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WO2004069983A3 - Architecture de microréacteur et procédés associés - Google Patents

Architecture de microréacteur et procédés associés Download PDF

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Publication number
WO2004069983A3
WO2004069983A3 PCT/US2003/025943 US0325943W WO2004069983A3 WO 2004069983 A3 WO2004069983 A3 WO 2004069983A3 US 0325943 W US0325943 W US 0325943W WO 2004069983 A3 WO2004069983 A3 WO 2004069983A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
reaction
chip
chips
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/025943
Other languages
English (en)
Other versions
WO2004069983A2 (fr
WO2004069983A9 (fr
Inventor
Seth T Rodgers
Peter A Russo
Howard B Schreyer
Sean J Leblanc
Andrey J Zarur
Xinyu Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprocessors Corp
Original Assignee
Bioprocessors Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/457,049 external-priority patent/US20040058437A1/en
Priority claimed from US10/457,015 external-priority patent/US20040058407A1/en
Priority to JP2005515706A priority Critical patent/JP2006521786A/ja
Application filed by Bioprocessors Corp filed Critical Bioprocessors Corp
Priority to CA002496017A priority patent/CA2496017A1/fr
Priority to EP03815293A priority patent/EP1567637A2/fr
Priority to AU2003303303A priority patent/AU2003303303A1/en
Priority to US10/664,067 priority patent/US20050032204A1/en
Publication of WO2004069983A2 publication Critical patent/WO2004069983A2/fr
Publication of WO2004069983A9 publication Critical patent/WO2004069983A9/fr
Anticipated expiration legal-status Critical
Publication of WO2004069983A3 publication Critical patent/WO2004069983A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne, dans son ensemble, des puces de réaction chimique, biologique et/ou biochimique et d'autres systèmes de réaction tels que des systèmes de microréacteur, ainsi que des systèmes et des procédés pour réaliser et utiliser de tels dispositifs. Dans un mode de réalisation, une puce ou un autre système de réaction sont conçus pour favoriser la croissance cellulaire à l'intérieur de ceux-ci. Dans certains modes de réalisation, les puces ou les autres systèmes de réaction comportent un ou plusieurs sites de réaction, lesquels peuvent être très petits, par exemple, avoir un volume inférieur à environ 1 ml. Dans un autre mode de réalisation, la puce peut détecter, mesurer et/ou contrôler un facteur environnemental, tel que température, pression, concentration de CO2, concentration de O2, humidité relative, pH, etc., associé à un ou plusieurs sites de réaction, au moyen d'un ou de plusieurs capteurs, actionneurs processeurs et/ou systèmes de contrôle. La présente invention porte également sur des matériaux et des systèmes dotés de contrôle d'humidité et/ou de gaz pour, par exemple, être utilisés avec une puce, ces matériaux pouvant présenter une grande perméabilité à l'oxygène et/ou une faible perméabilité à la vapeur d'eau. Cette invention porte aussi, dans son ensemble, à des composants interagissant avec la lumière et pouvant être utilisés dans des puces et d'autres systèmes de réaction. Ces composants peuvent comprendre des guides d'ondes, des fibres optiques, des sources de lumière, des photodétecteurs, des éléments optiques, etc.
PCT/US2003/025943 2001-04-10 2003-08-19 Architecture de microréacteur et procédés associés Ceased WO2004069983A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003303303A AU2003303303A1 (en) 2002-08-19 2003-08-19 Microreactor architecture and methods
EP03815293A EP1567637A2 (fr) 2002-08-19 2003-08-19 Architecture de micror acteur et procedes associes
JP2005515706A JP2006521786A (ja) 2002-08-19 2003-08-19 マイクロリアクター構造および方法
CA002496017A CA2496017A1 (fr) 2002-08-19 2003-08-19 Architecture de microreacteur et procedes associes
US10/664,067 US20050032204A1 (en) 2001-04-10 2003-09-16 Microreactor architecture and methods

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US22356202A 2002-08-19 2002-08-19
US10/223,562 2002-08-19
US40927302P 2002-09-09 2002-09-09
US60/409,273 2002-09-09
US45693403A 2003-06-05 2003-06-05
US45704803A 2003-06-05 2003-06-05
US45613303A 2003-06-05 2003-06-05
US10/457,015 2003-06-05
US10/457,049 US20040058437A1 (en) 2001-04-10 2003-06-05 Materials and reactor systems having humidity and gas control
US10/456,133 2003-06-05
US10/457,048 2003-06-05
US10/457,015 US20040058407A1 (en) 2001-04-10 2003-06-05 Reactor systems having a light-interacting component
US10/456,934 2003-06-05
US10/457,049 2003-06-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/664,067 Continuation US20050032204A1 (en) 2001-04-10 2003-09-16 Microreactor architecture and methods

Publications (3)

Publication Number Publication Date
WO2004069983A2 WO2004069983A2 (fr) 2004-08-19
WO2004069983A9 WO2004069983A9 (fr) 2005-02-03
WO2004069983A3 true WO2004069983A3 (fr) 2005-07-14

Family

ID=31892403

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/025956 Ceased WO2004016727A1 (fr) 2001-04-10 2003-08-19 Determination et/ou regulation de conditions environnementales d'un reacteur
PCT/US2003/025943 Ceased WO2004069983A2 (fr) 2001-04-10 2003-08-19 Architecture de microréacteur et procédés associés
PCT/US2003/025907 Ceased WO2004016729A2 (fr) 2002-04-10 2003-08-19 Systemes et procedes permettant de reguler le ph ainsi que d'autres conditions environnementales de reaction

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025956 Ceased WO2004016727A1 (fr) 2001-04-10 2003-08-19 Determination et/ou regulation de conditions environnementales d'un reacteur

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025907 Ceased WO2004016729A2 (fr) 2002-04-10 2003-08-19 Systemes et procedes permettant de reguler le ph ainsi que d'autres conditions environnementales de reaction

Country Status (5)

Country Link
EP (2) EP1567637A2 (fr)
JP (2) JP2006521786A (fr)
AU (3) AU2003303303A1 (fr)
CA (2) CA2496017A1 (fr)
WO (3) WO2004016727A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8679422B2 (en) 2004-12-03 2014-03-25 Cytonome/St, Llc Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US11027278B2 (en) 2002-04-17 2021-06-08 Cytonome/St, Llc Methods for controlling fluid flow in a microfluidic system

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
GB0210809D0 (en) * 2002-05-11 2002-06-19 Univ Durham Reactor
WO2007021762A2 (fr) 2005-08-09 2007-02-22 The University Of North Carolina At Chapel Hill Procedes et materiaux permettant de fabriquer des dispositifs microfluidiques
JP4664646B2 (ja) * 2004-10-20 2011-04-06 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞培養用マイクロチャンバーおよび細胞構造構築法
JP2008519598A (ja) * 2004-11-11 2008-06-12 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 細胞培養デバイス
DE102005004075B4 (de) * 2005-01-28 2008-04-03 Umicore Ag & Co. Kg Keramischer Mikroreaktor
DE102006030068A1 (de) 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
AU2007338862B2 (en) 2006-07-19 2014-02-06 Bionano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
US7811359B2 (en) 2007-01-18 2010-10-12 General Electric Company Composite membrane for separation of carbon dioxide
JP2008194029A (ja) * 2007-01-19 2008-08-28 Tosoh Corp 細胞融合装置及びそれを用いた細胞融合方法
CA2964611C (fr) 2007-03-28 2021-06-01 Bionano Genomics, Inc. Procedes d'analyse macromoleculaire utilisant des reseaux de nanocanaux
JP4963437B2 (ja) * 2007-03-30 2012-06-27 京セラ株式会社 流路体、配線基板、流路形成配線基板、流路形成方法、流路体の製造方法、ならびに流路体キット
US8389277B2 (en) 2007-10-11 2013-03-05 Agency For Science, Technology And Research Forming cell structure with transient linker in cage
EP2285950A1 (fr) * 2008-06-13 2011-02-23 FOSS Analytical A/S Procédé de contrôle de procédés biotechnologiques
WO2010002883A2 (fr) 2008-06-30 2010-01-07 Bionanomatrix, Inc. Procédés et dispositif pour analyse mono-moléculaire de génome entier
AU2009316628B2 (en) 2008-11-18 2016-06-16 Bionano Genomics, Inc. Polynucleotide mapping and sequencing
DE102014214077A1 (de) * 2014-07-18 2016-01-21 Hamilton Bonaduz Ag Laborbehälter, insbesondere Zellkulturbehälter, mit einer in das Behältervolumen hinein verlaufenden Gas-Ausgleichsleitung
SG11201706009PA (en) 2015-01-26 2017-08-30 Ube Industries Long-term cell-cultivation using polyimide porous membrane and cell-cryopreservation method using polyimide porous membrane
NL2020612B1 (en) 2017-12-22 2019-07-02 Illumina Inc Light detection devices with protective liner and methods of manufacturing same
CN109799012B (zh) * 2019-01-23 2021-01-22 河南工程学院 一种基于纤维素的类三明治结构压力传感器及其制备方法
JP7491136B2 (ja) * 2020-08-20 2024-05-28 大日本印刷株式会社 マイクロ流路構造体、マイクロ流路構造体の製造方法及びマイクロ流路デバイス
WO2023057602A1 (fr) * 2021-10-08 2023-04-13 Philip Morris Products S.A. Détection d'agents bioactifs dans un milieu environnant

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US6245295B1 (en) * 1995-05-31 2001-06-12 Bio Merieux, Inc. Sample testing apparatus with high oxygen permeable tape providing barrier for closed reaction chamber
WO2001092462A1 (fr) * 1999-05-28 2001-12-06 Ashby Scientific Ltd. Enceinte de culture
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EP1221617A2 (fr) * 2000-12-29 2002-07-10 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Essais biologiques
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
EP1226871A2 (fr) * 2001-01-24 2002-07-31 Ebara Corporation Sonde-puce réactive et syteme de detection reactif
WO2002100542A1 (fr) * 2001-06-08 2002-12-19 Centre National De La Recherche Scientifique Procede de fabrication d'une structure microfluidique, en particulier une puce a adn et structure obtenue par ledit procede

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US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6245295B1 (en) * 1995-05-31 2001-06-12 Bio Merieux, Inc. Sample testing apparatus with high oxygen permeable tape providing barrier for closed reaction chamber
WO2001092462A1 (fr) * 1999-05-28 2001-12-06 Ashby Scientific Ltd. Enceinte de culture
US20020055166A1 (en) * 2000-10-02 2002-05-09 Cannon Thomas F. Automated bioculture and bioculture experiments system
EP1221617A2 (fr) * 2000-12-29 2002-07-10 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Essais biologiques
EP1226871A2 (fr) * 2001-01-24 2002-07-31 Ebara Corporation Sonde-puce réactive et syteme de detection reactif
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
WO2002100542A1 (fr) * 2001-06-08 2002-12-19 Centre National De La Recherche Scientifique Procede de fabrication d'une structure microfluidique, en particulier une puce a adn et structure obtenue par ledit procede

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Title
See also references of EP1567637A2 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11027278B2 (en) 2002-04-17 2021-06-08 Cytonome/St, Llc Methods for controlling fluid flow in a microfluidic system
US8679422B2 (en) 2004-12-03 2014-03-25 Cytonome/St, Llc Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US9823252B2 (en) 2004-12-03 2017-11-21 Cytonome/St, Llc Unitary cartridge for particle processing
US10065188B2 (en) 2004-12-03 2018-09-04 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US10222378B2 (en) 2004-12-03 2019-03-05 Cytonome/St, Llc Unitary cartridge for particle processing
US10794913B2 (en) 2004-12-03 2020-10-06 Cytonome/St, Llc Unitary cartridge for particle processing
US10994273B2 (en) 2004-12-03 2021-05-04 Cytonome/St, Llc Actuation of parallel microfluidic arrays

Also Published As

Publication number Publication date
WO2004016727A1 (fr) 2004-02-26
EP1530626A1 (fr) 2005-05-18
JP2006521786A (ja) 2006-09-28
CA2496017A1 (fr) 2004-08-19
WO2004016729A3 (fr) 2005-06-30
JP2005536233A (ja) 2005-12-02
AU2003265491A1 (en) 2004-03-03
CA2495617A1 (fr) 2004-02-26
AU2003303303A1 (en) 2004-08-30
WO2004016729A2 (fr) 2004-02-26
WO2004016727A9 (fr) 2004-05-27
EP1567637A2 (fr) 2005-08-31
AU2003265491A8 (en) 2004-03-03
AU2003272223A1 (en) 2004-03-03
WO2004069983A2 (fr) 2004-08-19
WO2004069983A9 (fr) 2005-02-03
WO2004016727B1 (fr) 2004-07-08

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