[go: up one dir, main page]

WO2005063019A1 - Agent antimicrobien - Google Patents

Agent antimicrobien Download PDF

Info

Publication number
WO2005063019A1
WO2005063019A1 PCT/JP2004/019064 JP2004019064W WO2005063019A1 WO 2005063019 A1 WO2005063019 A1 WO 2005063019A1 JP 2004019064 W JP2004019064 W JP 2004019064W WO 2005063019 A1 WO2005063019 A1 WO 2005063019A1
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial agent
genus
wine
dihydro
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/019064
Other languages
English (en)
Japanese (ja)
Inventor
Shinji Yoshida
Munekazu Iinuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Enviro Chemicals Ltd
Original Assignee
Japan Enviro Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Enviro Chemicals Ltd filed Critical Japan Enviro Chemicals Ltd
Publication of WO2005063019A1 publication Critical patent/WO2005063019A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]

Definitions

  • the present invention relates to microorganisms having high safety (for example, in various buildings such as dwellings, stores, factories, warehouses, and hospitals, in various vehicles such as vehicles, ships, and aircraft, in fibers, leather, paints, and adhesives).
  • Chemicals such as chemicals, plastics and metalworking oils, bioactive products such as pharmaceuticals and agricultural chemicals, microorganisms capable of reproducing in cosmetics, foods, etc.).
  • microorganisms such as molds not only contaminate the aesthetics of the dwelling, but their spores can cause allergic bronchitis and asthma.
  • microorganisms such as molds also serve as nutrients such as mites, they indirectly cause atopic dermatitis.
  • yeast for example, yeast belonging to the genus Rhodotorula contaminates bathrooms and the like in red and black.
  • Microorganisms such as molds belonging to the genus Eurotium can grow in the air and in dry foods, and can also grow in a dry environment.
  • microorganisms inhabit a very wide area and degrade various articles.
  • Biological degradation of articles by microorganisms is not limited to the building and components of various transport vehicles (vehicles, ships, aircraft, etc.), and various articles such as natural products (leather, etc.), chemical products (synthetic fibers, It also occurs in synthetic leather, plastics, paints, adhesives, metalworking oils, etc., metals (iron, aluminum, etc.) products, bioactive products (pharmaceuticals, pesticides, etc.), foods and cosmetics.
  • Patent Document 1 discloses a wood preservative containing a compound such as power wine, yangonine, or methistin as an active ingredient. It is described as useful for preventing wood damage, wood decay by wood decay fungi, and wood contamination by wood contaminants. Further, in this document, 7,8-dihydrokine is exemplified together with a power wine, a 5,6-dehydropower wine, and the like.
  • Patent Document 2 Japanese Patent No. 3306054 is characterized in that it contains, as an active ingredient, an exudate of a plant belonging to moss species (Piper methysticum) or a treated product thereof, or a treated product thereof. Wood preservatives for fungicidal wood are disclosed.
  • a high-concentration acetone or methanol extract (125000 ⁇ g / ml) of the above-ground stem of moss (Piper methysticum) was used against the mixed spores of the four wood-contaminating bacteria described in Patent Document 1. It was described that mold growth was observed only on the side of the test sample when the test was applied.
  • Patent Document 3 discloses that
  • a wood preservative which is an antifungal agent for wood containing leaves of a plant belonging to Methysticum) or a processed product thereof as an active ingredient is disclosed.
  • a high-concentration acetone extract (125000 ⁇ g / ml) of mosquito (Piper methysticum) leaves was also used against mixed spores of the above four types of wood-contaminating bacteria described in Patent Document 1. When applied, it is stated that mold growth was observed only on the side of the specimen.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2003-252708 (Claims, Paragraph Number [0003])
  • Patent Document 2 Patent No. 3306054 (Claims, Paragraph Number [0032] — [0036])
  • Patent Documents 3 JP 2003-267802 A (Claims, paragraph number [0031] —
  • an object of the present invention is to provide an antimicrobial agent which has high safety and high controllability against specific microorganisms, and a method for controlling microorganisms using the same.
  • Another object of the present invention is to provide an antimicrobial agent capable of effectively controlling microorganisms contaminating a living environment that not only adversely affect humans and livestock, but also to be used in a highly airtight living environment, and to use the same. It is an object of the present invention to provide a method for controlling microorganisms.
  • Still another object of the present invention is to provide an antimicrobial agent capable of controlling microorganisms simply and with high efficiency, and a method for controlling microorganisms using the same.
  • the present inventors have conducted intensive studies to achieve the above object, and as a result, have found that they have a strong inhibitory activity on a specific microorganism, and have completed the present invention.
  • the present invention discloses the following antimicrobial agents.
  • the present invention also discloses the following antimicrobial agents.
  • (A) which is at least one selected from Alternaria sp. And Fusarium sp.
  • (F) A defatted plant of a plant belonging to the species of Piper methysticum or a processed product thereof was extracted with at least one extraction solvent selected from alcohols, esters, and ketones.
  • the present invention further includes a method for controlling or preventing the following microorganisms.
  • (G) A method for controlling or preventing microorganisms by applying the antimicrobial agent according to the above (A) to an object to be treated (or an area to be treated) in which microorganisms can grow or propagate.
  • the antimicrobial agent of the present invention contains 7,8-dihydropowered wine present in natural plants, it has high safety and high controllability against specific microorganisms. In addition, even when used in a highly airtight living environment, microorganisms that contaminate the living environment without adversely affecting humans and animals can be effectively controlled. Further, in the present invention, microorganisms can be controlled or prevented simply and efficiently.
  • the antimicrobial agent contains 7,8-dihydro wine as an active ingredient.
  • Bacteria, (2) Enzymes, and (3) Genus Alternaria, Cladosporium, Fusarium Microorganisms such as molds belonging to the genera (Fusarium) and Eurotium can be effectively controlled or prevented.
  • Plants rich in 7,8-dihydro-powered wines include plants belonging to the species Pipper methysticum.
  • the plant belonging to the species Kapi is Newgear It grows in the Polynesian Islands, etc., and includes wild species (Piper wichmannii) in addition to mosquito species (Piper methysticum).
  • Plants belonging to the mosquito species (Piper methysticum) are large herbs with a height of 2 to 3 m. In the Polynesian Islands, for example, their roots are crushed and squeezed, and dried roots are crushed and extracted with water. There is a custom of drinking soup as a luxury item.
  • Kaji (Piper methysticum) is sometimes called Likva, Likwaka ⁇ , Likvakava, Yangona, Shakao, etc., depending on the region.
  • the 7,8-dihydro wine is present both above and below the plant of the species belonging to the genus Piper methysticum.
  • the above-ground parts include stems (stems, branches, rinds, stems, etc.), leaves (leaves, petiole, etc.), flowers (flowers, bracts, stalks, florals, etc.), seeds (fruits, etc.) , Seeds, temporary seed coat, pericarp, etc.), and the underground part includes a root part (root, root bark, etc.) and a rhizome part (rhizome or rhizome, etc.). These sites can be used alone or in combination of two or more. Of these parts, 7,8-dihydro wines are more abundant in above-ground parts (for example, stems).
  • 7,8-dihydro wines have low solubility in water, and therefore cannot be efficiently extracted with water.
  • 7,8-dihydro power wines are often obtained by extracting with plants belonging to the species of mosquitoes (Piper methysticum) or by treating them with organic solvents.
  • Examples of the processed product include shreds, dried products, pulverized products, extracts, exudates, and the like.
  • the treated product can be obtained by subjecting the plant body to processing such as shredding, drying, pulverizing, extracting, and exuding (including the extraction of exudate from the plant). Drying, shredding, grinding, extracting, and exuding) can be used alone or in combination of two or more.
  • the exudate also includes substances separated and exuded in the cutting, drying, pulverizing processes, etc., using only exudates of plant vitality.
  • Examples of the extraction solvent for the plant or its processed product include alcohols (eg, methanol, ethanol, n -propanol, i-propanol, n-butanol, i-butanol, sec-butanol, t-butanol, monohydric alcohols such as n-octanol, 2-butyloctanol, lauryl alcohol, cyclohexanol; dihydric or polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, etc.); ethers [for example, Chain ethers (eg, ethyl ether, propyl ether, isopropyl ether , Dimethoxyethane, etc.), cyclic ethers (eg, dioxane, tetrahydrofuran, etc.), mono- or dialkylene glycol monoalkyl ethers (eg, cellosolves such as ethylene glycol, etc
  • the 7,8-dihydro-powered wine may be obtained by defatting a plant belonging to moss species (Piper methysticum) or a processed product thereof, and extracting the defatted product.
  • moss species Pier methysticum
  • impurities can be removed and high-purity 7,8-dihydro wines can be extracted.
  • the solvent used in the degreasing treatment include the aliphatic hydrocarbons and alicyclic hydrocarbons described above. These degreasing solvents can be used alone or in combination of two or more. Among these degreasing solvents, aliphatic hydrocarbons (for example, hexane) are preferred.
  • alcohols for example, monohydric alcohols having about 114 carbon atoms such as methanol, ethanol and i-propanol; dihydric alcohols such as ethylene glycol and propylene glycol
  • esters For example, ethyl acetate, butyl acetate, etc.
  • ketones eg, acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, etc.
  • methanol, ethanol, i-propanol, propylene glycol, Acetone and the like are preferred.
  • the amount of the solvent used in the degreasing treatment is 200-10000 parts by weight, preferably ⁇ 300-5000 parts by weight, and more preferably ⁇ 500-2000 parts by weight, based on 100 parts by weight of the plant to be extracted. It is about.
  • the extraction solvent may be used within a range that does not impair the extraction efficiency and the extraction operation. For example, 100 to 10,000 parts by weight, preferably 200 to 5000 parts by weight, per 100 parts by weight of the plant to be extracted. And more preferably about 300 to 2000 parts by weight.
  • the degreasing temperature and the extraction temperature are, for example, about 0 to 150 ° C, preferably about room temperature (for example, 15 to 25 ° C) to about 120 ° C.
  • the 7,8-dihydropower wine contained in the antimicrobial agent may be a pure product or a mixture.
  • a pure 7,8-dihydro wine can be synthesized by a method known in the literature (Acta Chemica Scandinavica B 30, 7: 613-678, 1976; Planta Med., 64: 504, 1998).
  • As the 7,8-dihydro wine it is preferable to use an extract from a plant rich in 7,8-dihydro wine.
  • the formulation of the antimicrobial agent used in the present invention is not particularly limited as long as it contains 7,8-dihydro wine, and examples of the formulation include a solution, a wettable powder, a water solvent, and a suspension.
  • Solidifying agents such as foaming agents, solidifying agents (compressed solidifying agents obtained by compressing powders and Z or granules, solidifying agents obtained by solidifying a fluid formulation with a cooling or coagulating agent, etc.) Is mentioned.
  • These formulation forms can be appropriately selected according to the purpose of use and the site of application. These preparations can be manufactured by a conventional method.
  • the liquid preparation and semisolid preparation can be produced, for example, by diluting the extract or exudate with a suitable liquid diluent or carrier.
  • a suitable liquid diluent or carrier In the case of a wettable powder, a solid diluent or a carrier may be further used.
  • liquefied gas fluorinated hydrocarbons, hydrocarbons, liquefied petroleum gas, dimethyl ether, etc.
  • compressed gas in the case of aerosols
  • liquefied gas fluorinated hydrocarbons, hydrocarbons, liquefied petroleum gas, dimethyl ether, etc.
  • compressed gas in the case of aerosols
  • liquefied gas fluorinated hydrocarbons, hydrocarbons, liquefied petroleum gas, dimethyl ether, etc.
  • compressed gas in the case of aerosols
  • liquefied gas fluorinated hydrocarbons, hydrocarbons, liquefied petroleum gas, dimethyl ether, etc.
  • compressed gas in the case of aerosols
  • liquid diluent or carrier examples include water, a plasticizer (for example, an ester plasticizer such as di-2-ethylhexyl adipate) and kerosene in addition to the above-mentioned extraction solvents.
  • a plasticizer for example, an ester plasticizer such as di-2-ethylhexyl adipate
  • kerosene in addition to the above-mentioned extraction solvents.
  • Petroleum-based solvents Aromatic coals such as ethyl naphthalene and phenyloxylethane Hydrogen hydride; phosphoric acid esters such as 2-ethylhexylphenyl phosphate may also be used.
  • solid diluent or carrier examples include diatomaceous earth, mica, clay, kaolin, talc, quartz powder, bentonite, and the like. These solid diluents or carriers can also be used alone or as a mixture of two or more.
  • the solid agent can be produced, for example, by diluting or granulating the extract or exudate with an appropriate solid diluent or carrier.
  • the solid diluent or carrier include, in addition to the solid diluents described above, talc such as talc powder and laurite powder, tares such as fine powder clay; mineral powders such as calcium carbonate; sulfur powder; urea powder Plant powders such as wood flour and starch; metal stones (such as fatty acid stones); and various carriers commonly used in residential preparations, agricultural chemicals or horticultural preparations. These solid diluents and carriers are often used as extenders. Solid diluents and carriers can be used alone or in combination of two or more.
  • liquid or semi-solid preparations are preferred in order to be efficiently applied to a site contaminated with microorganisms or a treated part, and particularly liquid preparations (for example, coating preparations, spray preparations, and aerosol preparations) are preferred. And the like).
  • the liquid to be ejected may be in the form of a mist or a foam, but is preferably in the form of a foam because of its high adhesion to a contaminated site.
  • the antimicrobial agent may be various additives depending on the type of the preparation, if necessary, for example, a stabilizer such as an antioxidant or an ultraviolet absorber; a binder; Emulsifiers, dispersants, spreading agents, wetting agents, penetrants; thickeners; flow aids; anti-caking agents; coagulants; ultraviolet scattering agents; Well.
  • a stabilizer such as an antioxidant or an ultraviolet absorber
  • antioxidants examples include 4,4′-thiobis 6-t-butyl-3-methylphenol and butylated hydroxysol (a mixture of 2 t-butyl-4-methoxyphenol and 3 t-butyl-4-methoxyphenol) ), P-octylphenol, mono (or di- or tri-)-(0; -methylbenzyl) phenol, 2,6-di-tert-butyl-p-talesol (BHT), pentaerythrityltetrakis [3- (3,5 Phenolic antioxidants such as —di-tert-butyl-4-hydroxyphenyl)] propionate; N, N ′ —di-2-naphthyl-p-phenylene Amine antioxidants such as amines; hydroquinoline antioxidants such as 2,5-di (t-amyl) hydroquinoline; sulfur-based antioxidants such as dilaurylthiodipropionate; triphenylphosphites and the like
  • Examples of the ultraviolet absorbent include benzotriazole compounds such as 2- (2'-hydroxy-5'methylphenyl) benzotriazole and 2- (2'-hydroxy-4'notatoxyl) benzotriazole; Benzophenone-based compounds such as 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4n-otatooxybenzophenone; salicylic acid-based compounds such as salicylic acid phenol and p-t butylphenol salicylate; 2-ethyl Xyl 2-cyano-3,3-diphenyl acrylate, 2 ethoxy-2'-bisethyl oxalate, dimethyl succinate 1- (2-hydroxyethyl) 4-hydroxy-2,2,6,6-tetramethylbiperidine And condensates.
  • benzotriazole compounds such as 2- (2'-hydroxy-5'methylphenyl) benzotriazole and 2- (2'-hydroxy-4'notatoxyl) benzotriazole
  • Benzophenone-based compounds such as 2-hydroxy-4
  • binder examples include carboxymethylcellulose sodium salt, methylcellulose, ethylcellulose, hydroxymethylcellulose, dextrin, pregelatinized starch, polybutyl alcohol, polybutylpyrrolidone, sodium lignosulfonate, and potassium ligninsulfonate. And the like.
  • the resin having a film forming ability includes, for example, polyolefins such as polyethylene and polypropylene, polyacetate butyl, polybutyl alcohol, acrylic resin, polychlorinated butyl, styrene resin, fluorine resin, and chlorinated resin.
  • Thermoplastic resins such as polyolefin, alkyd resin, polyamide, polyester; thermosetting resins such as phenol resin, urea resin, melamine resin, furan resin, unsaturated polyester resin, epoxy resin, etc. Can be exemplified.
  • emulsifier dispersant, spreading agent, wetting agent, and penetrating agent
  • conventional surfactants such as an ionic surfactant and a nonionic surfactant
  • a-on type surfactant include metal stones, sulfates such as alkyl sodium sulfate, alkylbenzene sulfonates such as sodium alkylbenzene sulfonate, sodium alkylnaphthalene sulfonate [for example, Takemoto Oil and Fat ( Alkylnaphthalenesulfonates such as trade name-Eucalgen BX-C], and dialkyl sodium 2-sulfosuccinate [eg, Neocol SW-C trade name, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.] Dialkyl sulfosuccinate, polycarboxylic acid type surfactant [for example, Toxa (trade name, manufactured by Sanyo Iridari Co., Ltd
  • Noon-based surfactants include, for example, polyoxyethylene alkyl ether, polyoxyethylene alkyl aryl ether [for example, manufactured by Daiichi Kogyo Seiyaku Co., Ltd., trade name: Inogen-J. ], Polyoxyethylene aryl ether, fatty acid polyhydric alcohol ester, fatty acid polyhydric alcohol polyoxyethylene, sucrose fatty acid ester, block copolymer of ethylene oxide and ethylene oxide propylene [for example, Sanyo-Daisei Co., Ltd., brand name New Pole ⁇ -64].
  • Examples of the thickener include polybutyl alcohol, xanthan gum, polyacrylic acid and salts thereof, and the like.
  • Examples of the flow aid include organic lubricants (eg, auxiliaries (eg, isopropyl phosphoric acid)), vitamins, petrolatum, polyethylene, fatty acid metal salts, paraffin, and silicone oil, and inorganic lubricants such as talc.
  • examples of the anti-caking agent include white carbon, diatomaceous earth, magnesium stearate, aluminum oxide, titanium dioxide and the like.
  • flocculant examples include liquid paraffin, ethylene glycol, jeti-lendlycol, triethylene glycol, and isobutylene polymer [for example, manufactured by Idemitsu Petrochemical Co., Ltd., trade name: IP Solvent-2835].
  • examples of the ultraviolet scattering agent include titanium dioxide.
  • examples of the water removing agent include desiccants such as anhydrous gypsum and silica gel powder. Colorants include, for example, organic or inorganic pigments and dyes.
  • the antimicrobial agent of the present invention may contain a compound having a known or commonly used antimicrobial action (antibacterial, antiseptic, or antifungal action) and the like.
  • Examples of the compound having an antimicrobial activity include, for example, 3 Promo 2,3 Jordo 2 propyl-rutyl carbonate, 3-Prodo 2 propyl butyl carbamate, 2,3,3-Toriodo arinorea Organic compounds such as norecone and parachlorophenylenole 3- 3-propanoreginolehonolemar; benzimidazole and benzothiazole such as 2- (4 thiazolyl) benzimidazole and 2-thiocyanomethylthiobenzozothiazole Compound; 1— (2— (2 ′, 4′—dichloromouth phenol) —1,3-dioxolan-2-ylmethyl) —1 Hl, 2, 4-triazole, 1-(2-(2 ', 4'-dichloromethyl)-4---propyl-1, 3-dioxolane-2-ylmethyl) 1H-1, 2, 4 triazole, ⁇ — (2 -— (4-chlorophen
  • R 1 and R 2 are the same or different and each represents a C alkyl group or a C
  • R 3 and R 4 are the same or different and represent a hydrogen atom, a hydroxyl group, an amino group, a C alkyl group or a C alkoxy group, and R 5 is a C alkylene group, a C alkyl group;
  • 1-6 1-6 2-18 3-18 represents a rene group, a phenylene group or a xylylene group, wherein R 1 — R 5 is a C alkyl group,
  • 1-6 1-6 Can be substituted with an alkoxy group, c alkoxy carboxy group or halogen
  • halogen examples include chlorine, fluorine, bromine, and iodine.
  • ⁇ — examples include a halogen ion (eg, Cl Br— and ⁇ ) and a nitrate ion (NO— ), And, for example, acetate ion (CH 2 COO—), propionate ion (
  • Organic acid ions such as CH 2 COO—). Of these ars, inorganic On is preferred.
  • Such a bisquaternary ammonium salt conjugate can be produced by a known method according to the specific compounds shown below, and specific examples thereof include, for example, N, N'-hexamethylenebis (4 rubumoylu 1-decylpyridi-pembromide) (dimer 38, made of pine rice), N, N-hexamethylenebis (4-lbumbamoyl-1-decylpyridi-pumacetate) (dimer 38A, made of ynui), 4, 4 '(tetramethylene dicarbyl diamino) bis (1 decyl pyridi-dimethyl bromide) (Dimer 136, made by Iny), 4, 4, 1 (tetramethylenedicarbyl diamino di) bis (1 decyl pyridi-dimethyl acetate) (dimer) 136A, manufactured by Inui Corporation), 1,4-tetramethylene bis (4 rubamoyl 1-hexadecy
  • These compounds having antimicrobial activity can be used alone or in combination of two or more.
  • compounds of the formula (I) are preferred. Particularly, when the compound of the formula (I) is combined with other compounds, excellent antimicrobial activity (antibacterial, antiseptic, or antibacterial) is obtained. (Mold effect).
  • the content of the 7,8-dihydro wine can be appropriately selected according to the dosage form and application method of the antimicrobial agent, and is not particularly limited.
  • the concentration of 7,8-dihydro-powered wine may be 0.01 to 80% by weight, preferably 0.05 to 50% by weight, more preferably 0.1 to 30% by weight in the antimicrobial agent. %.
  • 8-dihydro-force wine concentration for example 0.5 01- 50 wt%, rather preferably is 0. 05 20 wt 0/0, more preferably about 0.1 1 10 weight 0/0.
  • the antimicrobial agent of the present invention can effectively control or prevent specific power plants other than bacteria and yeasts.
  • the bacteria include bacteria belonging to the genus Bacillus such as Bacillus subtilis (Bacillus subtilis), bacteria belonging to the genus Escherichia such as Escherichia coli (Escherichia coli), and the like.
  • Bacteria belonging to the genus Pseudomonas, such as Pseudomonas aeruginosa; green fe J, can be exemplified.
  • yeasts for example, yeasts belonging to the genus Saccharomyces such as Saccharomyces cerevisiae (pan yeast) and Rhodotorula belonging to the genus Rhodotorula rubra such as Rhodotorula rubra. Examples include yeasts.
  • the molds include, for example, molds belonging to the genus Alternaria (Alternaria sp.), Such as Alternaria sp., And Cladosporium “Cladosporioides”
  • the genus belonging to the genus can be exemplified.
  • These microorganisms may adversely affect the human body, etc., as microbes containing spores and the like that not only aesthetically contaminate the inside of a house, but as pathogenic bacteria or as a causative agent of allergic bronchitis or asthma. is there.
  • these microorganisms can grow or reproduce on various substances that can be replaced only by biological substances (eg, plant-derived substances such as cotton and hemp, and animal-derived substances such as wool and leather).
  • biological substances eg, plant-derived substances such as cotton and hemp, and animal-derived substances such as wool and leather.
  • examples of such a substance include resins and the like such as paints, adhesives, and plastic members; rubbers such as natural rubber and synthetic rubber; synthetic fibers and their cloths (such as woven and nonwoven fabrics); Metals such as aluminums and stainless steels; ceramics such as concretes, pottery, and glass; Microorganisms use nutrients that adhere to these substances (e.g., foods, excretions of humans and animals, etc.), which can be grown using these substances as nutrient sources. Can grow.
  • bacteria such as Pseudomonas and fungi such as Cladosporium and Fusarium are easily propagated on cotton and hemp.
  • Bacteria such as the genus Bacillus and molds such as the genus Alternaria and Fusarium tend to breed on wool.
  • Bacteria such as (Bacillus) and molds such as Eurotium easily proliferate! /,
  • resins such as paints, adhesives, and plastic members include Clados polymer.
  • Molds such as the genus (Cladosporium), the genus Anorenaria (Alternaria) and the genus Eurotium are easy to breed. Molds such as Alternaria spp. Synthetic fibers include the genus Cladosporium, Alternaria
  • Aluminum includes bacteria such as Pseudomonas and Cladosporium.
  • Molds such as (Cladosporium) are easy to breed. Yeasts such as Rhodotorula and molds such as Cladosporium and Alternaria spawn easily on concrete. Molds such as the genus Eurotium are easy to breed in glasses!
  • Bacillus spp Bacteria such as the genus (Escherichia) and the genus Pseudomonas; Saccharomyces
  • Yeasts such as Saccharomyces and Rhodotorula
  • molds such as Alternaria, Cladosporium, Fusarium, and Eurotium are easily propagated. ! /.
  • microorganisms that grow or propagate on the above-described various substances can be appropriately controlled or prevented, so that the microorganisms originate from the growth or propagation of microorganisms that can effectively prevent contamination by microorganisms in a house.
  • Various diseases can be effectively prevented.
  • the antimicrobial agent can be effectively controlled or prevented by applying the antimicrobial agent to an object to be treated (or a treated part) in which the microorganism can grow or proliferate.
  • the antimicrobial agent of the present invention can be usefully applied to both home use and industrial use.
  • the substance to be treated (or the part to be treated) is not particularly limited as long as it is a place where a microorganism can grow or proliferate (or a place where a microorganism can proliferate). Or breeding section). Further, the antimicrobial agent may be applied to skin (for example, skin of limbs).
  • the portion to be processed may be in a dry state or a wet state depending on the type of microorganism.
  • the part to be treated may be (i) an article, part or member existing in a non-humid environment (or a dry environment), an article, part or member exposed to a GO wet environment, or (m) water content.
  • An article, a part, or a member that can be brought into contact with the object is exemplified.
  • the humid environment refers to, for example, a high humidity of 70 to 100% RH, preferably 80 to 100% RH, more preferably 90 to 100% RH, and particularly preferably about 95 to 100% RH. Environment is acceptable.
  • the frequency (or degree) of exposure of the treated part to a humid environment or the frequency (or degree) of contact with moisture may be intermittent or irregular, which need not be constant or regular.
  • contact with moisture includes dew condensation or contact with water droplets rather than just contact with the use of water.
  • articles, parts or members existing in a non-wet environment include foods, papers (books and the like), cloths [curtains, covers ( Sofa cover, table cloth, etc.), width or towels, etc.), rugs (carpets, mats, etc.), clothing, shoes, bedding, interior materials [wallpaper (including fat products), flooring , Panels, tatami mats, knockers, filters, etc.), exterior materials [earth and timber, building materials (wall materials, floor materials, ceiling materials, joints, tiles, windows, sashes, ventilation fans, exteriors, etc.), piping, etc.], Furniture (closets, shelves, tapes, chairs, waste bins, etc.), various types of equipment [electronics, electric appliances, precision equipment (cameras, telescopes, binoculars, etc.), etc.], various types of vehicles (vehicles) Aircraft, ships, rockets, etc.) or their components, crafts, soil, plants, etc. That.
  • water surrounding members for example, faucets, sinks) (Or sink), bath tub, toilet bowl, wash basin, drain hole, etc.
  • various water supplies eg, bathroom supplies (eg, basin, bath lid, shower curtain, bath rack, soap dish, soap bottle) , Shampoo or conditioner dispenser, scrubber, bath toy, drain hole packing, trash filter, etc .; kitchenware (triangular corner, sponge, drain bat, cutting board, chopsticks, towels, wash tub, drain hole packing, trash Tableware (ceramics, glass, etc.); Toiletries (toothbrush, cup, cup stand, soap dish, soap bottle, etc.); Supplies (paper holders, toiletries (mats, slippers, toilet seat covers, etc.), auxiliary toilet seats, potties, step tables, toilet brushes, brush cases, satellite cases, soap dishes, soap bottles, etc.) it can.
  • the site or member that can come into contact with moisture is not particularly limited as long as it can come into contact with moisture, and includes, for example, various household or industrial equipment.
  • an air conditioner or an air conditioning system Filter, etc.
  • electric toothbrush brush section, brush replacement section, etc.
  • refrigerator refrigerator room, vegetable room, freezer room, etc.
  • inner lid of washing machine especially fully automatic washing machine or around it
  • a humidifier a tank portion or the like
  • the method of applying the antimicrobial agent is not particularly limited as long as it can be applied to the object to be treated (or the part to be treated), and various embodiments can be mentioned.
  • the antimicrobial agent is It may be applied to the treatment section) by a method such as dipping, coating, spraying, spraying, pouring, or mixing.
  • the antimicrobial agent is prepared by holding a sheet-like base material such as a synthetic resin sheet, a water-soluble film, paper, and cloth by application, impregnation, kneading, or the like to prepare a sheet material, and the sheet material is treated with the object to be treated. (Or a part to be processed) or the like may be applied or attached.
  • the antimicrobial agent in order to efficiently apply the composition to an object to be treated (or an object to be treated), it is preferable that the antimicrobial agent is dipped, coated, sprayed, or the like.
  • the antimicrobial agent may be applied by directly or appropriately diluting and immersing the liquid agent, or by applying a liquid agent or a semi-solid agent to be applied.
  • the application amount of 7,8-dihydro power wine to the processed material (or processed portion) is, for example, 30 to 30000 ⁇ g / m, preferably 30 to 30000 ⁇ g / m, as the concentration in the processed material (or processed portion). It may be 50-15000 g / ml, more preferably about 80-10000 g Zml.
  • the antimicrobial agent of the present invention is highly safe for humans and animals and has no detrimental effect on the environment, but has high controllability. It can be used as an antimicrobial agent for natural products, chemical products, ceramic products, metal products, foods, cosmetics, bioactive products, and the components and components of these products. Also, in various highly airtight buildings (for example, houses such as apartment houses, stores, factories, warehouses, hospitals, etc.) and various transportation bodies (for example, vehicles, ships, aircraft, etc.), disinfectants and disinfectants are used. It is suitable as such.
  • Rh Rhodotorula rubra
  • A1 Alternaria sp.
  • a glucose agar medium supplemented with a predetermined amount of 7,8-dihydro wine is inoculated with the above test bacteria other than Eurotium tonophilum, and bacteria are incubated at 33 ° C for 18 hours. , Molds and yeasts were cultured at 28 ° C. for 3 days.
  • Eurotium tonophilum is an agar medium prepared by dissolving potato dextrose (3.9 g), NaCl (5 g), and gnorecose (10 g) in 100 ml of water. The cells were cultured at 28 ° C. for 3 hours. The minimum inhibitory concentration [MIC ( ⁇ g / ml)] was determined by a multiple dilution method of a predetermined amount. The results are shown in Table 1.
  • a solution was prepared by dissolving 3 parts by weight of 7,8-dihydro power wine in 97 parts by weight of ethanol.
  • 7,8-dihydro power wine 2 parts by weight, Vaseline 5 parts by weight, NAROACTY N100 (manufactured by Sanyo Chemical Industries, Ltd.) 5 parts by weight, propylene glycol 10 parts by weight, ethanol 11 parts by weight
  • An emulsion was prepared by mixing 20 parts by weight of a viscosity agent (1% aqueous solution of carboxyvinyl polymer) and 37 parts by weight of water.
  • Osmolin DA-50 (cationic surfactant type antibacterial agent, manufactured by Sanyo Chemical Industries, Ltd.) 15 parts by weight, 7,8-dihydro wine 1 part by weight, propylene glycol 10 parts by weight, ethanol 50 parts by weight , Water and 24 parts by weight of water to prepare a sprayable solution.
  • test specimens were placed on a cruciform plate with a 5 mm gap (joint) and solidified with a caulking agent to prepare test specimens. Similarly, a total of three specimens were prepared. Under high humidity (relative humidity of 95% or more), these specimens were subjected to Alternaria sp. (Alternaria sp.), Kufudoshoriumu (Claaosporium cladosponoides) and Fusarium (Fusarium sp.). The first test specimen, on which the mold had propagated, was washed with a brush and then coated with Formulation Example 1. As a control, the second specimen was used as a control.
  • test specimens were prepared, fungi were propagated, and the test specimens on which the mold had propagated were washed with water.
  • the same operation as in the first test specimen was performed except that the liquid preparation of Preparation Example 4 was sprayed on the obtained test specimen (the fourth test specimen) instead of the liquid preparation of Preparation Example 1. After a week, the development of mold was unrecognizable.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un agent antimicrobien comprenant de la 7,8-dihydrokawaïne en tant qu'ingrédient actif, agent antimicrobien capable d'éliminer ou d'empêcher le développement de bactéries telles que celles du genre Bacillus, escherichia et Pseudomonas, des levures telles que celles du genre saccharomyces et rhodotorula, des moisissures du genre alternaria, cladosporium, fusarium et eurotium. Ladite 7,8-dihydrokawaïne peut être obtenue à partir d'un extrait de solvant organique d'une plante appartenant à l'espèce piper methysticum ou une matière résultant du traitement de celle-ci. Cet agent antimicrobien possède une capacité d'élimination élevée, est très sûr pour l'homme et le bétail et n'a pas d'effet dangereux sur l'environnement.
PCT/JP2004/019064 2003-12-26 2004-12-21 Agent antimicrobien Ceased WO2005063019A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003434970 2003-12-26
JP2003-434970 2003-12-26

Publications (1)

Publication Number Publication Date
WO2005063019A1 true WO2005063019A1 (fr) 2005-07-14

Family

ID=34736580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/019064 Ceased WO2005063019A1 (fr) 2003-12-26 2004-12-21 Agent antimicrobien

Country Status (1)

Country Link
WO (1) WO2005063019A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3306054B1 (ja) * 2001-04-11 2002-07-24 武田薬品工業株式会社 木材保存剤
JP2003267802A (ja) * 2002-03-18 2003-09-25 Takeda Chem Ind Ltd 木材保存剤
WO2003088745A2 (fr) * 2002-04-16 2003-10-30 James Richard Von Krosigk Composiiton et procede de lutte contre des champignons produisant des spores et contre des bacteries

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3306054B1 (ja) * 2001-04-11 2002-07-24 武田薬品工業株式会社 木材保存剤
JP2003267802A (ja) * 2002-03-18 2003-09-25 Takeda Chem Ind Ltd 木材保存剤
WO2003088745A2 (fr) * 2002-04-16 2003-10-30 James Richard Von Krosigk Composiiton et procede de lutte contre des champignons produisant des spores et contre des bacteries

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VON HAENSEL R. ET AL: "FUNGISTATISCHE WIRKUNG DER KAWADROGE UND IHRER INHALTSSTOFFE", PLANTA MEDICA, vol. 14, no. 1, 1966, pages 1 - 9, XP009048508 *

Similar Documents

Publication Publication Date Title
RU2434382C2 (ru) Комбинации имазалила и соединений серебра
EP1347684B1 (fr) Composition antimicrobienne
JP5870101B2 (ja) ピリオン化合物とポリエチレンイミンとの抗微生物性組み合わせ
JP5385285B2 (ja) ピリメタニルと銀化合物の組み合わせ
US20020137631A1 (en) Anti-microbial composition
JP2004137241A (ja) 抗菌・防黴・防藻性組成物
JP2004339102A (ja) 抗菌・防黴・防藻性組成物
EP3313185B1 (fr) Compositions antimicrobiennes comprenant des antimicrobiens approuves pour l'alimentaire et zinc pyrithione
JP2011520825A (ja) ポリオールにより誘導された抗菌剤及び組成物
EP2470171B1 (fr) Dérivés d'acide amino-salicylique antimicrobien
WO2005063019A1 (fr) Agent antimicrobien
JP2004346124A (ja) 構造物の洗浄・保護方法および構造物用洗浄液剤・保護液剤キット
JP4968870B2 (ja) 工業用抗菌組成物及び抗菌方法
JP4543237B2 (ja) チオシアネート系抗菌防カビ剤
CN105400143B (zh) 一种木制品缝隙的修补组合物
JP4807717B2 (ja) 工業用抗菌組成物及び抗菌方法
JP4338022B2 (ja) （イソ）チオシアネート系抗菌防カビ剤
JP2001170908A (ja) 木材保存剤
JP2003160410A (ja) 工業用防腐防かび剤
JP4766641B2 (ja) 工業用抗菌組成物及び抗菌方法
WO2023224051A1 (fr) Agent antibactérien ou antiviral
WO2017162877A1 (fr) Compositions et procédés de traitement et de prévention d'une infestation par des acariens
KR20250016182A (ko) 개선된 살생물제
JP2004196739A (ja) 抗菌剤組成物
JP2002187803A (ja) 防カビ剤

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP