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WO2004000043A2 - Compositions nutraceutiques et supplements alimentaires renfermant du nadh - Google Patents

Compositions nutraceutiques et supplements alimentaires renfermant du nadh Download PDF

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Publication number
WO2004000043A2
WO2004000043A2 PCT/EP2003/006256 EP0306256W WO2004000043A2 WO 2004000043 A2 WO2004000043 A2 WO 2004000043A2 EP 0306256 W EP0306256 W EP 0306256W WO 2004000043 A2 WO2004000043 A2 WO 2004000043A2
Authority
WO
WIPO (PCT)
Prior art keywords
nadh
compositions
atp
lycopene
zinc
Prior art date
Application number
PCT/EP2003/006256
Other languages
English (en)
Other versions
WO2004000043A3 (fr
Inventor
Aldo Perani
Original Assignee
Dietetic S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dietetic S.P.A. filed Critical Dietetic S.P.A.
Priority to AU2003246430A priority Critical patent/AU2003246430A1/en
Priority to EP03760616A priority patent/EP1531690A2/fr
Publication of WO2004000043A2 publication Critical patent/WO2004000043A2/fr
Publication of WO2004000043A3 publication Critical patent/WO2004000043A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention refers to nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, in particular resveratrol and lycopene.
  • the compositions according to the invention are capable of stimulating the physiological production of energy (pro-energetic and anti-asthenic activity).
  • Nicotinamide adenine dinucelotide (NAD) in its reduced form (NADH) is a physiological substance which is found in all living cells; NAD is also defined as coenzyme I, as it is cofactor of several enzymes, which catalyze oxidoreduction reactions.
  • NAD coupled to dehydrogenase, oxidizes biological media by accepting hydrogen and it is then re-oxidized by flavoproteins.
  • NADH The most important role of NADH is the energy production through a mitochondrial process, the "oxidative phosphorylation", in which 3 ATP molecules are formed for every single NADH molecule and half oxygen molecule.
  • NADH is formed from glycolysis metabolites (lactate and pyruvate) and is carried into the mitochondrion thanks to two "shuttle” systems, glycerol phosphate and malate - aspartate.
  • NADH a tyrosine hydroxylase cofactor, the enzyme which converts L-Dopa in dopamine; further NADH has a direct stimulation action of tyrosine hydroxylase activity.
  • NADH also stimulates the endogenous adrenaline and noradrenaline bio-synthesis, thus it is effective in the therapy of depression (Birkmayer, J.G.D., Birkmayer W. New Trends in Clinical Neuropharmacology, Vol. 5 - n. 3 / 4 - 1991).
  • NADH is essential to poly (ADP-ribose) polymerase enzyme, its administration prevents DNA breaking processes and it inhibits stress oxidative phenomena (Adams et al. Annali New York Academy of Sciences, 1996, 786-135-131) and thanks to its anti-oxidative action, it may regenerate other important antioxidants thus protecting from damages caused by free radicals.
  • NADH is unstable to the pH of gastric juices, it may be orally administered only in gastro-protected form, preferably associated with vitamin E, sodium bicarbonate, ascorbic acid, sodium ascorbate, as disclosed in US 5,332,727 and in US 5,712,259.
  • Adenosine triphosphate is the coenzyme which is found in high concentration in mammal muscles, and it is required for high energy phosphates bonds.
  • the conversion of ATP in ADP (adenosine diphosphate) provides the energy required for most physiological processes of the organism.
  • exogenous ATP restores physiological ATP levels in myosin fibers, when they are lowered below a certain threshold (Chaudry IH, Yale J. Biol. Med. 1982; 55:1-10).
  • ATP oral pharmaceutical compositions have already been suggested for muscular and cerebral fatigue treatment.
  • Lycopene is a carotenoid, which is contained in high quantities in tomato skins and is characterized by high anti-oxidative properties. As it can be seen from more and more clinical studies, lycopene involves a series of advantages for health and, in particular, it provides valid protection against several epithelial tumours and cardiovascular diseases and it delayes body cells ageing.
  • Resveratrol (3,4,5-trihydroxystilbene) is a polyphenol to which anti- tumoural, anti-oxidant, anti-inflammatory and anti-thrombotic properties are ascribed. In particular, it has been shown that resveratrol modulates lipid metabolism and inhibits low-density lipoproteins LDL oxidation and platelets aggregation through copper capture. It is found in grapefruits, raisins, blackberries, peanuts, but especially in grape skin and in particular in red wine.
  • Zinc acts as regulator of enzymatic systems. Recent studies underline its fundamental role in cerebral functions and treatment of schizophrenia. Further, it improves reflex and mental quickness. DESCRIPTION OF THE INVENTION
  • the association of NADH, adenosine triphosphate (ATP) and antioxidants, in particular resveratrol, lycopene and optionally zinc is particularly advantageous, thanks to proenergetic synergistic effects between NADH and ATP and to the enhancement of the antioxidant/antiradical effect obtainable through the association of lycopene, resveratrol and zinc.
  • the present invention provides nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, preferably resveratrol and lycopene, and optionally zinc, useful for stimulating the organism to produce energy in physical fatigue states, while practicing sports and/or anyhow under all circumstances where energy consumption is expected and in the conditions under which the administering of NADH brings advantages.
  • compositions according to the invention preferably have the following percentage composition (by weight on the total composition):
  • Zinc will preferably be in the form of salts with organic acids, in particular lactate.
  • compositions according to the invention may be administered with the addition of suitable excipients, in form of hard capsules, soft capsules and tablets.
  • Tablets with gastroenteral coating which can be accomplished by conventional methods and excipients, are preferred.
  • Shellac Rubber a natural polymer, is applied on tablets by spraying in aqueous solution, further containing one or more plasticizing agents (glycerine, lauric acid, oleic acid, polyvinyl pyrrolidone in an amount comprised in the range from 0.5 to 4%, one or more anti-adhesive agents (talcum, silicon dioxide / colloidal silica), in an amount comprised in the range from 2 to 8%, and optionally one or more dye or opacifying agents.
  • plasticizing agents glycol, lauric acid, oleic acid, polyvinyl pyrrolidone
  • anti-adhesive agents talcum, silicon dioxide / colloidal silica
  • Shellac Rubber is used for tablet gastro-protection in an amount ranging from 2 to 8% by weight of the tablet itself.
  • the coating process occurs preferably through a rotating coating pan, at a temperature not above 34-35°C.
  • a cooling step is carried out at the end of the drying process.
  • a fluidized bed granulator-coater apparatus in which the solution to be applied is sprayed from one or more nozzles on the tablet mass kept in motion in a basket (or granulator bucket) by an air stream, which dries the tablets themselves at the same time, can be used as alternative to the rotating coating pan.
  • the tablets thus coated should be kept intact for at least 30 minutes in an aqueous solution at a pH of 1.5 at 37°C.
  • the formulations according to the invention preferably contain for each unitary dose from 1 to 10 mg NADH, preferably from 2 to 5 mg; from 1 to 10 mg resveratrol, preferably from 2 to 5 mg; from 1 to 10 mg lycopene, preferably from 2 to 5 mg; from 1 to 5 mg ATP, preferably from 2 to 4 mg; from 10 to 20 mg zinc, preferably from 15 to 17 mg.
  • compositions according to the invention administered once or twice a day, produce advantageous effects when a restoration of the energy store in fatigued, immuno-depressed organisms and in organisms, which underwent physiological disequilibria induced by the development of free radicals, is convenient.
  • the compositions according to the invention are particularly suitable for persons undertaking intensive trainings, for cognitive and mnemonic skills and in the treatment or prevention of depressions, fatigue, stress and in the ageing processes.
  • Example 1 formulation for 300 mg tablet
  • Example 2 formulation for 300 mg tablet
  • Example 3 formulation for 300 mg tablet
  • Example 4 formulation for 300 mg tablet

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne des compositions nutraceutiques et des suppléments alimentaires renfermant du NADH, de l'ATP et des antioxydants, en particulier du resvératrol et du lycopène. Lesdites compositions permettent de stimuler la production physiologique d'énergie (activité pro-énergétique et antiasthénique).
PCT/EP2003/006256 2002-06-21 2003-06-13 Compositions nutraceutiques et supplements alimentaires renfermant du nadh WO2004000043A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003246430A AU2003246430A1 (en) 2002-06-21 2003-06-13 Nutraceutic compositions and food supplements containing nadh
EP03760616A EP1531690A2 (fr) 2002-06-21 2003-06-13 Compositions nutraceutiques et supplements alimentaires renfermant du nadh

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI001366A ITMI20021366A1 (it) 2002-06-21 2002-06-21 Composizioni nutraceutiche e integratori alimentari contenenti nadh
ITMI2002A001366 2002-06-21

Publications (2)

Publication Number Publication Date
WO2004000043A2 true WO2004000043A2 (fr) 2003-12-31
WO2004000043A3 WO2004000043A3 (fr) 2004-03-04

Family

ID=11450057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006256 WO2004000043A2 (fr) 2002-06-21 2003-06-13 Compositions nutraceutiques et supplements alimentaires renfermant du nadh

Country Status (4)

Country Link
EP (1) EP1531690A2 (fr)
AU (1) AU2003246430A1 (fr)
IT (1) ITMI20021366A1 (fr)
WO (1) WO2004000043A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010132021A1 (fr) 2009-05-14 2010-11-18 Hsiehs Biotech (Singapore) Pte Ltd Complément alimentaire à base de lycopène et de resvératrol
WO2010132024A1 (fr) * 2009-05-14 2010-11-18 Hsiehs Biotech (Singapore) Pte Ltd Compositions de lycopène et de resvératrol pour l'activation des cellules nk aboutissant à un effet antinéoplasique
WO2018148930A1 (fr) * 2017-02-17 2018-08-23 纯菁生物科技（美国）有限公司 Utilisation de nadh ou fadh2 dans une intervention nutritionnelle pour un patient atteint d'un cancer
CN115299534A (zh) * 2022-09-14 2022-11-08 泓博元生命科技（深圳）有限公司 一种用于宠物能量速补和缓解疲劳的nadh组合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712259A (en) * 1996-04-22 1998-01-27 Birkmayer Pharmaceuticals NADH and NADPH pharmaceuticals for treating chronic fatigue syndrome
CH692837A5 (it) * 1997-07-02 2002-11-29 Lisapharma Spa Composizione farmaceutica per uso alimentare, dietetico o medicinale adatta a migliorare l'assorbimento orale dei polifenoli e particolarmente del resveratrolo presenti nell'uva e nei suoi p
IT1318565B1 (it) * 2000-06-09 2003-08-27 World Pharma Tech Ltd Integratore alimentare proenergetico a base di nadh octocosanolo evitamina e.
AU2002250942B2 (en) * 2001-02-14 2007-04-26 Rath Matthias Compositions of biochemical compounds involved in bioenergy metabolism of cells

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010132021A1 (fr) 2009-05-14 2010-11-18 Hsiehs Biotech (Singapore) Pte Ltd Complément alimentaire à base de lycopène et de resvératrol
WO2010132024A1 (fr) * 2009-05-14 2010-11-18 Hsiehs Biotech (Singapore) Pte Ltd Compositions de lycopène et de resvératrol pour l'activation des cellules nk aboutissant à un effet antinéoplasique
US20120121699A1 (en) * 2009-05-14 2012-05-17 Hsiehs Biotech (Singapore) Pte Ltd Lycopene and resveratrol dietary supplement
CN102481267A (zh) * 2009-05-14 2012-05-30 谢氏生技(新加坡)有限公司 用于nk细胞活化产生抗肿瘤作用的番茄红素和白藜芦醇组合物
JP2012526807A (ja) * 2009-05-14 2012-11-01 シェーズ バイオテック（シンガポール）プライベート リミテッド 抗腫瘍作用をもたらすｎｋ細胞活性化のためのリコピンおよびレスベラトロールを含む組成物
US20150132373A1 (en) * 2009-05-14 2015-05-14 Hsiehs Biotech (Singapore) Pte Ltd Lycopene and resveratrol dietary supplement
US9610255B2 (en) * 2009-05-14 2017-04-04 Hsiehs Biotech (Singapore) Pte Ltd Lycopene and resveratrol dietary supplement
WO2018148930A1 (fr) * 2017-02-17 2018-08-23 纯菁生物科技（美国）有限公司 Utilisation de nadh ou fadh2 dans une intervention nutritionnelle pour un patient atteint d'un cancer
CN115299534A (zh) * 2022-09-14 2022-11-08 泓博元生命科技（深圳）有限公司 一种用于宠物能量速补和缓解疲劳的nadh组合物及其制备方法

Also Published As

Publication number Publication date
AU2003246430A8 (en) 2004-01-06
ITMI20021366A0 (it) 2002-06-21
ITMI20021366A1 (it) 2003-12-22
AU2003246430A1 (en) 2004-01-06
WO2004000043A3 (fr) 2004-03-04
EP1531690A2 (fr) 2005-05-25

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