[go: up one dir, main page]

WO2004058948A3 - In vivo methods for validating the role of a tumor maintenance gene - Google Patents

In vivo methods for validating the role of a tumor maintenance gene Download PDF

Info

Publication number
WO2004058948A3
WO2004058948A3 PCT/US2003/041358 US0341358W WO2004058948A3 WO 2004058948 A3 WO2004058948 A3 WO 2004058948A3 US 0341358 W US0341358 W US 0341358W WO 2004058948 A3 WO2004058948 A3 WO 2004058948A3
Authority
WO
WIPO (PCT)
Prior art keywords
validating
role
vivo methods
tumor maintenance
maintenance gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/041358
Other languages
French (fr)
Other versions
WO2004058948A2 (en
Inventor
Ronan C O'hagan
Joerg Heyer
William Rideout
Anna Pavlova
Steven C Clark
Ronald Depinho
Tyler Jacks
Murray O Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aveo Pharmaceuticals Inc
Original Assignee
Genpath Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genpath Pharmaceuticals Inc filed Critical Genpath Pharmaceuticals Inc
Priority to AU2003300394A priority Critical patent/AU2003300394A1/en
Publication of WO2004058948A2 publication Critical patent/WO2004058948A2/en
Publication of WO2004058948A3 publication Critical patent/WO2004058948A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Methods of validating tumor maintenance functions of a candidate gene in a de novo cancer model and methods of establishing therapeutic windows of therapies targeting this gene.
PCT/US2003/041358 2002-12-24 2003-12-23 In vivo methods for validating the role of a tumor maintenance gene Ceased WO2004058948A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003300394A AU2003300394A1 (en) 2002-12-24 2003-12-23 In vivo methods for validating the role of a tumor maintenance gene

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43649902P 2002-12-24 2002-12-24
US60/436,499 2002-12-24
US45480203P 2003-03-12 2003-03-12
US60/454,802 2003-03-12

Publications (2)

Publication Number Publication Date
WO2004058948A2 WO2004058948A2 (en) 2004-07-15
WO2004058948A3 true WO2004058948A3 (en) 2004-10-14

Family

ID=32685458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041358 Ceased WO2004058948A2 (en) 2002-12-24 2003-12-23 In vivo methods for validating the role of a tumor maintenance gene

Country Status (2)

Country Link
AU (1) AU2003300394A1 (en)
WO (1) WO2004058948A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060222590A1 (en) * 2005-04-05 2006-10-05 Murray Robinson Directed complementation
WO2009006450A1 (en) * 2007-06-29 2009-01-08 Boston Biomedical, Inc. Bacteria-mediated gene modulation via microrna machinery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053050A1 (en) * 1998-04-08 1999-10-21 Commonwealth Scientific And Industrial Research Organisation Methods and means for obtaining modified phenotypes
WO2001029058A1 (en) * 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053050A1 (en) * 1998-04-08 1999-10-21 Commonwealth Scientific And Industrial Research Organisation Methods and means for obtaining modified phenotypes
WO2001029058A1 (en) * 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARTS ET AL: "Adenoviral Vectors Expressing siRNAs for Discovery and Validation of Gene Function", GENOME RESEARCH, vol. 13, October 2003 (2003-10-01), pages 2325 - 2332, XP002977775 *
KUMAR R. ET AL: "High-throughput selection of effective RNAi probes for gene silencing", GENOME RESEARCH, vol. 13, October 2003 (2003-10-01), pages 2333 - 2340, XP002292586 *

Also Published As

Publication number Publication date
AU2003300394A8 (en) 2004-07-22
AU2003300394A1 (en) 2004-07-22
WO2004058948A2 (en) 2004-07-15

Similar Documents

Publication Publication Date Title
AU2002352799A1 (en) Methods for evaluating drug-resistance gene expression in the cancer patient
WO2003072125A8 (en) Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides
EP1587837A3 (en) Prostate cancer diagnosis and treatment
ZA200709780B (en) Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues
AU2003235470A1 (en) Predictive markers in cancer therapy
AU2003226676A1 (en) Methods and compositions for the identification, assessment, and therapy of small cell lung cancer
AU2003220387A8 (en) Gene amplification in cancer
AU2003233179A1 (en) Nebulizer chamber with vertical exit and anti-spill system
AU2002342053A1 (en) Pancreatic cancer diagnosis and therapies
WO2001024684A3 (en) Methods for treatment of solid tumors and metastasis by gene therapy
AU2003282538A1 (en) Gene regulation with aptamer and modulator complexes for gene therapy
WO2004058948A3 (en) In vivo methods for validating the role of a tumor maintenance gene
MXPA03007036A (en) Method of cancer therapy.
AU2003284880A1 (en) Evaluation of breast cancer states and outcomes using gene expression profiles
AU2003256280A1 (en) Methods of delivering gene therapy agents
AU2002329534A1 (en) Modulation of antibody formation in mammals, applicability in gene therapy and animal model generation
AU2003295902A1 (en) Methods of therapy and diagnosis using targeting of cells that express p2y10
WO2004098510A3 (en) Cystic fibrosis therapy
AU2003283339A1 (en) Cancer therapy determination
WO2005003297A3 (en) Mptens as modifiers of the pten/igf pathway and methods of use
ZA200407358B (en) Microorganism for genetic therapeutic treatment ofproliferative diseases.
AU2003238722A8 (en) Cancer therapy by modulating cdc42-activity
AU2002953516A0 (en) Genetic therapy and genetic modification
AU2003267475A1 (en) Tumor targeting agents and uses thereof
AU2002365914A1 (en) Diagnostic and therapeutic methods using the h37 tumor suppressor gene

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP