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WO2004046366A3 - Verfahren zur mikrobiellen herstellung von stoffwechselprodukten - Google Patents

Verfahren zur mikrobiellen herstellung von stoffwechselprodukten Download PDF

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Publication number
WO2004046366A3
WO2004046366A3 PCT/DE2003/003826 DE0303826W WO2004046366A3 WO 2004046366 A3 WO2004046366 A3 WO 2004046366A3 DE 0303826 W DE0303826 W DE 0303826W WO 2004046366 A3 WO2004046366 A3 WO 2004046366A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolites
producing metabolites
microbial
way
ctaf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2003/003826
Other languages
English (en)
French (fr)
Other versions
WO2004046366A2 (de
Inventor
Axel Niebisch
Michael Bott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich GmbH filed Critical Forschungszentrum Juelich GmbH
Publication of WO2004046366A2 publication Critical patent/WO2004046366A2/de
Publication of WO2004046366A3 publication Critical patent/WO2004046366A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur mikrobiellen Herstellung von Stoffwechselprodukten. Durch das erfindungsgemässe Verfahren ist es nunmehr möglich, die Synthese von ATP gezielt zu beeinflussen und damit auch die Synthese von Stoffwechselprodukten zu steuern. Die Erfindung betrifft ein für Cytochrom aa3 Oxidase kodierendes Gen ctaF aus Corynebacterium glutamicum. Das ctaF Gen kodiert für ein Protein, welches die Funktion einer vierten Untereinheit der Cytochrom aa3 Oxidase aufweist.
PCT/DE2003/003826 2002-11-19 2003-11-19 Verfahren zur mikrobiellen herstellung von stoffwechselprodukten Ceased WO2004046366A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10254074A DE10254074A1 (de) 2002-11-19 2002-11-19 Verfahren zur mikrobiellen Herstellung von Stoffwechselprodukten
DE10254074.8 2002-11-19

Publications (2)

Publication Number Publication Date
WO2004046366A2 WO2004046366A2 (de) 2004-06-03
WO2004046366A3 true WO2004046366A3 (de) 2004-08-19

Family

ID=32318563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/003826 Ceased WO2004046366A2 (de) 2002-11-19 2003-11-19 Verfahren zur mikrobiellen herstellung von stoffwechselprodukten

Country Status (2)

Country Link
DE (1) DE10254074A1 (de)
WO (1) WO2004046366A2 (de)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038969A2 (de) * 1999-03-19 2000-09-27 Degussa-Hüls Aktiengesellschaft Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
EP1108790A2 (de) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Neue Polynukleotide
EP1170376A1 (de) * 2000-07-05 2002-01-09 Ajinomoto Co., Inc. Verfahren zur Herstellung von Substanzen unter Verwendung von Mikroorganismen
WO2002022799A2 (de) * 2000-09-14 2002-03-21 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen herstellung von stoffwechselprodukten, polynukleotide aus coryneformen bakterien sowie deren verwendung
EP1195433A2 (de) * 2000-09-06 2002-04-10 Ajinomoto Co., Inc. Atmungskette Enzymgene aus Coryneformbakterien

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038969A2 (de) * 1999-03-19 2000-09-27 Degussa-Hüls Aktiengesellschaft Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
EP1108790A2 (de) * 1999-12-16 2001-06-20 Kyowa Hakko Kogyo Co., Ltd. Neue Polynukleotide
EP1170376A1 (de) * 2000-07-05 2002-01-09 Ajinomoto Co., Inc. Verfahren zur Herstellung von Substanzen unter Verwendung von Mikroorganismen
EP1195433A2 (de) * 2000-09-06 2002-04-10 Ajinomoto Co., Inc. Atmungskette Enzymgene aus Coryneformbakterien
WO2002022799A2 (de) * 2000-09-14 2002-03-21 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen herstellung von stoffwechselprodukten, polynukleotide aus coryneformen bakterien sowie deren verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NIEBISCH AXEL ET AL: "Purification of a cytochrome bc-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 7 FEB 2003, vol. 278, no. 6, 7 February 2003 (2003-02-07), pages 4339 - 4346, XP002283681, ISSN: 0021-9258 *
SARASTE M ET AL: "THE BACILLUS-SUBTILIS CYTOCHROME-C OXIDASE VARIATIONS ON A CONSERVED PROTEIN THEME", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 195, no. 2, 1991, pages 517 - 526, XP008031335, ISSN: 0014-2956 *
WITT H ET AL: "Isolation, analysis, and deletion of the gene coding for subunit IV of cytochrome c oxidase in Paracoccus denitrificans.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 28 FEB 1997, vol. 272, no. 9, 28 February 1997 (1997-02-28), pages 5514 - 5517, XP002284314, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
DE10254074A1 (de) 2004-06-17
WO2004046366A2 (de) 2004-06-03

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