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WO2004096116A3 - Diazabicyclononene derivatives - Google Patents

Diazabicyclononene derivatives Download PDF

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Publication number
WO2004096116A3
WO2004096116A3 PCT/EP2004/004372 EP2004004372W WO2004096116A3 WO 2004096116 A3 WO2004096116 A3 WO 2004096116A3 EP 2004004372 W EP2004004372 W EP 2004004372W WO 2004096116 A3 WO2004096116 A3 WO 2004096116A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
preparation
pharmaceutical compositions
derivatives
diazabicyclononene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/004372
Other languages
French (fr)
Other versions
WO2004096116A2 (en
Inventor
Olivier Bezencon
Daniel Bur
Walter Fischli
Lubos Remen
Sylvia Richard-Bildstein
Thomas Weller
Thierry Sifferlen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actelion Pharmaceuticals Ltd
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Priority to JP2006505261A priority Critical patent/JP2006525259A/en
Priority to CA002521898A priority patent/CA2521898A1/en
Priority to EP04729414A priority patent/EP1622564A2/en
Priority to MXPA05011711A priority patent/MXPA05011711A/en
Priority to US10/555,382 priority patent/US20060223795A1/en
Priority to BRPI0409882-0A priority patent/BRPI0409882A/en
Priority to AU2004233577A priority patent/AU2004233577A1/en
Publication of WO2004096116A2 publication Critical patent/WO2004096116A2/en
Publication of WO2004096116A3 publication Critical patent/WO2004096116A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
PCT/EP2004/004372 2003-05-02 2004-04-26 Diazabicyclononene derivatives Ceased WO2004096116A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2006505261A JP2006525259A (en) 2003-05-02 2004-04-26 New diazabicyclononene derivatives
CA002521898A CA2521898A1 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives
EP04729414A EP1622564A2 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives
MXPA05011711A MXPA05011711A (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives.
US10/555,382 US20060223795A1 (en) 2003-05-02 2004-04-26 Novel diazabicyclononene derivatives
BRPI0409882-0A BRPI0409882A (en) 2003-05-02 2004-04-26 compounds, pharmaceutical compositions, method for the treatment or prophylaxis of diseases, and uses of compounds and one or more compounds in combination with other pharmacologically active compounds
AU2004233577A AU2004233577A1 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0304622 2003-05-02
EPPCT/EP03/04622 2003-05-02

Publications (2)

Publication Number Publication Date
WO2004096116A2 WO2004096116A2 (en) 2004-11-11
WO2004096116A3 true WO2004096116A3 (en) 2005-03-24

Family

ID=33395698

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004372 Ceased WO2004096116A2 (en) 2003-05-02 2004-04-26 Diazabicyclononene derivatives

Country Status (10)

Country Link
EP (1) EP1622564A2 (en)
JP (1) JP2006525259A (en)
KR (1) KR20060015573A (en)
CN (1) CN1780838A (en)
AU (1) AU2004233577A1 (en)
BR (1) BRPI0409882A (en)
CA (1) CA2521898A1 (en)
MX (1) MXPA05011711A (en)
RU (1) RU2005137571A (en)
WO (1) WO2004096116A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005040165A1 (en) * 2003-10-13 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene derivatives and their use as renin inhibitors
AU2004283854A1 (en) * 2003-10-23 2005-05-06 Actelion Pharmaceuticals Ltd Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors
WO2005054244A2 (en) * 2003-12-05 2005-06-16 Actelion Pharmaceuticals Ltd Azabicyclooctene and other tetrahydropyridine derivatives with a new side-chain
JP2008510755A (en) 2004-08-25 2008-04-10 アクテリオン ファーマシューティカルズ リミテッド Bicyclononene derivatives
WO2006021403A1 (en) * 2004-08-25 2006-03-02 Actelion Pharmaceuticals Ltd Bicyclononene derivatives
WO2006058546A1 (en) * 2004-12-01 2006-06-08 Actelion Pharmaceuticals Ltd Novel lactame derivatives as renin inhibitors
WO2006063610A1 (en) * 2004-12-17 2006-06-22 Actelion Pharmaceuticals Ltd Heteroaryl substituted diazabicyclononene derivatives
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
KR100938364B1 (en) * 2005-01-28 2010-01-22 액테리온 파마슈티칼 리미티드 7- ｛4- [2- (2,6-dichloro-4-methylphenoxy) ethoxy] phenyl｝ -3,9-diazabicyclo [3.3.1] non- as an inhibitor of renin for treating hypertension 6-ene-6-carboxylic acid cyclopropyl- (2,3-dimethylbenzyl) amide
WO2006131884A2 (en) * 2005-06-07 2006-12-14 Actelion Pharmaceuticals Ltd Thiazole substituted diazabicyclononane or-nonene derivatives as renin inhibitors
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
AU2006332124B2 (en) 2005-12-30 2011-03-03 Novartis Ag 3 , 5-substitgammaued piperidine compounds as renin inhibitors
WO2007104652A2 (en) * 2006-03-16 2007-09-20 Nicox S.A. Non-peptidic renin inhibitors nitroderivatives
CA2688057A1 (en) 2007-05-24 2008-11-27 Merck Frosst Canada Ltd. Novel case of renin inhibitors
NZ582098A (en) 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
EP2190811B1 (en) 2007-08-20 2013-08-07 Merck Canada Inc. Renin inhibitors
ES2548134T3 (en) 2008-05-05 2015-10-14 Actelion Pharmaceuticals Ltd. 3,4-substituted piperidine derivatives as renin inhibitors
JPWO2013038936A1 (en) * 2011-09-13 2015-03-26 タカラバイオ株式会社 Method for stopping peroxidase reaction and reaction stopper

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
WO2004002957A1 (en) * 2002-06-27 2004-01-08 Actelion Pharmaceuticals Ltd Novel tetrahydropyridine derivatives as renin inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
WO1997009311A1 (en) * 1995-09-07 1997-03-13 F. Hoffmann-La Roche Ag New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
WO2004002957A1 (en) * 2002-06-27 2004-01-08 Actelion Pharmaceuticals Ltd Novel tetrahydropyridine derivatives as renin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EL-ABBADY S A ET AL: "ENHANCED REACTIVITY OF PYRIDIN-3-OL TOWARDS 4-PHENYL-1,2,4-TRIAZOLINE 3,5-DIONE: FMO TREATMENT OF THE CYCLOADDITION PROCESS BY ASED-MO CALCULATIONS METHOD", ZAGAZIG JOURNAL OF PHARMACEUTICAL SCIENCES, FACULTY OF PHARMACY ZAGAZIG UNIVERSITY, CAIRO, EG, vol. 5, no. 1, June 1996 (1996-06-01), pages 68 - 74, XP001154254, ISSN: 1110-5089 *

Also Published As

Publication number Publication date
AU2004233577A1 (en) 2004-11-11
BRPI0409882A (en) 2006-05-23
CN1780838A (en) 2006-05-31
KR20060015573A (en) 2006-02-17
JP2006525259A (en) 2006-11-09
MXPA05011711A (en) 2006-01-23
EP1622564A2 (en) 2006-02-08
CA2521898A1 (en) 2004-11-11
RU2005137571A (en) 2006-05-10
WO2004096116A2 (en) 2004-11-11

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