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WO2005007842A3 - Crystal structure of cdp-me kinase and antimicrobal target - Google Patents

Crystal structure of cdp-me kinase and antimicrobal target Download PDF

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Publication number
WO2005007842A3
WO2005007842A3 PCT/GB2004/003024 GB2004003024W WO2005007842A3 WO 2005007842 A3 WO2005007842 A3 WO 2005007842A3 GB 2004003024 W GB2004003024 W GB 2004003024W WO 2005007842 A3 WO2005007842 A3 WO 2005007842A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdp
kinase
antimicrobal
target
crystal structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/003024
Other languages
French (fr)
Other versions
WO2005007842A2 (en
Inventor
William Nigel Hunter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Original Assignee
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Dundee filed Critical University of Dundee
Priority to GB0602714A priority Critical patent/GB2419595A/en
Publication of WO2005007842A2 publication Critical patent/WO2005007842A2/en
Publication of WO2005007842A3 publication Critical patent/WO2005007842A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a crystal of CDP-ME kinase complexed with its substrate CDP-ME and AMP-PNP and obtaining the crystal data relating to this and uses of the crystal data information for example to identify inhibitors of CDP-ME kinase.
PCT/GB2004/003024 2003-07-11 2004-07-12 Crystal structure of cdp-me kinase and antimicrobal target Ceased WO2005007842A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0602714A GB2419595A (en) 2003-07-11 2004-07-12 Crystal Structure Of CDP-ME Kinase And Antimicrobal Target

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0316271.6A GB0316271D0 (en) 2003-07-11 2003-07-11 Antimicrobial target
GBGB316271.6 2003-07-11

Publications (2)

Publication Number Publication Date
WO2005007842A2 WO2005007842A2 (en) 2005-01-27
WO2005007842A3 true WO2005007842A3 (en) 2005-04-14

Family

ID=27742008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003024 Ceased WO2005007842A2 (en) 2003-07-11 2004-07-12 Crystal structure of cdp-me kinase and antimicrobal target

Country Status (2)

Country Link
GB (2) GB0316271D0 (en)
WO (1) WO2005007842A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048340A2 (en) * 2001-12-05 2003-06-12 Vertex Pharmaceuticals Incorporated Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048340A2 (en) * 2001-12-05 2003-06-12 Vertex Pharmaceuticals Incorporated Crystal structure of mitogen-activated protein kinase-activated protein kinase 2 and binding pockets thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BURLEY STEPHEN K ET AL: "Structural genomics of proteins from conserved biochemical pathways and processes", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 12, no. 3, June 2002 (2002-06-01), pages 383 - 391, XP002309179, ISSN: 0959-440X *
FU ZHUJI ET AL: "The structure of a binary complex between a mammalian mevalonate kinase and ATP. Insights into the reaction mechanism and human inherited disease", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 20, 17 May 2002 (2002-05-17), pages 18134 - 18142, XP002309182, ISSN: 0021-9258 *
HUBBARD S R: "Crystal structure of the acfivated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 16, no. 18, 1997, pages 5572 - 5581, XP002088043, ISSN: 0261-4189 *
KEMP LAURIS E ET AL: "Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: An essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 10, 14 May 2002 (2002-05-14), pages 6591 - 6596, XP002309180, ISSN: 0027-8424 *
KRISHNA S SRI ET AL: "Structural basis for the catalysis and substrate specificity of homoserine kinase", BIOCHEMISTRY, vol. 40, no. 36, 11 September 2001 (2001-09-11), pages 10810 - 10818, XP002309181, ISSN: 0006-2960 *
LÜTTGEN ET AL: "Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D- erythritol", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 3, 1 February 2000 (2000-02-01), pages 1062 - 1067, XP002154082, ISSN: 0027-8424 *
MIALLAU LINDA ET AL: "Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2 C-methyl-D-erythritol kinase.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 16, 5 August 2003 (2003-08-05), pages 9173 - 9178, XP002309183, ISSN: 0027-8424 *
PDB: "Structure Explorer-1UEK", INTERNET ARTICLE, 17 June 2003 (2003-06-17), XP002309185, Retrieved from the Internet <URL:www.rcsb.org/pdb/cgi/explore.cgi?pdbid=1uek> [retrieved on 20041206] *
RICHARD S B ET AL: "Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase: An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 277, no. 10, 8 March 2002 (2002-03-08), pages 8667 - 8672, XP002242321, ISSN: 0021-9258 *
WADA TAKASHI ET AL: "Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 32, 8 August 2003 (2003-08-08), pages 30022 - 30027, XP002309184, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2005007842A2 (en) 2005-01-27
GB0602714D0 (en) 2006-03-22
GB0316271D0 (en) 2003-08-13
GB2419595A (en) 2006-05-03

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