[go: up one dir, main page]

WO2004087647A3 - 4-substituted quinolein derivatives with antimicrobial activity - Google Patents

4-substituted quinolein derivatives with antimicrobial activity Download PDF

Info

Publication number
WO2004087647A3
WO2004087647A3 PCT/FR2004/000783 FR2004000783W WO2004087647A3 WO 2004087647 A3 WO2004087647 A3 WO 2004087647A3 FR 2004000783 W FR2004000783 W FR 2004000783W WO 2004087647 A3 WO2004087647 A3 WO 2004087647A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
antimicrobial activity
ch2co2r
ch2oh
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2004/000783
Other languages
French (fr)
Other versions
WO2004087647A2 (en
Inventor
Antony Bigot
Michel Cheve
Ahmad Youssef El
Jean-Luc Malleron
Jean-Paul Martin
Serge Mignani
Guy Pantel
Baptiste Ronan
Michel Tabart
Fabrice Viviani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to CA002520764A priority Critical patent/CA2520764A1/en
Priority to YUP-2005/0806A priority patent/RS20050806A/en
Priority to EP04742385A priority patent/EP1611127A2/en
Priority to AU2004226207A priority patent/AU2004226207A1/en
Priority to JP2006505763A priority patent/JP2006522779A/en
Priority to EA200501526A priority patent/EA010403B1/en
Priority to HR20050855A priority patent/HRP20050855A2/en
Publication of WO2004087647A2 publication Critical patent/WO2004087647A2/en
Publication of WO2004087647A3 publication Critical patent/WO2004087647A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention concerns 4-substituted quinoline derivatives active as antimicrobial agents, of general formula (I), wherein: X1, X2, X3, X4 and X5 respectively represent >C-R'1 to >C-R'5, or not more than one represents N; Y represents CHR, CO, CROH, CRNH2, CRF or CF2, R being hydrogen or alkyl; m is 1, 2, or 3 and n is 0, 1 or 2; Z is CH2 or Z represents O, S, SO, SO2 and, in that case, n is equal to 2; R2 represents -CO2R, -CH2CO2R, -CH2-CH2CO2R, -CH2OH or -CH2-CH2OH, R being as defined above; R3 represents phenyl, heteroaryl or alk-R°3, wherein alk is an alkyl and R°3 represents various groups, optionally oxygenated, sulphured or aminated, in their enantiomeric or diastereoisomeric forms or mixtures thereof, and optionally in their syn or anti forms or mixtures thereof, as well as their salts.
PCT/FR2004/000783 2003-03-28 2004-03-29 4-substituted quinolein derivatives with antimicrobial activity Ceased WO2004087647A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002520764A CA2520764A1 (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives with antimicrobial activity
YUP-2005/0806A RS20050806A (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives,preparation methods and intermediates and pharmaceutical compositions compraising same
EP04742385A EP1611127A2 (en) 2003-03-28 2004-03-29 4-substitued quinolein derivatives with antimicrobial activity
AU2004226207A AU2004226207A1 (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives with antimicrobial activity
JP2006505763A JP2006522779A (en) 2003-03-28 2004-03-29 4-Substituted quinoline derivatives, methods for their preparation, intermediates and pharmaceutical compositions
EA200501526A EA010403B1 (en) 2003-03-28 2004-03-29 4-substituted quinonoline derivatives, preparation methods and intermediates and pharmaceutical composition comprising same
HR20050855A HRP20050855A2 (en) 2003-03-28 2004-03-29 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR03/03812 2003-03-28
FR0303812A FR2852954B1 (en) 2003-03-28 2003-03-28 QUINOLINE-4-SUBSTITUTED DERIVATIVES, METHODS AND PREPARATION INTERMEDIATES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
WO2004087647A2 WO2004087647A2 (en) 2004-10-14
WO2004087647A3 true WO2004087647A3 (en) 2005-01-27

Family

ID=32947235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/000783 Ceased WO2004087647A2 (en) 2003-03-28 2004-03-29 4-substituted quinolein derivatives with antimicrobial activity

Country Status (13)

Country Link
EP (1) EP1611127A2 (en)
JP (1) JP2006522779A (en)
KR (1) KR20050115321A (en)
CN (1) CN1795191A (en)
AR (1) AR043941A1 (en)
AU (1) AU2004226207A1 (en)
CA (1) CA2520764A1 (en)
EA (1) EA010403B1 (en)
FR (1) FR2852954B1 (en)
HR (1) HRP20050855A2 (en)
RS (1) RS20050806A (en)
TW (1) TW200505899A (en)
WO (1) WO2004087647A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618959B2 (en) 2002-11-05 2009-11-17 Smithklinebeecham Corp Antibacterial agents

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (en) * 2000-11-15 2002-12-27 Aventis Pharma Sa HETEROCYCLYLALCOYL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
AR040335A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd CYCLLOHEXAN OR CYCLHEXENE COMPOUND, USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE AND INTERMEDIATE COMPOUNDS OF UTILITY TO PREPARE SUCH COMPOUND
AR040336A1 (en) 2002-06-26 2005-03-30 Glaxo Group Ltd PIPERIDINE COMPOUND, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND PROCEDURE TO PREPARE SUCH COMPOUND
JP4704755B2 (en) 2002-11-05 2011-06-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Antibacterial agent
AU2003294565A1 (en) 2002-12-04 2004-06-23 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
GB0326148D0 (en) * 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
US7691850B2 (en) 2004-06-15 2010-04-06 Glaxo Group Limited Antibacterial agents
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
JP2009532423A (en) 2006-04-06 2009-09-10 グラクソ グループ リミテッド Pyrrolo-quinoxalinone derivatives as antibacterial agents
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
JP5404652B2 (en) * 2008-02-22 2014-02-05 アクテリオン ファーマシューティカルズ リミテッド Oxazolidinone derivatives
JP2012505866A (en) 2008-10-17 2012-03-08 グラクソ グループ リミテッド Tricyclic nitrogen compounds used as antibacterial agents
WO2010081874A1 (en) 2009-01-15 2010-07-22 Glaxo Group Limited Naphthyridin-2 (1 h)-one compounds useful as antibacterials
AR089929A1 (en) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd PROCESS TO MANUFACTURE A NAFTIRIDINE DERIVATIVE
AU2015304847B2 (en) 2014-08-22 2018-10-25 Glaxosmithkline Intellectual Property Development Limited Tricyclic nitrogen containing compounds for treating Neisseria gonorrhoea infection
UY36851A (en) 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007432A2 (en) * 1999-07-23 2001-02-01 Smithkline Beecham P.L.C. Aminopiperidine derivatives as antibacterials
FR2816618A1 (en) * 2000-11-15 2002-05-17 Aventis Pharma Sa New 4-(quinolin-4-yl-alkyl)-piperidine derivatives, are low toxicity antimicrobial agents effective against Gram positive and Gram negative bacterial infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
EP1355901A2 (en) * 2001-01-11 2003-10-29 Bristol-Myers Squibb Pharma Company 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007432A2 (en) * 1999-07-23 2001-02-01 Smithkline Beecham P.L.C. Aminopiperidine derivatives as antibacterials
FR2816618A1 (en) * 2000-11-15 2002-05-17 Aventis Pharma Sa New 4-(quinolin-4-yl-alkyl)-piperidine derivatives, are low toxicity antimicrobial agents effective against Gram positive and Gram negative bacterial infections

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618959B2 (en) 2002-11-05 2009-11-17 Smithklinebeecham Corp Antibacterial agents

Also Published As

Publication number Publication date
KR20050115321A (en) 2005-12-07
FR2852954A1 (en) 2004-10-01
AR043941A1 (en) 2005-08-17
AU2004226207A1 (en) 2004-10-14
RS20050806A (en) 2007-12-31
CN1795191A (en) 2006-06-28
FR2852954B1 (en) 2006-07-14
HRP20050855A2 (en) 2005-12-31
WO2004087647A2 (en) 2004-10-14
TW200505899A (en) 2005-02-16
CA2520764A1 (en) 2004-10-14
EA200501526A1 (en) 2006-04-28
EP1611127A2 (en) 2006-01-04
EA010403B1 (en) 2008-08-29
JP2006522779A (en) 2006-10-05

Similar Documents

Publication Publication Date Title
WO2004087647A3 (en) 4-substituted quinolein derivatives with antimicrobial activity
MY150630A (en) Amide derivative and insecticide containing the same
YU62803A (en) Isoxazoline derivative and herbicide comprising the same as active ingredient
TW200621156A (en) Fungicidal composition containing acid amide derivative
MXPA04005802A (en) Substituted phenyl derivatives.
EP1953154A4 (en) Morpholine type cinnamide compound
DK1613304T3 (en) DPP-IV inhibitors
MY140171A (en) Amino-1,3,5-triazines n-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators
MX2007012090A (en) Substituted pyrazolyl oxyphenyl derivatives used as herbicides.
DK1533304T3 (en) amide derivative
DE60228316D1 (en) Xanthinoxidaseinhibitoren
TW200744994A (en) Insecticidal 3-acylaminobenzanilides
WO2005016916A3 (en) Substituted quinolines serving as antimicrobial agents
FR2854160B1 (en) NOVEL HETEROCYCLIC DERIVATIVES OF 2-OXOTHIAZOLIDINE4-CARBOXYLIC ACID, USE AS ACTIVE PHOTOPROTECTION AGENT
DK0790248T3 (en) 3-Aza-piperidone (tetrahydropyrimidin-2-one) and 3-oxa-piperidone (1,3-oxazin-2-one) derivatives, their preparation and their use as tachykinin / neurokinin antagonists
WO2003068744A1 (en) Pyridine derivatives or salts thereof and cytokine production inhibitors containing the same
MY136297A (en) Piperazine derivatives having sst1 antagonistic activity
WO2005009965A8 (en) Nicotinamide derivatives useful as pde4 inhibitors
NO20060963L (en) Nicotinamide derivatives useful as PDE4 inhibitors
WO2001066527A8 (en) Substituted benzoylcyclohexenones
WO2007003603A3 (en) Fungicide mixtures based on 3-monosubstituted pyrazole carboxylic acid biphenyl amides
DE50303599D1 (en) 3-HETEROCYCLYL-SUBSTITUTED BENZOIC ACID DERIVATIVES
DE60108089D1 (en) HETEROCYCLIC OR BENZOL DERIVATIVES OF LIPONIC ACID, THEIR PREPARATION AND THEIR USE AS CEREALS
WO2001060822A8 (en) Amino acid derivatives and use thereof as nep, ace and ece inhibitors
EA200602045A1 (en) 2-substituted pyrimidines

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: P-2005/0806

Country of ref document: YU

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 170828

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2004742385

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006505763

Country of ref document: JP

Ref document number: P20050855A

Country of ref document: HR

WWE Wipo information: entry into national phase

Ref document number: 2520764

Country of ref document: CA

Ref document number: 1020057018388

Country of ref document: KR

Ref document number: 4385/DELNP/2005

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2004226207

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 200501526

Country of ref document: EA

ENP Entry into the national phase

Ref document number: 2004226207

Country of ref document: AU

Date of ref document: 20040329

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004226207

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 20048145109

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 1020057018388

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004742385

Country of ref document: EP