WO2004078178B1 - Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol use - Google Patents
Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol useInfo
- Publication number
- WO2004078178B1 WO2004078178B1 PCT/SE2004/000293 SE2004000293W WO2004078178B1 WO 2004078178 B1 WO2004078178 B1 WO 2004078178B1 SE 2004000293 W SE2004000293 W SE 2004000293W WO 2004078178 B1 WO2004078178 B1 WO 2004078178B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbon atoms
- alkenyl
- alkyl
- hydrogen
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to use of a buprenorphine compound or a pharmaceutical ac-ceptable salt or ester thereof for the preparation of a pharmaceutical composition for preventing or treating alcohol dependence and excessive alcohol use. It also concerns the use of a buprenorphine compound together with an opiate receptor antagonist and a method for treating or preventing of alcohol dependence and excessive alcohol use.
Claims
1. Use of a composition comprising a compound of the formula I:
and its non-toxic pharmaceutically-acceptable salts, wherein:
R is hydrogen or methyl,
Rl is hydrogen, alkyl, alkenyl or alkynyl of up to 8 carbon atoms or cycloalkyl methyl of 4-6 carbon atoms,
R2 is hydrogen, alkyl or alkenyl of up to 3 carbon atoms, phenyl or tolyl and
R3 is cycloalkyl of 5-7 carbon atoms, alkyl or alkenyl of up to 8 carbon atoms or alkyl or alkenyl of up to 8 carbon atoms substituted on one of the carbon atoms numbered 1-
4 (the carbon atom numbered 1 being adjacent to the carbon atom bearing the alcoholic hydroxy group) by cycloalkyl of 5-7 carbon atoms, phenyl, tolyl, alkoxy of
1-3 carbon atoms, phenoxy or tetrahydrofuryl or a pharmaceutical acceptable salt or ester thereof and an opiate receptor antagonist for the preparation of a pharmaceutical composition for preventing or treating alcohol dependence and excessive alcohol use.
2. Use of a composition according to claim 1, wherein the compound of formula I is buprehorphine.
3. Use according to any of claims 1-2, wherein the pharmaceutical composition further comprises a pharmaceutical acceptable carrier or excipient.
4. Use according to any of claims 1-3, wherein the opiate receptor antagonists is naltrexone.
5. A method for preventing or treating alcohol dependence or excessive alcohol use comprising identifying an individual at risk for developing or an invdividual suffering from alcohol dependence or excessive alcohol use and administering a pharmaceutically effective amount of a compound of the formula I:
R is hydrogen or methyl,
Rl is hydrogen, alkyl, alkenyl or alkynyl of up to 8 carbon atoms or cycloalkyl methyl of 4-6 carbon atoms,
R2 is hydrogen, alkyl or alkenyl of up to 3 carbon atoms, phenyl or tolyl and
R3 is cycloalkyl of 5-7 carbon atoms, alkyl or alkenyl of up to 8 carbon atoms or alkyl or alkenyl of up to 8 carbon atoms substituted on one of the carbon atoms numbered 1-
4 (the carbon atom numbered 1 being adjacent to the carbon atom bearing the alcoholic hydroxy group) by cycloalkyl of 5-7 carbon atoms, phenyl, tolyl, alkoxy of
1-3 carbon atoms, phenoxy or tetrahydrofuryl or a pharmaceutical acceptable salt or ester thereof and of an opiate receptor antagonist.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31998803P | 2003-03-03 | 2003-03-03 | |
| US60/319,988 | 2003-03-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004078178A1 WO2004078178A1 (en) | 2004-09-16 |
| WO2004078178B1 true WO2004078178B1 (en) | 2005-01-27 |
Family
ID=32961189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/SE2004/000293 Ceased WO2004078178A1 (en) | 2003-03-03 | 2004-03-03 | Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol use |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2004078178A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7511054B2 (en) | 2006-09-22 | 2009-03-31 | Alltranz Inc. | Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs |
| GB201111775D0 (en) | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4882335A (en) * | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
| AU765496C (en) * | 1999-08-27 | 2005-08-25 | Brookwood Pharmaceuticals Inc. | Injectable buprenorphine microparticle compositions and their use |
-
2004
- 2004-03-03 WO PCT/SE2004/000293 patent/WO2004078178A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004078178A1 (en) | 2004-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
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|
| AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
| B | Later publication of amended claims |
Effective date: 20040811 |
|
| 122 | Ep: pct application non-entry in european phase |