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WO2004003011A3 - Nuclear hormone receptor - Google Patents

Nuclear hormone receptor Download PDF

Info

Publication number
WO2004003011A3
WO2004003011A3 PCT/GB2003/002808 GB0302808W WO2004003011A3 WO 2004003011 A3 WO2004003011 A3 WO 2004003011A3 GB 0302808 W GB0302808 W GB 0302808W WO 2004003011 A3 WO2004003011 A3 WO 2004003011A3
Authority
WO
WIPO (PCT)
Prior art keywords
hormone receptor
nuclear hormone
protein
termed
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/002808
Other languages
French (fr)
Other versions
WO2004003011A2 (en
Inventor
Christopher Benjamin Phelps
Mark Alistair Farrow
Richard Joseph Fagan
Janet Marjorie Allen
Kathryn Elizabeth Allen
Ilana Stancovski
Valerie Nathalie Pierron
Tom Phillips
Caroline Ann Hunt
Zinat Ellaheh Enayat
Christopher Michael J Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inpharmatica Ltd
Original Assignee
Inpharmatica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inpharmatica Ltd filed Critical Inpharmatica Ltd
Priority to EP03761713A priority Critical patent/EP1519955A2/en
Priority to AU2003242849A priority patent/AU2003242849A1/en
Publication of WO2004003011A2 publication Critical patent/WO2004003011A2/en
Publication of WO2004003011A3 publication Critical patent/WO2004003011A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This invention relates to a protein, termed BAB47423.1, herein identified as a novel Nuclear Hormone Receptor and to the use of this protein and nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
PCT/GB2003/002808 2002-07-01 2003-07-01 Nuclear hormone receptor Ceased WO2004003011A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03761713A EP1519955A2 (en) 2002-07-01 2003-07-01 Nuclear hormone receptor
AU2003242849A AU2003242849A1 (en) 2002-07-01 2003-07-01 Nuclear hormone receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0215226.2A GB0215226D0 (en) 2002-07-01 2002-07-01 Protein
GB0215226.2 2002-07-01

Publications (2)

Publication Number Publication Date
WO2004003011A2 WO2004003011A2 (en) 2004-01-08
WO2004003011A3 true WO2004003011A3 (en) 2004-03-25

Family

ID=9939655

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/002808 Ceased WO2004003011A2 (en) 2002-07-01 2003-07-01 Nuclear hormone receptor

Country Status (4)

Country Link
EP (1) EP1519955A2 (en)
AU (1) AU2003242849A1 (en)
GB (1) GB0215226D0 (en)
WO (1) WO2004003011A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001009318A1 (en) * 1999-07-29 2001-02-08 Helix Research Institute Liver cancer-associated genes
CN1352259A (en) * 2000-11-06 2002-06-05 上海博德基因开发有限公司 New polypeptide-pterin molybdenum redox enzyme 126.39 and polynucleotide for encoding such polypeptide
WO2002052005A1 (en) * 2000-12-22 2002-07-04 Kazusa Dna Research Institute Foundation Novel genes and proteins encoded thereby
WO2002083921A2 (en) * 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
JP2002345492A (en) * 2002-02-26 2002-12-03 Kazusa Dna Kenkyusho Novel genes and proteins encoded by them

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001009318A1 (en) * 1999-07-29 2001-02-08 Helix Research Institute Liver cancer-associated genes
CN1352259A (en) * 2000-11-06 2002-06-05 上海博德基因开发有限公司 New polypeptide-pterin molybdenum redox enzyme 126.39 and polynucleotide for encoding such polypeptide
WO2002052005A1 (en) * 2000-12-22 2002-07-04 Kazusa Dna Research Institute Foundation Novel genes and proteins encoded thereby
WO2002083921A2 (en) * 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
JP2002345492A (en) * 2002-02-26 2002-12-03 Kazusa Dna Kenkyusho Novel genes and proteins encoded by them

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] XP002261890, retrieved from EBI Database accession no. Q96JN1 *
DATABASE EMBL [online] XP002262190, retrieved from EBI Database accession no. ABR01791 *
DATABASE EMBL [online] XP002262191, retrieved from EBI Database accession no. ABR01831 *
DATABASE EMBL [online] XP002267056, retrieved from EBI Database accession no. BD585294 *
MCDONNELL D P ET AL: "NUCLEAR HORMONE RECEPTORS AS TARGETS FOR NEW DRUG DISCOVERY", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 11, 1 November 1993 (1993-11-01), pages 1256 - 1261, XP002018219, ISSN: 0733-222X *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XX.THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 8, no. 2, q96jn1, 2001, pages 85 - 95, XP001030942, ISSN: 1340-2838, Retrieved from the Internet <URL:EMBL> *
SCHAPIRA M ET AL: "Rational discovery of novel nuclear hormone receptor antagonists", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 3, 1 February 2000 (2000-02-01), pages 1008 - 1013, XP002170486, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU2003242849A1 (en) 2004-01-19
AU2003242849A8 (en) 2004-01-19
WO2004003011A2 (en) 2004-01-08
EP1519955A2 (en) 2005-04-06
GB0215226D0 (en) 2002-08-14

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