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WO2004056867A3 - Ion channel for testing pharmacological active compounds - Google Patents

Ion channel for testing pharmacological active compounds Download PDF

Info

Publication number
WO2004056867A3
WO2004056867A3 PCT/GB2003/005502 GB0305502W WO2004056867A3 WO 2004056867 A3 WO2004056867 A3 WO 2004056867A3 GB 0305502 W GB0305502 W GB 0305502W WO 2004056867 A3 WO2004056867 A3 WO 2004056867A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion channel
active compounds
pharmacological active
ligand
testing pharmacological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/005502
Other languages
French (fr)
Other versions
WO2004056867A2 (en
Inventor
Lucia Sivilotti
Paul Groot-Kormelink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College London filed Critical University College London
Priority to AU2003295126A priority Critical patent/AU2003295126A1/en
Publication of WO2004056867A2 publication Critical patent/WO2004056867A2/en
Publication of WO2004056867A3 publication Critical patent/WO2004056867A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to ligand-gated ion channels in the nicotinic superfamily and methods for constraining their subunit composition. This invention provides a polypeptide chain comprising four or five of the subunits of a ligand-gated ion channel. This polypeptide chain is able to form a functional ligand-gated ion channel in combination with another subunit or on its own respectively.
PCT/GB2003/005502 2002-12-19 2003-12-18 Ion channel for testing pharmacological active compounds Ceased WO2004056867A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003295126A AU2003295126A1 (en) 2002-12-19 2003-12-18 Ion channel for testing pharmacological active compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0229586A GB0229586D0 (en) 2002-12-19 2002-12-19 Novel tool for testing pharmacological actives
GB0229586.3 2002-12-19

Publications (2)

Publication Number Publication Date
WO2004056867A2 WO2004056867A2 (en) 2004-07-08
WO2004056867A3 true WO2004056867A3 (en) 2004-09-23

Family

ID=9949988

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/005502 Ceased WO2004056867A2 (en) 2002-12-19 2003-12-18 Ion channel for testing pharmacological active compounds

Country Status (3)

Country Link
AU (1) AU2003295126A1 (en)
GB (1) GB0229586D0 (en)
WO (1) WO2004056867A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021502101A (en) * 2017-11-10 2021-01-28 ハワード ヒューズ メディカル インスティチュート Modified Ligand-Gated Ion Channels and Methods of Use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BAUMANN SABINE W ET AL: "Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 48, 29 November 2002 (2002-11-29), pages 46020 - 46025, XP002279648, ISSN: 0021-9258 *
BAUMANN SABINE W ET AL: "Subunit arrangement of gamma-aminobutyric acid type A receptors", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 39, 28 September 2001 (2001-09-28), pages 36275 - 36280, XP002279649, ISSN: 0021-9258 *
BROADBENT S ET AL.: "Human recombinant neuronal nicotinic receptors: expression of tandem subunit constructs", JOURNAL OF PHYSIOLOGY, vol. 547P, 2003, pages 13P, XP002279647 *
GROOT-KORMELINK PAUL J ET AL: "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: A reporter mutation approach", BRITISH JOURNAL OF PHARMACOLOGY, vol. 134, no. 4, October 2001 (2001-10-01), pages 789 - 796, XP002279650, ISSN: 0007-1188 *
PRYBYLOWSKI K. ET AL.: "Tandem Proteins to study NMDA receptor stoichiometry", SOCIETY FOR NEUROSCIENCE, vol. 25, 1999, pages 1487, XP002279651 *

Also Published As

Publication number Publication date
WO2004056867A2 (en) 2004-07-08
AU2003295126A8 (en) 2004-07-14
AU2003295126A1 (en) 2004-07-14
GB0229586D0 (en) 2003-01-22

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