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WO2004070051A3 - Protéomique chimique - Google Patents

Protéomique chimique Download PDF

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Publication number
WO2004070051A3
WO2004070051A3 PCT/US2003/003320 US0303320W WO2004070051A3 WO 2004070051 A3 WO2004070051 A3 WO 2004070051A3 US 0303320 W US0303320 W US 0303320W WO 2004070051 A3 WO2004070051 A3 WO 2004070051A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
drugs
drug candidates
new
technology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/003320
Other languages
English (en)
Other versions
WO2004070051A2 (fr
Inventor
Shane Climie
Leroi Victor Desouza
Henry S Duewel
Christopher Mark Hosfield
Linda Chiou-Lin Liao
Linda D B Mcbroom
Irving Sucholeiki
Leticia M Toledo-Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MDS Proteomics Inc
Original Assignee
MDS Proteomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MDS Proteomics Inc filed Critical MDS Proteomics Inc
Priority to AU2003214993A priority Critical patent/AU2003214993A1/en
Priority to PCT/US2003/003320 priority patent/WO2004070051A2/fr
Publication of WO2004070051A2 publication Critical patent/WO2004070051A2/fr
Publication of WO2004070051A3 publication Critical patent/WO2004070051A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

L'invention concerne des méthodes et des réactifs permettant d'identifier ou d'isoler des protéines cibles de composés chimiques (par exemple, médicaments-candidats) au moyen de la spectrométrie de masse. L'invention concerne une méthode permettant de piéger et d'identifier des protéines au moyen de sondes fixées à de petites molécules. Cette technique permet d'étendre le marché de médicaments connus grâce à la découverte de nouvelles cibles thérapeutiques; d'identifier le mécanisme de toxicité de candidats thérapeutiques ou de médicaments ayant échoué en phase clinique; d'identifier de nouveaux outils chimiques pour la validation de cibles par des moyens chimiques; d'identifier de nouvelles pistes thérapeutiques; et d'identifier le mécanisme d'action de médicaments et de candidats thérapeutiques. Un avantage clé de cette technique consiste en ce qu'elle permet d'identifier en une seule expérimentation de nombreuses protéines interagissant avec une sonde (ou 'appât').
PCT/US2003/003320 2003-02-03 2003-02-03 Protéomique chimique Ceased WO2004070051A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003214993A AU2003214993A1 (en) 2003-02-03 2003-02-03 Chemical proteomics
PCT/US2003/003320 WO2004070051A2 (fr) 2003-02-03 2003-02-03 Protéomique chimique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/003320 WO2004070051A2 (fr) 2003-02-03 2003-02-03 Protéomique chimique

Publications (2)

Publication Number Publication Date
WO2004070051A2 WO2004070051A2 (fr) 2004-08-19
WO2004070051A3 true WO2004070051A3 (fr) 2005-02-24

Family

ID=32848674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003320 Ceased WO2004070051A2 (fr) 2003-02-03 2003-02-03 Protéomique chimique

Country Status (2)

Country Link
AU (1) AU2003214993A1 (fr)
WO (1) WO2004070051A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7391020B2 (en) 2004-09-21 2008-06-24 Luc Bousse Electrospray apparatus with an integrated electrode

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US7105810B2 (en) 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
US7007710B2 (en) 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US7591883B2 (en) 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
CN110658314B (zh) * 2019-10-12 2021-06-29 四川大学 化合物的靶点的鉴定方法、化合物与靶标相互作用的检测方法和化合物药效的评价方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5780307A (en) * 1988-12-02 1998-07-14 Soldin; Steven J. Immunosuppressive drug binding proteins and use
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780307A (en) * 1988-12-02 1998-07-14 Soldin; Steven J. Immunosuppressive drug binding proteins and use
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7391020B2 (en) 2004-09-21 2008-06-24 Luc Bousse Electrospray apparatus with an integrated electrode

Also Published As

Publication number Publication date
AU2003214993A1 (en) 2004-08-30
AU2003214993A8 (en) 2004-08-30
WO2004070051A2 (fr) 2004-08-19

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