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WO2004082572A3 - Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 87 (gpr87) - Google Patents

Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 87 (gpr87) Download PDF

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Publication number
WO2004082572A3
WO2004082572A3 PCT/EP2004/002273 EP2004002273W WO2004082572A3 WO 2004082572 A3 WO2004082572 A3 WO 2004082572A3 EP 2004002273 W EP2004002273 W EP 2004002273W WO 2004082572 A3 WO2004082572 A3 WO 2004082572A3
Authority
WO
WIPO (PCT)
Prior art keywords
disorders
gpr87
diseases
therapeutics
diagnostics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/002273
Other languages
French (fr)
Other versions
WO2004082572A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of WO2004082572A2 publication Critical patent/WO2004082572A2/en
Publication of WO2004082572A3 publication Critical patent/WO2004082572A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human GPR87 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR87 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/002273 2003-03-18 2004-03-05 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 87 (gpr87) Ceased WO2004082572A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03006105 2003-03-18
EP03006105.5 2003-03-18

Publications (2)

Publication Number Publication Date
WO2004082572A2 WO2004082572A2 (en) 2004-09-30
WO2004082572A3 true WO2004082572A3 (en) 2005-01-06

Family

ID=33016835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002273 Ceased WO2004082572A2 (en) 2003-03-18 2004-03-05 Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 87 (gpr87)

Country Status (1)

Country Link
WO (1) WO2004082572A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1900377A1 (en) * 2006-09-12 2008-03-19 Boehringer Ingelheim International GmbH Inhibitors of GPR87 for cancer therapy
WO2010095461A1 (en) 2009-02-20 2010-08-26 国立大学法人東京大学 Novel monoclonal antibody, and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001044474A1 (en) * 1999-12-16 2001-06-21 Millennium Pharmaceuticals, Inc. 2871 receptor, a g-protein coupled receptor and methods of use thereof
WO2002092624A2 (en) * 2001-05-16 2002-11-21 Paradigm Therapeutics Limited G-protein coupled receptor
US20030017539A1 (en) * 1998-06-02 2003-01-23 Millennium Pharmaceuticals, Inc. Novel nucleic acid sequences encoding G-protein coupled receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017539A1 (en) * 1998-06-02 2003-01-23 Millennium Pharmaceuticals, Inc. Novel nucleic acid sequences encoding G-protein coupled receptors
WO2001044474A1 (en) * 1999-12-16 2001-06-21 Millennium Pharmaceuticals, Inc. 2871 receptor, a g-protein coupled receptor and methods of use thereof
WO2002092624A2 (en) * 2001-05-16 2002-11-21 Paradigm Therapeutics Limited G-protein coupled receptor

Also Published As

Publication number Publication date
WO2004082572A2 (en) 2004-09-30

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