and shorter transit times of the respective stool portions can be achieved.
  • hyperacidity can be buffered, in particular when calcium carbonate is used, as a particularly suitable carbonate in the source substrate pellets according to the invention.
  • pectin as a preferred dietary fiber.
  • this affects the absorption capacity of the pectin by cholesterol, which can lead to a lowering of the cholesterol level, and on the other hand it has a preventive effect against intestinal diseases.
  • a dry mixture consisting of 70% by mass of pectin (pectin amide AF 005), 20% by mass of microcrystalline cellulose (Vivapur type 101) and 10% by mass of calcium carbonate (Omyapure 35) was placed in a VG 25 vertical granulator from the company Made smooth.
  • Deonized water was added to the dry mixture for moistening with the same mass as the dry mixture.
  • the moist, dough-like mass was passed through a die of an extruder, extrusion being carried out to a diameter of approximately 1 mm.
  • the extrudate particles obtained in this way were spheronized in a P 50 pelletizer from Glatt. There was breaking and rounding.
  • the still moist pellets obtained in this way were dried in the fluidized bed of a GPCG 1.1 fluidized bed installation from Glatt to a residual moisture of about 6%.
  • the effect of the source substrate pellets produced in this way can be checked very simply in vitro.
  • a few grams of such source substrate pellets can be placed in a beaker containing dilute hydrochloric acid or other available acidic solution and the expected volume increase of at least 8 times can be observed after a short time.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne la production de pastilles substrat gonflantes comme forme d'administration par voie orale pour des fibres alimentaires, pouvant être utilisées notamment à des fins diététiques. Ces pastilles substrat gonflantes contiennent, outre au moins une fibre alimentaire, au moins 0,1 % en poids d'un carbonate et/ou d'un bicarbonate, les fibres alimentaires utilisées de préférence étant la pectine, l'alginate, la cellulose, l'hémicellulose, la lignine et/ou l'oligofructose. La production de ces pastilles s'effectue par extrusion d'un mélange de fibre(s) alimentaire(s) avec du carbonate et/ou du bicarbonate, présentant une consistance pâteuse.
PCT/DE2004/001823 2003-08-26 2004-08-13 Procede pour produire des pastilles substrat gonflantes comme forme d'administration par voie orale pour des fibres alimentaires et pastilles substrat gonflantes ainsi produites Ceased WO2005020720A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10339863.5 2003-08-26
DE10339863A DE10339863A1 (de) 2003-08-26 2003-08-26 Quellsubstratpellets als orale Darreichungsform für Ballaststoffe

Publications (1)

Publication Number Publication Date
WO2005020720A1 true WO2005020720A1 (fr) 2005-03-10

Family

ID=34202203

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/DE2003/003721 Ceased WO2005025336A1 (fr) 2003-08-26 2003-11-05 Pastilles de substrat source servant de forme d'administration orale de fibres dietetiques
PCT/DE2004/001823 Ceased WO2005020720A1 (fr) 2003-08-26 2004-08-13 Procede pour produire des pastilles substrat gonflantes comme forme d'administration par voie orale pour des fibres alimentaires et pastilles substrat gonflantes ainsi produites

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/003721 Ceased WO2005025336A1 (fr) 2003-08-26 2003-11-05 Pastilles de substrat source servant de forme d'administration orale de fibres dietetiques

Country Status (3)

Country Link
AU (1) AU2003286124A1 (fr)
DE (2) DE10339863A1 (fr)
WO (2) WO2005025336A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007044638A1 (fr) * 2005-10-07 2007-04-19 Mcneil Nutritionals, Llc Compositions et procedes pour la reduction de prise d'aliments et le controle de poids
WO2007044578A1 (fr) * 2005-10-07 2007-04-19 Mcneil Nutritionals, Llc Methodes permettant d'induire la satiete, de reduire la ration alimentaire et de reduire le poids
WO2007044637A1 (fr) * 2005-10-07 2007-04-19 Mcneil Nutritionals, Llc Methodes permettant de reduire l'apport calorique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812315A (en) * 1987-05-14 1989-03-14 Tarabishi M Hisham Diet pills
EP0412639A2 (fr) * 1989-08-11 1991-02-13 Borden, Inc. Pâtes riches en fibres, à teneur réduite en calories
EP0471217A2 (fr) * 1990-08-16 1992-02-19 Werner Ratjen Composition d'absorption orale
US5292518A (en) * 1988-06-28 1994-03-08 Hauser-Kuhrts Prolonged-release drug tablet formulations
WO2003051329A1 (fr) * 2001-12-17 2003-06-26 Beisel Guenther Produit d'administration orale et son procede de production

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445826A (en) * 1988-06-28 1995-08-29 Cibus Pharmaceutical, Inc. Delivery system containing a gel-forming dietary fiber and a drug
DE69423643T2 (de) * 1993-10-29 2000-09-07 R.P. Scherer Corp., Troy Schäumende gelatinkapselfüllung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812315A (en) * 1987-05-14 1989-03-14 Tarabishi M Hisham Diet pills
US5292518A (en) * 1988-06-28 1994-03-08 Hauser-Kuhrts Prolonged-release drug tablet formulations
EP0412639A2 (fr) * 1989-08-11 1991-02-13 Borden, Inc. Pâtes riches en fibres, à teneur réduite en calories
EP0471217A2 (fr) * 1990-08-16 1992-02-19 Werner Ratjen Composition d'absorption orale
WO2003051329A1 (fr) * 2001-12-17 2003-06-26 Beisel Guenther Produit d'administration orale et son procede de production

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007044638A1 (fr) * 2005-10-07 2007-04-19 Mcneil Nutritionals, Llc Compositions et procedes pour la reduction de prise d'aliments et le controle de poids
WO2007044578A1 (fr) * 2005-10-07 2007-04-19 Mcneil Nutritionals, Llc Methodes permettant d'induire la satiete, de reduire la ration alimentaire et de reduire le poids
WO2007044637A1 (fr) * 2005-10-07 2007-04-19 Mcneil Nutritionals, Llc Methodes permettant de reduire l'apport calorique

Also Published As

Publication number Publication date
DE10394330D2 (de) 2006-07-13
AU2003286124A1 (en) 2005-04-06
DE10339863A1 (de) 2005-03-24
WO2005025336A1 (fr) 2005-03-24

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