MXPA05011711A - Diazabicyclononene derivatives. - Google Patents
Diazabicyclononene derivatives.Info
- Publication number
- MXPA05011711A MXPA05011711A MXPA05011711A MXPA05011711A MXPA05011711A MX PA05011711 A MXPA05011711 A MX PA05011711A MX PA05011711 A MXPA05011711 A MX PA05011711A MX PA05011711 A MXPA05011711 A MX PA05011711A MX PA05011711 A MXPA05011711 A MX PA05011711A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- preparation
- pharmaceutical compositions
- derivatives
- diazabicyclononene
- Prior art date
Links
- QDFXRVAOBHEBGJ-UHFFFAOYSA-N 3-(cyclononen-1-yl)-4,5,6,7,8,9-hexahydro-1h-diazonine Chemical class C1CCCCCCC=C1C1=NNCCCCCC1 QDFXRVAOBHEBGJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- YJTZZSKGEPHUTF-UHFFFAOYSA-N 3,9-diazabicyclo[3.3.1]non-4-ene Chemical class C1NC=C2CCCC1N2 YJTZZSKGEPHUTF-UHFFFAOYSA-N 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0304622 | 2003-05-02 | ||
| PCT/EP2004/004372 WO2004096116A2 (en) | 2003-05-02 | 2004-04-26 | Diazabicyclononene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05011711A true MXPA05011711A (en) | 2006-01-23 |
Family
ID=33395698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05011711A MXPA05011711A (en) | 2003-05-02 | 2004-04-26 | Diazabicyclononene derivatives. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1622564A2 (en) |
| JP (1) | JP2006525259A (en) |
| KR (1) | KR20060015573A (en) |
| CN (1) | CN1780838A (en) |
| AU (1) | AU2004233577A1 (en) |
| BR (1) | BRPI0409882A (en) |
| CA (1) | CA2521898A1 (en) |
| MX (1) | MXPA05011711A (en) |
| RU (1) | RU2005137571A (en) |
| WO (1) | WO2004096116A2 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2540782A1 (en) * | 2003-10-13 | 2005-05-06 | Olivier Bezencon | Diazabicyclononene derivatives and their use as renin inhibitors |
| AU2004283854A1 (en) * | 2003-10-23 | 2005-05-06 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
| JP2007513107A (en) * | 2003-12-05 | 2007-05-24 | アクテリオン ファマシューティカルズ リミテッド | Diazabicyclononene and tetrahydropyridine derivatives with new side chains |
| WO2006021403A1 (en) * | 2004-08-25 | 2006-03-02 | Actelion Pharmaceuticals Ltd | Bicyclononene derivatives |
| JP2008510755A (en) | 2004-08-25 | 2008-04-10 | アクテリオン ファーマシューティカルズ リミテッド | Bicyclononene derivatives |
| WO2006058546A1 (en) * | 2004-12-01 | 2006-06-08 | Actelion Pharmaceuticals Ltd | Novel lactame derivatives as renin inhibitors |
| WO2006063610A1 (en) * | 2004-12-17 | 2006-06-22 | Actelion Pharmaceuticals Ltd | Heteroaryl substituted diazabicyclononene derivatives |
| GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
| CN101107248A (en) | 2005-01-28 | 2008-01-16 | 埃科特莱茵药品有限公司 | 7-{4-[2-(2,6-Dichloro-4-methylphenoxy)ethoxy]phenyl}-3,9-diazepine as a renin inhibitor for the treatment of hypertension Heterobicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide |
| WO2006131884A2 (en) * | 2005-06-07 | 2006-12-14 | Actelion Pharmaceuticals Ltd | Thiazole substituted diazabicyclononane or-nonene derivatives as renin inhibitors |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| JP5306821B2 (en) | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | 3,5-substituted piperidine compounds as renin inhibitors |
| WO2007104652A2 (en) * | 2006-03-16 | 2007-09-20 | Nicox S.A. | Non-peptidic renin inhibitors nitroderivatives |
| CA2688057A1 (en) | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd. | Novel case of renin inhibitors |
| EP2527338B1 (en) | 2007-06-25 | 2015-05-06 | Novartis AG | N5-(2-ethoxyethyl)-n3-(2-pyridinyl) -3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| EP2190811B1 (en) | 2007-08-20 | 2013-08-07 | Merck Canada Inc. | Renin inhibitors |
| JP4790871B2 (en) | 2008-05-05 | 2011-10-12 | メルク フロスト カナダ リミテツド | 3,4-Substituted piperidine derivatives as renin inhibitors |
| WO2013038936A1 (en) * | 2011-09-13 | 2013-03-21 | タカラバイオ株式会社 | Method for terminating peroxidase reaction, and terminating agent for said reaction |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3509161A (en) * | 1967-07-10 | 1970-04-28 | Boehringer & Soehne Gmbh | 3-phenyl-granatene-(2)-derivatives |
| IL123293A (en) * | 1995-09-07 | 2003-06-24 | Hoffmann La Roche | Piperidine derivatives, their preparation and pharmaceutical compositions containing them |
| BR0309498A (en) * | 2002-04-29 | 2005-02-15 | Actelion Pharmaceuticals Ltd | Compounds, pharmaceutical compositions, method for the treatment or prophylaxis of ras-related diseases, and use of compounds |
| PL375214A1 (en) * | 2002-06-27 | 2005-11-28 | Actelion Pharmaceuticals Ltd. | Novel tetrahydropyridine derivatives as renin inhibitors |
-
2004
- 2004-04-26 BR BRPI0409882-0A patent/BRPI0409882A/en not_active Application Discontinuation
- 2004-04-26 WO PCT/EP2004/004372 patent/WO2004096116A2/en not_active Ceased
- 2004-04-26 MX MXPA05011711A patent/MXPA05011711A/en not_active Application Discontinuation
- 2004-04-26 JP JP2006505261A patent/JP2006525259A/en active Pending
- 2004-04-26 CN CNA2004800116500A patent/CN1780838A/en active Pending
- 2004-04-26 RU RU2005137571/04A patent/RU2005137571A/en not_active Application Discontinuation
- 2004-04-26 CA CA002521898A patent/CA2521898A1/en not_active Abandoned
- 2004-04-26 KR KR1020057020788A patent/KR20060015573A/en not_active Withdrawn
- 2004-04-26 EP EP04729414A patent/EP1622564A2/en not_active Withdrawn
- 2004-04-26 AU AU2004233577A patent/AU2004233577A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1622564A2 (en) | 2006-02-08 |
| RU2005137571A (en) | 2006-05-10 |
| WO2004096116A3 (en) | 2005-03-24 |
| WO2004096116A2 (en) | 2004-11-11 |
| CN1780838A (en) | 2006-05-31 |
| BRPI0409882A (en) | 2006-05-23 |
| AU2004233577A1 (en) | 2004-11-11 |
| JP2006525259A (en) | 2006-11-09 |
| KR20060015573A (en) | 2006-02-17 |
| CA2521898A1 (en) | 2004-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |