[go: up one dir, main page]

WO2004028410A1 - Keratoprothese biointegrable - Google Patents

Keratoprothese biointegrable Download PDF

Info

Publication number
WO2004028410A1
WO2004028410A1 PCT/AU2003/001263 AU0301263W WO2004028410A1 WO 2004028410 A1 WO2004028410 A1 WO 2004028410A1 AU 0301263 W AU0301263 W AU 0301263W WO 2004028410 A1 WO2004028410 A1 WO 2004028410A1
Authority
WO
WIPO (PCT)
Prior art keywords
keratoprosthesis
channels
micrometers
keratoprosthesis according
diameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2003/001263
Other languages
English (en)
Inventor
Traian Chirila
Celia Rachel Hicks
Xia Lou
Geoffrey James Crawford
Ian Jeffrey Constable
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lions Eye Institute of Western Australia Inc
Original Assignee
Lions Eye Institute of Western Australia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2002951596A external-priority patent/AU2002951596A0/en
Application filed by Lions Eye Institute of Western Australia Inc filed Critical Lions Eye Institute of Western Australia Inc
Priority to AU2003264175A priority Critical patent/AU2003264175A1/en
Publication of WO2004028410A1 publication Critical patent/WO2004028410A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves

Definitions

  • This invention relates to a prosthetic corneal device that after implantation is capable of substantial incorporation into the host tissue by cellular invasion and tissue proliferation along a substantially circular peripheral zone which essentially is perforated with a plurality of channels.
  • the cornea is an essential component of the human eye, providing about 75% of the total dioptric power and protecting the globe against hostile factors in the environment.
  • An injured or diseased cornea requires its replacement with materials able to duplicate the characteristic of the natural cornea in order to perpetuate the corneal functions (light transmission, refraction and protection).
  • transplantation of human homologous corneal tissue is successful mainly in less complex pathological conditions, such as keratoconus or corneal dystrophies.
  • pathological conditions such as keratoconus or corneal dystrophies.
  • the rate of success of grafts drops significantly.
  • Such conditions may occur in alkali burns or in pathologies like ocular pemphigoid, Stevens-Johnson syndrome, trachoma or others.
  • the transplantation success rate is furthermore reduced by rejection of grafts or their late failure.
  • Keratoprostheses have been designed consisting of two distinct parts, namely a central optic cylindrical zone (commonly PMMA), and a surrounding skirt made of other materials such as metals, ceramics, preserved biological tissue and various polymers. However, all these modifications did not lower significantly the implant extrusion rate, as revealed in the aforementioned reviews.
  • keratoprosthesis consisting of a core made of hydrophilic poly(vinyl alcohol) copolymers that is surrounded by a skirt made of a hydrophobic melt-blown web prepared form polybutylene/polypropylene blends, both materials being supplied by 3M Company, St. Paul, Minn., USA.
  • this keratoprosthesis showed limited success in animal experiments.
  • U.S. Pat. Nos. 4,865,601 ; 4,932,968 and 5,282,851 disclose a keratoprosthesis which basically consists in its preferred version of a polyurethane core surrounded by a long multi-pronged haptic made of porous PTFE available commercially as Gore-Tex® from W. L. Gore & Associates, Flagstaff, Ariz., USA. This device had limited success in human patients, as disclosed in Caldwell D. R., "The soft keratoprosthesis", Transactions of the American Ophthalmological Society, vol. 95, pp. 751-802 (1997).
  • a keratoprosthesis consisting of a PMMA core surrounded by a skirt of porous PTFE was disclosed in Fr. Pat.
  • WO 01/95836 discloses a keratoprosthesis that, in one of the embodiments, has a skirt perforated with an unspecified number of small-diameter holes.
  • the skirt can be made of the same material as, or of different materials from that of the main body of keratoprosthesis.
  • This keratoprosthesis is specified to be implanted only anterior to Descemet's membrane, not as a full-thickness implant.
  • the skirt has the edges cut at right angles and is to be placed between stroma and Descemet's membrane.
  • the perforated skirt is aimed at promoting formation of collagen bridges between the stroma and Descemet's membrane, and at creating a barrier through its edges against the invasion of epithelial cells to the posterior face of the keratoprosthesis.
  • incidence of epithelial downgrowth was significant in the experimental animal trials with a device having 18 holes in the skirt, as disclosed in Kaminski S., Lacombe E., Duchesne B., Fernandez V. et al., "A new supradescemetic keratoprosthesis: a novel design", Proceedings of the 4 th KPro Study Group and 6 th IOSS Joint Meeting, Fort Lauderdale, May 4-5, 2001 , pp. 62- 63.
  • a keratoprosthesis consisting of a core made of poly(2-hydroxyethyl methacrylate), henceforth designated as PHEMA, and a skirt made also of porous PHEMA (sponge), joined together through an interpenetrating polymer network, as disclosed in U.S. Pat. Nos. 5,300,116 and 5,458,819, and for example in Chirila T. V., Vijayasekaran S., Home R., Chen Y. C. et al., "Interpenetrating polymer network (IPN) as a permanent joint between the elements of a new type of artificial cornea", Journal of Biomedical Materials Research, vol. 28, pp.
  • IPN Interpenetrating polymer network
  • a porous skirt where the pore-like morphology is provided by interstices of fibrous webs or by tortuous channels generating voids, and which is made either of a material different from the core material or of the same material, is inherently non-transparent and therefore cosmetically undesirable in a keratoprosthesis.
  • a porous skirt of this type also allows the adsorption of excessive amounts of inflammatory factors due to a large surface area, which may delay the healing process.
  • a keratoprosthesis comprising a central lenticular zone and a peripheral annular zone comprising a plurality of transverse channels penetrating the full thickness of the keratoprosthesis.
  • a one-piece keratoprosthesis comprising a central lenticular zone and a peripheral annular zone comprising a plurality of transverse channels penetrating the full thickness of the keratoprosthesis, wherein the distribution and frequency of the channels is selected to ensure at least a minimum surface area for the tissue- material interaction whilst providing for maximum integration of the host tissue into the material.
  • a one-piece keratoprosthesis which comprises at least 80 channels penetrating the full thickness of the keratoprosthesis and located proximate to the periphery of the prosthesis.
  • the channels are spaced apart such that the distance between them is substantially equal to their diameter.
  • the distance between neighbouring channels is not smaller than the diameter of said channels. More preferably, the distance between neighbouring channels is substantially equal to the diameter of said channels.
  • the channels may perforate the prosthesis at any angle.
  • they perforate the prosthesis at a substantially right, acute or obtuse angle formed between the central axis of the channels and the keratoprosthetic horizontal plane, defined as a plane tangential to the surface of the keratoprosthesis.
  • the channels are at an angle that facilitates biocolonialization.
  • holes of the correct size and distribution allow ingrowth and this ingrowth prevents encapsulation, while anchoring the device and effectively preventing epithelial downgrowth.
  • the keratoprosthesis may be made of rigid or flexible biocompatible transparent polymers, either hydrophobic or hydrophilic, selected from acrylic polymers, polyurethanes, polycarbonates, polysulfones, acrylic hydrogels, silicone elastomers, silicone hydrogels and any other material that is transparent and biologically acceptable.
  • the keratoprosthesis may be implanted using a simple surgical technique that generally will not require coverage with conjunctival flap.
  • Figure 1 is a plan view of the keratoprosthesis according to the present invention.
  • Figure 2 is a cross-sectional side view of a first embodiment of the keratoprosthesis of Figure 1 taken;
  • Figure 3 is a cross-sectional side view of a second embodiment of the keratoprosthesis of Figure 1 ;
  • Figure 4 is a cross-sectional side view of a third embodiment of the keratoprosthesis of Figure 1 ;
  • Figure 5 is an upper perspective view of the keratoprosthesis of Figure 1 ;
  • Figure 6 is a microphotograph of a PHEMA hydrogel sheet perforated with channels.
  • Figure 7 is a microphotograph of a histopathological section of the keratoprosthesis of Figure 1 explanated from a rabbit cornea showing a channel colonized by tissue.
  • derived and "derived from” shall be taken to indicate that a specific integer may be obtained from a particular source albeit not necessarily directly from that source.
  • the diameter of the channels used in the keratoprosthesis needs to be of such width to promote tissue biointegration with the supporting plate material.
  • a preferred embodiment of the present invention comprises a substantially circular or ellipsoidal device 10 of a convexo-concave lenticular shape in cross-section 12 (best seen in Figures 2, 3 and 4) with the radius or radii of curvature executed in accordance with the refractive index of the material of said device so as to provide the desired in-situ refractive power.
  • the device comprises a convex surface 14 and a concave surface 16.
  • the diameter of the device is preferably between about 7 and about 11 mm, more preferably between about 7.5 and about 8.5 mm and its maximum thickness is preferably between about 10 and about 600 micrometres, more preferably between about 200 and about 300 micrometres. Preferably the thickness at the edge 18 of the device 10 is minimized.
  • a desirable outcome of the keratoprosthesis of the present invention is the ability to prepare a device with a thinner edge profile than the keratoprostheses of the prior art, thereby minimizing the effects on the corneal stromal architecture.
  • the device is provided with a peripheral annular zone 20, comprising a plurality of transversal channels 22 penetrating the full thickness of the device and being placed within a region of a width determined by the diameter of the device.
  • a peripheral annular zone 20 comprising a plurality of transversal channels 22 penetrating the full thickness of the device and being placed within a region of a width determined by the diameter of the device.
  • the width of the peripheral annular zone available for perforations is between about 1.0 and 1.5 mm, most preferably of about 1.25 mm.
  • the channels may be circular or ellipsoidal, more preferably circular.
  • the diameter of the perforating channels is chosen to maximize the degree of biointegration by invading stromal corneal cells of the channels.
  • the diameters are between about 20 and about 200 micrometres, more preferably between about 30 and about 80 micrometres and most preferably of about 50 micrometres.
  • the number of channels varies in function with the available width along the periphery of device and of the diameter of the channels. Preferably, the distance between two neighbouring channels is not smaller than the diameter of said channels.
  • the number of channels may be selected from the following ranges; 80 and 100, 100 and 125, 125 and 150, 150 and 200, 200 and 250, 250 and 500, 500 and 1000, 1000 and 1500, 1500 and 2000, 2000 and 5000, 5000 and 10000, 10000 and 15000, 15000 and 20000, 20000 and 30000, or more than 30000.
  • the number of channels may be selected from any number defined in the ranges above.
  • the channels When the channels are placed at a distance between them equal to their diameter, this allows for a maximum of about 15000 channels of 20 micrometres in diameter, or for a maximum of about 200 channels of 200 micrometres in diameter, or, in a preferred embodiment, for a maximum of about 2700 channels of 50 micrometres in diameter.
  • the diameter of the channels and their number control the rate of biocolonization by proliferation of stromal cells and the biointegration of keratoprosthesis after its implantation.
  • the number of channels of 50 micrometres in diameter which are perforated in a keratoprosthesis of 7.5 mm in diameter is between about 1000 and about 2000. As will be recognized by those skilled in the art, this number may be appropriately estimated for various diameters of the keratoprosthesis. Likewise, the number of channels of any diameter may be appropriately estimated for various diameters of the keratoprosthesis.
  • a keratoprosthesis of this invention may contain channels of identical diameter or channels of various diameters.
  • the number of channels to be perforated will be influenced by the mechanical processing characteristics of the material and by the method employed to carry out the perforation.
  • the channels may be perforated at any angle between about 20 and about 160 degrees formed between the central axis of the channels and the keratoprosthetic horizontal plane, more preferably at a right angle.
  • a first embodiment of the invention depicting channels perforated perpendicularly onto the keratoprosthetic horizontal plane can be seen in Figure 2, a cross-sectional view through A-A of Figure 1.
  • a second embodiment of the invention depicting channels perforated at an obtuse angle with reference to the keratoprosthetic horizontal plane can be seen in Figure 3, a cross-sectional view through A-A of Figure 1.
  • a third embodiment of the invention, depicting channels perforated at an acute angle with reference to the keratoprosthetic horizontal plane can be seen in Figure 4, a cross-sectional view through A-A of Figure 1.
  • a non-perforated rim 24 is provided along the periphery, of a width preferably between about 150 and about 300 micrometres, more preferably of about 250 micrometres.
  • the keratoprosthesis of this invention is preferably made of rigid, semi-flexible or flexible biocompatible transparent polymers, either hydrophobic or hydrophilic, selected from acrylic polymers, polyurethanes, polycarbonates, polysulfones, acrylic hydrogels, silicone elastomers, silicone hydrogels and any other material that is transparent and biologically acceptable.
  • a variety of methods may be employed to fabricate the keratoprosthesis, including mold-casting of monomer mixtures or lathe-cutting of polymer blanks, and their modifications all known in the art of fabrication of ophthalmic lenticular devices.
  • the channels may be created by carrying out the perforation with hollow needles, punching, laser (UV or infrared) ablation, or by ultrahigh-pressure waterjet drilling. Without being limited by theory, it is believed that removal of polymeric material is necessary for the preparation of the channel rather than simply piercing the device.
  • the procedure disclosed in U.S. Pat. No. 6,423,093 may be employed, as such or modified.
  • the flap may be created with an automatic blade or an intrastromal laser as used for LASIK surgery.
  • the intrastromal pocket may be modified so that the device may be stepped down into a depression smaller than the diameter of the flap.
  • a posterior opening may be created at this stage.
  • the flap may be sutured or secured by contact lens placement. After a healing period of about 2 to 3 months, incisions using a trephine or laser means are made to create optionally either a posterior lamellar opening or an anterior flap opening or both, as required by the original pathological condition.
  • the frontal surface of the keratoprosthesis may be allowed to epithelialize, if appropriate polymers were used for the manufacture or surface treatment of the polymer with cell adhesion promoting agents or other means was carried out. Alternatively, the frontal prosthesis may be left as such and kept free of epithelial cells.
  • a desirable outcome of the keratoprosthesis of the present invention is the preparation of a device which is more cosmetically desirable than the keratoprostheses of the prior art and a device suitable for an extended range of eye conditions including low risk graft cases where otherwise a non-transparent skirt would severely affect cosmesis.
  • HEMA 2-hydroxyethyl methacrylate
  • distilled water (12.10 g)
  • ethylene dimethacrylate 132 ⁇ L
  • 10 % ( w / w ) ammonium persulphate in water 420 ⁇ L
  • N,N,N',N'-tetramethyleneethylenediamine was homogenized and poured between two glass plates spaced apart by plastic gaskets at a distance of 0.38 mm.
  • the glass plate enclosure was placed in a convection oven and maintained at 50 °C for 24 hr. The enclosure was removed from the oven, dismantled and the PHEMA hydrogel sheet removed and stored in distilled water.
  • the hydrogel sheet was perforated using a micro hole punching machine. Any such machine equipped with, for example, carbide-tipped punches and die inserts may be used for the purpose, for example, Model SK-5705 CNC (Schneider and Marquard Inc., Newton, NJ, USA). A hydrogel sheet that was perforated with this machine resulting in channels of 100 micrometers in diameter as is shown in Figure 6.
  • a micro hole punching machine Any such machine equipped with, for example, carbide-tipped punches and die inserts may be used for the purpose, for example, Model SK-5705 CNC (Schneider and Marquard Inc., Newton, NJ, USA).
  • a hydrogel sheet that was perforated with this machine resulting in channels of 100 micrometers in diameter as is shown in Figure 6.
  • the perforated lens was implanted into a lamellar pocket in the stroma of one rabbit where it was maintained for one month when the cornea was excised for histopathological examination. The microscopic examination of the explant indicated lack of fibrous encapsulation and firm biointegration of the material to the stroma.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention porte sur une kératoprothèse en une pièce (10) comprenant une zone lenticulaire centrale et une zone annulaire périphérique (20) comprenant une pluralité de canaux transversaux (22) pénétrant toute l'épaisseur de la kératoprothèse. La répartition et la fréquence des canaux sont sélectionnées de façon à assurer une superficie minimale dans l'interaction tissu-matériau tout en garantissant l'intégration maximum du tissu hôte dans le matériau.
PCT/AU2003/001263 2002-09-24 2003-09-24 Keratoprothese biointegrable Ceased WO2004028410A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003264175A AU2003264175A1 (en) 2002-09-24 2003-09-24 Biointegrable keratoprosthesis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41304302P 2002-09-24 2002-09-24
AU2002951596 2002-09-24
AU2002951596A AU2002951596A0 (en) 2002-09-24 2002-09-24 Biointegrable Keratoprosthesis
US60/413,043 2002-09-24

Publications (1)

Publication Number Publication Date
WO2004028410A1 true WO2004028410A1 (fr) 2004-04-08

Family

ID=32043752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2003/001263 Ceased WO2004028410A1 (fr) 2002-09-24 2003-09-24 Keratoprothese biointegrable

Country Status (1)

Country Link
WO (1) WO2004028410A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009071312A3 (fr) * 2007-12-06 2010-01-21 Coronis Gmbh Kératoprothèse
WO2014039495A1 (fr) * 2012-09-05 2014-03-13 University Of Miami Nouvelle kératoprothèse et système et procédé de réparation de la cornée l'utilisant
JP2021528136A (ja) * 2018-06-14 2021-10-21 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ 人工角膜
US12257368B2 (en) 2018-06-14 2025-03-25 W. L. Gore & Associates, Inc. Epithelializing microporous biomaterial for use in avascular environments and in corneal implants

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458870A (en) * 1964-05-25 1969-08-05 William Stone Jr Artificial corneal implants having a removable lens member
US4851003A (en) * 1988-01-05 1989-07-25 Lindstrom Richard L Corneal implant lens with fixation holes
US5019097A (en) * 1989-11-22 1991-05-28 Allergan, Inc. Corneal onlay lenses and methods for attaching same
US5405385A (en) * 1992-04-02 1995-04-11 Clemson University Intraocular lens with integrated means of fixation
US6324429B1 (en) * 1998-05-08 2001-11-27 Massachusetts Eye And Ear Infirmary Chronically implantable retinal prosthesis
US6322589B1 (en) * 1995-10-06 2001-11-27 J. Stuart Cumming Intraocular lenses with fixated haptics
WO2002039147A2 (fr) * 2000-11-10 2002-05-16 Rudolph Domino Lentille intraoculaire souple à focale variable

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458870A (en) * 1964-05-25 1969-08-05 William Stone Jr Artificial corneal implants having a removable lens member
US4851003A (en) * 1988-01-05 1989-07-25 Lindstrom Richard L Corneal implant lens with fixation holes
US5019097A (en) * 1989-11-22 1991-05-28 Allergan, Inc. Corneal onlay lenses and methods for attaching same
US5405385A (en) * 1992-04-02 1995-04-11 Clemson University Intraocular lens with integrated means of fixation
US6322589B1 (en) * 1995-10-06 2001-11-27 J. Stuart Cumming Intraocular lenses with fixated haptics
US6324429B1 (en) * 1998-05-08 2001-11-27 Massachusetts Eye And Ear Infirmary Chronically implantable retinal prosthesis
WO2002039147A2 (fr) * 2000-11-10 2002-05-16 Rudolph Domino Lentille intraoculaire souple à focale variable

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009071312A3 (fr) * 2007-12-06 2010-01-21 Coronis Gmbh Kératoprothèse
WO2014039495A1 (fr) * 2012-09-05 2014-03-13 University Of Miami Nouvelle kératoprothèse et système et procédé de réparation de la cornée l'utilisant
US9974646B2 (en) 2012-09-05 2018-05-22 University Of Miami Keratoprosthesis, and system and method of corneal repair using same
JP2021528136A (ja) * 2018-06-14 2021-10-21 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ 人工角膜
US12257368B2 (en) 2018-06-14 2025-03-25 W. L. Gore & Associates, Inc. Epithelializing microporous biomaterial for use in avascular environments and in corneal implants

Similar Documents

Publication Publication Date Title
JP7012770B2 (ja) 可逆的に変形可能な人工角膜および植え込むための方法
EP2067453B1 (fr) Prostokératoplastie
EP0446197B1 (fr) Protheses intraoculaires
Chirila et al. Artificial cornea
Lloyd et al. Ocular biomaterials and implants
Chirila An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application
US5282851A (en) Intraocular prostheses
Barber Keratoprostheses: past and present
KR960705513A (ko) 각막 이식물(Corneal onlays)
Caldwell The soft keratoprosthesis
JP2005515019A (ja) 角膜上に上皮皮弁を作製するため、および上皮皮弁または膜の下に眼用デバイスおよびレンズを配置するための方法、上皮薄層デバイスならびに上皮および眼用デバイスおよびレンズの構造
CA2263458A1 (fr) Emboiture de prothese oculaire
KR102736416B1 (ko) 인공 각막
Leibowitz et al. Progress in the development of a synthetic cornea
Hicks et al. Keratoprosthesis: preliminary results of an artificial corneal button as a full‐thickness implant in the rabbit model
WO2004028410A1 (fr) Keratoprothese biointegrable
Sugioka et al. Implantation of a keratoprosthesis of novel design in rabbits
Wnek et al. Corneal Implants/Traian V. Chirila, Celia R. Hicks
Li et al. Biomaterials: impact on keratoprosthesis implantation
Kim et al. Korea Seoul-type KPro: indications, contraindications, and surgical techniques
Mannis Prosthokeratoplasty in ocular surface disease
HK1241259A1 (en) Corneal implants
Shoviin The use of alloplastics: A new realm of refractive surgery?
Chowdhury ROAD TO ARTIFICIAL CORNEA-” KERATOPROSTHESIS”
CA2182184A1 (fr) Protheses intra-oculaires

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP