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WO2003102209A3 - Alternatively spliced isoforms of human hmg co-a reductase - Google Patents

Alternatively spliced isoforms of human hmg co-a reductase Download PDF

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Publication number
WO2003102209A3
WO2003102209A3 PCT/US2003/016337 US0316337W WO03102209A3 WO 2003102209 A3 WO2003102209 A3 WO 2003102209A3 US 0316337 W US0316337 W US 0316337W WO 03102209 A3 WO03102209 A3 WO 03102209A3
Authority
WO
WIPO (PCT)
Prior art keywords
seq
hmgcrsv4
hmgcrsv3
hmgcrsv2
hmgcrsv1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/016337
Other languages
French (fr)
Other versions
WO2003102209A2 (en
Inventor
Jason M Johnson
Christopher D Armour
John C Castle
Philip W Garrett-Engele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosetta Inpharmatics LLC
Original Assignee
Rosetta Inpharmatics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Inpharmatics LLC filed Critical Rosetta Inpharmatics LLC
Publication of WO2003102209A2 publication Critical patent/WO2003102209A2/en
Publication of WO2003102209A3 publication Critical patent/WO2003102209A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). The polynucleotide sequences of HMGCRsv1, HMGCRsv2, HMGCRsv3, and HMGCRsv4 are provided by SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5, and SEQ ID NO 7, respectively. The amino acid sequences for HMGCRsv1, HMGCRsv2, HMGCRsv3, and HMGCRsv4 are provided by SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 6, and SEQ ID NO 8, respectively. The present invention also provides methods for using HMGCRsv1, HMGCRsv2, HMGCRsv3, and HMGCRsv4 polynucleotides and proteins to screen for compounds that bind respectively to HMGCRsv1, HMGCRsv2, HMGCRsv3, and HMGCRsv4.
PCT/US2003/016337 2002-05-30 2003-05-23 Alternatively spliced isoforms of human hmg co-a reductase Ceased WO2003102209A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38518802P 2002-05-30 2002-05-30
US60/385,188 2002-05-30
US40715502P 2002-08-29 2002-08-29
US60/407,155 2002-08-29

Publications (2)

Publication Number Publication Date
WO2003102209A2 WO2003102209A2 (en) 2003-12-11
WO2003102209A3 true WO2003102209A3 (en) 2004-11-04

Family

ID=29715360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/016337 Ceased WO2003102209A2 (en) 2002-05-30 2003-05-23 Alternatively spliced isoforms of human hmg co-a reductase

Country Status (1)

Country Link
WO (1) WO2003102209A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8084209B2 (en) 2005-07-22 2011-12-27 Children's Hospital & Research Center Oakland HMGCR isoforms in prediction of efficacy and identification of cholesterol-modulating compounds
CN108220375A (en) * 2018-02-10 2018-06-29 海盐县凌特生物科技有限公司 The hypolipemic function peptide prepared using silkworm chrysalis as raw material

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BASSON M.E. ET AL: "Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis", MOLECULAR AND CELLULAR BIOLOGY, vol. 8, no. 9, September 1988 (1988-09-01), pages 3797 - 3808, XP002981008 *
DATABASE GENBANK [online] 9 July 2002 (2002-07-09), STRAUSBERG R.L. ET AL: "Homo sapiens 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, mRNA (cDNA clone MGC:45281 IMAGE:5212903), complete cds.", XP002981006, Database accession no. BC033692 *
LUSKEY K.L. AND STEVENS B.: "Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 18, 25 August 1985 (1985-08-25), pages 10271 - 10277, XP002981007 *

Also Published As

Publication number Publication date
WO2003102209A2 (en) 2003-12-11

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