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WO2002033058A3 - Novel cysteine proteases and uses thereof - Google Patents

Novel cysteine proteases and uses thereof Download PDF

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Publication number
WO2002033058A3
WO2002033058A3 PCT/GB2001/004698 GB0104698W WO0233058A3 WO 2002033058 A3 WO2002033058 A3 WO 2002033058A3 GB 0104698 W GB0104698 W GB 0104698W WO 0233058 A3 WO0233058 A3 WO 0233058A3
Authority
WO
WIPO (PCT)
Prior art keywords
cysteine proteases
novel cysteine
novel
proteins
acc4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/004698
Other languages
French (fr)
Other versions
WO2002033058A2 (en
Inventor
Richard Joseph Fagan
Christopher Benjamin Phelps
Alex Gutteridge
Russell Quenton Nicholls
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inpharmatica Ltd
Original Assignee
Inpharmatica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0025816A external-priority patent/GB0025816D0/en
Priority claimed from GB0102260A external-priority patent/GB0102260D0/en
Application filed by Inpharmatica Ltd filed Critical Inpharmatica Ltd
Priority to AU2001295778A priority Critical patent/AU2001295778A1/en
Publication of WO2002033058A2 publication Critical patent/WO2002033058A2/en
Publication of WO2002033058A3 publication Critical patent/WO2002033058A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to novel proteins, termed BAA83099.1, AAD46161.1, AAD38507.2 and ACC4, herein identified as cysteine proteases and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
PCT/GB2001/004698 2000-10-20 2001-10-22 Novel cysteine proteases and uses thereof Ceased WO2002033058A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001295778A AU2001295778A1 (en) 2000-10-20 2001-10-22 Novel cysteine proteases and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0025816.0 2000-10-20
GB0025816A GB0025816D0 (en) 2000-10-20 2000-10-20 Novel protein
GB0102260A GB0102260D0 (en) 2001-01-29 2001-01-29 Novel proteins
GB0102260.7 2001-01-29

Publications (2)

Publication Number Publication Date
WO2002033058A2 WO2002033058A2 (en) 2002-04-25
WO2002033058A3 true WO2002033058A3 (en) 2003-04-10

Family

ID=26245185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/004698 Ceased WO2002033058A2 (en) 2000-10-20 2001-10-22 Novel cysteine proteases and uses thereof

Country Status (2)

Country Link
AU (1) AU2001295778A1 (en)
WO (1) WO2002033058A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2153231B1 (en) 2007-06-01 2013-05-15 University of Lausanne Malt1 specific cleavage in assay and screening method
EP2015073A1 (en) * 2007-07-11 2009-01-14 University of Lausanne Malt1 specific cleavage in enzyme assay and screening method
CN111926096B (en) * 2020-08-21 2022-01-11 江南大学 Method for detecting plasmodium ovale infection by utilizing PCR (polymerase chain reaction) technology

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033268A1 (en) * 1995-04-21 1996-10-24 Merck & Co., Inc. Apopain
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2000073500A1 (en) * 1999-05-27 2000-12-07 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw MOLECULAR CHARACTERISATION OF CHROMOSOME TRANSLOCATION t(11;18)(q21;q21) AND ITS CORRELATION TO CARCINOGENESIS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033268A1 (en) * 1995-04-21 1996-10-24 Merck & Co., Inc. Apopain
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2000073500A1 (en) * 1999-05-27 2000-12-07 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw MOLECULAR CHARACTERISATION OF CHROMOSOME TRANSLOCATION t(11;18)(q21;q21) AND ITS CORRELATION TO CARCINOGENESIS

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
AKAGI T ET AL: "A NOVEL GENE, MALT1 AT 18Q21, IS INVOLVED IN T(11;18) (Q21;Q21) FOUND IN LOW-GRADE B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 18, no. 42, 14 October 1999 (1999-10-14), pages 5785 - 5794, XP000867839, ISSN: 0950-9232 *
AKAGI T ET AL: "MOLECULAR CYTOGENETIC DELINEATION OF THE BREAKPOINT AT 18Q21.1 IN LOW-GRADE B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE", GENES, CHROMOSOMES & CANCER, XX, XX, vol. 24, no. 4, April 1999 (1999-04-01), pages 315 - 321, XP000876511 *
DATABASE EMBL [online] 6 August 1999 (1999-08-06), AKAGI T. ET AL., XP002208269, retrieved from EMBL Database accession no. AB026118 *
DATABASE EMBL [online] 7 December 2000 (2000-12-07), UREN ET AL., XP002208270, retrieved from EMBL Database accession no. AF316597 *
DIERLAMM J ET AL: "The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21)p6 associated with mucosa-associated lymphoid tissue lymphomas.", BLOOD. UNITED STATES 1 JUN 1999, vol. 93, no. 11, 1 June 1999 (1999-06-01), pages 3601 - 3609, XP002148929, ISSN: 0006-4971 *
MOTEGI M ET AL: "API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products.", AMERICAN JOURNAL OF PATHOLOGY. UNITED STATES MAR 2000, vol. 156, no. 3, March 2000 (2000-03-01), pages 807 - 812, XP002207102, ISSN: 0002-9440 *
OTT ET AL: "The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberation in low grade but not high grade malignant non-Hodgkin's lymphomas of MALT type 1", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, 15 September 1997 (1997-09-15), pages 3944 - 3948, XP002129854, ISSN: 0008-5472 *
UREN A G ET AL: "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.", MOLECULAR CELL. UNITED STATES OCT 2000, vol. 6, no. 4, October 2000 (2000-10-01), pages 961 - 967, XP002207100, ISSN: 1097-2765 *

Also Published As

Publication number Publication date
AU2001295778A1 (en) 2002-04-29
WO2002033058A2 (en) 2002-04-25

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