[go: up one dir, main page]

WO2005007842A3 - Cible antimicrobienne - Google Patents

Cible antimicrobienne Download PDF

Info

Publication number
WO2005007842A3
WO2005007842A3 PCT/GB2004/003024 GB2004003024W WO2005007842A3 WO 2005007842 A3 WO2005007842 A3 WO 2005007842A3 GB 2004003024 W GB2004003024 W GB 2004003024W WO 2005007842 A3 WO2005007842 A3 WO 2005007842A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdp
kinase
antimicrobal
target
crystal structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/003024
Other languages
English (en)
Other versions
WO2005007842A2 (fr
Inventor
William Nigel Hunter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Original Assignee
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Dundee filed Critical University of Dundee
Priority to GB0602714A priority Critical patent/GB2419595A/en
Publication of WO2005007842A2 publication Critical patent/WO2005007842A2/fr
Publication of WO2005007842A3 publication Critical patent/WO2005007842A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L invention concerne un cristal de CDP-ME kinase mis en complexe avec son substrat CDP-ME et AMP-PNP et l'obtention des données de cristal ainsi que les utilisations des informations de données de cristal, par exemple, pour identifier des inhibiteurs de CDP-ME kinase.
PCT/GB2004/003024 2003-07-11 2004-07-12 Cible antimicrobienne Ceased WO2005007842A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0602714A GB2419595A (en) 2003-07-11 2004-07-12 Crystal Structure Of CDP-ME Kinase And Antimicrobal Target

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0316271.6A GB0316271D0 (en) 2003-07-11 2003-07-11 Antimicrobial target
GBGB316271.6 2003-07-11

Publications (2)

Publication Number Publication Date
WO2005007842A2 WO2005007842A2 (fr) 2005-01-27
WO2005007842A3 true WO2005007842A3 (fr) 2005-04-14

Family

ID=27742008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003024 Ceased WO2005007842A2 (fr) 2003-07-11 2004-07-12 Cible antimicrobienne

Country Status (2)

Country Link
GB (2) GB0316271D0 (fr)
WO (1) WO2005007842A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048340A2 (fr) * 2001-12-05 2003-06-12 Vertex Pharmaceuticals Incorporated Structure cristalline de proteine kinase 2 activee par la proteine kinase activee par des agents mitogenes et poches de fixation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048340A2 (fr) * 2001-12-05 2003-06-12 Vertex Pharmaceuticals Incorporated Structure cristalline de proteine kinase 2 activee par la proteine kinase activee par des agents mitogenes et poches de fixation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BURLEY STEPHEN K ET AL: "Structural genomics of proteins from conserved biochemical pathways and processes", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 12, no. 3, June 2002 (2002-06-01), pages 383 - 391, XP002309179, ISSN: 0959-440X *
FU ZHUJI ET AL: "The structure of a binary complex between a mammalian mevalonate kinase and ATP. Insights into the reaction mechanism and human inherited disease", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 20, 17 May 2002 (2002-05-17), pages 18134 - 18142, XP002309182, ISSN: 0021-9258 *
HUBBARD S R: "Crystal structure of the acfivated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 16, no. 18, 1997, pages 5572 - 5581, XP002088043, ISSN: 0261-4189 *
KEMP LAURIS E ET AL: "Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: An essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 10, 14 May 2002 (2002-05-14), pages 6591 - 6596, XP002309180, ISSN: 0027-8424 *
KRISHNA S SRI ET AL: "Structural basis for the catalysis and substrate specificity of homoserine kinase", BIOCHEMISTRY, vol. 40, no. 36, 11 September 2001 (2001-09-11), pages 10810 - 10818, XP002309181, ISSN: 0006-2960 *
LÜTTGEN ET AL: "Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D- erythritol", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 3, 1 February 2000 (2000-02-01), pages 1062 - 1067, XP002154082, ISSN: 0027-8424 *
MIALLAU LINDA ET AL: "Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2 C-methyl-D-erythritol kinase.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 16, 5 August 2003 (2003-08-05), pages 9173 - 9178, XP002309183, ISSN: 0027-8424 *
PDB: "Structure Explorer-1UEK", INTERNET ARTICLE, 17 June 2003 (2003-06-17), XP002309185, Retrieved from the Internet <URL:www.rcsb.org/pdb/cgi/explore.cgi?pdbid=1uek> [retrieved on 20041206] *
RICHARD S B ET AL: "Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 277, no. 10, 8 March 2002 (2002-03-08), pages 8667 - 8672, XP002242321, ISSN: 0021-9258 *
WADA TAKASHI ET AL: "Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 32, 8 August 2003 (2003-08-08), pages 30022 - 30027, XP002309184, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2005007842A2 (fr) 2005-01-27
GB0602714D0 (en) 2006-03-22
GB0316271D0 (en) 2003-08-13
GB2419595A (en) 2006-05-03

Similar Documents

Publication Publication Date Title
WO2005024695A3 (fr) Procedes pour coder des informations non biologiques sur des microreseaux
WO2007106787A3 (fr) Procédés et systèmes pour l&#39;établissement d&#39;une égalisation caractéristique
WO2006096282A3 (fr) Systeme et procede destines a fournir des informations de localisation a des applications
WO2007022363A3 (fr) Mecanisme de verification de la conformite
AU2003226941A1 (en) Antifouling composition comprising an enzyme in the absence of its substrate
WO2006056982A3 (fr) Systeme et procede d&#39;identification par defaut
AU2003275392A1 (en) Methods and systems for evaluation of business performance
WO2007146707A3 (fr) Améliorations apportées à un serveur d&#39;entreprise rfid
AU2003257209A1 (en) Subsystem based optical interrogation of sample
WO2004019247A8 (fr) Estimation des capacites d&#39;une organisation de gerer les relations avec le client
WO2004065570A3 (fr) Methodes de metallisation de molecules d&#39;acides nucleiques et methodes de fixation de molecules d&#39;acides nucleiques a des surfaces conductrices
WO2007053192A3 (fr) Attaches multipodes permettant des fixations a haute densite de fragments de molecules a activite redox a des substrats
AU2003274592A1 (en) Method to assign word class information
WO2005016116A3 (fr) Dispositifs hemostatiques contenant un precipite de proteine
WO2005007842A3 (fr) Cible antimicrobienne
AU2003224793A1 (en) Reversible association of nucleic acid with a carboxylated substrate
TW200746067A (en) Information recording medium and information recording method
AU2003231194A1 (en) Reliable conveyance of orthogonal space information
WO2004037974A3 (fr) Genes de fagopyritol synthase et leurs utilisations
EP1536425A3 (fr) Support d&#39;enregistrement d&#39;information optique et procédé d&#39;enregistrement d&#39;information
AU2002344845A1 (en) Visual database for linking geography to seismic data
BRPI0515397B8 (pt) métodos para detecção e identificação específicas de streptococcus agalactiae usando atividade de esterase, e meio de reação
AU2003278288A1 (en) Method of determining branched molecules from mass data
WO2003068927A3 (fr) Procede permettant d&#39;influencer l&#39;activite kinasique a l&#39;aide de ag879 et de derives de ag879
WO2004007680A3 (fr) Procedes pour identifier des composes qui modulent la synthese de l&#39;ige mediee par le recepteur il-4, au moyen d&#39;une adenosine kinase

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 0602714.8

Country of ref document: GB

Ref document number: 0602714

Country of ref document: GB

122 Ep: pct application non-entry in european phase