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WO2004070051A3 - Chemical proteomics - Google Patents

Chemical proteomics Download PDF

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Publication number
WO2004070051A3
WO2004070051A3 PCT/US2003/003320 US0303320W WO2004070051A3 WO 2004070051 A3 WO2004070051 A3 WO 2004070051A3 US 0303320 W US0303320 W US 0303320W WO 2004070051 A3 WO2004070051 A3 WO 2004070051A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
drugs
drug candidates
new
technology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/003320
Other languages
French (fr)
Other versions
WO2004070051A2 (en
Inventor
Shane Climie
Leroi Victor Desouza
Henry S Duewel
Christopher Mark Hosfield
Linda Chiou-Lin Liao
Linda D B Mcbroom
Irving Sucholeiki
Leticia M Toledo-Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MDS Proteomics Inc
Original Assignee
MDS Proteomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MDS Proteomics Inc filed Critical MDS Proteomics Inc
Priority to AU2003214993A priority Critical patent/AU2003214993A1/en
Priority to PCT/US2003/003320 priority patent/WO2004070051A2/en
Publication of WO2004070051A2 publication Critical patent/WO2004070051A2/en
Publication of WO2004070051A3 publication Critical patent/WO2004070051A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or 'bait').
PCT/US2003/003320 2003-02-03 2003-02-03 Chemical proteomics Ceased WO2004070051A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003214993A AU2003214993A1 (en) 2003-02-03 2003-02-03 Chemical proteomics
PCT/US2003/003320 WO2004070051A2 (en) 2003-02-03 2003-02-03 Chemical proteomics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/003320 WO2004070051A2 (en) 2003-02-03 2003-02-03 Chemical proteomics

Publications (2)

Publication Number Publication Date
WO2004070051A2 WO2004070051A2 (en) 2004-08-19
WO2004070051A3 true WO2004070051A3 (en) 2005-02-24

Family

ID=32848674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003320 Ceased WO2004070051A2 (en) 2003-02-03 2003-02-03 Chemical proteomics

Country Status (2)

Country Link
AU (1) AU2003214993A1 (en)
WO (1) WO2004070051A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7391020B2 (en) 2004-09-21 2008-06-24 Luc Bousse Electrospray apparatus with an integrated electrode

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US7105810B2 (en) 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
US7007710B2 (en) 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US7591883B2 (en) 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
CN110658314B (en) * 2019-10-12 2021-06-29 四川大学 Method for identifying the target of the compound, method for detecting the interaction between the compound and the target, and method for evaluating the efficacy of the compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5780307A (en) * 1988-12-02 1998-07-14 Soldin; Steven J. Immunosuppressive drug binding proteins and use
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780307A (en) * 1988-12-02 1998-07-14 Soldin; Steven J. Immunosuppressive drug binding proteins and use
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6197599B1 (en) * 1998-07-30 2001-03-06 Guorong Chin Method to detect proteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7391020B2 (en) 2004-09-21 2008-06-24 Luc Bousse Electrospray apparatus with an integrated electrode

Also Published As

Publication number Publication date
AU2003214993A1 (en) 2004-08-30
AU2003214993A8 (en) 2004-08-30
WO2004070051A2 (en) 2004-08-19

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