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WO2005054849A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor mc5 (mc5r) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor mc5 (mc5r) Download PDF

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Publication number
WO2005054849A3
WO2005054849A3 PCT/EP2004/013277 EP2004013277W WO2005054849A3 WO 2005054849 A3 WO2005054849 A3 WO 2005054849A3 EP 2004013277 W EP2004013277 W EP 2004013277W WO 2005054849 A3 WO2005054849 A3 WO 2005054849A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
diseases
mc5r
therapeutics
diagnostics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/013277
Other languages
French (fr)
Other versions
WO2005054849A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of WO2005054849A2 publication Critical patent/WO2005054849A2/en
Publication of WO2005054849A3 publication Critical patent/WO2005054849A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human MC5 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders,. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders,. The invention also features compounds which bind to and/or activate or inhibit the activity of MC5 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/013277 2003-12-06 2004-11-23 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor mc5 (mc5r) Ceased WO2005054849A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03028032 2003-12-06
EP03028032.5 2003-12-06

Publications (2)

Publication Number Publication Date
WO2005054849A2 WO2005054849A2 (en) 2005-06-16
WO2005054849A3 true WO2005054849A3 (en) 2005-08-11

Family

ID=34639278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/013277 Ceased WO2005054849A2 (en) 2003-12-06 2004-11-23 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor mc5 (mc5r)

Country Status (1)

Country Link
WO (1) WO2005054849A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000028002A1 (en) * 1998-11-09 2000-05-18 Merck & Co., Inc. Dna molecules encoding the melanocortin 5 receptor protein from rhesus monkey
WO2003040117A1 (en) * 2001-11-08 2003-05-15 Ortho-Mcneil Pharmaceutical Corporation Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators
US20030110518A1 (en) * 2001-09-28 2003-06-12 Houseknecht Karen L. Melanocortin-5 receptor sequences and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000028002A1 (en) * 1998-11-09 2000-05-18 Merck & Co., Inc. Dna molecules encoding the melanocortin 5 receptor protein from rhesus monkey
US20030110518A1 (en) * 2001-09-28 2003-06-12 Houseknecht Karen L. Melanocortin-5 receptor sequences and uses thereof
WO2003040117A1 (en) * 2001-11-08 2003-05-15 Ortho-Mcneil Pharmaceutical Corporation Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN ET AL: "Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 91, no. 6, 12 December 1997 (1997-12-12), pages 789 - 798, XP002083691, ISSN: 0092-8674 *
GRIECO P ET AL: "Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5.", JOURNAL OF PEPTIDE RESEARCH, vol. 62, no. 5, November 2003 (2003-11-01), pages 199 - 206, XP002317829, ISSN: 1397-002X *
VAN DER KRAAN MANOU ET AL: "Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands", ENDOCRINOLOGY, vol. 13, no. 5, May 1998 (1998-05-01), pages 2348 - 2355, XP002317830, ISSN: 0013-7227 *

Also Published As

Publication number Publication date
WO2005054849A2 (en) 2005-06-16

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