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WO2004093556A1 - Utilisation de la n-acetyl glucosamine comme additif pour produits laitiers - Google Patents

Utilisation de la n-acetyl glucosamine comme additif pour produits laitiers Download PDF

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Publication number
WO2004093556A1
WO2004093556A1 PCT/CN2004/000279 CN2004000279W WO2004093556A1 WO 2004093556 A1 WO2004093556 A1 WO 2004093556A1 CN 2004000279 W CN2004000279 W CN 2004000279W WO 2004093556 A1 WO2004093556 A1 WO 2004093556A1
Authority
WO
WIPO (PCT)
Prior art keywords
acetylglucosamine
dairy
test
acceptable salt
dairy products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2004/000279
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English (en)
Chinese (zh)
Inventor
Qiwang Xu
Junkang Liu
Zetao Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Army Medical University
Original Assignee
Third Military Medical University TMMU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Third Military Medical University TMMU filed Critical Third Military Medical University TMMU
Publication of WO2004093556A1 publication Critical patent/WO2004093556A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives

Definitions

  • the present invention relates to the use of N-acetylglucosamine or a dairy acceptable salt thereof as an additive in dairy products, and to dairy products comprising N-acetylglucosamine or a dairy acceptable salt thereof.
  • Dairy products are rich in nutrients and widely used, which are closely related to human survival and have become the main object of nutrition research.
  • the formation of new biological theories is naturally linked to dairy products.
  • the biological wave theory is a new theory of biology. It is the latest biological theory established and confirmed through experimental research based on the latest developments in modern physical and mathematical fields and the exploration of complexity. It is based on the actual situation of biology and medicine. "Research on the theory of biological waves", Chinese Journal of Microecology, 1994, 6 (6): 40-49).
  • the biological wave theory believes that the human body is an open system.
  • the metabolic process promotes the integration of biological dissipation and ecology, and performs the functions of life activities.
  • the biological wave theory is applied to nutrition, and the viewpoint that the conditions of nutrient utilization are determined is put forward, that is, the biological wave regulating factors promote the absorption and utilization of nutrients.
  • the inventors have surprisingly discovered through research that a new type of dairy product prepared from N-acetylglucosamine or an acceptable salt thereof as a dairy product additive has the characteristics of fast absorption and good effect compared with traditional dairy products. .
  • Another object of the present invention is to provide a dairy product comprising N-acetylglucosamine or an acceptable salt thereof.
  • Yet another object of the present invention is to provide a method for preparing a dairy product, which comprises adding N-acetylglucosamine or a dairy acceptable salt thereof to a raw dairy product.
  • the full name of the N-acetylglucosamine is N-acetyl-D-glucosamine (N-acetyl-D-glucosamine), the molecular formula is C 8 H 15 N0 6 , and the structural formula (I) is as follows:
  • Examples of acceptable salts of N-acetyl-D-glucosamine dairy products useful in the present invention include, but are not limited to, those salts formed with inorganic acids, such as hydrochloride, phosphate, hydrogen phosphate, and organic salts Those salts formed by acids, such as citrate, benzoate, ascorbate.
  • the dairy product of the present invention can be any form of dairy product commonly consumed in people's lives, for example, it can be liquid such as liquid milk; solid such as milk powder, cheese; semi-solid such as yogurt, water cream, and the like.
  • the dairy products may be ordinary dairy products, or various nutrition-fortified dairy products such as calcium-added milk.
  • N-acetyl-D-glucosamine or a dairy acceptable salt thereof can be added to dairy products, as long as the manner of addition is to N-acetyl-D-glucosamine or its dairy products. Acceptable salts and other active ingredients in dairy products have no adverse effects.
  • the N-acetyl-D-aminoglucose or a dairy acceptable salt thereof may be added to the milk powder in powder form.
  • the N-acetyl-D-glucosamine or a dairy acceptable salt thereof may be added to a liquid dairy product, and then the milk The products are sold as such, or are further prepared, for example, into milk powder, yoghurt, and the like by techniques known in the art.
  • the content of N-acetylglucosamine or its dairy-acceptable salt in dairy products is generally from OOlg / 100ml to 10g / 100ml. It is preferably 0.01 g / 100ml to 2g / 100mh. Based on the weight of solid active substance in dairy products, the content of N-acetylglucosamine or its dairy acceptable salts in dairy products is generally 0.1-10%, preferably 0.1 -2%.
  • novel dairy product of the present invention containing N-acetylhelylglucose or an acceptable salt of dairy product thereof has produced new beneficial effects on the body, and the effect is remarkable in the trial of the crowd.
  • Proteus mirabilis should meet the following biochemical response characteristics: motility (+), urease (+), lactose (-), glucose (+), H 2 S (-), phenylalanine deaminase (+ ).
  • LB medium Improved LB medium (composition: 1% tryptone, 0.5% yeast extract, 1% sodium chloride, 0.1% glucose, 0.002% TTC> PH7.2-7.4).
  • Test sample A compound of formula (I) with a final concentration of 0.5% was added to the LB plate, and Proteus mirabilis was spotted in the same way, and cultured for 9 hours at 37 ° C. 2. Test results and evaluation:
  • This experiment uses a biological wave fluctuation test model to study the wave-promoting effect of the compound of formula (I).
  • the compound of formula (I) can not only make bacterial cells show normal biological wave characteristics, but also make this wave show more subtle
  • the method of fluctuation shows that the compound of formula (I) can promote biological fluctuation.
  • This wave-promoting effect of the compound of formula (I) helps to explain the effect of N-acetylglucosamine on the effective absorption of dairy products.
  • Acute toxicology test including oral, intravenous and maximum dose test
  • Kunming mice were used for face testing.
  • the control group was orally administrated milk, and the test group was fed with N-acetylglucosamine (added amount: 0.1g / 100ml milk). ), Eating more and gaining weight significantly.
  • Kunming mice were used for testing. Female rats during pregnancy were first divided into experimental group and control group. The test group was orally administered with the dairy product of the present invention (N-acetylglucosamine O.lg / 100g milk powder was added to the commercially available milk powder), and the control group was orally administered with the commercially available milk powder and fed until the suckling rats were born for 15 days. The average body weight of the mice in the test group was significantly higher than that in the control group.
  • a face test of 36 volunteers showed that compared with ordinary milk, those who drank the dairy product of the present invention (added N-acetylglucosamine 0.1g / 100ml to sterilized fresh milk) reported an increase in appetite and a good appetite, especially with an For intestinal diseases, the effect is more obvious. After drinking, the conscious physical strength recovers quickly, the action is strong, the mental state is good, and the effective rate is more than 90%.
  • Example 5 Example of the preparation of a dairy product according to the invention
  • N-acetylglucosamine is added to the fermented yogurt in a solid form to prepare a yogurt with an N-acetylglucosamine content of 0.1 g / 100ml. 5. Add N-acetylglucosamine citrate to milk in the form of a 10% by weight aqueous solution to make liquid milk with a final N-acetylglucosamine content of 0.1g / 100ml.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention porte sur l'utilisation de la n-acétyl glucosamine comme additif pour produits laitiers et sur de nouveaux produits laitiers la comprenant qui procurent de nouveaux bénéfices à l'organisme, et dont les effets sont en particulier très significatifs dans les tests humains.
PCT/CN2004/000279 2003-03-27 2004-03-29 Utilisation de la n-acetyl glucosamine comme additif pour produits laitiers Ceased WO2004093556A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN03108274.2 2003-03-27
CNB031082742A CN100339014C (zh) 2003-03-27 2003-03-27 N－乙酰氨基葡萄糖在乳制品中的应用及包含n－乙酰氨基葡萄糖的乳制品

Publications (1)

Publication Number Publication Date
WO2004093556A1 true WO2004093556A1 (fr) 2004-11-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2004/000279 Ceased WO2004093556A1 (fr) 2003-03-27 2004-03-29 Utilisation de la n-acetyl glucosamine comme additif pour produits laitiers

Country Status (2)

Country Link
CN (1) CN100339014C (fr)
WO (1) WO2004093556A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009007660A1 (fr) 2007-07-04 2009-01-15 Mathieu Borge Compositions liquides ou pateuses destinees a l'apport en elements essentiels a la synthese et a la constitution des proteoglycanes, notamment pour le traitement de la degradation du cartilage
CN110367335A (zh) * 2019-08-30 2019-10-25 江西阳光乳业股份有限公司 一种保健型酸奶的制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106072653A (zh) * 2015-05-02 2016-11-09 邓渝 N-乙酰氨基葡萄糖的植物蛋白饮品及其应用
CN106333314A (zh) * 2015-07-09 2017-01-18 邓渝 N-乙酰氨基葡萄糖在蜂蜜制品中的应用及包含n-乙酰氨基葡萄糖的蜂蜜制品
CN120226697B (zh) * 2025-06-03 2025-08-12 内蒙古蒙牛乳业（集团）股份有限公司 一种改善骨关节健康的液态乳制品及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1519555A (fr) * 1966-07-26 1968-04-05 Expl Des Etablissements Larous Produit diététique pour nourrissons sevrés
FR2102030A5 (fr) * 1970-09-04 1972-03-31 Imasa
CN1095366C (zh) * 1996-12-27 2002-12-04 中国人民解放军第三军医大学 N－乙酰－d－氨基葡萄糖在制备治疗肠道疾病药物中的应用
WO2003012074A2 (fr) * 2001-07-30 2003-02-13 Den Kgl. Veterinær- Og Landbohøjskole Souches bacteriennes de l'acide lactique appartenant a une nouvelle espece de lactobacillus et utilisation desdites souches dans les industries alimentaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2101030A1 (en) * 1970-08-11 1972-03-31 Sogeras New biogical bifidogene complex - useful as infant diet supplement
ATE218065T1 (de) * 1996-08-09 2002-06-15 Mannatech Inc Zusammensetzungen auf pflanzliicher kohlenhydratbasis als nahrungsergänzungsstoffe

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1519555A (fr) * 1966-07-26 1968-04-05 Expl Des Etablissements Larous Produit diététique pour nourrissons sevrés
FR2102030A5 (fr) * 1970-09-04 1972-03-31 Imasa
CN1095366C (zh) * 1996-12-27 2002-12-04 中国人民解放军第三军医大学 N－乙酰－d－氨基葡萄糖在制备治疗肠道疾病药物中的应用
WO2003012074A2 (fr) * 2001-07-30 2003-02-13 Den Kgl. Veterinær- Og Landbohøjskole Souches bacteriennes de l'acide lactique appartenant a une nouvelle espece de lactobacillus et utilisation desdites souches dans les industries alimentaires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"The characters of N-acetyl-D-glucosamine and its use in food", FOOD SCIENCE AND TECHNOLOGY, vol. 6, 2001, pages 31 - 34 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009007660A1 (fr) 2007-07-04 2009-01-15 Mathieu Borge Compositions liquides ou pateuses destinees a l'apport en elements essentiels a la synthese et a la constitution des proteoglycanes, notamment pour le traitement de la degradation du cartilage
CN110367335A (zh) * 2019-08-30 2019-10-25 江西阳光乳业股份有限公司 一种保健型酸奶的制备方法

Also Published As

Publication number Publication date
CN100339014C (zh) 2007-09-26
CN1533700A (zh) 2004-10-06

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