[go: up one dir, main page]

WO2005044210A1 - Promoteur de recalcification, composition orale, aliment et boisson - Google Patents

Promoteur de recalcification, composition orale, aliment et boisson Download PDF

Info

Publication number
WO2005044210A1
WO2005044210A1 PCT/JP2004/013622 JP2004013622W WO2005044210A1 WO 2005044210 A1 WO2005044210 A1 WO 2005044210A1 JP 2004013622 W JP2004013622 W JP 2004013622W WO 2005044210 A1 WO2005044210 A1 WO 2005044210A1
Authority
WO
WIPO (PCT)
Prior art keywords
remineralization
calcium
concholine
food
oral composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/013622
Other languages
English (en)
Japanese (ja)
Inventor
Shuji Sakuma
Kiminori Atsumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sangi Co Ltd
Original Assignee
Sangi Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangi Co Ltd filed Critical Sangi Co Ltd
Priority to JP2005515237A priority Critical patent/JP4324591B2/ja
Publication of WO2005044210A1 publication Critical patent/WO2005044210A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a tooth mineral enamel remineralization accelerator, an oral composition, a food and a beverage produced by adding the remineralization accelerator.
  • Dental decay begins when the dental caries bacteria adhere to the tooth surface and form dental plaque, and the acid produced by the dental caries metabolizing food in the dental plaque demineralizes tooth enamel. As a result, an initial corrosion state occurs. Saliva remineralizes this demineralized part by the action of calcium and phosphorus in saliva, and has the function of returning the teeth to their original state.
  • dentifrices containing hydroxyapatite which is a type of fluoride or calcium phosphate and has a crystal structure similar to the inorganic components of teeth, have been manufactured.
  • remineralization of the demineralized portion is not sufficient only with the use of saliva, fluoride, or hydroxyapatite dentifrice.
  • xylitol and calcium phosphate in order to promote remineralization, xylitol and calcium phosphate, non-crystalline calcium phosphate, chewing gum containing calcium phosphated oligosaccharide, etc. are manufactured.
  • chewing gum containing calcium phosphate remineralization of the demineralized part is not always sufficient.
  • concholine is composed of 17 kinds of amino acids such as glycine, alanine, serine, leucine, aspartic acid, valine, proline, isoleucine, tyrosine, arginine, glutamic acid, threonine, lysine, phenylalanine, methionine, histidine and cystine.
  • Conkyorin is a protein contained in shells such as pearl oysters, white clams and black oyster clams, and pearls. About 90% of these pearls are calcium carbonate called aragonite, 5% of concholine, and 5% of others. It consists of the composition. The pearl is calcium carbonate The crystal and concholine are made to be stacked in multiple layers, and the luster and beautiful color tone peculiar to pearls are produced by the light interference effect.
  • Concholine powder can be obtained by removing acid by adding acid to a finely divided shell or pearl of shells such as pearl oysters, white-necked pearl clams, and black oyster clams, and then removing concholine.
  • a hydrolyzed product of the concholine protein obtained by further hydrolyzing this concholine is hydrolyzed concholine.
  • the above concholine powder and Z or hydrolyzed concholine are dissolved or dispersed in a suitable liquid, or mixed with or adsorbed on a suitable powder carrier, and optionally an emulsifier,
  • a dispersing agent, a suspending agent, a spreading agent, a penetrating agent, a wetting agent, a stabilizing agent, and the like can be added, and the composition can be formulated into an emulsion, a wettable powder, a powder, or a tablet and used.
  • concholine as a food can be expected to have an effect on skin gloss and astringency, an antioxidant effect, an inhibitory effect on generation of active oxygen, and a histamine inhibitory effect. Is disclosed in JP-A-8-173091. In addition, it has been found that the incorporation of a concholine hydrolyzate into a food has an effect of improving liver function, and the “food” is disclosed in JP-A-2003-24008.
  • Patent Document 1 JP-A-8-173091
  • Patent Document 2 Japanese Patent Application Laid-Open No. 2003-24008
  • the present invention provides an oral composition having an excellent remineralizing effect capable of effectively promoting remineralization of demineralized enamel and thereby actively inhibiting dental erosion. It is intended to provide food and beverages.
  • remineralization of teeth is promoted by using concholine powder and / or hydrolyzed concholine, and by using these together with a calcium compound, remineralization of teeth is further reduced.
  • the inventors have found that it is accelerated, and have accomplished the present invention.
  • the oral composition, food and beverage of the present invention contain the above-mentioned tooth enamel remineralization accelerator. It is manufactured by adding soy sauce. It has been found that the use of concholine powder and / or hydrolyzed concholine promotes remineralization of teeth, and that the use of these together with calcium compounds further promotes remineralization of teeth. The present inventors have found that the remineralization of teeth is further promoted by using hydroxyapatite in combination with lymphoda, Z or hydrolyzed conchioline, and accomplished the present invention.
  • the above-mentioned concholine powder and / or hydrolyzed concholine have excellent affinity for skin and hair as cosmetics, and as a powerful moisturizing component and moisturizing component, and have a gentle and refreshing feel to the skin.
  • foods have been known to have effects on skin gloss and astringency, antioxidation effects, active oxygen generation inhibition effects, histamine suppression effects, liver function improvement effects, etc. It has been found that those containing lymphoid powder and / or hydrolyzed conchiolin ⁇ , concholine powder and / or hydrolyzed conchioline and a calcium compound as active ingredients have the effect of promoting remineralization of tooth enamel. It has been found that oral compositions, foods and beverages to which a calcification accelerator has been added have an effect of promoting remineralization of tooth enamel.
  • Calcium compounds used in oral compositions, foods and drinks are obtained by crushing natural hard tissues such as bones and eggshells of fish, amphibians, reptiles, birds or animals belonging to mammals inhabiting seawater or freshwater. Powder, calcium chloride, calcium carbonate, calcium lactate, calcium dalconate, hydroxyapatite, tricalcium phosphate, citric acid phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, calcium oxide, etc. . Particularly, hydroxyapatite, which is a kind of calcium phosphate, is preferable.
  • Hydroxyapatite crystals constituting the enamel on the tooth surface are composed of calcium phosphate and are considered to be effective as a supply source of calcium and phosphoric acid.
  • calcium compounds that are abundantly contained in the natural hard tissue as described above are used in the present invention in addition to those synthesized by ordinary methods.
  • Fish bones, pork bones, cow bones and the like of edible fish such as.
  • Examples of the oral composition of the present invention include dentifrices such as toothpaste, powdered toothpaste, and liquid toothpaste, rinsing lj, lozenges, troches, and chewing gums. , Sweets such as tablet confections, gummy jelly, chocolate, biscuits, snacks, etc., ice creams, sorbets, frozen desserts such as frozen desserts, beverages, breads, hot cakes, dairy products, hams, sausages, etc. Fish meat products, side dishes, pudding, soups, jams, etc.
  • dentifrices such as toothpaste, powdered toothpaste, and liquid toothpaste, rinsing lj, lozenges, troches, and chewing gums.
  • Sweets such as tablet confections, gummy jelly, chocolate, biscuits, snacks, etc., ice creams, sorbets, frozen desserts such as frozen desserts, beverages, breads, hot cakes, dairy products, hams, sausages, etc.
  • Fish meat products side dishes, pudding, soups, jams
  • the added amount of concholine powder and / or hydrolyzed concholine to the oral composition, food, or beverage, the amount of calcium compound added, and the amount of added calcium compound and hydroxyapatite can be determined depending on the form of the composition.
  • the amount of concholine powder and / or hydrolyzed concholine is preferably 0.00001% by weight or more, and the amount of calcium compound or hydroxyapatite is preferably 0.001 to 50.0% by weight. More preferably, the addition amount of concholine powder and / or hydrolyzed concholine is 0.0001 to 80.0% by weight, and the addition amount of a calcium compound or hydroxyapatite is 0.01 to 30.0% by weight.
  • a method of adding a conoline powder and / or a hydrolyzed concholine, and further a calcium compound to the composition as necessary a method of manufacturing the product may be used. Alternatively, the remaining raw materials may be mixed.
  • concholine powder, hydrolyzed concholine, and a calcium compound are added, they may be mixed in advance and added to the mixture.
  • concholine powder, hydrolyzed concholine, and potassium compound may be added separately.
  • the oral composition, food, and beverage of the present invention include, in addition to the components described above, an oral composition, a food It can contain additives, wetting agents, foaming agents, flavors, sweeteners, preservatives, various active ingredients, and the like, which are commonly used in products and beverages. Specific examples of these components are shown below.
  • Abrasives calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate and the like.
  • Moisture 'j glycerin, propylene glycol, polyethylene glycol and the like.
  • Blowing agents sodium lauryl sulfate, N-lauroyl sarcosine sodium, nonionic surfactants, etc.
  • Thickeners hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, carboxybutyl polymer, chitan sun gum and the like.
  • Preservatives paraoxybenzoate, alkyldiaminoethyldaricin hydrochloride, methylparaben, ethylparaben, sodium benzoate and the like.
  • Flavors menthol, spearmint oil, lemon oil, you-cutting oil, etc.
  • Sweetener saccharin sodium, stevia extract, aspartame and the like.
  • the remineralization accelerator of the present invention contains concholine powder, hydrolyzed concholine, calcium compound, and hydroxyapatite as active ingredients, and is manufactured by adding the remineralization accelerator described above. All of the oral compositions, foods and beverages of the present invention are advantageous for effectively promoting remineralization of demineralized tooth enamel and actively inhibiting dental erosion.
  • the “control surface” in the figure is a part for comparing the degree of the remineralization effect of the “oral composition, food, beverage” in Examples and Comparative Examples. It is a state that maintains the state of "carious”. Artificial caries (3.5 x 3. Omm window) area Of which, it is a half part.
  • FIG. 1 is a photograph showing a control surface and a treated surface of a crown by a contact microradiogram (CMR).
  • CMR contact microradiogram
  • FIG. 2 is a drawing in which the photograph shown in FIG. 1 is drawn using dark ink and the explanation of the state of each part is applied Q.
  • processing surface in the figure refers to a portion where the specimens of Examples and Comparative Examples acted as follows.
  • test substances for dentifrices and drinks, use a suspension solution of artificial saliva as a test solution, and for troches, chewing gum, candy, jelly, etc., pulverize finely and dissolve in water from each test substance.
  • a test solution was obtained by extracting a sex component and forming a suspension with artificial saliva.
  • An artificial initial caries test sample was prepared by removing the dirt and deposits on the enamel surface using the crown of a human extracted tooth that had not been subjected to dental preservation and prosthesis treatment. Create a 3.5 x 3. Omm window with Nail Enamel for the test target site, and place it in 0.1 M lactate buffer (pH 4.5, 3. Omm CaCl, 1.8 mm KHPO, 0.5% CMC). . C, soak for 7 days
  • the test substance was prepared by adjusting a dentifrice, a liquid dentifrice, a liquid dentifrice, or a beverage in the form of a suspension solution with artificial saliva as a test solution. After pulverization, a water-soluble component was extracted from each test substance, and a suspension with artificial saliva was used as a test solution. [0037] In the remineralization acceleration test, the artificial initial caries specimen prepared above was immersed in each test solution for 24 hours, and then the specimen was parallelized to the tooth axis with a micro cutter.
  • the piece was cut to a thickness of about 50 Oxm, and then the section was polished using a kneading whetstone and a natural whetstone under water injection so as to become a parallel thin section of about 100 xm thickness.
  • CMR contact microradiogram
  • Table 10 shows the results of confirming the effect of promoting the remineralization of the oral composition by the remineralization acceleration test method described above.
  • Example 1 Example 2 (Example 3 Example 4 Example 5 Remineralization rate «) 1.4 16.5 11,8 17.3 10.1 5.2
  • Table 11 shows the results of confirming the effect of promoting remineralization of foods and beverages by the aforementioned remineralization acceleration test method.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Confectionery (AREA)

Abstract

Problèmes: obtenir une composition orale qui peut efficacement promouvoir la recalcification de l'émail de la dent décalcifiée au niveau de sa surface et qui peut positivement supprimer les caries dentaires. Solution: un promoteur de recalcification pour l'émail de la dent comprenant de la conchioline et/ou de la conchioline hydrolysée comme principe efficace auquel un composé de calcium, en particulier de préférence hydroxyapatite, est ajouté.
PCT/JP2004/013622 2003-11-11 2004-09-17 Promoteur de recalcification, composition orale, aliment et boisson Ceased WO2005044210A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2005515237A JP4324591B2 (ja) 2003-11-11 2004-09-17 再石灰化促進剤、口腔用組成物、食品、飲料

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003-381008 2003-11-11
JP2003381008 2003-11-11

Publications (1)

Publication Number Publication Date
WO2005044210A1 true WO2005044210A1 (fr) 2005-05-19

Family

ID=34567261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/013622 Ceased WO2005044210A1 (fr) 2003-11-11 2004-09-17 Promoteur de recalcification, composition orale, aliment et boisson

Country Status (2)

Country Link
JP (1) JP4324591B2 (fr)
WO (1) WO2005044210A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014009212A (ja) * 2012-07-02 2014-01-20 Mikimoto Pharmaceut Co Ltd コラーゲン産生促進剤
JP2020059689A (ja) * 2018-10-09 2020-04-16 炭プラスラボ株式会社 経口組成物

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309209A (en) * 1970-07-13 1973-03-07 Colgate Palmolive Co Dentrifrices
JPH01199907A (ja) * 1988-02-04 1989-08-11 Masatoshi Kato 歯磨き剤
JPH069354A (ja) * 1992-06-30 1994-01-18 Sunstar Inc 口腔用組成物
JPH08173091A (ja) * 1994-12-27 1996-07-09 Mikimoto Pharmaceut Co Ltd 食 品
JPH0940539A (ja) * 1995-08-02 1997-02-10 Sangi Co Ltd 歯磨組成物
JPH1087502A (ja) * 1996-09-10 1998-04-07 Sunstar Inc 口腔用組成物
JPH1121208A (ja) * 1997-07-02 1999-01-26 Rengo Co Ltd 抗菌剤
JPH11349462A (ja) * 1998-06-08 1999-12-21 Lion Corp 口腔用組成物
JP2002167318A (ja) * 2000-11-30 2002-06-11 Lion Corp 固体口腔用組成物
WO2002067871A2 (fr) * 2001-02-28 2002-09-06 Ezaki Glico Co., Ltd. Compositions dotees d'une activite anti-caries dentaires
JP2003238372A (ja) * 2002-02-20 2003-08-27 Kao Corp 口腔用組成物

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309209A (en) * 1970-07-13 1973-03-07 Colgate Palmolive Co Dentrifrices
JPH01199907A (ja) * 1988-02-04 1989-08-11 Masatoshi Kato 歯磨き剤
JPH069354A (ja) * 1992-06-30 1994-01-18 Sunstar Inc 口腔用組成物
JPH08173091A (ja) * 1994-12-27 1996-07-09 Mikimoto Pharmaceut Co Ltd 食 品
JPH0940539A (ja) * 1995-08-02 1997-02-10 Sangi Co Ltd 歯磨組成物
JPH1087502A (ja) * 1996-09-10 1998-04-07 Sunstar Inc 口腔用組成物
JPH1121208A (ja) * 1997-07-02 1999-01-26 Rengo Co Ltd 抗菌剤
JPH11349462A (ja) * 1998-06-08 1999-12-21 Lion Corp 口腔用組成物
JP2002167318A (ja) * 2000-11-30 2002-06-11 Lion Corp 固体口腔用組成物
WO2002067871A2 (fr) * 2001-02-28 2002-09-06 Ezaki Glico Co., Ltd. Compositions dotees d'une activite anti-caries dentaires
JP2003238372A (ja) * 2002-02-20 2003-08-27 Kao Corp 口腔用組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014009212A (ja) * 2012-07-02 2014-01-20 Mikimoto Pharmaceut Co Ltd コラーゲン産生促進剤
JP2020059689A (ja) * 2018-10-09 2020-04-16 炭プラスラボ株式会社 経口組成物

Also Published As

Publication number Publication date
JPWO2005044210A1 (ja) 2008-06-12
JP4324591B2 (ja) 2009-09-02

Similar Documents

Publication Publication Date Title
CN103826605B (zh) 口腔用组合物
TWI382852B (zh) 一種口腔保健用磷酸鈣複合物及其製法與組合物
RU2696495C2 (ru) Средство для ухода за полостью рта и пищевой продукт или напиток
KR101904165B1 (ko) 치약용 조성물
JP3689803B2 (ja) 歯牙エナメル質の再石灰化促進剤及び口腔用組成物並びに飲食物
JP5720546B2 (ja) 歯磨剤組成物及び歯牙の再石灰化促進剤
CN103889398A (zh) 口腔组合物
JPWO2017085927A1 (ja) 口腔用組成物
RU2457829C2 (ru) Минерально-витаминный комплекс для укрепления эмали зубов, композиция для гигиены полости рта и зубная паста
RU2119328C1 (ru) Зубная паста
CN102358746A (zh) 表面活性钙磷酸盐
JP4937583B2 (ja) 口腔用組成物
KR101293893B1 (ko) 가수분해 실크를 함유하는 구강용 조성물
JP4546139B2 (ja) 口腔用組成物
JP4324591B2 (ja) 再石灰化促進剤、口腔用組成物、食品、飲料
WO2005023210A1 (fr) Agent, composition orale, aliment et boisson favorisant la recalcification
JP2004018396A (ja) 再石灰化促進剤、口腔用組成物、食品及び飲料
CN110913834B (zh) 口腔护理产品和方法
JP7027315B2 (ja) 口腔用組成物
JP4241274B2 (ja) チューインガム
WO2014054257A1 (fr) Composition de dentifrice
JP5004505B2 (ja) 口腔用組成物
JP2015127310A (ja) 口腔用組成物
JP2005068093A (ja) 再石灰化促進剤、口腔用組成物、食品、及び飲料

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2005515237

Country of ref document: JP

122 Ep: pct application non-entry in european phase