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WO2004071389A3 - Non-steroidal infalmmation inhibitors - Google Patents

Non-steroidal infalmmation inhibitors Download PDF

Info

Publication number
WO2004071389A3
WO2004071389A3 PCT/EP2004/001507 EP2004001507W WO2004071389A3 WO 2004071389 A3 WO2004071389 A3 WO 2004071389A3 EP 2004001507 W EP2004001507 W EP 2004001507W WO 2004071389 A3 WO2004071389 A3 WO 2004071389A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
represents hydrogen
nr8cor9
conr8r9
coor7
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/001507
Other languages
French (fr)
Other versions
WO2004071389A2 (en
Inventor
Michael David Barker
Derek Anthony Demaine
David House
Graham George Adam Inglis
Michael John Johnston
Haydn Terence Jones
Simon John Fawcett Macdonald
Iain Mcfarlane Mclay
Stephen Shanahan
Philip Alan Skone
Maria Victoria Vinader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0303523A external-priority patent/GB0303523D0/en
Priority claimed from GB0305717A external-priority patent/GB0305717D0/en
Priority claimed from GB0305721A external-priority patent/GB0305721D0/en
Priority claimed from GB0316865A external-priority patent/GB0316865D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of WO2004071389A2 publication Critical patent/WO2004071389A2/en
Publication of WO2004071389A3 publication Critical patent/WO2004071389A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of formula (I) wherein: n represents an integer 0, 1 or 2; X represents, O, S, NR6a, or CHR6b; R1 represents hydrogen, halogen such as F, Cl or Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7 or CONR8R9; R2 represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7 or CONR8R9; R3 represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7, CONR8R9; R4 represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR8R9 such as NH2, NR8COR9 such as -NHCHO or -NHCOCH3, COOR7 or CONR8R9; R5 represents H, C1-6 alkyl, or C1-6 alkenyl; R6a represents hydrogen, C1-6 alkyl, CO2C1-3 alkyl, COC1-3 alkyl or SO2C1-3 alkyl; R6b represents hydrogen, or C1-6 alkyl; R7 represents hydrogen, C1-6 alkyl, C1-3 alkyleneSiC1-3 alkyl such as -CH2CH2Si(CH3)3; R8 and R9 independently represent hydrogen or C1-6 alkyl; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.
PCT/EP2004/001507 2003-02-15 2004-02-13 Non-steroidal infalmmation inhibitors Ceased WO2004071389A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0303523A GB0303523D0 (en) 2003-02-15 2003-02-15 Compounds
GB0303523.5 2003-02-15
GB0305721.3 2003-03-13
GB0305717A GB0305717D0 (en) 2003-03-13 2003-03-13 Compounds
GB0305717.1 2003-03-13
GB0305721A GB0305721D0 (en) 2003-03-13 2003-03-13 Compounds
GB0316865.5 2003-07-18
GB0316865A GB0316865D0 (en) 2003-07-18 2003-07-18 Compounds

Publications (2)

Publication Number Publication Date
WO2004071389A2 WO2004071389A2 (en) 2004-08-26
WO2004071389A3 true WO2004071389A3 (en) 2004-12-02

Family

ID=32872852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001507 Ceased WO2004071389A2 (en) 2003-02-15 2004-02-13 Non-steroidal infalmmation inhibitors

Country Status (1)

Country Link
WO (1) WO2004071389A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60318188T2 (en) 2002-03-26 2008-12-11 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield GLUCOCORTICOID MIMETICS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USE
UY28526A1 (en) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
WO2006000398A1 (en) * 2004-06-28 2006-01-05 Glaxo Group Limited 2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators
GB0418045D0 (en) 2004-08-12 2004-09-15 Glaxo Group Ltd Compounds
EP1836166B1 (en) * 2004-12-27 2009-06-17 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB0513297D0 (en) * 2005-06-29 2005-08-03 Glaxo Group Ltd Novel compounds
GB0611587D0 (en) * 2006-06-12 2006-07-19 Glaxo Group Ltd Novel compounds
WO2008000777A2 (en) * 2006-06-29 2008-01-03 Glaxo Group Limited Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use
KR20090097908A (en) 2006-12-06 2009-09-16 베링거 인겔하임 인터내셔날 게엠베하 Glucocorticoid mimetics, methods of preparation thereof, pharmaceutical compositions and uses thereof
JP2010513394A (en) * 2006-12-20 2010-04-30 グラクソ グループ リミテッド Pyrazole derivatives as non-steroidal glucocorticoid receptor ligands
EP2300472B1 (en) 2008-06-06 2012-01-18 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US9382245B2 (en) 2013-10-11 2016-07-05 Yale University Compounds and methods for treating HIV infections
CA3209170A1 (en) * 2021-03-23 2022-09-29 Eli Lilly And Company Glucocorticoid receptor agonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032584A2 (en) * 1998-11-27 2000-06-08 Schering Aktiengesellschaft Nonsteroidal antiinflammatories
WO2002010143A1 (en) * 2000-07-28 2002-02-07 Schering Aktiengesellschaft Non-steroidal inflammation inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032584A2 (en) * 1998-11-27 2000-06-08 Schering Aktiengesellschaft Nonsteroidal antiinflammatories
WO2002010143A1 (en) * 2000-07-28 2002-02-07 Schering Aktiengesellschaft Non-steroidal inflammation inhibitors

Also Published As

Publication number Publication date
WO2004071389A2 (en) 2004-08-26

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