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WO2004085604A1 - Utilisation de n-acetylglucosamine en tant qu'additif pour le vin et vin comportant de la n-acetylglucosamine - Google Patents

Utilisation de n-acetylglucosamine en tant qu'additif pour le vin et vin comportant de la n-acetylglucosamine Download PDF

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Publication number
WO2004085604A1
WO2004085604A1 PCT/CN2004/000274 CN2004000274W WO2004085604A1 WO 2004085604 A1 WO2004085604 A1 WO 2004085604A1 CN 2004000274 W CN2004000274 W CN 2004000274W WO 2004085604 A1 WO2004085604 A1 WO 2004085604A1
Authority
WO
WIPO (PCT)
Prior art keywords
wine
acetylglucosamine
test
acceptable derivative
acetyl glucosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2004/000274
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English (en)
Chinese (zh)
Inventor
Qiwang Xu
Junkang Liu
Zetao Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Army Medical University
Original Assignee
Third Military Medical University TMMU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Third Military Medical University TMMU filed Critical Third Military Medical University TMMU
Publication of WO2004085604A1 publication Critical patent/WO2004085604A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G1/00—Preparation of wine or sparkling wine

Definitions

  • N-acetylglucosamine as an additive in wine and wine containing N-acetylglucosamine
  • the present invention relates to the use of N-acetylglucosamine or an acceptable derivative of a wine product as an additive in wine, wine containing N-acetylglucosamine or an acceptable derivative of a wine product, and a method for preparing wine.
  • Another type of work is to add Chinese herbal medicines with health effects in wine.
  • This kind of alcohol is essentially only using alcohol as a carrier for drugs, not for the purpose of reducing drinking damage.
  • N-acetylglucosamine or acceptable derivatives of alcoholic products are added to wine in an appropriate proportion and drunk.
  • the crowd test shows that the symptoms of dizziness are significantly reduced, the drunken response does not occur or it is postponed after increasing the amount of drinking, and can effectively calm Subsequent drunk reactions after drinking wine, such as thirst, poor language expression, and general discomfort.
  • the inventors established a model of biological wave growth in the research of biological wave theory, and further studied the molecular mechanism of biological wave growth, and put forward the principle of micro-heterogeneous changes in the biological wave of biological organisms.
  • the speed of biological wave changes is fast or slow, depending on the degree of change in the external environment.
  • the rapidly changing environment After receiving the harmful substances to stimulate the body, the rapidly changing environment has led to a heterologous micro occurs, so that imbalance between the body 5 and the environment caused by such damage occurs and symptoms of injury or systemic symptoms of local molecular biology
  • proteins, especially various enzymes are unstable or even lose function under changed conditions, especially temperature changes and the presence of microbial metabolites.
  • Still another object of the present invention is to provide a method for preparing wine, comprising the step of adding N-acetylglucosamine or an acceptable derivative thereof to a raw wine to prepare a finished wine.
  • N-acetylglucosamine N-acetyl-D-glucosamine
  • molecular formula C 8 H 15 N0 6
  • structural formula (I) is expressed as follows:
  • N-acetyl-D-glucosamine examples include, but are not limited to: salts with inorganic acids, such as hydrochloride phosphate hydrogen phosphate, and organic salts with acids such as citraconic acid sample benzoate, ascorbate ⁇
  • N-acetyl-D-glucosamine or an acceptable derivative thereof can be directly added to the raw wine to prepare a finished wine.
  • N-acetyl-D-glucosamine or an acceptable derivative thereof can be added to the raw wine in the form of an aqueous solution.
  • N-acetyl-D-glucosamine or an acceptable derivative thereof can be packaged in combination with the wine composition and added to the wine before it is consumed by the drinker.
  • the wine suitable for the purpose of the present invention may be any wine, such as, for example, raw grape wine, distilled wine such as dry red wine, dry white wine, and the like.
  • N-acetylglucosamine or acceptable derivatives of alcoholic products in wine The content may be from 0.001 g / 100 ml to 10 g / 100 ml, preferably from 0.01 g / 100 ml to 5 g / 100 ml.
  • N-acetylglucosamine or an acceptable derivative of alcoholic products is used as an additive in wine, which can control the damage of harmful substances such as ethanol in the wine to the body, and the effective rate can reach more than 95%.
  • Proteus mirabilis should meet the following biochemical response characteristics: motility (+), urease (+), lactose (-), glucose (+), H 2 S (-), phenylalanine deaminase (+ ).
  • LB medium Improved LB medium (Composition: 1% tryptone, 0.5% yeast extract, 1% sodium chloride ⁇ . 1% glucose, 2% TTC, pH 7.2-7. 4 ⁇ 1.3 Test method:
  • Test sample A compound of formula (I) with a final concentration of 0.5% was added to the LB plate, and Proteus mirabilis was spotted in the same way, and cultured for 9 hours at 37 ° C.
  • This test uses a biological wave test model to study the compounds of formula (I).
  • the compound of formula (I) can not only make bacterial cells show normal biological wave characteristics, but also make this fluctuation show a more subtle fluctuation mode, indicating that the compound of formula (I) can promote biological fluctuations. .
  • This wave-promoting effect helps explain the effect of N-acetylglucosamine or an acceptable derivative thereof in controlling damage after drinking.
  • Acute toxicology test including oral, intravenous and maximum dose test
  • a commercially available wine (alcohol content of 12 degrees) was administered to the control group of mice; the wine of the present invention (that is, wine alcohol content: 12 degrees and N-acetylglucosamine content of 0.1% by weight) was used to administer the experimental group of mice Gavage, test group and control group Experiments were performed on 30 mice each.
  • the rats When administered at a dose of 0.2ml / 20g / times (that is, 0.2ml wine per 20g mouse weight), the rats were fed every 10 minutes.
  • 18 mice in the control group fainted within 1 hour and lost consciousness.
  • Nine rats were unstable and 3 died; when the test group reached this dose, 2 rats were unconscious, 4 rats showed slight standing instability, and the remaining rats were basically normal.
  • the results of the control group and the test group were quite different.
  • Test wine composition 0.1% by weight of N-acetylglucosamine was added to the commercially available wine. The test subjects generally responded well, 45 of them reported no dizziness, including 23 of them who reported that the drunken response was lighter after drinking and the total effective rate was over 90%.
  • a commercially available wine + 0.1% by weight of N-acetylglucosamine hydrochloride was used for the test, and similar results were obtained, of which 46 people reported no dizziness, including 23 people who reported a lighter drunk response after drinking 5 and the total effective rate was more than 2%.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention se rapporte à l'utilisation, en tant qu'additif pour le vin, de la N-acétylglucosamine ou de dérivés acceptables pour produits alcoolisés, à un vin peu nocif qui comporte de la N-acétylglucosamine ou des dérivés acceptables pour produits alcoolisés, et au procédé de fabrication de ce vin. La N-acétylglucosamine ou des dérivés acceptables pour produits alcoolisés utilisés en tant qu'additif peuvent servir à maîtriser la nocivité pour le corps d'une substance nuisible du vin, par exemple, de l'alcool ou analogue, le taux d'efficacité pouvant être supérieur à 95 %.
PCT/CN2004/000274 2003-03-27 2004-03-29 Utilisation de n-acetylglucosamine en tant qu'additif pour le vin et vin comportant de la n-acetylglucosamine Ceased WO2004085604A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN03108275.0 2003-03-27
CNA031082750A CN1534089A (zh) 2003-03-27 2003-03-27 N-乙酰氨基葡萄糖作为添加剂在葡萄酒中的应用及包含n-乙酰氨基葡萄糖的葡萄酒

Publications (1)

Publication Number Publication Date
WO2004085604A1 true WO2004085604A1 (fr) 2004-10-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2004/000274 Ceased WO2004085604A1 (fr) 2003-03-27 2004-03-29 Utilisation de n-acetylglucosamine en tant qu'additif pour le vin et vin comportant de la n-acetylglucosamine

Country Status (2)

Country Link
CN (1) CN1534089A (fr)
WO (1) WO2004085604A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1611895A4 (fr) * 2003-03-27 2008-02-20 Univ Pla 3Rd Military Medical Utilisation de la n-acetyl-d-aminoglycosamine dans le traitement de lesions organiques associees a la toxicite de medicaments ou de produits chimiques
WO2009007660A1 (fr) 2007-07-04 2009-01-15 Mathieu Borge Compositions liquides ou pateuses destinees a l'apport en elements essentiels a la synthese et a la constitution des proteoglycanes, notamment pour le traitement de la degradation du cartilage

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102199513A (zh) * 2011-03-01 2011-09-28 邱阳 一种抗氧化保健酒
CN106072653A (zh) * 2015-05-02 2016-11-09 邓渝 N-乙酰氨基葡萄糖的植物蛋白饮品及其应用
CN106333314A (zh) * 2015-07-09 2017-01-18 邓渝 N-乙酰氨基葡萄糖在蜂蜜制品中的应用及包含n-乙酰氨基葡萄糖的蜂蜜制品
CN112375633A (zh) * 2020-11-26 2021-02-19 江苏双林海洋生物药业有限公司 一种氨基葡萄糖酒及其制造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156175A (zh) * 1996-12-27 1997-08-06 中国人民解放军第三军医大学 以n-乙酰-d-氨基葡萄糖作为添加剂的保健酒

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156175A (zh) * 1996-12-27 1997-08-06 中国人民解放军第三军医大学 以n-乙酰-d-氨基葡萄糖作为添加剂的保健酒

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUANG GUANG-FU ET AL.: "The advance of polysaccharide biomedical materials chitin and chitosan", CHINESE BULLETIN OF MACROMOLECULE, no. 3, 2001, pages 43 - 49 *
LU YONG-ZHANG: "Magic chitoson", JIAN XI CHEMICAL INDUSTRY, no. 3, 1997, pages 34 - 35 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1611895A4 (fr) * 2003-03-27 2008-02-20 Univ Pla 3Rd Military Medical Utilisation de la n-acetyl-d-aminoglycosamine dans le traitement de lesions organiques associees a la toxicite de medicaments ou de produits chimiques
WO2009007660A1 (fr) 2007-07-04 2009-01-15 Mathieu Borge Compositions liquides ou pateuses destinees a l'apport en elements essentiels a la synthese et a la constitution des proteoglycanes, notamment pour le traitement de la degradation du cartilage

Also Published As

Publication number Publication date
CN1534089A (zh) 2004-10-06

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